DE102010021637A1 - Substituierte 5-Fluor-1H-Pyrazolopyridine und ihre Verwendung - Google Patents

Substituierte 5-Fluor-1H-Pyrazolopyridine und ihre Verwendung Download PDF

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Publication number
DE102010021637A1
DE102010021637A1 DE102010021637A DE102010021637A DE102010021637A1 DE 102010021637 A1 DE102010021637 A1 DE 102010021637A1 DE 102010021637 A DE102010021637 A DE 102010021637A DE 102010021637 A DE102010021637 A DE 102010021637A DE 102010021637 A1 DE102010021637 A1 DE 102010021637A1
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Prior art keywords
compound
formula
salts
solvates
compounds
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Withdrawn
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DE102010021637A
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German (de)
English (en)
Inventor
wird später genannt werden Erfinder
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Bayer Pharma AG
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Bayer Schering Pharma AG
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Application filed by Bayer Schering Pharma AG filed Critical Bayer Schering Pharma AG
Priority to DE102010021637A priority Critical patent/DE102010021637A1/de
Priority to UY0001033396A priority patent/UY33396A/es
Priority to US13/111,856 priority patent/US8420656B2/en
Priority to KR1020127033603A priority patent/KR101881174B1/ko
Priority to PH1/2012/502320A priority patent/PH12012502320A1/en
Priority to PL11720806T priority patent/PL2576547T3/pl
Priority to NZ603799A priority patent/NZ603799A/en
Priority to PL11722786T priority patent/PL2576548T3/pl
Priority to JOP/2011/0171A priority patent/JO3199B1/ar
Priority to UAA201214902A priority patent/UA109660C2/uk
Priority to CA2955143A priority patent/CA2955143C/en
Priority to AU2011257335A priority patent/AU2011257335B2/en
Priority to PCT/EP2011/058431 priority patent/WO2011147809A1/de
Priority to CN201180036565.XA priority patent/CN103038232B/zh
Priority to DK11722786.8T priority patent/DK2576548T3/en
Priority to JP2013511644A priority patent/JP5883852B2/ja
Priority to AU2011257336A priority patent/AU2011257336B2/en
Priority to EP11720806.6A priority patent/EP2576547B1/de
Priority to MX2012013324A priority patent/MX2012013324A/es
Priority to SI201130602T priority patent/SI2576548T1/sl
Priority to JP2013511643A priority patent/JP5896991B2/ja
Priority to MEP-2016-64A priority patent/ME02393B/me
Priority to KR1020127033601A priority patent/KR101862420B1/ko
Priority to HUE11720806A priority patent/HUE026912T2/en
Priority to EA201291336A priority patent/EA023631B9/ru
Priority to SI201130781A priority patent/SI2576547T1/sl
Priority to RS20160263A priority patent/RS54704B1/sr
Priority to BR122020023470-9A priority patent/BR122020023470B1/pt
Priority to MEP-2015-147A priority patent/ME02207B/me
Priority to PH1/2012/502322A priority patent/PH12012502322A1/en
Priority to MYPI2012701008A priority patent/MY170094A/en
Priority to BR112012030010-5A priority patent/BR112012030010A2/pt
Priority to EP11722786.8A priority patent/EP2576548B1/en
Priority to EA201291309A priority patent/EA030735B9/ru
Priority to MA35391A priority patent/MA34248B1/fr
Priority to HRP20160370TT priority patent/HRP20160370T1/hr
Priority to RS20150600A priority patent/RS54261B1/sr
Priority to MA35392A priority patent/MA34249B1/fr
Priority to PCT/EP2011/058433 priority patent/WO2011147810A1/en
Priority to SG2012082152A priority patent/SG185460A1/en
Priority to CN201180026010.7A priority patent/CN102939289B/zh
Priority to HK13109548.3A priority patent/HK1182112B/xx
Priority to US13/816,020 priority patent/US10189856B2/en
Priority to SG2012085767A priority patent/SG185690A1/en
Priority to NZ603800A priority patent/NZ603800A/en
Priority to PT117227868T priority patent/PT2576548E/pt
Priority to UAA201214901A priority patent/UA116521C2/uk
Priority to CA2800709A priority patent/CA2800709C/en
