DE2220766C3 - Bleomycine und diese enthaltende Arzneimittel - Google Patents

Bleomycine und diese enthaltende Arzneimittel

Info

Publication number
DE2220766C3
DE2220766C3 DE19722220766 DE2220766A DE2220766C3 DE 2220766 C3 DE2220766 C3 DE 2220766C3 DE 19722220766 DE19722220766 DE 19722220766 DE 2220766 A DE2220766 A DE 2220766A DE 2220766 C3 DE2220766 C3 DE 2220766C3
Authority
DE
Germany
Prior art keywords
water
acid
product
adsorbed
acetone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE19722220766
Other languages
German (de)
English (en)
Other versions
DE2220766A1 (de
DE2220766B2 (de
Inventor
Mamoru Kunishima
Midori Matsubara
Yuya Yono Nakayama
Hamao Tokio Umezawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Kayaku Co Ltd
Original Assignee
Nippon Kayaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP46027553A external-priority patent/JPS5010841B1/ja
Priority claimed from JP7543071A external-priority patent/JPS5031122B2/ja
Application filed by Nippon Kayaku Co Ltd filed Critical Nippon Kayaku Co Ltd
Publication of DE2220766A1 publication Critical patent/DE2220766A1/de
Publication of DE2220766B2 publication Critical patent/DE2220766B2/de
Application granted granted Critical
Publication of DE2220766C3 publication Critical patent/DE2220766C3/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D333/40—Thiophene-2-carboxylic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07G—COMPOUNDS OF UNKNOWN CONSTITUTION
    • C07G11/00—Antibiotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
    • C07K9/003—Peptides being substituted by heterocyclic radicals, e.g. bleomycin, phleomycin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
DE19722220766 1971-04-28 1972-04-27 Bleomycine und diese enthaltende Arzneimittel Expired DE2220766C3 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP46027553A JPS5010841B1 (enrdf_load_stackoverflow) 1971-04-28 1971-04-28
JP7543071A JPS5031122B2 (enrdf_load_stackoverflow) 1971-09-29 1971-09-29

Publications (3)

Publication Number Publication Date
DE2220766A1 DE2220766A1 (de) 1972-11-16
DE2220766B2 DE2220766B2 (de) 1978-01-12
DE2220766C3 true DE2220766C3 (de) 1978-08-24

Family

ID=26365487

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19722220766 Expired DE2220766C3 (de) 1971-04-28 1972-04-27 Bleomycine und diese enthaltende Arzneimittel

Country Status (7)

Country Link
CA (1) CA982122A (enrdf_load_stackoverflow)
CH (2) CH575912A5 (enrdf_load_stackoverflow)
CS (1) CS167982B2 (enrdf_load_stackoverflow)
DE (1) DE2220766C3 (enrdf_load_stackoverflow)
FR (1) FR2134653B1 (enrdf_load_stackoverflow)
GB (1) GB1360312A (enrdf_load_stackoverflow)
NL (1) NL150802B (enrdf_load_stackoverflow)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4057618A (en) * 1976-04-30 1977-11-08 University Patents, Inc. Radioiodinated bleomycin
JPS58116497A (ja) * 1981-12-29 1983-07-11 Microbial Chem Res Found アミノプロピルアミノブレオマイシン誘導体及びその製造法

Also Published As

Publication number Publication date
FR2134653A1 (enrdf_load_stackoverflow) 1972-12-08
DE2220766A1 (de) 1972-11-16
CH577465A5 (enrdf_load_stackoverflow) 1976-07-15
NL150802B (nl) 1976-09-15
CA982122A (en) 1976-01-20
GB1360312A (en) 1974-07-17
CS167982B2 (en) 1976-05-28
NL7205753A (enrdf_load_stackoverflow) 1972-10-31
CH575912A5 (enrdf_load_stackoverflow) 1976-05-31
AU4153072A (en) 1973-06-14
DE2220766B2 (de) 1978-01-12
FR2134653B1 (enrdf_load_stackoverflow) 1975-12-26

