DE10196483B4 - Behandlung von Sonnenbrand - Google Patents
Behandlung von Sonnenbrand Download PDFInfo
- Publication number
- DE10196483B4 DE10196483B4 DE10196483.8A DE10196483A DE10196483B4 DE 10196483 B4 DE10196483 B4 DE 10196483B4 DE 10196483 A DE10196483 A DE 10196483A DE 10196483 B4 DE10196483 B4 DE 10196483B4
- Authority
- DE
- Germany
- Prior art keywords
- diclofenac
- topical
- sunburn
- diclofenac sodium
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 206010042496 Sunburn Diseases 0.000 title claims abstract description 17
- 238000011282 treatment Methods 0.000 title claims abstract description 15
- 229960001193 diclofenac sodium Drugs 0.000 claims abstract description 25
- JGMJQSFLQWGYMQ-UHFFFAOYSA-M sodium;2,6-dichloro-n-phenylaniline;acetate Chemical compound [Na+].CC([O-])=O.ClC1=CC=CC(Cl)=C1NC1=CC=CC=C1 JGMJQSFLQWGYMQ-UHFFFAOYSA-M 0.000 claims abstract description 25
- 230000000699 topical effect Effects 0.000 claims abstract description 22
- 239000000203 mixture Substances 0.000 claims abstract description 19
- 239000003814 drug Substances 0.000 claims abstract 2
- DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 description 33
- 229960001259 diclofenac Drugs 0.000 description 18
- 239000000499 gel Substances 0.000 description 15
- 229940068196 placebo Drugs 0.000 description 14
- 239000000902 placebo Substances 0.000 description 14
- 229940063674 voltaren Drugs 0.000 description 13
- 229960005466 diclofenac diethylammonium Drugs 0.000 description 11
- 206010015150 Erythema Diseases 0.000 description 10
- KPHWPUGNDIVLNH-UHFFFAOYSA-M diclofenac sodium Chemical compound [Na+].[O-]C(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl KPHWPUGNDIVLNH-UHFFFAOYSA-M 0.000 description 10
- 241000700159 Rattus Species 0.000 description 9
- 239000000839 emulsion Substances 0.000 description 8
- 230000005855 radiation Effects 0.000 description 7
- 239000012049 topical pharmaceutical composition Substances 0.000 description 6
- 238000009472 formulation Methods 0.000 description 5
- 231100000673 dose–response relationship Toxicity 0.000 description 4
- 208000008035 Back Pain Diseases 0.000 description 3
- 208000002193 Pain Diseases 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 239000000853 adhesive Substances 0.000 description 3
- 230000001070 adhesive effect Effects 0.000 description 3
- 229940121363 anti-inflammatory agent Drugs 0.000 description 3
- 239000002260 anti-inflammatory agent Substances 0.000 description 3
- -1 benzopyrone compound Chemical class 0.000 description 3
- 239000006071 cream Substances 0.000 description 3
- 231100000321 erythema Toxicity 0.000 description 3
- 239000002674 ointment Substances 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 241000700198 Cavia Species 0.000 description 2
- 208000000112 Myalgia Diseases 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 229960000942 diclofenac epolamine Drugs 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 230000037380 skin damage Effects 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 230000000475 sunscreen effect Effects 0.000 description 2
- 239000000516 sunscreening agent Substances 0.000 description 2
- 230000029663 wound healing Effects 0.000 description 2
- WSWCOQWTEOXDQX-MQQKCMAXSA-M (E,E)-sorbate Chemical compound C\C=C\C=C\C([O-])=O WSWCOQWTEOXDQX-MQQKCMAXSA-M 0.000 description 1
- 241000700199 Cavia porcellus Species 0.000 description 1
- 208000034656 Contusions Diseases 0.000 description 1
- 201000011275 Epicondylitis Diseases 0.000 description 1
- 244000194101 Ginkgo biloba Species 0.000 description 1
