MX2007007262A - Metabolitos de analogos de ciclosporina. - Google Patents
Metabolitos de analogos de ciclosporina.Info
- Publication number
- MX2007007262A MX2007007262A MX2007007262A MX2007007262A MX2007007262A MX 2007007262 A MX2007007262 A MX 2007007262A MX 2007007262 A MX2007007262 A MX 2007007262A MX 2007007262 A MX2007007262 A MX 2007007262A MX 2007007262 A MX2007007262 A MX 2007007262A
- Authority
- MX
- Mexico
- Prior art keywords
- metabolites
- isa247
- methods
- formation
- synthetic methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
Abstract
Se describen los metabolitos aislados del analogo de ciclosporina ISA247, incluyendo los metodos in vitro para su preparacion. Los metabolitos comprenden una modificacion quimica de ISA247, en donde la modificacion es al menos una reaccion seleccionada del grupo que consiste de hidroxilacion, N-desmetilacion, formacion de diol, formacion de epoxido, y fosforilacion por ciclizacion intramolecular, sulfatacion, formacion de glucuronido y glucosilacion. Los metodos de preparacion incluyen los metodos semi-sinteticos, en donde los metabolitos de ISA247 son producidos a traves de los extractos microsomales de celulas hepaticas de animal, o de cultivos utilizando microorganismos, y metodos completamente sinteticos, tales como la modificacion quimica del compuesto progenitor o los metabolismos aislados utilizando metodos sinteticos organicos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US63739204P | 2004-12-17 | 2004-12-17 | |
PCT/CA2005/001926 WO2006063470A1 (en) | 2004-12-17 | 2005-12-19 | Metabolites of cyclosporin analogs |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2007007262A true MX2007007262A (es) | 2007-10-19 |
Family
ID=36587506
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2007007262A MX2007007262A (es) | 2004-12-17 | 2005-12-19 | Metabolitos de analogos de ciclosporina. |
Country Status (14)
Country | Link |
---|---|
US (1) | US20060223743A1 (es) |
EP (1) | EP1828229A4 (es) |
JP (1) | JP2008524122A (es) |
KR (1) | KR20070100284A (es) |
CN (1) | CN101120012A (es) |
AU (1) | AU2005316095A1 (es) |
BR (1) | BRPI0517207A (es) |
CA (1) | CA2592343A1 (es) |
IL (1) | IL183908A0 (es) |
MX (1) | MX2007007262A (es) |
TN (1) | TNSN07225A1 (es) |
TW (1) | TW200635954A (es) |
WO (1) | WO2006063470A1 (es) |
ZA (1) | ZA200705475B (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7696165B2 (en) | 2006-03-28 | 2010-04-13 | Albany Molecular Research, Inc. | Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders |
US7696166B2 (en) | 2006-03-28 | 2010-04-13 | Albany Molecular Research, Inc. | Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders |
AU2007271088A1 (en) * | 2006-07-06 | 2008-01-10 | Ares Trading S.A. | An oral pharmaceutical composition of an anilinopyrimidine, its preparation and use thereof |
US20100094560A1 (en) * | 2006-08-15 | 2010-04-15 | Prometheus Laboratories Inc. | Methods for diagnosing irritable bowel syndrome |
EP2151450A1 (de) * | 2008-07-29 | 2010-02-10 | Sandoz AG | Verfahren zur Aufarbeitung von mikrobiologisch hergestellten zyklischen Oligopeptiden |
US20130190223A1 (en) * | 2008-07-30 | 2013-07-25 | Isotechnika Pharma Inc. | Nonimmunosuppressive cyclosporine analogue molecules |
RU2012126681A (ru) * | 2009-06-02 | 2014-01-10 | НИКАН ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи | Антагонизм рецептора формил-пептида человека для лечения заболеваний |
MX353720B (es) * | 2010-12-15 | 2018-01-25 | Contravir Pharmaceuticals Inc | Moleculas analogas de ciclosporina modificadas en el aminoacido 1 y 3. |
AR090964A1 (es) * | 2012-05-09 | 2014-12-17 | Novartis Ag | Proceso para la elaboracion de undecapeptidos ciclicos |
