DD142342A5 - Verfahren zur herstellung von 6-substituierten thiaazaverbindungen - Google Patents

Verfahren zur herstellung von 6-substituierten thiaazaverbindungen Download PDF

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Publication number
DD142342A5
DD142342A5 DD79210799A DD21079979A DD142342A5 DD 142342 A5 DD142342 A5 DD 142342A5 DD 79210799 A DD79210799 A DD 79210799A DD 21079979 A DD21079979 A DD 21079979A DD 142342 A5 DD142342 A5 DD 142342A5
Authority
DD
German Democratic Republic
Prior art keywords
lower alkyl
substituted
hydroxy
amino
alkyl
Prior art date
Application number
DD79210799A
Other languages
German (de)
English (en)
Inventor
Jacques Gosteli
Ivan Ernest
Marc Lang
Robert B Woodward
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of DD142342A5 publication Critical patent/DD142342A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/568—Four-membered rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DD79210799A 1978-02-02 1979-02-02 Verfahren zur herstellung von 6-substituierten thiaazaverbindungen DD142342A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH114078 1978-02-02

Publications (1)

Publication Number Publication Date
DD142342A5 true DD142342A5 (de) 1980-06-18

Family

ID=4203421

Family Applications (1)

Application Number Title Priority Date Filing Date
DD79210799A DD142342A5 (de) 1978-02-02 1979-02-02 Verfahren zur herstellung von 6-substituierten thiaazaverbindungen

Country Status (23)

Country Link
US (2) US4692442A (da)
EP (2) EP0003960B1 (da)
JP (3) JPS54119486A (da)
AR (1) AR228236A1 (da)
AT (1) AT362876B (da)
AU (1) AU519317B2 (da)
CA (1) CA1340273C (da)
CS (1) CS222279B2 (da)
DD (1) DD142342A5 (da)
DK (1) DK160099C (da)
ES (1) ES477336A1 (da)
FI (1) FI73219C (da)
GB (1) GB2013674A (da)
GR (1) GR72911B (da)
HU (1) HU182017B (da)
IE (1) IE48776B1 (da)
IL (1) IL56557A (da)
NO (1) NO158679C (da)
NZ (1) NZ189530A (da)
PL (1) PL122371B1 (da)
PT (1) PT69166A (da)
SU (1) SU925252A3 (da)
ZA (1) ZA79433B (da)

Families Citing this family (90)