- 208000008930 Low Back Pain Diseases 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 description 1
- 208000010040 Sprains and Strains Diseases 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 150000008375 benzopyrones Chemical class 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000009519 contusion Effects 0.000 description 1
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 1
- DCERVXIINVUMKU-UHFFFAOYSA-N diclofenac epolamine Chemical compound OCC[NH+]1CCCC1.[O-]C(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCERVXIINVUMKU-UHFFFAOYSA-N 0.000 description 1
- 229960004515 diclofenac potassium Drugs 0.000 description 1
- KXZOIWWTXOCYKR-UHFFFAOYSA-M diclofenac potassium Chemical compound [K+].[O-]C(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl KXZOIWWTXOCYKR-UHFFFAOYSA-M 0.000 description 1
- DOBMPNYZJYQDGZ-UHFFFAOYSA-N dicoumarol Chemical compound C1=CC=CC2=C1OC(=O)C(CC=1C(OC3=CC=CC=C3C=1O)=O)=C2O DOBMPNYZJYQDGZ-UHFFFAOYSA-N 0.000 description 1
- 229960001912 dicoumarol Drugs 0.000 description 1
- HIZKPJUTKKJDGA-UHFFFAOYSA-N dicumarol Natural products O=C1OC2=CC=CC=C2C(=O)C1CC1C(=O)C2=CC=CC=C2OC1=O HIZKPJUTKKJDGA-UHFFFAOYSA-N 0.000 description 1
- HPNMFZURTQLUMO-UHFFFAOYSA-O diethylammonium Chemical compound CC[NH2+]CC HPNMFZURTQLUMO-UHFFFAOYSA-O 0.000 description 1
- 210000002889 endothelial cell Anatomy 0.000 description 1
- XBRDBODLCHKXHI-UHFFFAOYSA-N epolamine Chemical compound OCCN1CCCC1 XBRDBODLCHKXHI-UHFFFAOYSA-N 0.000 description 1
- 230000000763 evoking effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 230000000302 ischemic effect Effects 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000004530 micro-emulsion Substances 0.000 description 1
- 208000013465 muscle pain Diseases 0.000 description 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 description 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 1
- 239000007764 o/w emulsion Substances 0.000 description 1
- 230000008816 organ damage Effects 0.000 description 1
- 201000008482 osteoarthritis Diseases 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000036470 plasma concentration Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 239000002089 prostaglandin antagonist Substances 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000010410 reperfusion Effects 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 235000003441 saturated fatty acids Nutrition 0.000 description 1
- 150000004671 saturated fatty acids Chemical class 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 229940075554 sorbate Drugs 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Polarising Elements (AREA)
- Magnetic Heads (AREA)
- Semiconductor Lasers (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00118968.7 | 2000-09-01 | ||
| EP00118968 | 2000-09-01 | ||
| PCT/EP2001/010041 WO2002017905A2 (en) | 2000-09-01 | 2001-08-30 | Treatment of burns |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE10196483B4 true DE10196483B4 (de) | 2023-08-24 |
Family
ID=8169725
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE10196483.8A Expired - Lifetime DE10196483B4 (de) | 2000-09-01 | 2001-08-30 | Behandlung von Sonnenbrand |
| DE10196483T Granted DE10196483T1 (de) | 2000-09-01 | 2001-08-30 | Behandlung von Verbrennungen |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE10196483T Granted DE10196483T1 (de) | 2000-09-01 | 2001-08-30 | Behandlung von Verbrennungen |
Country Status (31)
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR041021A1 (es) * | 2002-08-22 | 2005-04-27 | Novartis Consumer Health Sa | Composicion topica |