Priority to ES11720806.6T priority patent/ES2567795T3/es
Priority to MX2012013574A priority patent/MX2012013574A/es
Priority to MYPI2012700999A priority patent/MY164356A/en
Priority to ARP110101777A priority patent/AR081628A1/es
Priority to CA2800697A priority patent/CA2800697C/en
Priority to HRP20150987TT priority patent/HRP20150987T1/hr
Priority to PE2012002172A priority patent/PE20130402A1/es
Priority to HK13111320.3A priority patent/HK1183868B/xx
Priority to DK11720806.6T priority patent/DK2576547T3/en
Priority to HUE11722786A priority patent/HUE025162T2/en
Priority to ES11722786.8T priority patent/ES2549979T3/es
Priority to CU2012000161A priority patent/CU24086B1/es
Priority to TW100118222A priority patent/TWI516263B/zh
Publication of DE102010021637A1 publication Critical patent/DE102010021637A1/de
Priority to IL223050A priority patent/IL223050A/en
Priority to CO12208156A priority patent/CO6640226A2/es
Priority to IL223128A priority patent/IL223128A/en
Priority to CL2012003226A priority patent/CL2012003226A1/es
Priority to GT201200313A priority patent/GT201200313A/es
Priority to ZA2012/08824A priority patent/ZA201208824B/en
Priority to DO2012000299A priority patent/DOP2012000299A/es
Priority to TNP2012000550A priority patent/TN2012000550A1/en
Priority to TNP2012000549A priority patent/TN2012000549A1/en
Priority to CL2012003281A priority patent/CL2012003281A1/es
Priority to ECSP12012310 priority patent/ECSP12012310A/es
Priority to CR20120596A priority patent/CR20120596A/es
Priority to CR20120597A priority patent/CR20120597A/es
Priority to US13/851,373 priority patent/US8921377B2/en
Priority to US14/552,122 priority patent/US9266885B2/en
Priority to CY20151100818T priority patent/CY1116703T1/el
Priority to US14/996,678 priority patent/US20160129004A1/en
Priority to CY20161100301T priority patent/CY1117372T1/el
Priority to US15/348,545 priority patent/US9993476B2/en
Priority to IL249669A priority patent/IL249669B/en
Priority to US15/981,598 priority patent/US10736896B2/en
Priority to US16/919,385 priority patent/US11439642B2/en
Priority to CY2021021C priority patent/CY2021021I2/el
Priority to LTPA2021518C priority patent/LTC2576547I2/lt
Priority to HUS2100032C priority patent/HUS2100032I1/hu
Priority to FR21C1038C priority patent/FR21C1038I2/fr
Priority to LU00221C priority patent/LUC00221I2/fr
Priority to NO2021032C priority patent/NO2021032I1/no
Priority to NL301146C priority patent/NL301146I2/nl
Priority to US17/820,667 priority patent/US12064429B2/en
Withdrawn legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/04—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/05—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing at least two sulfo groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
    • C07C57/145—Maleic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE102010021637A 2010-05-26 2010-05-26 Substituierte 5-Fluor-1H-Pyrazolopyridine und ihre Verwendung Withdrawn DE102010021637A1 (de)

Priority Applications (91)

Application Number Priority Date Filing Date Title
DE102010021637A DE102010021637A1 (de) 2010-05-26 2010-05-26 Substituierte 5-Fluor-1H-Pyrazolopyridine und ihre Verwendung
UY0001033396A UY33396A (es) 2010-05-26 2011-05-19 5-fluoro-1h-pirazolopiridinas sustituidas y su uso
US13/111,856 US8420656B2 (en) 2010-05-26 2011-05-19 Substituted 5-fluoro-1H-pyrazolopyridines and their use
KR1020127033603A KR101881174B1 (ko) 2010-05-26 2011-05-24 전신 경화증 （ＳＳｃ）의 치료를 위한 ｓＧＣ 자극제, ｓＧＣ 활성화제의 단독으로의 및 ＰＤＥ5 억제제와의 조합물의 용도
PH1/2012/502320A PH12012502320A1 (en) 2010-05-26 2011-05-24 Substituted 5-fluoro-1h-pyrazolopyridines and use thereof
PL11720806T PL2576547T3 (pl) 2010-05-26 2011-05-24 Podstawiona 5-fluoro-1H-pirazolopirydyna i jej zastosowanie
NZ603799A NZ603799A (en) 2010-05-26 2011-05-24 The use of sgc stimulators, sgc activators, alone and combinations with pde5 inhibitors for the treatment of systemic sclerosis (ssc).
