CN103443119B - 在氨基酸1和3位修改的环孢菌素类似分子 - Google Patents
在氨基酸1和3位修改的环孢菌素类似分子 Download PDFInfo
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- CN103443119B CN103443119B CN201180067449.4A CN201180067449A CN103443119B CN 103443119 B CN103443119 B CN 103443119B CN 201180067449 A CN201180067449 A CN 201180067449A CN 103443119 B CN103443119 B CN 103443119B
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
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- A—HUMAN NECESSITIES
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- Organic Chemistry (AREA)
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Abstract
Description
Claims (21)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201710804889.2A CN107496902B (zh) | 2010-12-15 | 2011-12-14 | 在氨基酸1和3位修改的环孢菌素类似分子 |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US42357610P | 2010-12-15 | 2010-12-15 | |
US61/423,576 | 2010-12-15 | ||
PCT/CA2011/050773 WO2012079172A1 (en) | 2010-12-15 | 2011-12-14 | Cyclosporine analogue molecules modified at amino acid 1 and 3 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201710804889.2A Division CN107496902B (zh) | 2010-12-15 | 2011-12-14 | 在氨基酸1和3位修改的环孢菌素类似分子 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN103443119A CN103443119A (zh) | 2013-12-11 |
CN103443119B true CN103443119B (zh) | 2017-09-22 |
Family
ID=46243924
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201710804889.2A Active CN107496902B (zh) | 2010-12-15 | 2011-12-14 | 在氨基酸1和3位修改的环孢菌素类似分子 |
CN201180067449.4A Active CN103443119B (zh) | 2010-12-15 | 2011-12-14 | 在氨基酸1和3位修改的环孢菌素类似分子 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201710804889.2A Active CN107496902B (zh) | 2010-12-15 | 2011-12-14 | 在氨基酸1和3位修改的环孢菌素类似分子 |
Country Status (25)
Country | Link |
---|---|
US (2) | US9200038B2 (zh) |
EP (2) | EP2651965B1 (zh) |
JP (3) | JP6144627B2 (zh) |
KR (3) | KR102305423B1 (zh) |
CN (2) | CN107496902B (zh) |
AU (1) | AU2011342284C1 (zh) |
BR (1) | BR112013014890B1 (zh) |
CA (1) | CA2821009C (zh) |
DK (1) | DK2651965T3 (zh) |
ES (1) | ES2705750T3 (zh) |
HK (1) | HK1243633A1 (zh) |
HR (1) | HRP20190096T1 (zh) |
HU (1) | HUE042490T2 (zh) |
IL (1) | IL226792A (zh) |
LT (1) | LT2651965T (zh) |
MX (1) | MX353720B (zh) |
MY (2) | MY165152A (zh) |
NZ (1) | NZ611620A (zh) |
PL (1) | PL2651965T3 (zh) |
PT (1) | PT2651965T (zh) |
RU (1) | RU2630690C9 (zh) |
SG (2) | SG191069A1 (zh) |
SI (1) | SI2651965T1 (zh) |
TR (1) | TR201900128T4 (zh) |
WO (1) | WO2012079172A1 (zh) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9890198B2 (en) | 2010-12-03 | 2018-02-13 | S&T Global Inc. | Cyclosporin derivatives and uses thereof |
SG191069A1 (en) * | 2010-12-15 | 2013-07-31 | Isotechnika Pharma Inc | Cyclosporine analogue molecules modified at amino acid 1 and 3 |
EP2855508B1 (en) | 2012-06-01 | 2018-02-14 | Allergan, Inc. | Cyclosporin a analogs |
US20160002299A1 (en) * | 2013-03-01 | 2016-01-07 | Ucl Business Plc | Non-immunosuppressive cyclosporin derivatives as antiviral agents |
AU2014311346A1 (en) * | 2013-08-26 | 2016-03-17 | Enanta Pharmaceuticals, Inc. | Cyclosporin analogues for preventing or treating hepatitis C |
WO2016112321A1 (en) | 2015-01-08 | 2016-07-14 | Allergan, Inc. | Cyclosporin derivatives wherein the mebmt sidechain has been cyclized |
CN109476705B (zh) * | 2016-05-17 | 2024-02-27 | 美国科技环球有限公司 | 新型环孢菌素衍生物及其用途 |
AU2017370942A1 (en) | 2016-12-07 | 2019-06-13 | Progenity Inc. | Gastrointestinal tract detection methods, devices and systems |
WO2018106928A1 (en) | 2016-12-08 | 2018-06-14 | Contravir Pharmaceuticals, Inc. | Treatment and prevention of hbv diseases by cyclosporine analogue molecules modified at amino acides 1 and 3 |
JP2020513280A (ja) | 2016-12-14 | 2020-05-14 | プロジェニティ, インコーポレイテッド | 消化管疾病の免疫抑制剤による治療 |
TW201902507A (zh) | 2017-04-14 | 2019-01-16 | 美商康特維爾製藥公司 | 治療病毒感染之組合療法 |
EP3612540A1 (en) | 2017-04-20 | 2020-02-26 | Rising Tide Foundation | Triphenylphosphonium-tethered tetracycyclines for use in treating cancer |
US20230041197A1 (en) | 2018-06-20 | 2023-02-09 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an immunomodulator |
CA3110250A1 (en) | 2018-08-22 | 2020-02-27 | Bacainn Therapeutics, Ltd. | Cyclosporine compositions and methods of use |
IL295498A (en) * | 2020-02-25 | 2022-10-01 | Hepion Pharmaceuticals Inc | Use of cyclosporine analogs for cancer treatment |
CA3172689A1 (en) * | 2020-03-26 | 2021-09-30 | Ching-Pong Mak | Cyclophilin inhibitors and uses thereof |
CA3199530A1 (en) * | 2020-11-29 | 2022-06-02 | Hepion Pharmaceuticals, Inc. | Use of cyclosporine analogues as antithrombotic agents |
CN113173974A (zh) | 2021-03-18 | 2021-07-27 | 北京大学深圳研究生院 | 环孢素衍生物的合成方法 |
CN115677533B (zh) * | 2021-07-30 | 2023-12-05 | 沈阳化工研究院有限公司 | 一种4-庚基苯甲腈的制备方法 |
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US7696166B2 (en) * | 2006-03-28 | 2010-04-13 | Albany Molecular Research, Inc. | Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders |
WO2010138422A1 (en) * | 2009-05-27 | 2010-12-02 | Allergan, Inc. | Cyclosporin derivatives for enhancing the growth of hair |
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EP0296122B1 (en) | 1987-06-17 | 1993-09-29 | Sandoz Ag | Cyclosporins and their use as pharmaceuticals |
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