LT2651965T - Ciklosporino analogo molekulės su modifikuotomis 1 ir 3 aminorūgštimis - Google Patents

Ciklosporino analogo molekulės su modifikuotomis 1 ir 3 aminorūgštimis

Info

Publication number
LT2651965T
LT2651965T LTEP11848865.9T LT11848865T LT2651965T LT 2651965 T LT2651965 T LT 2651965T LT 11848865 T LT11848865 T LT 11848865T LT 2651965 T LT2651965 T LT 2651965T
Authority
LT
Lithuania
Prior art keywords
amino acid
molecules modified
analogue molecules
cyclosporine analogue
cyclosporine
Prior art date
Application number
LTEP11848865.9T
Other languages
English (en)
Inventor
Alexander Hegmans
Bruce Fenske
Dan Trepanier
Mark Abel
Shin Sugiyama
Daren R. Ure
Original Assignee
Contravir Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Contravir Pharmaceuticals, Inc. filed Critical Contravir Pharmaceuticals, Inc.
Publication of LT2651965T publication Critical patent/LT2651965T/lt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A—HUMAN NECESSITIES
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    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
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  • Gastroenterology & Hepatology (AREA)
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  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Transplantation (AREA)
LTEP11848865.9T 2010-12-15 2011-12-14 Ciklosporino analogo molekulės su modifikuotomis 1 ir 3 aminorūgštimis LT2651965T (lt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42357610P 2010-12-15 2010-12-15
PCT/CA2011/050773 WO2012079172A1 (en) 2010-12-15 2011-12-14 Cyclosporine analogue molecules modified at amino acid 1 and 3

Publications (1)

Publication Number Publication Date
LT2651965T true LT2651965T (lt) 2019-01-10

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
LTEP11848865.9T LT2651965T (lt) 2010-12-15 2011-12-14 Ciklosporino analogo molekulės su modifikuotomis 1 ir 3 aminorūgštimis

Country Status (25)

Country Link
US (2) US9200038B2 (lt)
EP (2) EP2651965B1 (lt)
JP (3) JP6144627B2 (lt)
KR (3) KR102305423B1 (lt)
CN (2) CN103443119B (lt)
AU (1) AU2011342284C1 (lt)
BR (1) BR112013014890B1 (lt)
CA (1) CA2821009C (lt)
DK (1) DK2651965T3 (lt)
ES (1) ES2705750T3 (lt)
HR (1) HRP20190096T1 (lt)
HU (1) HUE042490T2 (lt)
IL (1) IL226792A (lt)
LT (1) LT2651965T (lt)
MX (1) MX353720B (lt)
MY (2) MY192981A (lt)
NZ (1) NZ611620A (lt)
PH (1) PH12013501213A1 (lt)
PL (1) PL2651965T3 (lt)
PT (1) PT2651965T (lt)
RU (1) RU2630690C9 (lt)
SG (2) SG191069A1 (lt)
SI (1) SI2651965T1 (lt)
TR (1) TR201900128T4 (lt)
WO (1) WO2012079172A1 (lt)

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LT2651965T (lt) * 2010-12-15 2019-01-10 Contravir Pharmaceuticals, Inc. Ciklosporino analogo molekulės su modifikuotomis 1 ir 3 aminorūgštimis
CA2874548A1 (en) * 2012-06-01 2013-12-05 Allergan, Inc. Cyclosporin a analogs
US20160002299A1 (en) * 2013-03-01 2016-01-07 Ucl Business Plc Non-immunosuppressive cyclosporin derivatives as antiviral agents
KR20160045136A (ko) * 2013-08-26 2016-04-26 이난타 파마슈티칼스, 인코포레이티드 C형 간염을 예방 또는 치료하기 위한 사이클로스포린 유사체
WO2016112321A1 (en) 2015-01-08 2016-07-14 Allergan, Inc. Cyclosporin derivatives wherein the mebmt sidechain has been cyclized
JP2019518745A (ja) * 2016-05-17 2019-07-04 エス アンド ティー グローバル インク． 新規シクロスポリン誘導体及びその使用
CA3046489A1 (en) 2016-12-07 2018-06-14 Progenity Inc. Gastrointestinal tract detection methods, devices and systems
WO2018106928A1 (en) 2016-12-08 2018-06-14 Contravir Pharmaceuticals, Inc. Treatment and prevention of hbv diseases by cyclosporine analogue molecules modified at amino acides 1 and 3
TW201834690A (zh) 2016-12-14 2018-10-01 美商寶珍那提公司 以免疫抑制劑治療胃腸道疾病
AR111464A1 (es) 2017-04-14 2019-07-17 Contravir Pharmaceuticals Inc Terapia combinada para el tratamiento de infecciones virales
EP3612540A1 (en) 2017-04-20 2020-02-26 Rising Tide Foundation Triphenylphosphonium-tethered tetracycyclines for use in treating cancer
WO2019246312A1 (en) 2018-06-20 2019-12-26 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with an immunomodulator
CA3110250A1 (en) * 2018-08-22 2020-02-27 Bacainn Therapeutics, Ltd. Cyclosporine compositions and methods of use
US20230063768A1 (en) 2019-02-07 2023-03-02 The Regents Of The University Of California Immunophilin binding agents and uses thereof
IL295452A (en) 2020-02-19 2022-10-01 Hepion Pharmaceuticals Inc Use of cyclosporine analogues for treating fibrosis
JP2023515569A (ja) * 2020-02-25 2023-04-13 ヘピオン ファーマシューティカルズ インコーポレイテッド 癌を治療するためのシクロスポリン類似体の使用
KR20220158760A (ko) 2020-03-26 2022-12-01 파사이트 메디컬 테크놀로지 (상하이) 컴퍼니 리미티드 사이클로필린 저해제 및 그 용도
WO2021190603A1 (en) * 2020-03-26 2021-09-30 Farsight Medical Technology (Shanghai) Co., Ltd. Cyclophilin inhibitors and uses thereof
CN116829168A (zh) * 2020-11-29 2023-09-29 海必恩制药公司 环孢菌素类似物作为抗血栓形成剂的用途
CN113173974B (zh) * 2021-03-18 2024-09-06 北京大学深圳研究生院 环孢素衍生物的合成方法
CN115677533B (zh) * 2021-07-30 2023-12-05 沈阳化工研究院有限公司 一种4-庚基苯甲腈的制备方法
IT202300001116A1 (it) * 2023-01-25 2024-07-25 Indena Spa Processo per la preparazione di un intermedio utile per la sintesi di voclosporina
KR20260018851A (ko) * 2023-06-02 2026-02-09 파사이트 메디컬 테크놀로지 (상하이) 컴퍼니 리미티드 사이클로필린 저해제 및 그 용도
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