BR9909730B1 - dihidropirimidinas, bem como processo para a preparação e aplicação das mesmas. - Google Patents
dihidropirimidinas, bem como processo para a preparação e aplicação das mesmas.Info
- Publication number
- BR9909730B1 BR9909730B1 BRPI9909730-3A BR9909730A BR9909730B1 BR 9909730 B1 BR9909730 B1 BR 9909730B1 BR 9909730 A BR9909730 A BR 9909730A BR 9909730 B1 BR9909730 B1 BR 9909730B1
- Authority
- BR
- Brazil
- Prior art keywords
- dihydropyrimidines
- processes
- preparation
- well
- application
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19817264A DE19817264A1 (de) | 1998-04-18 | 1998-04-18 | Neue Dihydropyrimidine |
PCT/EP1999/002344 WO1999054326A1 (de) | 1998-04-18 | 1999-04-07 | Dihydropyrimidine |
Publications (2)
Publication Number | Publication Date |
---|---|
BR9909730A BR9909730A (pt) | 2000-12-19 |
BR9909730B1 true BR9909730B1 (pt) | 2012-09-04 |
Family
ID=7864972
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI9909730-3A BR9909730B1 (pt) | 1998-04-18 | 1999-04-07 | dihidropirimidinas, bem como processo para a preparação e aplicação das mesmas. |
BRPI9917862A BRPI9917862B8 (pt) | 1998-04-18 | 1999-04-07 | dihidropirimidinas, bem como processo para a preparação e aplicação das mesmas. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI9917862A BRPI9917862B8 (pt) | 1998-04-18 | 1999-04-07 | dihidropirimidinas, bem como processo para a preparação e aplicação das mesmas. |
Country Status (37)
Country | Link |
---|---|
US (3) | US6696451B1 (pt) |
EP (1) | EP1080086B1 (pt) |
JP (2) | JP4590097B2 (pt) |
KR (1) | KR100636771B1 (pt) |
CN (1) | CN1159311C (pt) |
AR (1) | AR018187A1 (pt) |
AT (1) | ATE223401T1 (pt) |
AU (1) | AU740318B2 (pt) |
BG (1) | BG64649B1 (pt) |
BR (2) | BR9909730B1 (pt) |
CA (1) | CA2328780C (pt) |
CO (1) | CO5021127A1 (pt) |
CU (1) | CU23049A3 (pt) |
CZ (1) | CZ293482B6 (pt) |
DE (2) | DE19817264A1 (pt) |
DK (1) | DK1080086T3 (pt) |
ES (1) | ES2183548T3 (pt) |
GT (1) | GT199900056A (pt) |
HK (1) | HK1039119A1 (pt) |
HU (1) | HUP0102372A3 (pt) |
ID (1) | ID27263A (pt) |
IL (2) | IL138584A0 (pt) |
MY (1) | MY126527A (pt) |
NO (2) | NO321985B1 (pt) |
NZ (1) | NZ507569A (pt) |
PE (1) | PE20000427A1 (pt) |
PL (1) | PL193898B1 (pt) |
PT (1) | PT1080086E (pt) |
RU (1) | RU2245881C9 (pt) |
SI (1) | SI1080086T1 (pt) |
SK (1) | SK286407B6 (pt) |
SV (1) | SV1999000047A (pt) |
TR (1) | TR200003011T2 (pt) |
TW (1) | TW548274B (pt) |
UA (1) | UA63998C2 (pt) |
WO (1) | WO1999054326A1 (pt) |
ZA (1) | ZA200005136B (pt) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU4289100A (en) * | 1999-03-25 | 2000-10-16 | Bayer Aktiengesellschaft | Dihydropyrimidines and their use in the treatment of hepatitis |
EP1193259A4 (en) | 1999-06-23 | 2003-01-29 | Ajinomoto Kk | dihydropyrimidine |
AU3009801A (en) * | 1999-12-22 | 2001-07-03 | Bayer Aktiengesellschaft | Combinations of medicaments for treating viral diseases |
DE10012823A1 (de) * | 2000-03-16 | 2001-09-20 | Bayer Ag | Arzneimittel gegen virale Erkrankungen |
DE10013125A1 (de) * | 2000-03-17 | 2001-09-20 | Bayer Ag | Arzneimittel gegen virale Erkrankungen |
DE10013126A1 (de) * | 2000-03-17 | 2001-09-20 | Bayer Ag | Arzneimittel gegen virale Erkrankungen |
