DD264614A5 - Verfahren zur herstellung eines temperaturstabilen breitband-antibiotikums - Google Patents

Verfahren zur herstellung eines temperaturstabilen breitband-antibiotikums Download PDF

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Publication number
DD264614A5
DD264614A5 DD87310253A DD31025387A DD264614A5 DD 264614 A5 DD264614 A5 DD 264614A5 DD 87310253 A DD87310253 A DD 87310253A DD 31025387 A DD31025387 A DD 31025387A DD 264614 A5 DD264614 A5 DD 264614A5
Authority
DD
German Democratic Republic
Prior art keywords
zwitterion
chloride
salt
sodium
calcium
Prior art date
Application number
DD87310253A
Other languages
German (de)
English (en)
Inventor
Murray A Kaplan
Joseph B Bogardus
Nageswara R Palepu
Original Assignee
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Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by �������`�����@�������k�� filed Critical �������`�����@�������k��
Publication of DD264614A5 publication Critical patent/DD264614A5/de

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Cephalosporin Compounds (AREA)
DD87310253A 1987-01-09 1987-12-10 Verfahren zur herstellung eines temperaturstabilen breitband-antibiotikums DD264614A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/001,945 US4808617A (en) 1985-12-18 1987-01-09 Lyophilized or precipitated cephalosporin zwitterion and salt combination

Publications (1)

Publication Number Publication Date
DD264614A5 true DD264614A5 (de) 1989-02-08

Family

ID=21698538

Family Applications (1)

Application Number Title Priority Date Filing Date
DD87310253A DD264614A5 (de) 1987-01-09 1987-12-10 Verfahren zur herstellung eines temperaturstabilen breitband-antibiotikums

Country Status (33)

Country Link
US (1) US4808617A (fr)
JP (1) JP2568226B2 (fr)
KR (1) KR950010154B1 (fr)
AR (1) AR243501A1 (fr)
AT (1) AT388672B (fr)
AU (1) AU606361B2 (fr)
BE (1) BE1002114A3 (fr)
CA (1) CA1307464C (fr)
CH (1) CH676202A5 (fr)
CS (1) CS265249B2 (fr)
CY (1) CY1679A (fr)
DD (1) DD264614A5 (fr)
DE (1) DE3740588C2 (fr)
DK (1) DK166404B1 (fr)
ES (1) ES2008951A6 (fr)
FI (1) FI89006C (fr)
FR (1) FR2609396B1 (fr)
GB (1) GB2199746B (fr)
GR (1) GR871860B (fr)
HK (1) HK5593A (fr)
HU (1) HU199686B (fr)
IE (1) IE61238B1 (fr)
IL (1) IL84346A (fr)
IT (1) IT1215666B (fr)
LU (1) LU87102A1 (fr)
NL (1) NL193266C (fr)
OA (1) OA08796A (fr)
PT (1) PT86157B (fr)
SE (1) SE467910B (fr)
SG (1) SG114792G (fr)
SU (1) SU1575942A3 (fr)
YU (1) YU46689B (fr)
ZA (1) ZA88114B (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4910301A (en) * 1985-08-05 1990-03-20 Bristol-Myers Company Cefepime cephalosporin salts
CA2011116C (fr) * 1989-03-06 1999-11-16 Murray A. Kaplan Dihydrochlorure de bmy-28142 lyophilise pour usage parenteral
DE19539574A1 (de) 1995-10-25 1997-04-30 Boehringer Mannheim Gmbh Zubereitungen und Verfahren zur Stabilisierung biologischer Materialien mittels Trocknungsverfahren ohne Einfrieren
WO2005094800A2 (fr) * 2004-03-31 2005-10-13 Lupin Ltd. Composition de cefepime co-precipite et procede de preparation correspondant
WO2006109324A2 (fr) * 2005-04-13 2006-10-19 Lupin Limited Procedes de preparation de sels d'addition acides de cefepime amorphes
JP5491119B2 (ja) * 2009-10-02 2014-05-14 日東電工株式会社 薬物含有微粒子を含む医薬組成物およびその製造方法
KR102329764B1 (ko) 2013-03-15 2021-11-23 머크 샤프 앤드 돔 코포레이션 세프톨로잔 항균성 조성물
US9872906B2 (en) 2013-03-15 2018-01-23 Merck Sharp & Dohme Corp. Ceftolozane antibiotic compositions
US20140274991A1 (en) 2013-03-15 2014-09-18 Cubist Pharmaceuticals, Inc. Ceftolozane pharmaceutical compositions
WO2015035376A2 (fr) 2013-09-09 2015-03-12 Calixa Therapeutics, Inc. Traitement d'infections au moyen de ceftolozane/tazobactam chez des sujets ayant une fonction rénale altérée
US8906898B1 (en) 2013-09-27 2014-12-09 Calixa Therapeutics, Inc. Solid forms of ceftolozane
US9949982B2 (en) 2014-09-04 2018-04-24 Shionogi & Co., Ltd. Preparation containing cephalosporin having a catechol moiety