| EP2055298A1 (en) | 2007-10-30 | 2009-05-06 | Novartis AG | Topical composition |
| CN105395544A (zh) * | 2014-08-23 | 2016-03-16 | 南京海纳医药科技有限公司 | 双氯芬酸依泊胺凝胶制备方法及药物用途 |
| CA2959601A1 (en) | 2014-09-10 | 2016-03-17 | Novartis Ag | Topical diclofenac sodium compositions |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59170011A (ja) | 1983-03-16 | 1984-09-26 | Pola Chem Ind Inc | 日焼け防止化粧料 |
| US4551475A (en) | 1981-02-24 | 1985-11-05 | Ciba-Geigy Corporation | Pharmaceutical preparations for topical application which contain salts of alkanecarboxylic acids |
| WO1988006889A1 (fr) | 1987-03-09 | 1988-09-22 | Oxo Chemie Gmbh | Composition, en particulier anti-inflammatoire |
| EP0313303A2 (en) | 1987-10-22 | 1989-04-26 | The Procter & Gamble Company | Photoprotection compositions comprising tocopherol sorbate and an anti-inflammatory agent |
| US4917886A (en) | 1982-10-07 | 1990-04-17 | Ciba-Geigy Corporation | Novel topically administrable pharmaceutical compositions |
| EP0372527A1 (en) | 1988-12-09 | 1990-06-13 | Altergon S.A. | Topical compositions containing diclofenac |
| EP0621263A2 (en) | 1993-04-23 | 1994-10-26 | Teikoku Seiyaku Co., Ltd. | External anti-inflammatory and analgesic plaster preparation |
| WO1996017624A1 (en) | 1994-12-07 | 1996-06-13 | Warner-Lambert Company | Sunscreen-wound healing composition |
| DE19844116A1 (de) | 1998-08-06 | 2000-02-24 | Vascular Biotech Gmbh | Wirkstoffkombination insbesondere zur Prophylaxe und Therapie von ischämischen Organschäden und Reperfusionssyndromen |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE8210781U1 (de) * | 1982-04-16 | 1982-06-24 | Unilever N.V., 3000 Rotterdam | Staubdichte Faltschachtel |
| RU2008002C1 (ru) * | 1989-03-23 | 1994-02-28 | Центр по химии лекарственных средств | Противовоспалительный состав и способ его получения |
| ATE334689T1 (de) * | 1995-11-13 | 2006-08-15 | Univ Northwest | Verabreichungsmedium für analgetische, entzündungshemmende und antipyretische wirkstoffe und pharmazeutische zusammensetzungen enthaltend solches medium und wirkstoffe |
| JP4181232B2 (ja) * | 1997-07-18 | 2008-11-12 | 帝國製薬株式会社 | ジクロフェナクナトリウム含有油性外用貼付製剤 |
| KR19990026792A (ko) * | 1997-09-26 | 1999-04-15 | 김윤 | 디클로페낙 디에틸암모늄염을 함유한 매트릭스형 패취제제 |
| EP0923937B1 (en) * | 1997-12-08 | 2004-03-10 | Council of Scientific and Industrial Research | A herbal formulation useful as a therapeutic and cosmetic application for the treatment of general skin disorders |
| RU2140258C1 (ru) * | 1999-03-17 | 1999-10-27 | Открытое акционерное общество "Химико-фармацевтический комбинат "Акрихин" | Гидрофильная фармацевтическая композиция, обладающая противовоспалительным действием |
| AU5460800A (en) * | 1999-06-02 | 2000-12-18 | Aviana Biopharm | Pharmaceutical transdermal compositions |
| US6368618B1 (en) * | 1999-07-01 | 2002-04-09 | The University Of Georgia Research Foundation, Inc. | Composition and method for enhanced transdermal absorption of nonsteroidal anti-inflammatory drugs |
| DE10025328A1 (de) * | 2000-05-23 | 2001-12-06 | Lohmann Therapie Syst Lts | Acetylsalicylsäure enthaltendes superfizielles therapeutisches System zur Behandlung von Hautschmerzen |
-
2001
- 2001-07-20 TW TW090117812A patent/TWI290464B/zh not_active IP Right Cessation
- 2001-08-07 GR GR20010100390A patent/GR1004434B/el unknown
- 2001-08-27 BE BE2001/0561A patent/BE1014352A5/fr not_active IP Right Cessation
- 2001-08-27 FR FR0111126A patent/FR2813530B1/fr not_active Expired - Fee Related