DE10125131A1 (de) | 2001-05-23 | 2002-12-05 | Bayer Ag | Verfahren zur Spaltung des Methyl 4-(2-chlor-4-fluorphenyl)-2-(3,5-difluor-2-pyridinyl)-6-methyl-1,4-dihydro-5-pyrmidincarboxylat-Racemats |
US20040092735A1 (en) * | 2002-11-08 | 2004-05-13 | Orchid Chemicals & Pharmaceuticals Limited | Process for the preparation of cefuroxime sodium |
CN101104604B (zh) * | 2006-07-10 | 2011-03-02 | 北京摩力克科技有限公司 | 光学纯二氢嘧啶类化合物及其用于制备治疗和预防病毒性疾病的药物的用途 |
CN101104617B (zh) * | 2006-07-10 | 2010-06-23 | 北京摩力克科技有限公司 | 二氢嘧啶类化合物及其用于制备治疗和预防病毒性疾病的药物的用途 |
RU2452733C2 (ru) * | 2007-04-27 | 2012-06-10 | Пэдью Фарма Л.П. | Антагонисты trpv1 и их применение |
EP2514750B1 (en) | 2007-06-18 | 2013-11-20 | Sunshine Lake Pharma Co., Ltd | Bromo-phenyl substituted thiazolyl dihydropyrimidines |
KR20100029829A (ko) | 2007-07-12 | 2010-03-17 | 노파르티스 아게 | 텔비부딘을 함유하는 경구 제약 용액제 |
US20130267517A1 (en) | 2012-03-31 | 2013-10-10 | Hoffmann-La Roche Inc. | Novel 4-methyl-dihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection |
CN103626752B (zh) * | 2012-08-24 | 2015-08-12 | 广东东阳光药业有限公司 | 二氢嘧啶类化合物及其在药物中的应用 |
ES2617906T3 (es) | 2012-09-10 | 2017-06-20 | F. Hoffmann-La Roche Ag | 6-Aminoácido heteroarildihidropirimidinas para el tratamiento y la profilaxis de la infección por virus de la hepatitis B |
CN103664899B (zh) * | 2012-09-11 | 2017-06-16 | 广东东阳光药业有限公司 | 杂芳基取代的二氢嘧啶类化合物及其在药物中的应用 |
RU2015121940A (ru) * | 2012-11-09 | 2016-12-27 | Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн | Альтернативные применения эффекторов сборки вируса гепатита в (hbv) |
DE112014001468T5 (de) | 2013-03-15 | 2015-11-26 | Fisher & Paykel Healthcare Limited | Komponenten für medizinische Kreisläufe |
TW201609652A (zh) * | 2013-11-12 | 2016-03-16 | 陶氏農業科學公司 | 用於氟化化合物之過程(三) |
JP6524081B2 (ja) | 2013-11-19 | 2019-06-05 | サンシャイン・レイク・ファーマ・カンパニー・リミテッドSunshine Lake Pharma Co.,Ltd. | ジヒドロピリミジン化合物及び医薬におけるその適用 |
WO2015078393A1 (en) | 2013-11-27 | 2015-06-04 | Sunshine Lake Pharma Co., Ltd. | Processes for preparing dihydropyrimidine derivatives and intermediates thereof |
US9771358B2 (en) | 2014-03-28 | 2017-09-26 | Sunshine Lake Pharma Co., Ltd. | Dihydropyrimidine compounds and their application in pharmaceuticals |
NZ727601A (en) * | 2014-05-30 | 2022-01-28 | Qilu Pharmaceutical Co Ltd | Dihydropyrimido fused ring derivative as hbv inhibitor |
CN105153164B (zh) * | 2014-05-30 | 2018-10-30 | 齐鲁制药有限公司 | 作为hbv抑制剂的二氢嘧啶并环衍生物 |
JP2018504414A (ja) | 2015-02-07 | 2018-02-15 | サンシャイン・レイク・ファーマ・カンパニー・リミテッドSunshine Lake Pharma Co.,Ltd. | ジヒドロピリミジン誘導体の複合体及び塩並びにそれらの医薬品への応用 |
AU2018291688B2 (en) * | 2017-06-27 | 2022-02-03 | Janssen Pharmaceutica Nv | Heteroaryldihydropyrimidine derivatives and methods of treating hepatitis B infections |
US10759774B2 (en) | 2017-09-28 | 2020-09-01 | The Curators Of The University Of Missouri | Inhibitors of hepatitis B virus targeting capsid assembly |
US11267825B2 (en) | 2017-11-02 | 2022-03-08 | Aicuris Gmbh & Co. Kg | Highly active amino-thiazole substituted indole-2-carboxamides active against the hepatitis B virus (HBV) |
CN111527087A (zh) | 2017-11-02 | 2020-08-11 | 艾库里斯有限及两合公司 | 具有抗乙型肝炎病毒(hbv)活性的新的高活性的吡唑并-哌啶取代的吲哚-2-甲酰胺 |
JP2021523160A (ja) * | 2018-05-08 | 2021-09-02 | ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー | ジヒドロピリミジン誘導体及びhbv感染又はhbv誘導性疾患の治療におけるその使用 |
