CZ220695A3 - Process for preparing trans-6-£(2-substituted pyrrol-1-yl)alkyl|-pyran-2-ones, intermediates for such process and pharmaceutical preparations - Google Patents

Process for preparing trans-6-£(2-substituted pyrrol-1-yl)alkyl|-pyran-2-ones, intermediates for such process and pharmaceutical preparations

Info

Publication number
CZ220695A3
CZ220695A3 CZ952206A CZ220695A CZ220695A3 CZ 220695 A3 CZ220695 A3 CZ 220695A3 CZ 952206 A CZ952206 A CZ 952206A CZ 220695 A CZ220695 A CZ 220695A CZ 220695 A3 CZ220695 A3 CZ 220695A3
Authority
CZ
Czechia
Prior art keywords
pyran
ones
alkyl
intermediates
pharmaceutical preparations
Prior art date
Application number
CZ952206A
Other languages
English (en)
Other versions
CZ284365B6 (cs
Inventor
Donald Eugene Butler
Tung Van Le
Thomas Norman Nanninga
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of CZ220695A3 publication Critical patent/CZ220695A3/cs
Publication of CZ284365B6 publication Critical patent/CZ284365B6/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CZ952206A 1993-03-03 1994-02-24 Způsob výroby trans-6-(2-(substituovaný pyrrol-1-yl)alkyl)-pyran-2-onů, meziprodukty pro tento způsob a farmaceutické prostředky CZ284365B6 (cs)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/025,701 US5298627A (en) 1993-03-03 1993-03-03 Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis

Publications (2)

Publication Number Publication Date
CZ220695A3 true CZ220695A3 (en) 1995-12-13
CZ284365B6 CZ284365B6 (cs) 1998-11-11

Family

ID=21827596

Family Applications (4)

Application Number Title Priority Date Filing Date
CZ952206A CZ284365B6 (cs) 1993-03-03 1994-02-24 Způsob výroby trans-6-(2-(substituovaný pyrrol-1-yl)alkyl)-pyran-2-onů, meziprodukty pro tento způsob a farmaceutické prostředky
CZ98479A CZ47998A3 (cs) 1993-03-03 1994-02-24 Pyrrolkarboxamidy a farmaceutické prostředky na jejich bázi
CZ98478A CZ285555B6 (cs) 1993-03-03 1994-02-24 Pyrrolkarboxamidy a farmaceutické prostředky na jejich bázi
CZ98477A CZ285554B6 (cs) 1993-03-03 1994-02-24 Způsob výroby trans-6-[2-(substituovaný pyrrol-1-yl)alkyl]-pyran-2-onu

Family Applications After (3)

Application Number Title Priority Date Filing Date
CZ98479A CZ47998A3 (cs) 1993-03-03 1994-02-24 Pyrrolkarboxamidy a farmaceutické prostředky na jejich bázi
CZ98478A CZ285555B6 (cs) 1993-03-03 1994-02-24 Pyrrolkarboxamidy a farmaceutické prostředky na jejich bázi
CZ98477A CZ285554B6 (cs) 1993-03-03 1994-02-24 Způsob výroby trans-6-[2-(substituovaný pyrrol-1-yl)alkyl]-pyran-2-onu

Country Status (19)

Country Link
US (8) US5298627A (cs)
EP (1) EP0687263B1 (cs)
JP (1) JP3510253B2 (cs)
KR (1) KR100302431B1 (cs)
AT (1) ATE156127T1 (cs)
AU (1) AU677047B2 (cs)
CA (1) CA2155952C (cs)
CZ (4) CZ284365B6 (cs)
DE (1) DE69404632T2 (cs)
DK (1) DK0687263T3 (cs)
ES (1) ES2108435T3 (cs)
FI (3) FI109999B (cs)
GR (1) GR3024784T3 (cs)
HU (1) HU222177B1 (cs)
NO (3) NO308529B1 (cs)
NZ (1) NZ262830A (cs)
RU (1) RU2138497C1 (cs)
SK (4) SK281110B6 (cs)
WO (1) WO1994020492A1 (cs)

Families Citing this family (151)

* Cited by examiner, † Cited by third party
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