HUE042490T2 - 1-es és 3-as aminosav-pozícióban módosított ciklosporin analóg molekulák - Google Patents
1-es és 3-as aminosav-pozícióban módosított ciklosporin analóg molekulákInfo
- Publication number
- HUE042490T2 HUE042490T2 HUE11848865A HUE11848865A HUE042490T2 HU E042490 T2 HUE042490 T2 HU E042490T2 HU E11848865 A HUE11848865 A HU E11848865A HU E11848865 A HUE11848865 A HU E11848865A HU E042490 T2 HUE042490 T2 HU E042490T2
- Authority
- HU
- Hungary
- Prior art keywords
- amino acid
- molecules modified
- analogue molecules
- cyclosporine analogue
- cyclosporine
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Biochemistry (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Transplantation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42357610P | 2010-12-15 | 2010-12-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE042490T2 true HUE042490T2 (hu) | 2019-07-29 |
Family
ID=46243924
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE11848865A HUE042490T2 (hu) | 2010-12-15 | 2011-12-14 | 1-es és 3-as aminosav-pozícióban módosított ciklosporin analóg molekulák |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US9200038B2 (hu) |
| EP (2) | EP2651965B1 (hu) |
| JP (3) | JP6144627B2 (hu) |
| KR (3) | KR102305423B1 (hu) |
| CN (2) | CN103443119B (hu) |
| AU (1) | AU2011342284C1 (hu) |
| BR (1) | BR112013014890B1 (hu) |
| CA (1) | CA2821009C (hu) |
| DK (1) | DK2651965T3 (hu) |
| ES (1) | ES2705750T3 (hu) |
| HK (1) | HK1243633A1 (hu) |
| HR (1) | HRP20190096T1 (hu) |
| HU (1) | HUE042490T2 (hu) |
| IL (1) | IL226792A (hu) |
| LT (1) | LT2651965T (hu) |
| MX (1) | MX353720B (hu) |
| MY (2) | MY165152A (hu) |
| NZ (1) | NZ611620A (hu) |
| PL (1) | PL2651965T3 (hu) |
| PT (1) | PT2651965T (hu) |
| RU (1) | RU2630690C9 (hu) |
| SG (2) | SG10201510236XA (hu) |
| SI (1) | SI2651965T1 (hu) |
| TR (1) | TR201900128T4 (hu) |
| WO (1) | WO2012079172A1 (hu) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9890198B2 (en) | 2010-12-03 | 2018-02-13 | S&T Global Inc. | Cyclosporin derivatives and uses thereof |
| JP6144627B2 (ja) * | 2010-12-15 | 2017-06-07 | コントラヴィア ファーマシューティカルズ、インク． | アミノ酸１および３で修飾されたシクロスポリン類似体分子 |
| CN104487449A (zh) * | 2012-06-01 | 2015-04-01 | 阿勒根公司 | 环孢菌素a类似物 |
| EP2961767B1 (en) * | 2013-03-01 | 2018-09-26 | UCL Business PLC | Non-immunosuppressive cyclosporin derivatives as antiviral agents |
| EP3038626A4 (en) * | 2013-08-26 | 2017-04-19 | Enanta Pharmaceuticals, Inc. | Cyclosporin analogues for preventing or treating hepatitis c |
| WO2016112321A1 (en) | 2015-01-08 | 2016-07-14 | Allergan, Inc. | Cyclosporin derivatives wherein the mebmt sidechain has been cyclized |
| EP3458470A4 (en) * | 2016-05-17 | 2020-04-22 | S&T Global Inc. | NEW CYCLOSPOR DERIVATIVES AND USES THEREOF |
| US20180193003A1 (en) | 2016-12-07 | 2018-07-12 | Progenity Inc. | Gastrointestinal tract detection methods, devices and systems |
| WO2018106928A1 (en) | 2016-12-08 | 2018-06-14 | Contravir Pharmaceuticals, Inc. | Treatment and prevention of hbv diseases by cyclosporine analogue molecules modified at amino acides 1 and 3 |
| AU2017378406A1 (en) | 2016-12-14 | 2019-06-13 | Biora Therapeutics, Inc. | Treatment of a disease of the gastrointestinal tract with an immunosuppressant |
| US20180296588A1 (en) | 2017-04-14 | 2018-10-18 | Contravir Pharmaceuticals, Inc. | Combination therapy for treating viral infections |
| WO2018193114A1 (en) | 2017-04-20 | 2018-10-25 | Novintum Biotechnology Gmbh | Triphenylphosphonium-tethered tetracycyclines for use in treating cancer |
| US20230041197A1 (en) | 2018-06-20 | 2023-02-09 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an immunomodulator |
| EP3840769A4 (en) * | 2018-08-22 | 2022-06-22 | Bacainn Biotherapeutics, Ltd. | CYCLOSPORINE COMPOSITIONS AND METHODS OF USE |
| BR112022016960A2 (pt) * | 2020-02-25 | 2022-10-25 | Hepion Pharmaceuticals Inc | Uso de análogos de ciclosporina para tratamento de câncer |
| CN115315432A (zh) * | 2020-03-26 | 2022-11-08 | 睿诺医疗科技（上海）有限公司 | 亲环蛋白抑制剂及其用途 |
| CA3199530A1 (en) * | 2020-11-29 | 2022-06-02 | Hepion Pharmaceuticals, Inc. | Use of cyclosporine analogues as antithrombotic agents |