US11053235B2 (en) | 2018-08-09 | 2021-07-06 | Janssen Sciences Ireland Unlimited Company | Substituted 1,4-dihydropyrimidines for the treatment of HBV infection or HBV-induced diseases |
AR116947A1 (es) | 2018-11-02 | 2021-06-30 | Aicuris Gmbh & Co Kg | Derivados de urea 6,7-dihidro-4h-pirazolo[1,5-a]pirazinas-indol-2-carboxamidas activas contra el virus de la hepatitis b (vhb) |
UY38434A (es) | 2018-11-02 | 2020-05-29 | Aicuris Gmbh & Co Kg | Nuevas 6,7-dihidro-4h-pirazolo[1,5-a]pirazin indol-2-carboxamidas activas contra el virus de la hepatitis b (hbv) |
UY38439A (es) | 2018-11-02 | 2020-05-29 | Aicuris Gmbh & Co Kg | Novedosas urea 6,7-dihidro-4h-pirazolo[4,3-c]piridinas activas contra el virus de la hepatitis b (vhb) |
AR117188A1 (es) | 2018-11-02 | 2021-07-21 | Aicuris Gmbh & Co Kg | Derivados de urea 6,7-dihidro-4h-pirazolo[1,5-a]pirazinas activas contra el virus de la hepatitis b (vhb) |
AR116948A1 (es) | 2018-11-02 | 2021-06-30 | Aicuris Gmbh & Co Kg | Derivados de urea 6,7-dihidro-4h-pirazolo[1,5-a]pirazinas activas contra el virus de la hepatitis b (vhb) |
AU2019373679A1 (en) | 2018-11-02 | 2021-05-27 | Aicuris Gmbh & Co. Kg | Novel urea 6,7-dihydro-4H-thiazolo(5,4-c)pyridines active against the hepatitis B virus (HBV) |
KR20210106421A (ko) | 2018-12-20 | 2021-08-30 | 얀센 파마슈티카 엔.브이. | 헤테로아릴디히드로피리미딘 유도체 및 b형 간염 감염의 치료 방법 |
AU2020265390A1 (en) | 2019-04-30 | 2021-12-23 | Aicuris Gmbh & Co. Kg | Novel phenyl and pyridyl ureas active against the hepatitis B virus (HBV) |
CA3138385A1 (en) | 2019-04-30 | 2020-11-05 | Aicuris Gmbh & Co. Kg | Novel indolizine-2-carboxamides active against the hepatitis b virus (hbv) |
WO2020221811A1 (en) | 2019-04-30 | 2020-11-05 | Aicuris Gmbh & Co. Kg | Novel oxalyl piperazines active against the hepatitis b virus (hbv) |
JP2022530522A (ja) | 2019-04-30 | 2022-06-29 | アイクリス ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | B型肝炎ウイルス(hbv)に対し活性な新規のインドール-2-カルボキサミド |
WO2020255016A1 (en) | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Combination of hepatitis b virus (hbv) vaccines and dihydropyrimidine derivatives as capsid assembly modulators |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH550189A (de) | 1971-01-08 | 1974-06-14 | Ciba Geigy Ag | Verfahren zur herstellung von neuen dibenzo (b,f) thiepincarbonsaeuren. |
CH569043A5 (pt) | 1973-01-23 | 1975-11-14 | Ciba Geigy Ag | |
US4371537A (en) * | 1981-08-13 | 1983-02-01 | The Dow Chemical Company | Sulfur-substituted phenoxypyridines having antiviral activity |
DE3234684A1 (de) * | 1982-09-18 | 1984-03-22 | Bayer Ag, 5090 Leverkusen | Neue dihydropyrimidine, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln |
JPS60185764A (ja) * | 1984-03-05 | 1985-09-21 | Wako Pure Chem Ind Ltd | ピリジン誘導体の新規な製造法 |
US4698340A (en) * | 1984-07-19 | 1987-10-06 | Fujisawa Pharmaceutical Co., Ltd. | Pyrimidine derivatives, processes for preparation thereof and composition containing the same |
US4727073A (en) | 1984-10-01 | 1988-02-23 | Fujisawa Pharmaceutical Co., Ltd. | Pyrimidine derivatives and composition of the same |
GB8906168D0 (en) * | 1989-03-17 | 1989-05-04 | Pfizer Ltd | Therapeutic agents |
KR20000053201A (ko) | 1996-11-12 | 2000-08-25 | 한스 루돌프 하우스, 헨리테 브룬너, 베아트리체 귄터 | 제초제로서 유용한 피라졸 유도체 |
