MX2018005540A - Tratamiento de dislipemia mixta. - Google Patents

Tratamiento de dislipemia mixta.

Info

Publication number
MX2018005540A
MX2018005540A MX2018005540A MX2018005540A MX2018005540A MX 2018005540 A MX2018005540 A MX 2018005540A MX 2018005540 A MX2018005540 A MX 2018005540A MX 2018005540 A MX2018005540 A MX 2018005540A MX 2018005540 A MX2018005540 A MX 2018005540A
Authority
MX
Mexico
Prior art keywords
methods
treatment
preventing
delaying
mixed dyslipidemia
Prior art date
Application number
MX2018005540A
Other languages
English (en)
Inventor
L Bisgaier Charles
Carmen Oniciu Daniela
Original Assignee
Gemphire Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gemphire Therapeutics Inc filed Critical Gemphire Therapeutics Inc
Publication of MX2018005540A publication Critical patent/MX2018005540A/es

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    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/194Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
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    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
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    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
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  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Inorganic Chemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)

Abstract

Métodos y formulaciones para reducir los niveles elevados de lípidos y apolipoproteína B en sujetos que tienen hiperlipemia tipo IIb. Métodos para la prevención, el retraso o la regresión de las complicaciones de los trastornos lipídicos, inclusive; hiperlipemia tipo IIb, NAFLD y NASH. Métodos para la prevención o el retraso de episodios cardiovasculares primarios y secundarios. Kits útiles para tales métodos. Métodos para la reducción de la fibrosis hepática. Métodos para la reducción de los niveles de fibrinógeno en plasma.
MX2018005540A 2015-11-06 2016-11-07 Tratamiento de dislipemia mixta. MX2018005540A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562252147P 2015-11-06 2015-11-06
US201562252195P 2015-11-06 2015-11-06
PCT/US2016/060837 WO2017079748A1 (en) 2015-11-06 2016-11-07 Treatment of mixed dyslipidemia

Publications (1)

Publication Number Publication Date
MX2018005540A true MX2018005540A (es) 2018-11-09

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ID=58663111

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2018005540A MX2018005540A (es) 2015-11-06 2016-11-07 Tratamiento de dislipemia mixta.
MX2018005096A MX2018005096A (es) 2015-11-06 2016-11-07 Combinaciones de gemcabeno para el tratamiento de enfermedad cardiovascular.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2018005096A MX2018005096A (es) 2015-11-06 2016-11-07 Combinaciones de gemcabeno para el tratamiento de enfermedad cardiovascular.

Country Status (16)

Country Link
US (4) US9849104B2 (es)
EP (2) EP3370713A4 (es)
JP (2) JP2018532808A (es)
KR (2) KR20180073597A (es)
CN (2) CN108348491A (es)
AU (2) AU2016348638A1 (es)
BR (2) BR112018009238A8 (es)
CA (2) CA3000016A1 (es)
HK (2) HK1257929A1 (es)
IL (2) IL258819A (es)
MA (1) MA43190A (es)
MX (2) MX2018005540A (es)
PH (1) PH12018500972A1 (es)
RU (2) RU2018120599A (es)
SG (2) SG11201803442UA (es)
WO (2) WO2017079748A1 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9719068B2 (en) 2010-05-06 2017-08-01 Children's Hospital Medical Center Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
CA2949834A1 (en) 2014-05-28 2015-12-03 James Macormack Wells Methods and systems for converting precursor cells into gastric tissues through directed differentiation
JP6804438B2 (ja) 2014-10-17 2020-12-23 チルドレンズ ホスピタル メディカル センター 多能性幹細胞を使用するヒト小腸のin vivoモデル、並びにそれを作製、及び使用する方法
BR112017009876A2 (pt) 2014-11-14 2017-12-19 Gemphire Therapeutics Inc processos e intermediários para a preparação de éteres de dialcano terminados em ácido alfa,ômega-dicarboxílico
MX2018005540A (es) * 2015-11-06 2018-11-09 Gemphire Therapeutics Inc Tratamiento de dislipemia mixta.
CA3016641A1 (en) 2016-05-05 2017-11-09 Children's Hospital Medical Center Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same
CN109689685A (zh) 2016-07-08 2019-04-26 斯塔滕生物技术有限公司 抗apoc3抗体及其使用方法
US10588880B2 (en) 2016-09-28 2020-03-17 Eiger Biopharmaceuticals, Inc. Methods and pharmaceutical compositions for the treatment of non-alcoholic steatohepatitis
CA3041714A1 (en) 2016-11-04 2018-05-11 Children's Hospital Medical Center Liver organoid disease models and methods of making and using same
CN110062764A (zh) 2016-12-05 2019-07-26 儿童医院医学中心 结肠类器官及其制备和使用方法
TW201902471A (zh) * 2017-04-18 2019-01-16 美商珍費爾醫療公司 賈卡賓尼(gemcabene)、其醫藥上可接受之鹽、彼等之組成物及使用彼等之方法
MA50958A (fr) 2017-04-21 2020-10-14 Staten Biotechnology B V Anticorps anti-apoc3 et leurs méthodes d'utilisation
US20180338922A1 (en) * 2017-05-26 2018-11-29 Esperion Therapeutics, Inc. Fixed dose formulations
JP6937195B2 (ja) * 2017-09-01 2021-09-22 興和株式会社 医薬組成物
US10538583B2 (en) 2017-10-31 2020-01-21 Staten Biotechnology B.V. Anti-APOC3 antibodies and compositions thereof
WO2019087115A1 (en) 2017-10-31 2019-05-09 Staten Biotechnology B.V. Anti-apoc3 antibodies and methods of use thereof
JP2021504479A (ja) * 2017-11-28 2021-02-15 アイガー・バイオファーマシューティカルズ・インコーポレイテッドEiger Biopharmaceuticals, Inc. 非アルコール性脂肪性肝炎の処置のための方法および医薬組成物
US20210330684A1 (en) * 2018-10-12 2021-10-28 Icahn School Of Medicine At Mount Sinai Azd3355 (lesogaberan) for treatment and prevention of nonalcoholic steatohepatitis (nash), liver fibrosis, and other liver conditions
KR20210093900A (ko) * 2018-10-18 2021-07-28 젬파이어 세러퓨틱스 인코포레이티드 젬카빈, 이의 약학적으로 허용가능한 염, 이의 조성물 및 이의 사용 방법
CN112851660B (zh) * 2019-11-12 2022-03-18 广东药科大学 含有小檗碱的酸-碱加成盐、其制备方法及其作为药物的用途
CN114957119B (zh) * 2022-05-05 2023-06-16 武汉大学中南医院 一种四氢喹啉螺1,3-茚二酮类衍生物及其制备方法与应用

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT381664B (de) 1984-02-07 1986-11-10 Steyr Daimler Puch Ag Einrichtung zur ueberwachung elektrischer, von einer gesteuerten wechselstromquelle gespeister widerstandsschweissvorgaenge, insbesondere punktschweissungen
US5133974A (en) * 1989-05-05 1992-07-28 Kv Pharmaceutical Company Extended release pharmaceutical formulations
CA2039763A1 (en) 1990-04-30 1991-10-31 Henry Y. Pan Combination of pravastatin and a fibric acid derivative, and method for treating dyslipidemia using such combination
US5298627A (en) 1993-03-03 1994-03-29 Warner-Lambert Company Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
US5648387A (en) 1995-03-24 1997-07-15 Warner-Lambert Company Carboxyalkylethers, formulations, and treatment of vascular diseases
US5798375A (en) 1995-07-03 1998-08-25 Sankyo Company, Limited Treatment of arteriosclerosis and xanthoma
WO1997016187A1 (en) 1995-10-31 1997-05-09 Merck & Co., Inc. Muscarine antagonists
WO1997016181A1 (en) 1995-11-03 1997-05-09 University Of Kentucky Method for the intranasal administration of l-dopa prodrugs
NZ520176A (en) * 1997-07-31 2005-02-25 Kos Life Sciences Inc Combinations of HMG-CoA reductase inhibitors and nicotinic acid compounds and methods for treating hyperlipidemia once a day at night
NZ503982A (en) * 1997-12-12 2002-03-28 Warner Lambert Co Statin-carboxyalkylether combinations useful for treating vascular disorders and diabetes mellitus
US20030105154A1 (en) * 2001-10-24 2003-06-05 Bisgaier Charles Larry Statin-carboxyalkylether combinations
US6861555B2 (en) 2000-01-25 2005-03-01 Warner-Lambert Company Calcium dicarboxylate ethers, methods of making same, and treatment of vascular disease and diabetes therewith
US20030229044A1 (en) * 2002-03-29 2003-12-11 Lawrence Steinman Use of statins and other immunomodulatory agents in the treatment of autoimmune disease
AR040588A1 (es) * 2002-07-26 2005-04-13 Schering Corp Formulacion farmaceutica que comprende un inhibidor de la absorcion del colesterol y un inhibidor de una hmg- co a reductasa
JP2006508973A (ja) * 2002-11-15 2006-03-16 ワーナー−ランバート カンパニー リミティド ライアビリティー カンパニー Crpを低下させ、かつ全身性炎症を軽減する方法
US20040229954A1 (en) * 2003-05-16 2004-11-18 Macdougall Diane Elaine Selective manipulation of triglyceride, HDL and LDL parameters with 6-(5-carboxy-5-methyl-hexyloxy)-2,2-dimethylhexanoic acid monocalcium salt
JP2006131559A (ja) * 2004-11-05 2006-05-25 Takeda Chem Ind Ltd 含窒素複素環化合物
CA2588216A1 (en) * 2004-11-22 2006-05-26 Dexcel Pharma Technologies Ltd. Stable atorvastatin formulations
MX2007011031A (es) * 2005-03-08 2008-04-21 Reliant Pharmaceuticals Inc Tratamiento con estatina y acidos grasos omega-3 y un producto de combinacion de los mismos.
US20090186834A1 (en) * 2005-03-24 2009-07-23 Microbia, Inc. Diphenylheterocycle cholesterol absorption inhibitors
US20090297496A1 (en) * 2005-09-08 2009-12-03 Childrens Hospital Medical Center Lysosomal Acid Lipase Therapy for NAFLD and Related Diseases