| CN113173974A (zh) | 2021-03-18 | 2021-07-27 | 北京大学深圳研究生院 | 环孢素衍生物的合成方法 |
| CN115677533B (zh) * | 2021-07-30 | 2023-12-05 | 沈阳化工研究院有限公司 | 一种4-庚基苯甲腈的制备方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US4210581A (en) | 1975-11-04 | 1980-07-01 | Sandoz Ltd. | Organic compounds |
| CH614931A5 (hu) | 1975-11-04 | 1979-12-28 | Sandoz Ag | |
| US4256108A (en) | 1977-04-07 | 1981-03-17 | Alza Corporation | Microporous-semipermeable laminated osmotic system |
| US4160452A (en) | 1977-04-07 | 1979-07-10 | Alza Corporation | Osmotic system having laminated wall comprising semipermeable lamina and microporous lamina |
| DE2819094A1 (de) | 1977-05-10 | 1978-11-23 | Sandoz Ag | Cyclosporin-derivate, ihre verwendung und herstellung |
| SE448386B (sv) | 1978-10-18 | 1987-02-16 | Sandoz Ag | Nya cyklosporinderivat, forfarande for framstellning av dem samt farmaceutisk komposition innehallande dem |
| US4396542A (en) | 1980-02-14 | 1983-08-02 | Sandoz Ltd. | Method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production |
| EP0034567B1 (en) | 1980-02-14 | 1984-11-07 | Sandoz Ag | A method for the total synthesis of cyclosporins and novel cyclosporins |
| US4265874A (en) | 1980-04-25 | 1981-05-05 | Alza Corporation | Method of delivering drug with aid of effervescent activity generated in environment of use |
| US4384996A (en) | 1981-01-09 | 1983-05-24 | Sandoz Ltd. | Novel cyclosporins |
| CH667274A5 (de) | 1984-03-23 | 1988-09-30 | Sandoz Ag | Cyclosporine, ihre herstellung und diese enthaltende pharmazeutische zusammensetzungen. |
| JPS6182786A (ja) | 1984-09-28 | 1986-04-26 | ブラザー工業株式会社 | ミシン |
| EP0194972B1 (en) | 1985-03-11 | 1992-07-29 | Sandoz Ag | Novel cyclosporins |
| US4764503A (en) | 1986-11-19 | 1988-08-16 | Sandoz Ltd. | Novel cyclosporins |
| US4798823A (en) | 1987-06-03 | 1989-01-17 | Merck & Co., Inc. | New cyclosporin analogs with modified "C-9 amino acids" |
| US4885276A (en) | 1987-06-03 | 1989-12-05 | Merck & Co., Inc. | Cyclosporin analogs with modified "C-9 amino acids" |
| ES2059558T3 (es) | 1987-06-17 | 1994-11-16 | Sandoz Ag | Ciclosporins y su uso como productos farmaceuticos. |
| DE3851268T2 (de) | 1987-06-19 | 1995-01-26 | Sandoz Ag | Zyklische Peptolide. |
| DE3888357T2 (de) | 1987-06-22 | 1994-09-15 | Merck & Co Inc | Cyclosporin-Derivate, die eine modifizierte Aminosäure auf Stellung 8 tragen. |
| GB8717300D0 (en) | 1987-07-22 | 1987-08-26 | Nat Res Dev | Cyclosporins |
| US5227467A (en) | 1987-08-03 | 1993-07-13 | Merck & Co., Inc. | Immunosuppressive fluorinated cyclosporin analogs |
| US4914188A (en) | 1987-11-16 | 1990-04-03 | Merck & Co., Inc. | Novel 6-position cyclosporin analogs as non-immunosuppressive antagonists of cyclosporin binding to cyclophilin |
| US5236899A (en) | 1987-11-16 | 1993-08-17 | Merck & Co., Inc. | 6-position cyclosporin a analogs as modifiers of cytotoxic drug resistance |
| US5604092A (en) | 1988-12-05 | 1997-02-18 | The Trustees Of Columbia University In The City Of New York | Method for the detection of HIV-1 using a cyclosporine-specific monoclonal antibody that reacts with the P24 Gag protein |
| AU4958590A (en) | 1988-12-05 | 1990-07-10 | Trustees Of Columbia University In The City Of New York, The | Novel derivatives of cyclosporine a, antibodies directed thereto and uses thereof |
| US5284826A (en) | 1989-07-24 | 1994-02-08 | Sandoz Ltd. | 0-hydroxyethyl and acyloxyethyl derivatives of [ser]8 cyclosporins |
| US5214130A (en) | 1990-02-27 | 1993-05-25 | Merck & Co., Inc. | Synthesis of novel immunosuppressive cyclosporin analogs with modified amino acids at position-8 |
| US5122511A (en) | 1990-02-27 | 1992-06-16 | Merck & Co., Inc. | Immunosuppressive cyclosporin analogs with modified amino acids at position-8 |
| DK0484281T4 (da) | 1990-11-02 | 2001-02-05 | Novartis Ag | Cyclosporiner |
| GB9204466D0 (en) | 1992-03-02 | 1992-04-15 | Sandoz Ltd | Improvements in or relating to organic compounds |
| WO1997011092A1 (fr) | 1994-04-07 | 1997-03-27 | Nippon Shinyaku Co., Ltd. | Derives de phosphates de cyclosporine et composition medicinale |
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