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3953439A (en) * 1973-08-01 1976-04-27 Smithkline Corporation Substituted phenylglycylcephalosporins
US4029655A (en) * 1975-04-11 1977-06-14 Eli Lilly And Company Method of preparing stable sterile crystalline cephalosporins for parenteral administration
US4406899A (en) * 1982-03-04 1983-09-27 Bristol-Myers Company Cephalosporins
CA1213882A (fr) * 1982-03-04 1986-11-12 Jun Okumura Cephalosporines
JPS6045514A (ja) * 1983-08-22 1985-03-12 Shionogi & Co Ltd 安定な抗菌性凍結乾燥製剤
US4604386A (en) * 1984-07-09 1986-08-05 Eli Lilly And Company 3-(alkynylalkyloxy) cephalosporins
JPS61130223A (ja) * 1984-11-28 1986-06-18 Shionogi & Co Ltd 抗菌性凍結乾燥製剤
FR2585705B1 (fr) * 1985-08-05 1989-01-13 Bristol Myers Co Sels de cephalosporine et compositions injectables

Also Published As

Publication number Publication date
FI875122A0 (fi) 1987-11-19
ZA88114B (fr) 1988-06-27
AT388672B (de) 1989-08-10
FI89006B (fi) 1993-04-30
DE3740588C2 (de) 1996-07-11
CS265249B2 (en) 1989-10-13
KR950010154B1 (ko) 1995-09-11
DE3740588A1 (de) 1988-07-21
FI89006C (fi) 1993-08-10
DK577387A (da) 1988-07-10
CS15888A2 (en) 1989-01-12
JPS63208522A (ja) 1988-08-30
JP2568226B2 (ja) 1996-12-25
GB2199746A (en) 1988-07-20
DK577387D0 (da) 1987-11-03
YU46689B (sh) 1994-04-05
OA08796A (fr) 1989-03-31
SG114792G (en) 1992-12-24
HU199686B (en) 1990-03-28
GB2199746B (en) 1990-10-24
AR243501A1 (es) 1993-08-31
IT8819013A0 (it) 1988-01-07
YU2388A (en) 1989-10-31
IL84346A (en) 1992-05-25
ATA341687A (de) 1989-01-15
GR871860B (en) 1988-05-10
IL84346A0 (en) 1988-04-29
IE61238B1 (en) 1994-10-19
LU87102A1 (fr) 1988-08-23
CA1307464C (fr) 1992-09-15
FR2609396B1 (fr) 1993-01-29
CY1679A (en) 1993-10-10
GB8725875D0 (en) 1987-12-09
BE1002114A3 (fr) 1990-07-10
IE872970L (en) 1988-07-09
NL193266B (nl) 1999-01-04
SE8800036D0 (sv) 1988-01-08
SU1575942A3 (ru) 1990-06-30
DK166404B1 (da) 1993-05-17
SE8800036L (sv) 1988-07-10
SE467910B (sv) 1992-10-05
FR2609396A1 (fr) 1988-07-15
AU8085687A (en) 1989-05-11
HUT46223A (en) 1988-10-28
FI875122A (fi) 1988-07-10
US4808617A (en) 1989-02-28
ES2008951A6 (es) 1989-08-16
AU606361B2 (en) 1991-02-07
NL193266C (nl) 1999-05-06
KR880008811A (ko) 1988-09-13
CH676202A5 (fr) 1990-12-28
PT86157B (pt) 1991-02-08
NL8800025A (nl) 1988-08-01
PT86157A (en) 1987-12-01
HK5593A (en) 1993-02-05
IT1215666B (it) 1990-02-22

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Legal Events

Date Code Title Description
IF04 In force in the year 2004

Expiry date: 20071211