PL2651965T3 - Cząsteczki analogów cyklosporyny modyfikowane w aminokwasach 1 i 3 - Google Patents
Cząsteczki analogów cyklosporyny modyfikowane w aminokwasach 1 i 3Info
- Publication number
- PL2651965T3 PL2651965T3 PL11848865T PL11848865T PL2651965T3 PL 2651965 T3 PL2651965 T3 PL 2651965T3 PL 11848865 T PL11848865 T PL 11848865T PL 11848865 T PL11848865 T PL 11848865T PL 2651965 T3 PL2651965 T3 PL 2651965T3
- Authority
- PL
- Poland
- Prior art keywords
- amino acid
- molecules modified
- analogue molecules
- cyclosporine analogue
- cyclosporine
- Prior art date
Links
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical class CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title 1
- 150000001413 amino acids Chemical class 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P31/14—Antivirals for RNA viruses
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Transplantation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42357610P | 2010-12-15 | 2010-12-15 | |
| EP11848865.9A EP2651965B1 (en) | 2010-12-15 | 2011-12-14 | Cyclosporine analogue molecules modified at amino acid 1 and 3 |
| PCT/CA2011/050773 WO2012079172A1 (en) | 2010-12-15 | 2011-12-14 | Cyclosporine analogue molecules modified at amino acid 1 and 3 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2651965T3 true PL2651965T3 (pl) | 2019-04-30 |
Family
ID=46243924
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL11848865T PL2651965T3 (pl) | 2010-12-15 | 2011-12-14 | Cząsteczki analogów cyklosporyny modyfikowane w aminokwasach 1 i 3 |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US9200038B2 (pl) |
| EP (2) | EP3461835A1 (pl) |
| JP (3) | JP6144627B2 (pl) |
| KR (3) | KR102011339B1 (pl) |
| CN (2) | CN107496902B (pl) |
| AU (1) | AU2011342284C1 (pl) |
| BR (1) | BR112013014890B1 (pl) |
| CA (1) | CA2821009C (pl) |
| DK (1) | DK2651965T3 (pl) |
| ES (1) | ES2705750T3 (pl) |
| HR (1) | HRP20190096T1 (pl) |
| HU (1) | HUE042490T2 (pl) |
| IL (1) | IL226792A (pl) |
| LT (1) | LT2651965T (pl) |
| MX (1) | MX353720B (pl) |
| MY (2) | MY192981A (pl) |
| NZ (1) | NZ611620A (pl) |
| PH (1) | PH12013501213A1 (pl) |
| PL (1) | PL2651965T3 (pl) |
| PT (1) | PT2651965T (pl) |
| RU (1) | RU2630690C9 (pl) |
| SG (2) | SG10201510236XA (pl) |
| SI (1) | SI2651965T1 (pl) |
| TR (1) | TR201900128T4 (pl) |
| WO (1) | WO2012079172A1 (pl) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9890198B2 (en) | 2010-12-03 | 2018-02-13 | S&T Global Inc. | Cyclosporin derivatives and uses thereof |
| KR102011339B1 (ko) * | 2010-12-15 | 2019-08-16 | 콘트라빌 파마슈티컬스, 인코퍼레이티드 | 아미노산 1 및 3에서 변형된 사이클로스포린 유사체 분자 |
| CA2874548A1 (en) * | 2012-06-01 | 2013-12-05 | Allergan, Inc. | Cyclosporin a analogs |
| WO2014132084A1 (en) * | 2013-03-01 | 2014-09-04 | Ucl Business Plc | Non-immunosuppressive cyclosporin derivatives as antiviral agents |
| SG11201601274QA (en) * | 2013-08-26 | 2016-03-30 | Enanta Pharm Inc | Cyclosporin analogues for preventing or treating hepatitis c |
| WO2016112321A1 (en) | 2015-01-08 | 2016-07-14 | Allergan, Inc. | Cyclosporin derivatives wherein the mebmt sidechain has been cyclized |
| WO2017200984A1 (en) * | 2016-05-17 | 2017-11-23 | S&T Global Inc. | Novel cyclosporin derivatives and uses thereof |
| US10610104B2 (en) | 2016-12-07 | 2020-04-07 | Progenity, Inc. | Gastrointestinal tract detection methods, devices and systems |
| WO2018106928A1 (en) | 2016-12-08 | 2018-06-14 | Contravir Pharmaceuticals, Inc. | Treatment and prevention of hbv diseases by cyclosporine analogue molecules modified at amino acides 1 and 3 |
| CA3046023A1 (en) | 2016-12-14 | 2018-06-21 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an immunosuppressant |
| US20180296588A1 (en) | 2017-04-14 | 2018-10-18 | Contravir Pharmaceuticals, Inc. | Combination therapy for treating viral infections |