SE9702564D0 (sv) | 1997-07-02 | 1997-07-02 | Astra Ab | New compounds |
-
1998
- 1998-04-18 DE DE19817264A patent/DE19817264A1/de not_active Withdrawn
-
1999
- 1999-04-07 DE DE59902573T patent/DE59902573D1/de not_active Expired - Lifetime
- 1999-04-07 EP EP99920603A patent/EP1080086B1/de not_active Expired - Lifetime
- 1999-04-07 CZ CZ20003871A patent/CZ293482B6/cs not_active IP Right Cessation
- 1999-04-07 KR KR1020007011527A patent/KR100636771B1/ko not_active IP Right Cessation
- 1999-04-07 RU RU2000129148/04A patent/RU2245881C9/ru active
- 1999-04-07 BR BRPI9909730-3A patent/BR9909730B1/pt not_active IP Right Cessation
- 1999-04-07 PL PL99343481A patent/PL193898B1/pl unknown
- 1999-04-07 JP JP2000544665A patent/JP4590097B2/ja not_active Expired - Lifetime
- 1999-04-07 CA CA002328780A patent/CA2328780C/en not_active Expired - Lifetime
- 1999-04-07 IL IL13858499A patent/IL138584A0/xx active IP Right Grant
- 1999-04-07 ES ES99920603T patent/ES2183548T3/es not_active Expired - Lifetime
- 1999-04-07 PT PT99920603T patent/PT1080086E/pt unknown
- 1999-04-07 DK DK99920603T patent/DK1080086T3/da active
- 1999-04-07 SK SK1565-2000A patent/SK286407B6/sk not_active IP Right Cessation
- 1999-04-07 BR BRPI9917862A patent/BRPI9917862B8/pt not_active IP Right Cessation
- 1999-04-07 WO PCT/EP1999/002344 patent/WO1999054326A1/de active IP Right Grant
- 1999-04-07 ID IDW20002111A patent/ID27263A/id unknown
- 1999-04-07 TR TR2000/03011T patent/TR200003011T2/xx unknown
- 1999-04-07 CN CNB998074950A patent/CN1159311C/zh not_active Expired - Lifetime
- 1999-04-07 AU AU38133/99A patent/AU740318B2/en not_active Expired
- 1999-04-07 CU CU20000220A patent/CU23049A3/es unknown
- 1999-04-07 AT AT99920603T patent/ATE223401T1/de active
- 1999-04-07 NZ NZ507569A patent/NZ507569A/en not_active IP Right Cessation
- 1999-04-07 SI SI9930139T patent/SI1080086T1/xx unknown
- 1999-04-07 HU HU0102372A patent/HUP0102372A3/hu unknown
- 1999-04-07 US US09/673,592 patent/US6696451B1/en not_active Expired - Lifetime
- 1999-04-15 PE PE1999000309A patent/PE20000427A1/es not_active IP Right Cessation
- 1999-04-16 CO CO99022937A patent/CO5021127A1/es unknown
- 1999-04-16 MY MYPI99001481A patent/MY126527A/en unknown
- 1999-04-16 SV SV1999000047A patent/SV1999000047A/es active IP Right Grant
- 1999-04-16 GT GT199900056A patent/GT199900056A/es unknown
- 1999-04-16 TW TW088106067A patent/TW548274B/zh active
- 1999-04-16 AR ARP990101779A patent/AR018187A1/es active IP Right Grant
- 1999-07-04 UA UA2000116511A patent/UA63998C2/uk unknown
-
2000
- 2000-09-20 IL IL138584A patent/IL138584A/en not_active IP Right Cessation
- 2000-09-26 ZA ZA200005136A patent/ZA200005136B/xx unknown
- 2000-09-29 BG BG104812A patent/BG64649B1/bg unknown
- 2000-10-17 NO NO20005215A patent/NO321985B1/no not_active IP Right Cessation
-
2002
- 2002-01-21 HK HK02100473A patent/HK1039119A1/xx not_active IP Right Cessation
-
2004
- 2004-02-17 US US10/781,075 patent/US20040167135A1/en not_active Abandoned
- 2004-12-01 NO NO20045259A patent/NO329020B1/no not_active IP Right Cessation
-
2006
- 2006-12-15 US US11/639,955 patent/US7514565B2/en not_active Expired - Fee Related
-
2010
- 2010-07-23 JP JP2010165860A patent/JP5237332B2/ja not_active Expired - Lifetime