Similar Documents

Publication Publication Date Title
DE1935967C3 (de) Naphthacenderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
DE2025624C2 (de) 5'-0-Ester von ara-Cytidin und Verfahren zu ihrer Herstellung
DE2220766C3 (de) Bleomycine und diese enthaltende Arzneimittel
DE2618009C3 (de) 1-N-<a-Hydroxy-to-aminoacyl)- derivate des 3'-Deoxykanamycin A und diese enthaltende Arzneimittel
DE2724597B2 (de) 3'-Desoxykanamycin C und 3',4'-Didesoxykanamycin C, deren Salze, Verfahren zu deren Herstellung und diese Verbindungen enthaltende antibakterielle Mittel
DE2022656A1 (de) Aminoaethansulfonylderivate und Verfahren zu ihrer Herstellung
DE2828933A1 (de) 3- eckige klammer auf (s)-1'-phenylaethylamino eckige klammer zu -propylaminobleomycin, verfahren zu seiner herstellung und diese verbindung enthaltendes arzneimittel
DE2127734A1 (de) Neue Nitrofuranderivate und Verfahren zu ihrer Herstellung
DE2408666C3 (de) Antibiotische Verbindungen, deren nicht-toxische, pharmakologisch verträgliche Salze und Hydrate und Verfahren zu deren Herstellung
DE1961947A1 (de) 6,7-Diacyloxy-tetrahydroisochinolinverbindungen und Verfahren zu ihrer Herstellung
DE2057188C3 (de) Erythromycyl-B-amin und Verfahren zu dessen Herstellung
DE2428641C2 (de) 5"-Amino-4',5"-didesoxy-ambutyrosin A, dessen Hydrate und Salze, Verfahren zu deren Herstellung und diese Verbindungen enthaltende pharmazeutische Mittel
DE2616749A1 (de) 0-2,6-diamino-2,3,6-trideoxy-alpha- d-ribo-hexopyranosyl-(1 groesser als 4)- 0-eckige klammer auf 5-amino-5-deoxy- beta-d-xylofuranosyl-(1 groesser als 5) eckige klammer zu - n 1 hoch - eckige klammer auf (s)-4-amino-2-hydroxy-1-oxobutyl eckige klammer zu - 2-deoxystreptamin) und dessen saeureadditionssalze
DE1805280C3 (de) Verfahren zur Herstellung von Cyclopeptiden, bestimmte Cyclopeptide und diese enthaltende pharmazeutische Zusammensetzungen
AT406372B (de) Lysin-prolin-derivate
DE2742950C2 (de) 4-N-Alkyl-Fortimicin B-Derivate, deren Salze und ihre Verwendung bei der Bekämpfung bakterieller Infektionen
DE2166270A1 (de) Aminoaethansulfonylderivate
DE2631462C3 (de) Derivate des Antibiotikums XK-62-2, deren Salze mit Säuren, Verfahren zu ihrer Herstellung und ihre Verwendung bei der Bekämpfung bakterieller Infektionen
DE2902292A1 (de) Verfahren zur herstellung von 4-aminobuttersaeure und deren derivaten
DE69124241T2 (de) Verfahren zur herstellung von sulfonylpristinamycin iib
DE3008359A1 (de) N-methylbleomycin-antibiotika
DE1966878C3 (de) S-ButylamincM-phenoxy-S-sulfamylbenzoesäure und deren Derivate, Verfahren zu ihrer Herstellung und diese enthaltende Mittel
DE2136622A1 (enrdf_load_stackoverflow)
DE977519C (de) Verfahren zur Herstellung von 1-Phenyl-2-dihalogenacetamino-1, 3-propandiolen
AT206590B (de) Verfahren zur Herstellung von neuen am Indolstickstoff substituierten Derivaten der Lysergsäure-Reihe

Legal Events

Date Code Title Description
C3 Grant after two publication steps (3rd publication)
8339 Ceased/non-payment of the annual fee