BR112018007857A2 - combinações de gemcabene para o tratamento de doença cardiovascular - Google Patents
combinações de gemcabene para o tratamento de doença cardiovascularInfo
- Publication number
- BR112018007857A2 BR112018007857A2 BR112018007857A BR112018007857A BR112018007857A2 BR 112018007857 A2 BR112018007857 A2 BR 112018007857A2 BR 112018007857 A BR112018007857 A BR 112018007857A BR 112018007857 A BR112018007857 A BR 112018007857A BR 112018007857 A2 BR112018007857 A2 BR 112018007857A2
- Authority
- BR
- Brazil
- Prior art keywords
- gemcabene
- combinations
- treatment
- cardiovascular disease
- cardiovascular
- Prior art date
Links
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
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- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
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- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
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- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Obesity (AREA)
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- Biophysics (AREA)
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- Gastroenterology & Hepatology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Inorganic Chemistry (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
Abstract
a presente invenção refere-se a composições farmacêuticas formuladas para incluir uma estatina e gemcabene, em que a composição é útil para tratar, prevenir ou reduzir sintomas de indicações cardio-vasculares e metabólicas que envolvem níveis elevados de colesterol ldl, triglicerídeos ou ambos.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562252147P | 2015-11-06 | 2015-11-06 | |
US201562252195P | 2015-11-06 | 2015-11-06 | |
PCT/US2016/060849 WO2017079755A1 (en) | 2015-11-06 | 2016-11-07 | Gemcabene combinations for the treatment of cardiovascular disease |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112018007857A2 true BR112018007857A2 (pt) | 2018-10-30 |
Family
ID=58663111
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112018009238A BR112018009238A8 (pt) | 2015-11-06 | 2016-11-07 | tratamento de dislipidemia mista |
BR112018007857A BR112018007857A2 (pt) | 2015-11-06 | 2016-11-07 | combinações de gemcabene para o tratamento de doença cardiovascular |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112018009238A BR112018009238A8 (pt) | 2015-11-06 | 2016-11-07 | tratamento de dislipidemia mista |
Country Status (16)
Country | Link |
---|---|
US (4) | US9849104B2 (pt) |
EP (2) | EP3370713A4 (pt) |
JP (2) | JP2018536710A (pt) |
KR (2) | KR20180073665A (pt) |
CN (2) | CN108366957A (pt) |
AU (2) | AU2016349634A1 (pt) |
BR (2) | BR112018009238A8 (pt) |
CA (2) | CA3000016A1 (pt) |
HK (2) | HK1257929A1 (pt) |
IL (2) | IL258819A (pt) |
MA (1) | MA43190A (pt) |
MX (2) | MX2018005096A (pt) |
PH (1) | PH12018500972A1 (pt) |
RU (2) | RU2018120726A (pt) |
SG (2) | SG10201912754UA (pt) |
WO (2) | WO2017079748A1 (pt) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2011140441A2 (en) | 2010-05-06 | 2011-11-10 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into intestinal tissues through directed differentiation |
EP3712254A1 (en) | 2014-05-28 | 2020-09-23 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into gastric tissues through directed differentiation |
US11584916B2 (en) | 2014-10-17 | 2023-02-21 | Children's Hospital Medical Center | Method of making in vivo human small intestine organoids from pluripotent stem cells |
MX2017006200A (es) | 2014-11-14 | 2017-11-17 | Gemphire Therapeutics Inc | Procesos e intermediarios para preparar dialcano eteres terminados con acido a, ?-dicarboxilico. |
EP3370713A4 (en) * | 2015-11-06 | 2019-10-23 | Gemphire Therapeutics Inc. | TREATMENT OF MIXED DYSLIPIDEMIA |
EP4177335A1 (en) | 2016-05-05 | 2023-05-10 | Children's Hospital Medical Center | Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same |
JP2019525772A (ja) | 2016-07-08 | 2019-09-12 | スターテン・バイオテクノロジー・ベー・フェー | 抗apoc3抗体およびその使用方法 |
EP3518918A4 (en) | 2016-09-28 | 2020-04-22 | Eiger Biopharmaceuticals, Inc. | METHOD AND PHARMACEUTICAL COMPOSITIONS FOR TREATING NON-ALCOHOLIC STEATOHEPATITIS |
CN117229994A (zh) | 2016-11-04 | 2023-12-15 | 儿童医院医学中心 | 肝类器官疾病模型以及其制备和使用方法 |
SG10202105768WA (en) | 2016-12-05 | 2021-06-29 | Childrens Hospital Med Ct | Colonic organoids and methods of making and using same |
CA3059073A1 (en) * | 2017-04-18 | 2018-10-25 | Daniela Carmen Oniciu | Gemcabene, pharmaceutically acceptable salts thereof, compositions thereof and methods of use therefor |
WO2018193427A1 (en) | 2017-04-21 | 2018-10-25 | Staten Biotechnology B.V. | Anti-apoc3 antibodies and methods of use thereof |
US20180338922A1 (en) * | 2017-05-26 | 2018-11-29 | Esperion Therapeutics, Inc. | Fixed dose formulations |
JP6937195B2 (ja) * | 2017-09-01 | 2021-09-22 | 興和株式会社 | 医薬組成物 |
US10538583B2 (en) | 2017-10-31 | 2020-01-21 | Staten Biotechnology B.V. | Anti-APOC3 antibodies and compositions thereof |
MA50516A (fr) | 2017-10-31 | 2020-09-09 | Staten Biotechnology B V | Anticorps anti-apoc3 et leurs procédés d'utilisation |
JP2021504479A (ja) * | 2017-11-28 | 2021-02-15 | アイガー・バイオファーマシューティカルズ・インコーポレイテッドEiger Biopharmaceuticals, Inc. | 非アルコール性脂肪性肝炎の処置のための方法および医薬組成物 |
US20210330684A1 (en) * | 2018-10-12 | 2021-10-28 | Icahn School Of Medicine At Mount Sinai | Azd3355 (lesogaberan) for treatment and prevention of nonalcoholic steatohepatitis (nash), liver fibrosis, and other liver conditions |
KR20210093900A (ko) * | 2018-10-18 | 2021-07-28 | 젬파이어 세러퓨틱스 인코포레이티드 | 젬카빈, 이의 약학적으로 허용가능한 염, 이의 조성물 및 이의 사용 방법 |
CN112851660B (zh) * | 2019-11-12 | 2022-03-18 | 广东药科大学 | 含有小檗碱的酸-碱加成盐、其制备方法及其作为药物的用途 |
CN114957119B (zh) * | 2022-05-05 | 2023-06-16 | 武汉大学中南医院 | 一种四氢喹啉螺1,3-茚二酮类衍生物及其制备方法与应用 |
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- 2016-11-07 EP EP16863175.2A patent/EP3370703A4/en not_active Withdrawn
- 2016-11-07 AU AU2016349634A patent/AU2016349634A1/en not_active Abandoned
- 2016-11-07 WO PCT/US2016/060837 patent/WO2017079748A1/en active Application Filing
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