* Cited by examiner, † Cited by third party
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US4880793A (en) * 1978-07-24 1989-11-14 Merck & Co., Inc. Combination of thienamycin-type antibiotics with dipeptidase inhibitors
US5071843A (en) * 1978-07-24 1991-12-10 Merck & Co., Inc. Combination of 2-substituted carbapenems with dipeptidase inhibitors
JPS5625110A (en) * 1978-12-18 1981-03-10 Bristol Myers Co Antibacterial
US4282150A (en) 1978-12-18 1981-08-04 Bristol-Myers Company 2,6-Disubstituted penem compounds
US4272437A (en) 1978-12-18 1981-06-09 Bristol-Myers Company Antibacterial agents, and 4-thio azetidinone intermediates
ATE3041T1 (de) * 1979-01-10 1983-04-15 Schering Corporation 2-penem-verbindungen, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen.
IL59081A0 (en) * 1979-01-10 1980-05-30 Schering Corp 2-penem compounds and a method for preparing them
IT1193922B (it) * 1979-02-24 1988-08-31 Erba Farmitalia Agenti antibatterici ed inibitori di beta -lattamasi e loro preparazione
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US4378314A (en) 1979-09-21 1983-03-29 Bristol Myers Company Antibacterial agents and metal containing azetidinone intermediates therefore
US4374065A (en) 1979-09-21 1983-02-15 Bristol-Myers Company Antibacterial agents of the β-lactam type
US4443463A (en) * 1979-11-05 1984-04-17 Schering Corporation (5R,6S,8R)-6-(1-Hydroxyethyl)-2-(hydroxyalkylthio)-penem-3-carboxylates
ATE12773T1 (de) * 1980-02-28 1985-05-15 Schering Corp 2-penem-verbindungen, sie enthaltende pharmazeutische zusammensetzungen und verfahren zu ihrer herstellung.
SE8101464L (sv) * 1980-03-10 1981-09-11 Sankyo Co 2-penem-3-karboxylsyraderivat, deras framstellning och anvendning
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DE3176517D1 (en) * 1980-04-24 1987-12-17 Beecham Group Plc Beta-lactam compounds, their preparation and use
US4395418A (en) * 1980-06-06 1983-07-26 Sankyo Company Limited Penem-3-carboxylic acid derivatives
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DE3167198D1 (en) * 1980-08-16 1984-12-20 Beecham Group Plc Process for the preparation of 2-thio penem derivatives and intermediates therefor
ATE21105T1 (de) * 1980-11-06 1986-08-15 Hoechst Uk Ltd 7-oxo-4-thia-1-aza(3.2.0)heptan- und 7-oxo-4-thia-1-aza-(3.2.0)hept-2-en-derivate.
US4347183A (en) * 1981-02-02 1982-08-31 Schering Corporation Process for the synthesis of penems and carbapenems
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EP0070204B1 (en) * 1981-07-15 1987-11-19 Sumitomo Pharmaceuticals Company, Limited Carboxylic beta-lactam compounds and the preparation thereof
JPS58116487A (ja) * 1981-12-28 1983-07-11 Sumitomo Chem Co Ltd 新規なβ−ラクタム化合物及びその製造法
JPS58198486A (ja) * 1982-05-14 1983-11-18 Sankyo Co Ltd ペネムまたはカルバペネム−３−カルボン酸誘導体およびその製法
JPS5835190A (ja) * 1981-08-25 1983-03-01 Sankyo Co Ltd ペネム−３−カルボン酸誘導体
CA1190236A (en) * 1981-10-23 1985-07-09 Edward J.J. Grabowski Antibiotic synthesis
US4411906A (en) * 1981-11-25 1983-10-25 Schering Corporation (5R,6S,8R)-6-(1-Hydroxyethyl)-2-(2-fluoroethylthio)-penem-3-carboxylates
NL8204720A (nl) * 1981-12-11 1983-07-01 Erba Farmitalia Werkwijze voor het bereiden van optisch actieve penemverbindingen.
NO831160L (no) * 1982-04-08 1983-10-10 Erba Farmitalia Fremstilling av substituerte penem-derivater
JPS591464A (ja) * 1982-06-26 1984-01-06 Sankyo Co Ltd β−ラクタム化合物及びその製法
ATE35270T1 (de) * 1982-07-08 1988-07-15 Hoechst Uk Ltd Antibakterielle penem-derivate.
DE3372968D1 (en) * 1982-11-16 1987-09-17 Ciba Geigy Ag Heterocyclyl-thio compounds, process for their preparation, pharmaceutical compositions containing them and their use
US4540580A (en) * 1982-11-16 1985-09-10 Schering Corporation 2-[(1'R)-1'-Aminoalkyl]penems
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US4540579A (en) * 1982-11-16 1985-09-10 Schering Corporation 2-[(R) Amino acid alkyl]penems
DE3366926D1 (en) * 1982-11-16 1986-11-20 Schering Corp Penems, pharmaceutical compositions containing them, process for preparing them
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US4435413A (en) 1983-01-28 1984-03-06 Schering Corporation (5R-6S,8R)-6-(1-Hydroxyethyl)-2-(2-glycylaminoethylthio)-penem-3-carboxylic acid
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EP0125208A1 (de) * 1983-05-06 1984-11-14 Ciba-Geigy Ag Aminoniederalkyl-penem-Verbindungen, Verfahren zu ihrer Herstellung, pharmazeutische Präparate, welche diese Verbindungen enthalten, und Verwendung von letzteren
CA1283906C (en) * 1983-05-09 1991-05-07 Makoto Sunagawa .beta.-LACTAM COMPOUNDS AND PRODUCTION THEREOF
US4725678A (en) * 1983-06-10 1988-02-16 Pfizer Inc. Azetidinone intermediates for the preparation of penem derivatives
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US4619783A (en) * 1983-06-10 1986-10-28 Pfizer Inc. Process and intermediates for the preparation of penem derivatives
US4554103A (en) * 1983-07-14 1985-11-19 Schering Corporation Preparation of 4-acyloxyazetidinones from acyl nitrates and penams
GB8321677D0 (en) * 1983-08-11 1983-09-14 Erba Farmitalia Preparation of penems
US4656165A (en) * 1983-09-02 1987-04-07 Ciba-Geigy Corporation Aminomethyl penem compounds
US4584133A (en) * 1983-11-07 1986-04-22 Schering Corporation Process for the production of penems
US4587241A (en) * 1983-11-28 1986-05-06 Schering Corporation Heterocyclic substituted penems
US5229381A (en) * 1983-12-01 1993-07-20 Merck & Co., Inc. Substituted azetidinones as anti-inflammatory and antidegenerative agents
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US4617300A (en) * 1984-09-21 1986-10-14 Schering Corporation 2(N-heterocyclyl) penems
ATE93520T1 (de) * 1984-10-01 1993-09-15 Ciba Geigy Ag Verfahren zur herstellung von optisch aktiven acyloxyazetidinonen.
US4761408A (en) * 1984-11-02 1988-08-02 Ciba-Geigy Corporation Crystalline aminomethyl compound
JPH075463B2 (ja) * 1985-03-09 1995-01-25 サントリー株式会社 抗菌剤
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DE3752124T2 (de) * 1986-01-17 1998-03-26 Beecham Group Plc Verfahren zur Herstellung von Penem Derivaten und Zwischenprodukte zu dieser Herstellung
US4806637A (en) * 1986-03-17 1989-02-21 Schering Corporation 6-(Hydroxyethyl)-2-(heterocyclylthio)-penem-3-carboxylates
US4826832A (en) * 1986-05-06 1989-05-02 Ciba-Geigy Corporation Penen compounds
JP2526046B2 (ja) * 1986-12-26 1996-08-21 サントリー株式会社 ペネム誘導体、その製造法およびその用途
DE3882730D1 (de) * 1987-02-11 1993-09-09 Ciba Geigy Ag Bicyclische beta-lactam-carbonsaeuren.
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US5198544A (en) * 1989-04-29 1993-03-30 Hoechst Aktiengesellschaft Process for the preparation of penem compounds
US5100880A (en) * 1991-03-20 1992-03-31 Merck & Co., Inc. Novel betalactam elastase inhibitors containing phosphorous acid derivatives at the 4-position of the 2-azetidinone
US5104862A (en) * 1991-03-20 1992-04-14 Merck & Co., Inc. Bethalactam elastase inhibitors containing phosphorous acid derivatives at the 4-position of the 2-azetidinone
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ES2700575T3 (es) 2013-03-12 2019-02-18 Gladius Pharmaceuticals Corp 3-Estiril-cefalosporinas derivadas
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Also Published As