FR2891459B1 (fr) * 2005-09-30 2007-12-28 Flamel Technologies Sa Microparticules a liberation modifiee d'au moins un principe actif et forme galenique orale en comprenant
WO2007075702A2 (en) * 2005-12-21 2007-07-05 Schering Corporation Treatment of nonalcoholic fatty liver disease using cholesterol lowering agents and h3 receptor antagonist/inverse agonist
JP5457830B2 (ja) * 2006-04-03 2014-04-02 オディディ,イサ オルガノゾル被膜を含む制御放出送達デバイス
WO2008016968A2 (en) 2006-08-03 2008-02-07 Trustees Of Tufts College Non-flushing niacin analogues, and methods of use thereof
WO2008023869A1 (en) * 2006-08-24 2008-02-28 Hanall Pharmaceutical Co., Ltd. Combined pharmeceutical formulation with controlled-release comprising dihydropyridine calcium channel blockers and hmg-coa reductase inhibitors
FI20080353A0 (fi) * 2008-05-09 2008-05-09 Atacama Labs Oy Prosessi erittäin korkean lääkepitoisuuden tabletin valmistamiseksi
WO2008091863A1 (en) 2007-01-23 2008-07-31 Kalypsys, Inc. Sulfonyl-substituted bicyclic compounds as ppar modulators for the treatment of non-alcoholic steatohepatitis
US20100144864A1 (en) * 2007-04-05 2010-06-10 Ironwood Pharmaceuticals, Inc. Soluble guanylate cyclase (sgc) modulators for treatment of lipid related disorders
US8969514B2 (en) * 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
US9307371B2 (en) 2008-01-18 2016-04-05 Verizon Patent And Licensing Inc. Method and system for SMS/MMS messaging to a connected device
MX2010012514A (es) * 2008-05-20 2011-05-30 Cerenis Therapeutics S A Niacina y un medicamento nsaid para tratamiento combinado.
US20110082119A1 (en) * 2008-06-13 2011-04-07 Takashi Yano Prophylactic/ameliorating or therapeutic agent for non-alcoholic steatohepatitis
WO2011051966A2 (en) 2009-10-12 2011-05-05 Ipca Laboratories Limited Pharmaceutical compositions for the treatment/prophylaxis of non-alcoholic fatty liver disease
AU2011203986C1 (en) * 2010-01-08 2015-03-05 Ionis Pharmaceuticals, Inc. Modulation of angiopoietin-like 3 expression
EP2584899B1 (en) * 2010-06-24 2018-01-10 Trustees Of Tufts College Niacin mimetics, and use thereof
TR201005325A2 (tr) * 2010-06-30 2012-01-23 Bi̇lgi̇ç Mahmut Atorvastatin ve aspirin içeren farmasötik formülasyonlar
ES2608177T3 (es) * 2010-12-27 2017-04-06 Gemphire Therapeutics Inc. Gemcabeno y derivados para el tratamiento de la pancreatitis
EP2604256B1 (en) * 2011-12-14 2016-04-13 Hexal AG Multi layer coatings
CN102525942A (zh) * 2012-01-05 2012-07-04 金陵药业股份有限公司 一种阿托伐他汀钙肠溶微丸及其制备方法
MX367352B (es) * 2012-01-06 2019-08-16 Gemphire Therapeutics Inc Metodos para reducir el riesgo de padecer una enfermedad cardiovascular.
JP6633609B2 (ja) * 2014-03-20 2020-01-22 エスペリオン・セラピューティクス・インコーポレイテッドEsperion Therapeutics, Inc. 肝疾患および他の医学的障害の処置のためのカルボキシ−シクロプロピルウンデカノール化合物
CN104127391B (zh) * 2014-08-05 2016-08-24 李宝齐 一种含有阿托伐他汀钙的固体药物组合物
MX2018005540A (es) * 2015-11-06 2018-11-09 Gemphire Therapeutics Inc Tratamiento de dislipemia mixta.
CN105434391A (zh) * 2016-01-18 2016-03-30 上海蓝心医药科技有限公司 阿托伐他汀钙肠溶片及其制备方法和应用

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