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR9909730B1 (pt) | dihidropirimidinas, bem como processo para a preparação e aplicação das mesmas. | |
BR9712808B1 (pt) | indol-3-glioxilamidas n-substituìdas, bem como aplicação, medicamento e processo para a preparação das mesmas. | |
BR9913455B1 (pt) | Formulações de microcápsulas, bem como processo para preparação e emprego das mesmas | |
BR9804504B1 (pt) | isoquinolina-3-carboxamidas substituÍdas, processo para a preparaÇço das mesmas e medicamento. | |
LU93311I2 (fr) | Mancozèbe, valifenalate | |
BR9807502B1 (pt) | compostos orgÂnicos, processo para sua preparaÇço, bem como composiÇço e aplicaÇço dos mesmos. | |
ID26326A (id) | Deripat-deripat 2 purin 9 il tetrahiderofuran 3,4 diol | |
BR9807685B1 (pt) | ftalazinas, preparaÇço farmacÊutica que as compreende, bem como uso das mesmas. | |
BR9911914B1 (pt) | n-arilamidas do ácido sulfonilaminocarboxìlico substituìdas por enxofre, processo para sua preparação, bem como preparações farmacêuticas que compreendem as mesmas. | |
BR0015985B1 (pt) | aplique, e, aeronave. | |
BR9813857B1 (pt) | Processo para a preparação de um desinfetante aquoso, e, desinfetante aquoso. | |
BR9802491B1 (pt) | emulsço méltipla estavael, e, processo para formar a mesma. | |
BR9801181B1 (pt) | gênero alimentìcio fortificado com cálcio, bem como processo para preparação do mesmo. | |
BR0112482B1 (pt) | processo para preparar um elastÈmero de termocura de poliuretano, e, elastÈmero de termocura. | |
BR9914484B1 (pt) | Formulações de microcápsulas, bem como processo para a preparação e aplicação das mesmas | |
BR0008984B1 (pt) | alimento tipo aperitivo, e, processo para preparaÇço de alimento tipo aperitivo. | |
BR9913389B1 (pt) | agentes de preparaÇço, bem como precesso para sua preparaÇço. | |
BR0109988B1 (pt) | elemento eletroquìmico, e, processo para preparar o mesmo. | |
BRPI9914571B1 (pt) | composto, processo para sua preparação, uso do mesmo, bem como composição farmacêutica. | |
BR0015675B1 (pt) | composição de gel aerado, estável em armazenagem, e, processo para a produção da mesma. | |
DE59812250D1 (de) | Gehstütze, stock oder dgl. | |
PT1053224E (pt) | Bifenilsulfonilcianamida, processo para a sua preparacao e sua utilizacao como medicamento | |
BR9916171B1 (pt) | massas de moldagem, processo para a preparaÇço e uso das mesmas, bem como artigo moldado. | |
IT1316059B1 (it) | Depigmentanti cutanei. | |
ITTO20010836A0 (it) | Cella di elettrodeposizione ed elettrodialisi. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B25A | Requested transfer of rights approved |
Owner name: BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) Free format text: TRANSFERIDO DE: BAYER AKTIENGESELLSCHAFT |
|
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 04/09/2012, OBSERVADAS AS CONDICOES LEGAIS. |
|
B25D | Requested change of name of applicant approved | ||
B25A | Requested transfer of rights approved | ||
B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE A 22A ANUIDADE. |
|
B24J | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12) |
Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2622 DE 06-04-2021 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |