CZ293482B6 - DihydropyrimidinyŹ způsob jejich výrobyŹ léčiva tyto látky obsahující a jejich použití - Google Patents

DihydropyrimidinyŹ způsob jejich výrobyŹ léčiva tyto látky obsahující a jejich použití Download PDF

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Publication number
CZ293482B6
CZ293482B6 CZ20003871A CZ20003871A CZ293482B6 CZ 293482 B6 CZ293482 B6 CZ 293482B6 CZ 20003871 A CZ20003871 A CZ 20003871A CZ 20003871 A CZ20003871 A CZ 20003871A CZ 293482 B6 CZ293482 B6 CZ 293482B6
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CZ
Czechia
Prior art keywords
group
carbon atoms
formula
substituted
alkyl
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CZ20003871A
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Czech (cs)
English (en)
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CZ20003871A3 (cs
Inventor
Stoltefussájürgen
Goldmannásiegfried
Krämeráthomas
Schlemmerákarl@Heinz
Niewöhneráulrich
Paessensáarnold
Graefáerwin
Lottmannástefan
Deresákark
Weberáolaf
Stöltingájörn
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Bayeráaktiengesellschaft
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Application filed by Bayeráaktiengesellschaft filed Critical Bayeráaktiengesellschaft
Publication of CZ20003871A3 publication Critical patent/CZ20003871A3/cs
Publication of CZ293482B6 publication Critical patent/CZ293482B6/cs

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/20Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D239/22Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84Nitriles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Saccharide Compounds (AREA)
CZ20003871A 1998-04-18 1999-04-07 DihydropyrimidinyŹ způsob jejich výrobyŹ léčiva tyto látky obsahující a jejich použití CZ293482B6 (cs)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19817264A DE19817264A1 (de) 1998-04-18 1998-04-18 Neue Dihydropyrimidine

Publications (2)

Publication Number Publication Date
CZ20003871A3 CZ20003871A3 (cs) 2001-01-17
CZ293482B6 true CZ293482B6 (cs) 2004-05-12

Family

ID=7864972

Family Applications (1)

Application Number Title Priority Date Filing Date
CZ20003871A CZ293482B6 (cs) 1998-04-18 1999-04-07 DihydropyrimidinyŹ způsob jejich výrobyŹ léčiva tyto látky obsahující a jejich použití

Country Status (36)

Country Link
US (3) US6696451B1 (esLanguage)
EP (1) EP1080086B1 (esLanguage)
JP (2) JP4590097B2 (esLanguage)
KR (1) KR100636771B1 (esLanguage)
CN (1) CN1159311C (esLanguage)
AR (1) AR018187A1 (esLanguage)
AT (1) ATE223401T1 (esLanguage)
AU (1) AU740318B2 (esLanguage)
BG (1) BG64649B1 (esLanguage)
BR (2) BRPI9917862B8 (esLanguage)
CA (1) CA2328780C (esLanguage)
CO (1) CO5021127A1 (esLanguage)
CU (1) CU23049A3 (esLanguage)
CZ (1) CZ293482B6 (esLanguage)
DE (2) DE19817264A1 (esLanguage)
DK (1) DK1080086T3 (esLanguage)
ES (1) ES2183548T3 (esLanguage)
GT (1) GT199900056A (esLanguage)
HU (1) HUP0102372A3 (esLanguage)
ID (1) ID27263A (esLanguage)
IL (2) IL138584A0 (esLanguage)
MY (1) MY126527A (esLanguage)
NO (2) NO321985B1 (esLanguage)
NZ (1) NZ507569A (esLanguage)
PE (1) PE20000427A1 (esLanguage)
PL (1) PL193898B1 (esLanguage)
PT (1) PT1080086E (esLanguage)
RU (1) RU2245881C9 (esLanguage)
SI (1) SI1080086T1 (esLanguage)
SK (1) SK286407B6 (esLanguage)
SV (1) SV1999000047A (esLanguage)
TR (1) TR200003011T2 (esLanguage)
TW (1) TW548274B (esLanguage)
UA (1) UA63998C2 (esLanguage)
WO (1) WO1999054326A1 (esLanguage)
ZA (1) ZA200005136B (esLanguage)

