CZ283630B6 - Chromanový derivát, způsob jeho výroby a farmaceutický prostředek s jeho obsahem - Google Patents

Chromanový derivát, způsob jeho výroby a farmaceutický prostředek s jeho obsahem Download PDF

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Publication number
CZ283630B6
CZ283630B6 CS906578A CS657890A CZ283630B6 CZ 283630 B6 CZ283630 B6 CZ 283630B6 CS 906578 A CS906578 A CS 906578A CS 657890 A CS657890 A CS 657890A CZ 283630 B6 CZ283630 B6 CZ 283630B6
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CZ
Czechia
Prior art keywords
formula
group
carbon atoms
alkyl
derivative
Prior art date
Application number
CS906578A
Other languages
Czech (cs)
English (en)
Inventor
Lars-Gunnar Larsson
Rolf Norén
Lucy Anna Renyi
Svante Bertil Ross
Daniel Dungan Sohn
Björn Eric Svensson
Seth Olov Thorberg
Original Assignee
Aktiebolaget Astra
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aktiebolaget Astra filed Critical Aktiebolaget Astra
Publication of CZ657890A3 publication Critical patent/CZ657890A3/cs
Publication of CZ283630B6 publication Critical patent/CZ283630B6/cs

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Bakery Products And Manufacturing Methods Therefor (AREA)
  • Liquid Crystal Substances (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Threshing Machine Elements (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Curing Cements, Concrete, And Artificial Stone (AREA)
  • Harvester Elements (AREA)
  • Apparatuses For Bulk Treatment Of Fruits And Vegetables And Apparatuses For Preparing Feeds (AREA)
  • Medicinal Preparation (AREA)
CS906578A 1989-12-22 1990-12-21 Chromanový derivát, způsob jeho výroby a farmaceutický prostředek s jeho obsahem CZ283630B6 (cs)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE8904361A SE8904361D0 (sv) 1989-12-22 1989-12-22 New chroman and thiochroman derivatives

Publications (2)

Publication Number Publication Date
CZ657890A3 CZ657890A3 (cs) 1998-02-18
CZ283630B6 true CZ283630B6 (cs) 1998-05-13

Family

ID=20377869

Family Applications (1)

Application Number Title Priority Date Filing Date
CS906578A CZ283630B6 (cs) 1989-12-22 1990-12-21 Chromanový derivát, způsob jeho výroby a farmaceutický prostředek s jeho obsahem

Country Status (42)