PL11722786T PL2576548T3 (pl) 2010-05-26 2011-05-24 Zastosowanie stymulatorów sGC, aktywatorów sGC, pojedynczo i w kombinacjach z inhibitorami PDE5, w leczeniu twardziny układowej (SSc)
JOP/2011/0171A JO3199B1 (ar) 2010-05-26 2011-05-24 مركبات 5- فلورو-1h- بيرازولوبيريدينات مستبدلة واستخدامها
UAA201214902A UA109660C2 (xx) 2010-05-26 2011-05-24 Заміщені 5-фтор-1h-піразолопіридини та їх застосування
CA2955143A CA2955143C (en) 2010-05-26 2011-05-24 The use of sgc stimulators, sgc activators, alone and combinations with pde5 inhibitors for the treatment of systemic sclerosis (ssc).
AU2011257335A AU2011257335B2 (en) 2010-05-26 2011-05-24 Substituted 5-fluoro-1H-pyrazolopyridines and use thereof
PCT/EP2011/058431 WO2011147809A1 (de) 2010-05-26 2011-05-24 Substituierte 5-fluor-1h-pyrazolopyridine und ihre verwendung
CN201180036565.XA CN103038232B (zh) 2010-05-26 2011-05-24 单独的和与PDE5抑制剂相组合的sGC刺激剂、sGC活化剂用于治疗系统性硬化症(SSc)的用途
DK11722786.8T DK2576548T3 (en) 2010-05-26 2011-05-24 USE OF sGC stimulators, sGC activators alone and in combination with PDE5 inhibitors for treating systemic sclerosis (SSc)
JP2013511644A JP5883852B2 (ja) 2010-05-26 2011-05-24 全身性強皮症（ＳＳｃ）を処置するためのｓＧＣ刺激剤、ｓＧＣアクチベーター単独およびＰＤＥ５阻害剤との組み合わせ剤の使用
AU2011257336A AU2011257336B2 (en) 2010-05-26 2011-05-24 The use of sGC stimulators, sGC activators, alone and combinations with PDE5 inhibitors for the treatment of systemic sclerosis (SSc).
EP11720806.6A EP2576547B1 (de) 2010-05-26 2011-05-24 Substituierte 5-fluor-1h-pyrazolopyridine und ihre verwendung
MX2012013324A MX2012013324A (es) 2010-05-26 2011-05-24 5-fluoro-1h-pirazolopiridinas sustituidas y su uso.