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AU4289100A (en) * 1999-03-25 2000-10-16 Bayer Aktiengesellschaft Dihydropyrimidines and their use in the treatment of hepatitis
AU5568400A (en) 1999-06-23 2001-01-09 Ajinomoto Co., Inc. Novel dihydropyrimidine derivatives
WO2001045712A1 (de) * 1999-12-22 2001-06-28 Bayer Aktiengesellschaft Arzneimittelkombinationen gegen virale erkrankungen
DE10012823A1 (de) 2000-03-16 2001-09-20 Bayer Ag Arzneimittel gegen virale Erkrankungen
DE10013125A1 (de) * 2000-03-17 2001-09-20 Bayer Ag Arzneimittel gegen virale Erkrankungen
DE10013126A1 (de) * 2000-03-17 2001-09-20 Bayer Ag Arzneimittel gegen virale Erkrankungen
DE10125131A1 (de) 2001-05-23 2002-12-05 Bayer Ag Verfahren zur Spaltung des Methyl 4-(2-chlor-4-fluorphenyl)-2-(3,5-difluor-2-pyridinyl)-6-methyl-1,4-dihydro-5-pyrmidincarboxylat-Racemats
US20040092735A1 (en) * 2002-11-08 2004-05-13 Orchid Chemicals & Pharmaceuticals Limited Process for the preparation of cefuroxime sodium
CN101104617B (zh) * 2006-07-10 2010-06-23 北京摩力克科技有限公司 二氢嘧啶类化合物及其用于制备治疗和预防病毒性疾病的药物的用途
CN101104604B (zh) * 2006-07-10 2011-03-02 北京摩力克科技有限公司 光学纯二氢嘧啶类化合物及其用于制备治疗和预防病毒性疾病的药物的用途
RU2452733C2 (ru) * 2007-04-27 2012-06-10 Пэдью Фарма Л.П. Антагонисты trpv1 и их применение
EP2514750B1 (en) 2007-06-18 2013-11-20 Sunshine Lake Pharma Co., Ltd Bromo-phenyl substituted thiazolyl dihydropyrimidines
US8445457B2 (en) 2007-07-12 2013-05-21 Novartis Ag Oral pharmaceutical solutions containing telbivudine
US20130267517A1 (en) 2012-03-31 2013-10-10 Hoffmann-La Roche Inc. Novel 4-methyl-dihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection
TWI668217B (zh) * 2012-08-24 2019-08-11 廣東東陽光藥業有限公司 二氫嘧啶類化合物及其在藥物中的應用
HK1210152A1 (en) 2012-09-10 2016-04-15 F. Hoffmann-La Roche Ag 6-amino acid heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection
CN103664899B (zh) * 2012-09-11 2017-06-16 广东东阳光药业有限公司 杂芳基取代的二氢嘧啶类化合物及其在药物中的应用
CA2889892A1 (en) * 2012-11-09 2014-05-15 Indiana University Research And Technology Corporation Alternative uses for hbv assembly effectors
TW201609652A (zh) * 2013-11-12 2016-03-16 陶氏農業科學公司 用於氟化化合物之過程(三)
US9498479B2 (en) 2013-11-19 2016-11-22 Sunshine Lake Pharma Co., Ltd. Dihydropyrimidine compounds and their application in pharmaceuticals
US9643962B2 (en) 2013-11-27 2017-05-09 Sunshine Lake Pharma Co., Ltd. Processes for preparing dihydropyrimidine derivatives and intermediates thereof
AU2015236982B2 (en) 2014-03-28 2017-12-14 Sunshine Lake Pharma Co., Ltd. Dihydropyrimidine compounds and their application in pharmaceuticals
CN105153164B (zh) * 2014-05-30 2018-10-30 齐鲁制药有限公司 作为hbv抑制剂的二氢嘧啶并环衍生物
WO2015180631A1 (zh) 2014-05-30 2015-12-03 南京明德新药研发股份有限公司 作为hbv抑制剂的二氢嘧啶并环衍生物
RU2017127611A (ru) 2015-02-07 2019-03-07 Саншайн Лейк Фарма Ко., Лтд. Комплексные соединения и соли производных дигидропиримидина и их применение в фармацевтических препаратах
