BR112018009238A2 - tratamento de dislipidemia mista - Google Patents
tratamento de dislipidemia mistaInfo
- Publication number
- BR112018009238A2 BR112018009238A2 BR112018009238A BR112018009238A BR112018009238A2 BR 112018009238 A2 BR112018009238 A2 BR 112018009238A2 BR 112018009238 A BR112018009238 A BR 112018009238A BR 112018009238 A BR112018009238 A BR 112018009238A BR 112018009238 A2 BR112018009238 A2 BR 112018009238A2
- Authority
- BR
- Brazil
- Prior art keywords
- methods
- treatment
- hyperlipidemia
- type iib
- levels
- Prior art date
Links
Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
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- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A61K9/2013—Organic compounds, e.g. phospholipids, fats
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- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Inorganic Chemistry (AREA)
- Ophthalmology & Optometry (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Child & Adolescent Psychology (AREA)
Abstract
métodos e formulações para reduzir níveis elevados de lipídios e apolipoproteína b em indivíduos com hiperlipidemia do tipo iib. métodos para prevenir, atrasar ou regredir complicações de distúrbios lipídicos incluindo; hiperlipidemia do tipo iib, nafld e nash. métodos para prevenir ou atrasar eventos cardiovasculares primários e secundários. kits úteis para tais métodos. métodos para reduzir fibrose hepática. métodos para reduzir níveis de fibrinogênio plasmático.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562252147P | 2015-11-06 | 2015-11-06 | |
US201562252195P | 2015-11-06 | 2015-11-06 | |
PCT/US2016/060837 WO2017079748A1 (en) | 2015-11-06 | 2016-11-07 | Treatment of mixed dyslipidemia |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112018009238A2 true BR112018009238A2 (pt) | 2018-11-06 |
BR112018009238A8 BR112018009238A8 (pt) | 2019-02-26 |
Family
ID=58663111
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112018009238A BR112018009238A8 (pt) | 2015-11-06 | 2016-11-07 | tratamento de dislipidemia mista |
BR112018007857A BR112018007857A2 (pt) | 2015-11-06 | 2016-11-07 | combinações de gemcabene para o tratamento de doença cardiovascular |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112018007857A BR112018007857A2 (pt) | 2015-11-06 | 2016-11-07 | combinações de gemcabene para o tratamento de doença cardiovascular |
Country Status (16)
Country | Link |
---|---|
US (4) | US9849104B2 (pt) |
EP (2) | EP3370713A4 (pt) |
JP (2) | JP2018532808A (pt) |
KR (2) | KR20180073597A (pt) |
CN (2) | CN108348491A (pt) |
AU (2) | AU2016348638A1 (pt) |
BR (2) | BR112018009238A8 (pt) |
CA (2) | CA3000016A1 (pt) |
HK (2) | HK1257929A1 (pt) |
IL (2) | IL258819A (pt) |
MA (1) | MA43190A (pt) |
MX (2) | MX2018005540A (pt) |
PH (1) | PH12018500972A1 (pt) |
RU (2) | RU2018120599A (pt) |
SG (2) | SG11201803442UA (pt) |
WO (2) | WO2017079748A1 (pt) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
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US9719068B2 (en) | 2010-05-06 | 2017-08-01 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into intestinal tissues through directed differentiation |
CA2949834A1 (en) | 2014-05-28 | 2015-12-03 | James Macormack Wells | Methods and systems for converting precursor cells into gastric tissues through directed differentiation |
JP6804438B2 (ja) | 2014-10-17 | 2020-12-23 | チルドレンズ ホスピタル メディカル センター | 多能性幹細胞を使用するヒト小腸のin vivoモデル、並びにそれを作製、及び使用する方法 |
BR112017009876A2 (pt) | 2014-11-14 | 2017-12-19 | Gemphire Therapeutics Inc | processos e intermediários para a preparação de éteres de dialcano terminados em ácido alfa,ômega-dicarboxílico |
MX2018005540A (es) * | 2015-11-06 | 2018-11-09 | Gemphire Therapeutics Inc | Tratamiento de dislipemia mixta. |
CA3016641A1 (en) | 2016-05-05 | 2017-11-09 | Children's Hospital Medical Center | Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same |
CN109689685A (zh) | 2016-07-08 | 2019-04-26 | 斯塔滕生物技术有限公司 | 抗apoc3抗体及其使用方法 |
US10588880B2 (en) | 2016-09-28 | 2020-03-17 | Eiger Biopharmaceuticals, Inc. | Methods and pharmaceutical compositions for the treatment of non-alcoholic steatohepatitis |
CA3041714A1 (en) | 2016-11-04 | 2018-05-11 | Children's Hospital Medical Center | Liver organoid disease models and methods of making and using same |
CN110062764A (zh) | 2016-12-05 | 2019-07-26 | 儿童医院医学中心 | 结肠类器官及其制备和使用方法 |
TW201902471A (zh) * | 2017-04-18 | 2019-01-16 | 美商珍費爾醫療公司 | 賈卡賓尼(gemcabene)、其醫藥上可接受之鹽、彼等之組成物及使用彼等之方法 |
MA50958A (fr) | 2017-04-21 | 2020-10-14 | Staten Biotechnology B V | Anticorps anti-apoc3 et leurs méthodes d'utilisation |
US20180338922A1 (en) * | 2017-05-26 | 2018-11-29 | Esperion Therapeutics, Inc. | Fixed dose formulations |
JP6937195B2 (ja) * | 2017-09-01 | 2021-09-22 | 興和株式会社 | 医薬組成物 |
US10538583B2 (en) | 2017-10-31 | 2020-01-21 | Staten Biotechnology B.V. | Anti-APOC3 antibodies and compositions thereof |
WO2019087115A1 (en) | 2017-10-31 | 2019-05-09 | Staten Biotechnology B.V. | Anti-apoc3 antibodies and methods of use thereof |
JP2021504479A (ja) * | 2017-11-28 | 2021-02-15 | アイガー・バイオファーマシューティカルズ・インコーポレイテッドEiger Biopharmaceuticals, Inc. | 非アルコール性脂肪性肝炎の処置のための方法および医薬組成物 |
US20210330684A1 (en) * | 2018-10-12 | 2021-10-28 | Icahn School Of Medicine At Mount Sinai | Azd3355 (lesogaberan) for treatment and prevention of nonalcoholic steatohepatitis (nash), liver fibrosis, and other liver conditions |
KR20210093900A (ko) * | 2018-10-18 | 2021-07-28 | 젬파이어 세러퓨틱스 인코포레이티드 | 젬카빈, 이의 약학적으로 허용가능한 염, 이의 조성물 및 이의 사용 방법 |
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