Country Link
EP (1) EP0460169B1 (en, 2012)
JP (1) JP2879972B2 (en, 2012)
KR (1) KR0178991B1 (en, 2012)
CN (1) CN1037438C (en, 2012)
AT (1) ATE138918T1 (en, 2012)
AU (1) AU641204B2 (en, 2012)
CA (1) CA2047237C (en, 2012)
CY (1) CY1991A (en, 2012)
CZ (1) CZ283630B6 (en, 2012)
DE (1) DE69027311T2 (en, 2012)
DK (1) DK0460169T3 (en, 2012)
DZ (1) DZ1469A1 (en, 2012)
EG (1) EG19749A (en, 2012)
ES (1) ES2087993T3 (en, 2012)
FI (1) FI102177B (en, 2012)
GR (1) GR3020497T3 (en, 2012)
HK (1) HK55897A (en, 2012)
HR (1) HRP920851B1 (en, 2012)
HU (1) HU211860A9 (en, 2012)
ID (1) ID945B (en, 2012)
IE (1) IE80753B1 (en, 2012)
IL (1) IL96712A (en, 2012)
IS (1) IS1665B (en, 2012)
LT (1) LT3967B (en, 2012)
LV (2) LV10449B (en, 2012)
MX (1) MX23889A (en, 2012)
NO (1) NO180336C (en, 2012)
NZ (1) NZ236407A (en, 2012)
PH (1) PH30797A (en, 2012)
PL (3) PL164608B1 (en, 2012)
PT (1) PT96304B (en, 2012)
RU (1) RU2092483C1 (en, 2012)
SA (1) SA90110186B1 (en, 2012)
SE (1) SE8904361D0 (en, 2012)
SG (1) SG48043A1 (en, 2012)
SI (1) SI9012429B (en, 2012)
SK (1) SK657890A3 (en, 2012)
TW (1) TW221056B (en, 2012)
UA (1) UA34416C2 (en, 2012)
WO (1) WO1991009853A1 (en, 2012)
YU (2) YU47936B (en, 2012)
ZA (1) ZA909708B (en, 2012)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5420151A (en) * 1989-12-22 1995-05-30 Aktiebolaget Astra Chroman derivatives
CA2048846A1 (en) * 1990-08-15 1992-02-16 Craig Steven Hoechstetter Ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes, 3-aminochromanes, and aminothiochromanes
DK0498590T3 (da) * 1991-02-08 1997-05-05 Lilly Co Eli Ringsubstituerede 2-amino-1,2,3,4-tetrahydronaphthalener
HRP920935A2 (en) * 1991-10-08 1995-08-31 Astra Ab New therapeutically active compound
SE9103745D0 (sv) * 1991-12-18 1991-12-18 Wikstroem Haakan Aryl-triflates and related compounds
FR2691149B1 (fr) * 1992-05-18 1994-07-08 Adir Nouveaux composes thiochromaniques, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
US5434174A (en) * 1992-07-17 1995-07-18 Eli Lilly And Company Isoxazole derivatives for the treatment of irritable bowel syndrome
SE9301732D0 (sv) * 1993-05-18 1993-05-18 Haakan Wilhelm Wikstroem New centrally acting 5-,6-,7-, and 8-substituted sulphone esters of n-monosubstituted 2-aminotetralins
SE9703377D0 (sv) * 1997-09-18 1997-09-18 Astra Ab New compounds
SE9703378D0 (sv) * 1997-09-18 1997-09-18 Astra Ab New compounds
TW555757B (en) * 1998-07-31 2003-10-01 Akzo Nobel Nv Aminomethylcarboxylic acid derivatives
US6184226B1 (en) 1998-08-28 2001-02-06 Scios Inc. Quinazoline derivatives as inhibitors of P-38 α
WO2002055013A2 (en) 2001-01-16 2002-07-18 Astrazeneca Ab Therapeutic chromone compounds
WO2002055014A2 (en) * 2001-01-16 2002-07-18 Astrazeneca Ab Therapeutic chroman compounds
BR0206512A (pt) 2001-01-16 2004-01-06 Astrazeneca Ab Composto, método de tratamento de um ser humano ou animal que sofre de depressão, ansiedade generalizada, distúrbios da alimentação, demência, distúrbio do p nico, distúrbios do sono, distúrbios gastrointestinais, distúrbios motores, distúrbios endócrinos, vasoespasmo e disfunção sexual, uso de um composto, e, processo para preparar um composto.
RU2193559C1 (ru) * 2001-05-16 2002-11-27 Пермская государственная фармацевтическая академия 2,4-ксилидид и м-фенетидид 2-ацетилиминокумарин-3-карбоновой кислоты, обладающие антикоагулянтной активностью
WO2003007956A1 (en) 2001-07-20 2003-01-30 Psychogenics, Inc. Treatment for attention-deficit hyperactivity disorder
US7125904B2 (en) 2002-10-11 2006-10-24 Portela & C.A., S.A. Peripherally-selective inhibitors of dopamine-β-hydroxylase and method of their preparation
SE0301796D0 (sv) * 2003-06-19 2003-06-19 Astrazeneca Ab New use II
SE0301795D0 (sv) * 2003-06-19 2003-06-19 Astrazeneca Ab New use I
WO2008080120A2 (en) * 2006-12-22 2008-07-03 Wyeth 3-amino chromane derivatives
SA08290245B1 (ar) * 2007-04-23 2012-02-12 استرازينيكا ايه بي مشتقات كربو كساميد جديدة من -n (8-اريل رباعي هيدرو نفثالين غير متجانس- 2- يل) أو -n (5-اريل كرومان غير متجانس -3-يل) لعلاج الألم
CN101712672B (zh) * 2008-10-06 2013-02-06 中国中医科学院中药研究所 一种治疗心脑血管系统疾病新化合物及其制备方法、用途
DE102010041948A1 (de) 2010-10-04 2012-04-05 Mahle International Gmbh Filtereinrichtung
GB201316410D0 (en) 2013-09-13 2013-10-30 Bial Portela & Ca Sa Processes for preparing peripherally-selective inhibitors of dopamine-?-hydroxylase and intermediates for use therein