| EP3612540A1 (en) | 2017-04-20 | 2020-02-26 | Rising Tide Foundation | Triphenylphosphonium-tethered tetracycyclines for use in treating cancer |
| US20230041197A1 (en) | 2018-06-20 | 2023-02-09 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an immunomodulator |
| JP7482874B2 (ja) * | 2018-08-22 | 2024-05-14 | バカイン バイオセラピューティクス， リミテッド | シクロスポリン組成物および使用方法 |
| MX2022010201A (es) | 2020-02-19 | 2022-09-19 | Hepion Pharmaceuticals Inc | Uso de analogos de ciclosporina para el tratamiento de la fibrosis. |
| US20210269479A1 (en) * | 2020-02-25 | 2021-09-02 | Hepion Pharmaceuticals, Inc. | Use of cyclosporine analogues for treating cancer |
| KR20220158761A (ko) | 2020-03-26 | 2022-12-01 | 파사이트 메디컬 테크놀로지 (상하이) 컴퍼니 리미티드 | 사이클로스포린 유도체의 제조 |
| AU2021244763A1 (en) * | 2020-03-26 | 2022-10-06 | Farsight Medical Technology (Shanghai) Co., Ltd. | Cyclophilin inhibitors and uses thereof |
| US20220168385A1 (en) * | 2020-11-29 | 2022-06-02 | Hepion Pharmaceuticals, Inc. | Use of cyclosporine analogues as antithrombotic agents |
| CN113173974B (zh) * | 2021-03-18 | 2024-09-06 | 北京大学深圳研究生院 | 环孢素衍生物的合成方法 |
| CN115677533B (zh) * | 2021-07-30 | 2023-12-05 | 沈阳化工研究院有限公司 | 一种4-庚基苯甲腈的制备方法 |
| IT202300001116A1 (it) * | 2023-01-25 | 2024-07-25 | Indena Spa | Processo per la preparazione di un intermedio utile per la sintesi di voclosporina |
| TW202502801A (zh) * | 2023-06-02 | 2025-01-16 | 大陸商睿諾醫療科技（上海）有限公司 | 親環蛋白抑制劑及其用途 |
| WO2024254480A2 (en) * | 2023-06-08 | 2024-12-12 | Hepion Pharmaceuticals, Inc. | Solid state forms of rencofilstat |
Family Cites Families (100)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH614931A5 (pl) | 1975-11-04 | 1979-12-28 | Sandoz Ag | |
| US4210581A (en) | 1975-11-04 | 1980-07-01 | Sandoz Ltd. | Organic compounds |
| US4256108A (en) | 1977-04-07 | 1981-03-17 | Alza Corporation | Microporous-semipermeable laminated osmotic system |
| US4160452A (en) | 1977-04-07 | 1979-07-10 | Alza Corporation | Osmotic system having laminated wall comprising semipermeable lamina and microporous lamina |
| DE2819094A1 (de) | 1977-05-10 | 1978-11-23 | Sandoz Ag | Cyclosporin-derivate, ihre verwendung und herstellung |
| SE448386B (sv) | 1978-10-18 | 1987-02-16 | Sandoz Ag | Nya cyklosporinderivat, forfarande for framstellning av dem samt farmaceutisk komposition innehallande dem |
| EP0098456B1 (en) | 1980-02-14 | 1989-05-24 | Sandoz Ag | Peptides comprising a (1s,2r,3r)- or (1r,2s,3s)-1-nitrilo-1-carbonyl-3-methyl-2-oxy-heptane or -hept-5-ene residue useful in the total synthesis of cyclosporins, and processes for their production |
| US4396542A (en) | 1980-02-14 | 1983-08-02 | Sandoz Ltd. | Method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production |
| US4265874A (en) | 1980-04-25 | 1981-05-05 | Alza Corporation | Method of delivering drug with aid of effervescent activity generated in environment of use |
| DE3260468D1 (en) | 1981-01-09 | 1984-09-06 | Sandoz Ag | Novel cyclosporins |
| CH667274A5 (de) | 1984-03-23 | 1988-09-30 | Sandoz Ag | Cyclosporine, ihre herstellung und diese enthaltende pharmazeutische zusammensetzungen. |
| JPS6182786A (ja) | 1984-09-28 | 1986-04-26 | ブラザー工業株式会社 | ミシン |
| EP0194972B1 (en) * | 1985-03-11 | 1992-07-29 | Sandoz Ag | Novel cyclosporins |
| US4764503A (en) | 1986-11-19 | 1988-08-16 | Sandoz Ltd. | Novel cyclosporins |
| US4798823A (en) | 1987-06-03 | 1989-01-17 | Merck & Co., Inc. | New cyclosporin analogs with modified "C-9 amino acids" |
| US4885276A (en) | 1987-06-03 | 1989-12-05 | Merck & Co., Inc. | Cyclosporin analogs with modified "C-9 amino acids" |
| EP0296122B1 (en) | 1987-06-17 | 1993-09-29 | Sandoz Ag | Cyclosporins and their use as pharmaceuticals |
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