AR111963A1 (es) * | 2017-05-26 | 2019-09-04 | Univ California | Método y moléculas |
WO2019196953A1 (en) * | 2018-04-13 | 2019-10-17 | National Institute Of Biological Sciences, Beijing | Ntcp inhibitors |
CN110174363A (zh) * | 2019-01-09 | 2019-08-27 | 北京九强生物技术股份有限公司 | 6-磷酸葡萄糖脱氢酶突变体及其在制备检测试剂中的用途 |
CN113388002A (zh) * | 2021-06-10 | 2021-09-14 | 梯尔希(南京)药物研发有限公司 | 一种环孢菌素相关化合物的制备方法 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE95193T1 (de) * | 1987-06-17 | 1993-10-15 | Sandoz Ag | Cyclosporine und deren benutzung als arzneimittel. |
US5202310A (en) * | 1990-06-06 | 1993-04-13 | Levy Gary A | Cyclosporine metabolites |
US5834266A (en) * | 1993-02-12 | 1998-11-10 | President & Fellows Of Harvard College | Regulated apoptosis |
US5716928A (en) * | 1995-06-07 | 1998-02-10 | Avmax, Inc. | Use of essential oils to increase bioavailability of oral pharmaceutical compounds |
ATE423130T1 (de) * | 1997-10-08 | 2009-03-15 | Isotechnika Inc | Deuterierte cyclosporin-analoga und ihre verwendung als immunmodulierende agenzien |
US6784156B2 (en) * | 2001-03-05 | 2004-08-31 | Enanta Pharmaceuticals, Inc. | Cyclosporins for the treatment of respiratory diseases |
DK1714977T3 (da) * | 2001-10-19 | 2009-07-06 | Isotechnika Inc | Syntese af cyclosporinanaloger |
PL210697B1 (pl) * | 2001-10-19 | 2012-02-29 | Isotechnika Inc | Kompozycja zawierająca mieszaninę izomerów analogu cyklosporyny i zastosowanie tej mieszaniny |
US20040110666A1 (en) * | 2002-12-04 | 2004-06-10 | Or Yat Sun | Cyclosporins for the treatment of immune disorders |
US7012065B2 (en) * | 2003-02-07 | 2006-03-14 | Enanta Pharmaceuticals, Inc. | Cyclosporins for the treatment of immune disorders |
CA2518265A1 (en) * | 2003-03-17 | 2004-09-30 | Albany Molecular Research, Inc. | Novel cyclosporins |
US20040266669A1 (en) * | 2003-06-20 | 2004-12-30 | Wu Frank X. H. | Cyclosporin derivatives for the treatment of immune disorders |
-
2005
- 2005-12-19 MX MX2007007262A patent/MX2007007262A/es not_active Application Discontinuation
- 2005-12-19 AU AU2005316095A patent/AU2005316095A1/en not_active Abandoned
- 2005-12-19 KR KR1020077015724A patent/KR20070100284A/ko not_active Application Discontinuation
- 2005-12-19 CN CNA2005800481960A patent/CN101120012A/zh active Pending
- 2005-12-19 JP JP2007545805A patent/JP2008524122A/ja not_active Withdrawn
- 2005-12-19 BR BRPI0517207-1A patent/BRPI0517207A/pt not_active IP Right Cessation
- 2005-12-19 EP EP05825030A patent/EP1828229A4/en not_active Withdrawn
- 2005-12-19 US US11/313,239 patent/US20060223743A1/en not_active Abandoned
- 2005-12-19 CA CA002592343A patent/CA2592343A1/en not_active Abandoned
- 2005-12-19 WO PCT/CA2005/001926 patent/WO2006063470A1/en active Application Filing
- 2005-12-19 TW TW094144998A patent/TW200635954A/zh unknown
-
2007
- 2007-06-13 IL IL183908A patent/IL183908A0/en unknown
- 2007-06-14 TN TNP2007000225A patent/TNSN07225A1/fr unknown
- 2007-07-04 ZA ZA200705475A patent/ZA200705475B/en unknown
Also Published As
Publication number | Publication date |
---|---|
WO2006063470B1 (en) | 2006-08-03 |
BRPI0517207A (pt) | 2008-09-30 |
CA2592343A1 (en) | 2006-06-22 |
IL183908A0 (en) | 2007-10-31 |
WO2006063470A1 (en) | 2006-06-22 |
TW200635954A (en) | 2006-10-16 |
CN101120012A (zh) | 2008-02-06 |
JP2008524122A (ja) | 2008-07-10 |
AU2005316095A1 (en) | 2006-06-22 |
US20060223743A1 (en) | 2006-10-05 |
EP1828229A1 (en) | 2007-09-05 |
ZA200705475B (en) | 2008-07-30 |
EP1828229A4 (en) | 2010-06-30 |
KR20070100284A (ko) | 2007-10-10 |
TNSN07225A1 (en) | 2008-11-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |