DE2537070C2 - - Google Patents

Info

Publication number
DE2537070C2
DE2537070C2 DE2537070A DE2537070A DE2537070C2 DE 2537070 C2 DE2537070 C2 DE 2537070C2 DE 2537070 A DE2537070 A DE 2537070A DE 2537070 A DE2537070 A DE 2537070A DE 2537070 C2 DE2537070 C2 DE 2537070C2
Authority
DE
Germany
Prior art keywords
general formula
carboxylic acid
hydroxy
thiophene
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2537070A
Other languages
German (de)
English (en)
Other versions
DE2537070A1 (de
Inventor
Otto Prof. Dr. Hromatka
Dieter Dr. Wien At Binder
Rudolf Dr. Basel Ch Pfister
Paul Dr. Allschwil Ch Zeller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F HOFFMANN-LA ROCHE and Co AG BASEL CH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH1158274A external-priority patent/CH608500A5/de
Priority claimed from CH1215774A external-priority patent/CH608501A5/de
Application filed by F HOFFMANN-LA ROCHE and Co AG BASEL CH filed Critical F HOFFMANN-LA ROCHE and Co AG BASEL CH
Publication of DE2537070A1 publication Critical patent/DE2537070A1/de
Application granted granted Critical
Publication of DE2537070C2 publication Critical patent/DE2537070C2/de
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Manufacturing Of Printed Wiring (AREA)
  • Electroplating Methods And Accessories (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DE19752537070 1974-08-26 1975-08-20 Thiazinderivate Granted DE2537070A1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH1158274A CH608500A5 (en) 1974-08-26 1974-08-26 Process for the preparation of thiazine derivatives
CH1215774A CH608501A5 (en) 1974-09-09 1974-09-09 Process for the preparation of thiazine derivatives

Publications (2)

Publication Number Publication Date
DE2537070A1 DE2537070A1 (de) 1976-03-18
DE2537070C2 true DE2537070C2 (ja) 1987-06-25

Family

ID=25708582

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19752537070 Granted DE2537070A1 (de) 1974-08-26 1975-08-20 Thiazinderivate

Country Status (20)

Country Link
JP (1) JPS5826758B2 (ja)
AR (1) AR216288A1 (ja)
AT (1) AT350064B (ja)
BR (1) BR7505463A (ja)
DD (1) DD124119A5 (ja)
DE (1) DE2537070A1 (ja)
DK (1) DK137835B (ja)
FI (1) FI59253C (ja)
FR (3) FR2282893A1 (ja)
GB (1) GB1519811A (ja)
HU (1) HU173739B (ja)
IE (1) IE41457B1 (ja)
IL (1) IL47877A (ja)
LU (2) LU73257A1 (ja)
NL (2) NL183582C (ja)
NO (1) NO146096C (ja)
PL (1) PL106076B1 (ja)
SE (1) SE412066B (ja)
SU (1) SU603338A3 (ja)
YU (1) YU40266B (ja)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2704485A1 (de) * 1977-02-03 1978-08-10 Thomae Gmbh Dr K Neue 2,5-dihydro-1,2-thiazino eckige klammer auf 5,6-b eckige klammer zu indol-3-carboxamid-1,1-dioxide, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
LU78009A1 (de) * 1977-08-22 1979-05-23 Hoffmann La Roche Verfahren zur herstellung von thiazinderivaten
AU518216B2 (en) * 1977-09-06 1981-09-17 Hafslund Nycomed Pharma Aktiengesellschaft Thienothiazine derivatives
ZA784958B (en) * 1977-09-06 1979-08-29 Hoffmann La Roche Thiazine derivatives
DE2838377A1 (de) * 1978-09-02 1980-03-20 Thomae Gmbh Dr K Neue 4-hydroxy-2h eckige klammer auf 1 eckige klammer zu benzothieno eckige klammer auf 2,3-e eckige klammer zu -1,2- thiazin-3-carboxamid-1,1-dioxide sowie deren salze, deren verwendung und verfahren zu ihrer herstellung
AU5811280A (en) * 1979-06-13 1980-12-18 F. Hoffmann-La Roche Ag Thiazine derivatives
JPS58109492A (ja) * 1981-12-22 1983-06-29 Mitsui Toatsu Chem Inc チエノチアジン誘導体およびそれを含有する医薬組成物
ATE26720T1 (de) * 1982-09-09 1987-05-15 Hoffmann La Roche Thieno(2,3-e)-1,2-thiazin-derivate.
JPS60163533U (ja) * 1984-04-02 1985-10-30 ホシデン株式会社 リ−ル台の制動装置
JPH0318748Y2 (ja) * 1985-12-18 1991-04-19
ATA39088A (de) 1988-02-18 1990-06-15 Binder Dieter Dr Basisch substituierte thienoisothiazol-3(2h)-on-1,1-dioxide und ihre pharmazeutisch vertraeglichen salze, verfahren zu ihrer herstellung und ihre verwendung
AT400437B (de) * 1993-12-14 1995-12-27 Chem Pharm Forsch Gmbh Neue n-heterocyclische thienothiazincarboxamide, verfahren zu ihrer herstellung und ihre verwendung
AT400568B (de) * 1994-05-18 1996-01-25 Chem Pharm Forsch Gmbh Neue n-heterocyclische thienothiazincarboxamide, verfahren zu ihrer herstellung und ihre verwendung
EP0658559A1 (de) * 1993-12-14 1995-06-21 Chemisch Pharmazeutische Forschungsgesellschaft m.b.H. Thienothiazinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als 5-dipoxygenase und Cyclooxygenaseinhibitoren
US5538966A (en) * 1994-01-21 1996-07-23 Alcon Laboratories, Inc. Carbonic anhydrase inhibitors
IT1308633B1 (it) 1999-03-02 2002-01-09 Nicox Sa Nitrossiderivati.
CN1171892C (zh) * 2001-06-25 2004-10-20 李晶 具有抗炎镇痛活性的噻吩并噻嗪化合物及其制备方法和用途

Also Published As

Publication number Publication date
NL183582C (nl) 1988-12-01
FR2303803A1 (fr) 1976-10-08
AU8418675A (en) 1977-02-24
FI59253C (fi) 1981-07-10
DK381175A (ja) 1976-02-27
LU88312I2 (de) 1994-09-09
YU40266B (en) 1985-12-31
IL47877A0 (en) 1975-11-25
NL7510057A (nl) 1976-03-01
IL47877A (en) 1978-10-31
DK137835C (ja) 1978-10-16
IE41457B1 (en) 1980-01-02
ATA655975A (de) 1978-10-15
NL183582B (nl) 1988-07-01
SE412066B (sv) 1980-02-18
GB1519811A (en) 1978-08-02
FR2309558A1 (fr) 1976-11-26
NL930080I2 (nl) 1994-01-03
AR216288A1 (es) 1979-12-14
NO146096B (no) 1982-04-19
DE2537070A1 (de) 1976-03-18
DD124119A5 (ja) 1977-02-02
DK137835B (da) 1978-05-16
FR2282893A1 (fr) 1976-03-26
FI59253B (fi) 1981-03-31
SU603338A3 (ru) 1978-04-15
LU73257A1 (ja) 1977-04-15
FR2282893B1 (ja) 1980-05-16
YU216675A (en) 1982-08-31
NL930080I1 (nl) 1993-09-16
SE7509446L (sv) 1976-02-27
PL106076B1 (pl) 1979-11-30
BR7505463A (pt) 1976-08-03
JPS5148694A (ja) 1976-04-26
NO752932L (ja) 1976-02-27
IE41457L (en) 1976-02-26
JPS5826758B2 (ja) 1983-06-04
FR2309558B1 (ja) 1979-05-04
HU173739B (hu) 1979-08-28
FI752398A (ja) 1976-02-27
AT350064B (de) 1979-05-10
FR2303803B1 (ja) 1979-07-13
NO146096C (no) 1982-07-28

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Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
D2 Grant after examination
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: F. HOFFMANN-LA ROCHE AG, BASEL, CH

8328 Change in the person/name/address of the agent

Free format text: LEDERER, F., DIPL.-CHEM. DR., 8000 MUENCHEN RIEDERER FRHR. VON PAAR ZU SCHOENAU, A., DIPL.-ING., PAT.-ANWAELTE, 8300 LANDSHUT