EP3645516A4 (en) 2017-06-27 2021-07-07 Janssen Pharmaceutica NV HETEROARYLDIHYDROPYRIMIDE DERIVATIVES AND METHODS OF TREATMENT OF HEPATITIS B INFECTIONS
US10759774B2 (en) 2017-09-28 2020-09-01 The Curators Of The University Of Missouri Inhibitors of hepatitis B virus targeting capsid assembly
AR115131A1 (es) 2017-11-02 2020-12-02 Aicuris Gmbh & Co Kg Altamente activas indolo-2-carboxamidas sustituidas con pirazolo-pirimidina activas contra el virus de la hepatitis b (vhb)
TW201930315A (zh) 2017-11-02 2019-08-01 德商艾庫瑞斯公司 具抗b型肝炎病毒(hbv)活性之新穎高活性胺基-噻唑取代之吲哚-2-甲醯胺
KR20210006412A (ko) * 2018-05-08 2021-01-18 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 디히드로피리미딘 유도체 및 hbv 감염 또는 hbv-유도성 질환의 치료에 있어서의 이의 용도
US11053235B2 (en) 2018-08-09 2021-07-06 Janssen Sciences Ireland Unlimited Company Substituted 1,4-dihydropyrimidines for the treatment of HBV infection or HBV-induced diseases
EA202191221A1 (ru) * 2018-11-02 2021-08-04 Айкурис Гмбх Унд Ко. Кг НОВЫЕ МОЧЕВИНО-6,7-ДИГИДРО-4H-ТИАЗОЛО[5,4-c]ПИРИДИНЫ, АКТИВНЫЕ ПРОТИВ ВИРУСА ГЕПАТИТА В (HBV)
AR116947A1 (es) 2018-11-02 2021-06-30 Aicuris Gmbh & Co Kg Derivados de urea 6,7-dihidro-4h-pirazolo[1,5-a]pirazinas-indol-2-carboxamidas activas contra el virus de la hepatitis b (vhb)
UY38434A (es) 2018-11-02 2020-05-29 Aicuris Gmbh & Co Kg Nuevas 6,7-dihidro-4h-pirazolo[1,5-a]pirazin indol-2-carboxamidas activas contra el virus de la hepatitis b (hbv)
UY38439A (es) 2018-11-02 2020-05-29 Aicuris Gmbh & Co Kg Novedosas urea 6,7-dihidro-4h-pirazolo[4,3-c]piridinas activas contra el virus de la hepatitis b (vhb)
AR116948A1 (es) 2018-11-02 2021-06-30 Aicuris Gmbh & Co Kg Derivados de urea 6,7-dihidro-4h-pirazolo[1,5-a]pirazinas activas contra el virus de la hepatitis b (vhb)
AR117188A1 (es) 2018-11-02 2021-07-21 Aicuris Gmbh & Co Kg Derivados de urea 6,7-dihidro-4h-pirazolo[1,5-a]pirazinas activas contra el virus de la hepatitis b (vhb)
CA3124317A1 (en) 2018-12-20 2020-06-25 Janssen Pharmaceutica Nv Heteroaryldihydropyrimidine derivatives and methods of treating hepatitis b infections
MX2021013105A (es) 2019-04-30 2021-11-17 Aicuris Gmbh & Co Kg Nuevas oxalil piperazinas activas contra el virus de la hepatitis b (vhb).
CA3138385A1 (en) 2019-04-30 2020-11-05 Aicuris Gmbh & Co. Kg Novel indolizine-2-carboxamides active against the hepatitis b virus (hbv)
MX2021013086A (es) 2019-04-30 2021-11-17 Aicuris Gmbh & Co Kg Nuevas fenil y piridil ureas activas contra el virus de la hepatitis b (vhb).
SG11202111236UA (en) 2019-04-30 2021-11-29 Aicuris Gmbh & Co Kg Novel indole-2-carboxamides active against the hepatitis b virus (hbv)
WO2020255016A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and dihydropyrimidine derivatives as capsid assembly modulators