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE63744T1 (de) * 1985-09-03 1991-06-15 Ciba Geigy Ag 3-amino-dihydro-(1>-benzopyrane und benzothiopyrane.
US4801605A (en) * 1986-08-29 1989-01-31 Ciba-Geigy Corporation 3-amino-dihydro-[1]-benzopyrans and benzothiopyrans
SE8605504D0 (sv) * 1986-12-19 1986-12-19 Astra Laekemedel Ab Novel chroman derivatives
US5258287A (en) * 1988-03-22 1993-11-02 Genentech, Inc. DNA encoding and methods of production of insulin-like growth factor binding protein BP53

Also Published As

Publication number Publication date
SA90110186B1 (ar) 2001-11-11
RU2092483C1 (ru) 1997-10-10
JPH04503682A (ja) 1992-07-02
CY1991A (en) 1997-09-05
NO180336B (no) 1996-12-23
YU242990A (sh) 1993-10-20
FI102177B1 (fi) 1998-10-30
ID945B (id) 1996-09-20
SG48043A1 (en) 1998-04-17
CA2047237A1 (en) 1991-06-23
SK280261B6 (sk) 1999-10-08
SI9012429A (en) 1997-12-31
CN1052669A (zh) 1991-07-03
EP0460169A1 (en) 1991-12-11
UA34416C2 (uk) 2001-03-15
YU47936B (sh) 1996-05-20
NO180336C (no) 1997-04-02
KR920701193A (ko) 1992-08-11
PL293066A1 (en) 1992-08-10
MX23889A (es) 1993-10-01
IE80753B1 (en) 1999-01-13
HRP920851B1 (en) 2000-02-29
ES2087993T3 (es) 1996-08-01
PH30797A (en) 1997-10-17
SK657890A3 (en) 1999-10-08
JP2879972B2 (ja) 1999-04-05
LV11894A (lv) 1997-12-20
FI102177B (fi) 1998-10-30
NO913273D0 (no) 1991-08-21
PT96304B (pt) 1998-09-30
CA2047237C (en) 2003-02-11
AU641204B2 (en) 1993-09-16
GR3020497T3 (en) 1996-10-31
LTIP1730A (en) 1995-08-25
TW221056B (en, 2012) 1994-02-11
PL164609B1 (en) 1994-08-31
HRP920851A2 (en) 1995-10-31
ZA909708B (en) 1991-08-28
DE69027311T2 (de) 1996-10-24
NZ236407A (en) 1993-08-26
DK0460169T3 (da) 1996-09-23
KR0178991B1 (ko) 1999-03-20
IS1665B (is) 1997-07-04
YU72191A (sh) 1995-01-31
PL164592B1 (pl) 1994-08-31
FI913943A0 (fi) 1991-08-21
CN1037438C (zh) 1998-02-18
HU211860A9 (en) 1995-12-28
EP0460169B1 (en) 1996-06-05
SI9012429B (sl) 1998-10-31
YU47923B (sh) 1996-05-20
IS3662A7 (is) 1991-06-23
IE904535A1 (en) 1991-07-03
WO1991009853A1 (en) 1991-07-11
PT96304A (pt) 1991-09-30
LV11894B (en) 1998-05-20
PL164608B1 (pl) 1994-08-31
PL293065A1 (en) 1992-08-10
HK55897A (en) 1997-05-09
ATE138918T1 (de) 1996-06-15
NO913273L (no) 1991-10-08
LT3967B (en) 1996-05-27
SE8904361D0 (sv) 1989-12-22
IL96712A (en) 1995-08-31
LV10449A (lv) 1995-02-20
EG19749A (en) 1996-01-31
DE69027311D1 (en) 1996-07-11
CZ657890A3 (cs) 1998-02-18
IL96712A0 (en) 1991-09-16
AU6977091A (en) 1991-07-24
LV10449B (en) 1995-10-20
DZ1469A1 (fr) 2004-09-13

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IF00 In force as of 2000-06-30 in czech republic
MM4A Patent lapsed due to non-payment of fee

Effective date: 20061221