SI201130602T SI2576548T1 (sl) 2010-05-26 2011-05-24 Uporaba sGC stimulatorjev, sGC aktivatorjev, samih in v kombinacijah s PDE5 inhibitorji za zdravljenje sistemske skleroze
JP2013511643A JP5896991B2 (ja) 2010-05-26 2011-05-24 置換された５−フルオロ−１ｈ−ピラゾロピリジン及びそれらの使用
MEP-2016-64A ME02393B (me) 2010-05-26 2011-05-24 Supstituisani 5-fluor-1h-pirazolopiridini i njihova primjena
KR1020127033601A KR101862420B1 (ko) 2010-05-26 2011-05-24 치환된 ５－플루오로－１ｈ－피라졸로피리딘 및 그의 용도
HUE11720806A HUE026912T2 (en) 2010-05-26 2011-05-24 Substituted 5-fluoro-1h-pyrazolopyridines and use thereof
EA201291336A EA023631B9 (ru) 2010-05-26 2011-05-24 Замещенные 5-фтор-1h-пиразолопиридины и их применение
SI201130781A SI2576547T1 (sl) 2010-05-26 2011-05-24 Substituirani 5-fluoro-1H-pirazolopiridini in njihova uporaba
RS20160263A RS54704B1 (sr) 2010-05-26 2011-05-24 Supstituisani 5-fluor-1h-pirazolopiridini i njihova primena
BR122020023470-9A BR122020023470B1 (pt) 2010-05-26 2011-05-24 Processo para preparação de 5-flúor-1h-pirazolopiridinas substituídas
MEP-2015-147A ME02207B (me) 2010-05-26 2011-05-24 UPOTREBA sGC STIMULATORA, sGC AKTIVATORA, POJEDINAČNO I U KOMBINACIJI SA PDE5 INHIBITORIMA ZA TRETMAN SISTEMSKE SKLEROZE (SSc)
PH1/2012/502322A PH12012502322A1 (en) 2010-05-26 2011-05-24 The use of sgc stimulators, sgc activators, alone and combinations with pde5 inhibitors for the treatment of systemic sclerosis (ssc)
MYPI2012701008A MY170094A (en) 2010-05-26 2011-05-24 The use of sgc stimulators, sgc activators, alone and combinations with pde5 inhibitors for the treatment of systemic sclerosis (ssc).
BR112012030010-5A BR112012030010A2 (pt) 2010-05-26 2011-05-24 5-flúor-1h-pirazolopiridinas substituídas e seu uso
EP11722786.8A EP2576548B1 (en) 2010-05-26 2011-05-24 THE USE OF sGC STIMULATORS, sGC ACTIVATORS, ALONE AND COMBINATIONS WITH PDE5 INHIBITORS FOR THE TREATMENT OF SYSTEMIC SCLEROSIS (SSc)
EA201291309A EA030735B9 (ru) 2010-05-26 2011-05-24 ПРИМЕНЕНИЕ sGC СТИМУЛЯТОРОВ ДЛЯ ЛЕЧЕНИЯ СИСТЕМНОГО СКЛЕРОЗА (SSc)
MA35391A MA34248B1 (fr) 2010-05-26 2011-05-24 5-fluoro-1h-pyrazolopyridines substituées et leur utilisation
HRP20160370TT HRP20160370T1 (hr) 2010-05-26 2011-05-24 Supstituirani 5-fluoro-1h-pirazolopiridini i njihova uporaba
RS20150600A RS54261B1 (sr) 2010-05-26 2011-05-24 Upotreba sgc stimulatora, sgc aktivatora, pojedinačno i u kombinaciji sa pde5 inhibitorima za tretman sistemske skleroze (ssc)
MA35392A MA34249B1 (fr) 2010-05-26 2011-05-24 Utilisation de stimulateurs de la sgc, d'activateurs de la sgc, seuls et en association avec des inhibiteurs de la pde5 en vue du traitement de la sclérodermie systémique
PCT/EP2011/058433 WO2011147810A1 (en) 2010-05-26 2011-05-24 THE USE OF sGC STIMULATORS, sGC ACTIVATORS, ALONE AND COMBINATIONS WITH PDE5 INHIBITORS FOR THE TREATMENT OF SYSTEMIC SCLEROSIS (SSc).
SG2012082152A SG185460A1 (en) 2010-05-26 2011-05-24 Substituted 5-fluoro-1h-pyrazolopyridines and use thereof
CN201180026010.7A CN102939289B (zh) 2010-05-26 2011-05-24 取代的5-氟-1h-吡唑并吡啶类化合物及其用途
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HUS2100032C HUS2100032I1 (hu) 2010-05-26 2021-08-27 Helyettesített 5-fluor-1H-pirazolopiridin-származékok és alkalmazásuk
FR21C1038C FR21C1038I2 (fr) 2010-05-26 2021-08-30 5-fluoro-1h-pyrazolopyridines substituees et leur utilisation
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US17/820,667 US12064429B2 (en) 2010-05-26 2022-08-18 Substituted 5-fluoro-1H-pyrazolopyridines and their use

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