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KR20000053201A (ko) * 1996-11-12 2000-08-25 한스 루돌프 하우스, 헨리테 브룬너, 베아트리체 귄터 제초제로서 유용한 피라졸 유도체
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Publication number Publication date
BG104812A (en) 2001-06-29
HK1039119A1 (en) 2002-04-12
HUP0102372A3 (en) 2003-01-28
PE20000427A1 (es) 2000-06-25
TR200003011T2 (tr) 2001-01-22
JP4590097B2 (ja) 2010-12-01
RU2245881C9 (ru) 2006-02-10
WO1999054326A1 (de) 1999-10-28
JP5237332B2 (ja) 2013-07-17
SK15652000A3 (sk) 2001-04-09
CA2328780A1 (en) 1999-10-28
PT1080086E (pt) 2002-12-31
ZA200005136B (en) 2001-03-02
PL343481A1 (en) 2001-08-27
NO20005215L (no) 2000-12-13
IL138584A0 (en) 2001-10-31
BR9909730B1 (pt) 2012-09-04
WO1999054326A8 (de) 1999-12-29
JP2010241837A (ja) 2010-10-28
BG64649B1 (bg) 2005-10-31
PL193898B1 (pl) 2007-03-30
CA2328780C (en) 2008-09-23
MY126527A (en) 2006-10-31
SK286407B6 (sk) 2008-09-05
DE59902573D1 (en) 2002-10-10
US20070117812A1 (en) 2007-05-24
KR20010042788A (ko) 2001-05-25
NO20005215D0 (no) 2000-10-17
DE19817264A1 (de) 1999-10-21
US7514565B2 (en) 2009-04-07
JP2002512243A (ja) 2002-04-23
US6696451B1 (en) 2004-02-24
GT199900056A (es) 2000-10-07
AR018187A1 (es) 2001-10-31
KR100636771B1 (ko) 2006-10-23
NO329020B1 (no) 2010-07-26
SI1080086T1 (en) 2003-02-28
TW548274B (en) 2003-08-21
CN1159311C (zh) 2004-07-28
HUP0102372A2 (hu) 2001-12-28
IL138584A (en) 2006-09-05
ID27263A (id) 2001-03-22
BR9909730A (pt) 2000-12-19
NO20045259L (no) 2000-12-13
AU740318B2 (en) 2001-11-01
DK1080086T3 (da) 2002-12-23
US20040167135A1 (en) 2004-08-26
CU23049A3 (es) 2005-06-24
SV1999000047A (es) 2000-06-23
BRPI9917862B8 (pt) 2021-05-25
NZ507569A (en) 2002-04-26
CO5021127A1 (es) 2001-03-27
EP1080086A1 (de) 2001-03-07
BRPI9917862A2 (esLanguage) 2010-12-07
NO321985B1 (no) 2006-07-31
BRPI9917862B1 (pt) 2013-05-07
RU2245881C2 (ru) 2005-02-10
UA63998C2 (uk) 2004-02-16
ATE223401T1 (de) 2002-09-15
CZ20003871A3 (cs) 2001-01-17
EP1080086B1 (de) 2002-09-04
CN1305471A (zh) 2001-07-25
AU3813399A (en) 1999-11-08
ES2183548T3 (es) 2003-03-16

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