- 2001-08-28 IT IT2001MI001820A patent/ITMI20011820A1/it unknown
- 2001-08-30 JP JP2002522879A patent/JP2004507497A/ja active Pending
- 2001-08-30 ES ES200350010A patent/ES2201941B1/es not_active Expired - Fee Related
- 2001-08-30 DE DE10196483.8A patent/DE10196483B4/de not_active Expired - Lifetime
- 2001-08-30 AT AT0918401A patent/AT504040B1/de not_active IP Right Cessation
- 2001-08-30 AU AU8770601A patent/AU8770601A/xx active Pending
- 2001-08-30 KR KR1020037003022A patent/KR100880056B1/ko not_active Expired - Fee Related
- 2001-08-30 RU RU2003108858/15A patent/RU2314802C2/ru active
- 2001-08-30 DE DE10196483T patent/DE10196483T1/de active Granted
- 2001-08-30 CN CNB018149340A patent/CN100350905C/zh not_active Expired - Fee Related
- 2001-08-30 CA CA2414921A patent/CA2414921C/en not_active Expired - Fee Related
- 2001-08-30 HU HU0300876A patent/HU230783B1/hu unknown
- 2001-08-30 PL PL35980701A patent/PL359807A1/xx not_active Application Discontinuation
- 2001-08-30 US US10/363,497 patent/US20030187069A1/en not_active Abandoned
- 2001-08-30 CZ CZ20030574A patent/CZ303849B6/cs not_active IP Right Cessation
- 2001-08-30 CH CH00305/03A patent/CH695416A5/de not_active IP Right Cessation
- 2001-08-30 WO PCT/EP2001/010041 patent/WO2002017905A2/en not_active Ceased
- 2001-08-30 IL IL15381601A patent/IL153816A0/xx unknown
- 2001-08-30 MX MXPA03001830A patent/MXPA03001830A/es active IP Right Grant
- 2001-08-30 AU AU2001287706A patent/AU2001287706B2/en not_active Ceased
- 2001-08-30 LU LU91009A patent/LU91009B1/de active
- 2001-08-30 GB GB0304150A patent/GB2381455B/en not_active Expired - Fee Related
- 2001-08-30 AR ARP010104137A patent/AR030522A1/es unknown
- 2001-08-31 NL NL1018862A patent/NL1018862C2/nl not_active IP Right Cessation
-
2003
- 2003-01-06 IL IL153816A patent/IL153816A/en active IP Right Grant
- 2003-01-10 ZA ZA200300284A patent/ZA200300284B/en unknown
- 2003-02-18 NO NO20030767A patent/NO330590B1/no not_active IP Right Cessation
- 2003-02-24 DK DK200300274A patent/DK200300274A/da not_active Application Discontinuation
- 2003-02-25 FI FI20030276A patent/FI119840B/fi not_active IP Right Cessation
- 2003-02-28 SE SE0300535A patent/SE527137C2/sv unknown
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4551475A (en) | 1981-02-24 | 1985-11-05 | Ciba-Geigy Corporation | Pharmaceutical preparations for topical application which contain salts of alkanecarboxylic acids |
| US4917886A (en) | 1982-10-07 | 1990-04-17 | Ciba-Geigy Corporation | Novel topically administrable pharmaceutical compositions |
| JPS59170011A (ja) | 1983-03-16 | 1984-09-26 | Pola Chem Ind Inc | 日焼け防止化粧料 |
| WO1988006889A1 (fr) | 1987-03-09 | 1988-09-22 | Oxo Chemie Gmbh | Composition, en particulier anti-inflammatoire |
| EP0313303A2 (en) | 1987-10-22 | 1989-04-26 | The Procter & Gamble Company | Photoprotection compositions comprising tocopherol sorbate and an anti-inflammatory agent |
| EP0372527A1 (en) | 1988-12-09 | 1990-06-13 | Altergon S.A. | Topical compositions containing diclofenac |
| EP0621263A2 (en) | 1993-04-23 | 1994-10-26 | Teikoku Seiyaku Co., Ltd. | External anti-inflammatory and analgesic plaster preparation |
| WO1996017624A1 (en) | 1994-12-07 | 1996-06-13 | Warner-Lambert Company | Sunscreen-wound healing composition |
| DE19844116A1 (de) | 1998-08-06 | 2000-02-24 | Vascular Biotech Gmbh | Wirkstoffkombination insbesondere zur Prophylaxe und Therapie von ischämischen Organschäden und Reperfusionssyndromen |
Non-Patent Citations (1)
| Title |
|---|
| JP 59170011 A (engl. Übersetzung) |
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