Publication number Publication date
NO158679C (no) 1988-10-19
JPH045677B2 (da) 1992-02-03
GR72911B (da) 1984-01-05
PL122371B1 (en) 1982-07-31
IE790191L (en) 1979-08-02
GB2013674A (en) 1979-08-15
AU519317B2 (en) 1981-11-26
JPH01110668A (ja) 1989-04-27
JPS62129264A (ja) 1987-06-11
JPH0329789B2 (da) 1991-04-25
DK160099C (da) 1991-06-24
SU925252A3 (ru) 1982-04-30
CA1340273C (en) 1998-12-15
PL213133A1 (da) 1980-03-10
DK43279A (da) 1979-08-03
EP0042026B1 (de) 1986-01-08
IE48776B1 (en) 1985-05-15
US4692442A (en) 1987-09-08
EP0003960A1 (de) 1979-09-19
AR228236A1 (es) 1983-02-15
EP0003960B1 (de) 1983-06-29
NZ189530A (en) 1982-02-23
IL56557A (en) 1982-01-31
JPH0314037B2 (da) 1991-02-25
DK160099B (da) 1991-01-28
ZA79433B (en) 1980-02-27
EP0042026A1 (de) 1981-12-23
JPS54119486A (en) 1979-09-17
PT69166A (de) 1979-03-01
IL56557A0 (en) 1979-03-12
CS222279B2 (en) 1983-06-24
AT362876B (de) 1981-06-25
US4952690A (en) 1990-08-28
FI73219B (fi) 1987-05-29
ES477336A1 (es) 1979-07-01
AU4384379A (en) 1979-08-09
NO790332L (no) 1979-08-03
FI73219C (fi) 1987-09-10
NO158679B (no) 1988-07-11
HU182017B (en) 1983-12-28
FI790321A (fi) 1979-08-03
ATA74579A (de) 1980-11-15

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