BR112015003729A8 - Composto de fórmula estrutural i; composição farmacêutica; método de tratamento de uma doença mediada por caminho do hif; método de tratamento de uma doença causada por proliferação anormal de células; e método para alcançar um efeito em um paciente - Google Patents
Composto de fórmula estrutural i; composição farmacêutica; método de tratamento de uma doença mediada por caminho do hif; método de tratamento de uma doença causada por proliferação anormal de células; e método para alcançar um efeito em um pacienteInfo
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- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A—HUMAN NECESSITIES
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A—HUMAN NECESSITIES
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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- A—HUMAN NECESSITIES
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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- A—HUMAN NECESSITIES
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- C07D—HETEROCYCLIC COMPOUNDS
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- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
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- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Abstract
COMPOSTO DE FÓRMULA ESTRUTURAL I; COMPOSIÇÃO FARMACÊUTICA; MÉTODO DE TRATAMENTO DE UMA DOENÇA MEDIADA POR CAMINHO DO HIF; MÉTODO DE TRATAMENTO DE UMA DOENÇA CAUSADA POR PROLIFERAÇÃO ANORMAL DE CÉLULAS; E MÉTODO PARA ALCANÇAR UM EFEITO EM UM PACIENTE. A presente invenção refere-se a compostos e métodos que podem ser úteis como inibidores da atividade de caminho do HIF para o tratamento ou prevenção de câncer e outras doenças mediadas por hipoxia.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US201261743131P | 2012-08-24 | 2012-08-24 | |
PCT/US2013/056346 WO2014031936A2 (en) | 2012-08-24 | 2013-08-23 | Heterocyclic modulators of hif activity for treatment of disease |
Publications (2)
Publication Number | Publication Date |
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BR112015003729A8 true BR112015003729A8 (pt) | 2017-07-04 |
BR112015003729A2 BR112015003729A2 (pt) | 2018-06-05 |
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Family Applications (1)
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BR112015003729A BR112015003729A2 (pt) | 2012-08-24 | 2013-08-23 | composto de fórmula estrutural i; composição farmacêutica; método de tratamento de uma doença mediada por caminho do hif; método de tratamento de uma doença causada por proliferação anormal de células; e método para alcançar um efeito em um paciente |
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US (4) | US9018380B2 (pt) |
EP (1) | EP2888255B1 (pt) |
JP (1) | JP6453218B2 (pt) |
CN (1) | CN104736535B (pt) |
AU (1) | AU2013305633B2 (pt) |
BR (1) | BR112015003729A2 (pt) |
CA (1) | CA2882306A1 (pt) |
DK (1) | DK2888255T3 (pt) |
ES (1) | ES2691643T3 (pt) |
HK (1) | HK1206713A1 (pt) |
HU (1) | HUE040025T2 (pt) |
IL (1) | IL237378B (pt) |
NZ (1) | NZ704799A (pt) |
RU (1) | RU2698197C2 (pt) |
WO (1) | WO2014031936A2 (pt) |
ZA (1) | ZA201501024B (pt) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
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JP6453218B2 (ja) | 2012-08-24 | 2019-01-16 | ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム | 疾患を治療するためのhif活性の複素環式修飾物質 |
CN112500338A (zh) | 2013-03-15 | 2021-03-16 | 全球血液疗法股份有限公司 | 化合物及其用于调节血红蛋白的用途 |
EA201992707A1 (ru) | 2013-11-18 | 2020-06-30 | Глобал Блад Терапьютикс, Инк. | Соединения и их применения для модуляции гемоглобина |
ES2726648T3 (es) | 2014-02-25 | 2019-10-08 | Univ Texas | Sales de moduladores heterocíclicos de la actividad del HIF para el tratamiento de enfermedades |
US20170298055A1 (en) | 2014-09-17 | 2017-10-19 | Ironwood Pharmaceuticals, Inc. | sGC STIMULATORS |
WO2016202935A1 (en) | 2015-06-19 | 2016-12-22 | Bayer Pharma Aktiengesellschaft | Glucose transport inhibitors |
AU2017289318A1 (en) * | 2016-06-30 | 2018-11-29 | Basilea Pharmaceutica International AG | Mitochondrial inhibitors for the treatment of proliferation disorders |
WO2019072978A1 (en) | 2017-10-12 | 2019-04-18 | Basilea Pharmaceutica International AG | MITOCHONDRIAL INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS |
WO2019115709A1 (en) | 2017-12-14 | 2019-06-20 | Basilea Pharmaceutica International AG | Mitochondrial inhibitors for the treatment of proliferation disorders |
CA3121202A1 (en) | 2018-11-30 | 2020-06-04 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
US20220226342A1 (en) * | 2019-06-28 | 2022-07-21 | The Johns Hopkins University | Compositions and methods of treating liver cancers |
CN112300145B (zh) * | 2019-07-31 | 2023-07-21 | 上海宇耀生物科技有限公司 | 一类靶向stat3双功能磷酸化位点的三芳香环类化合物及其应用 |
CN111548320B (zh) * | 2019-10-09 | 2023-03-24 | 贵州大学 | 一类1,3,4-噁二唑酰肼类化合物及其制备方法和应用 |
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US3048581A (en) | 1960-04-25 | 1962-08-07 | Olin Mathieson | Acetals and ketals of 16, 17-dihydroxy steroids |
US3749712A (en) | 1970-09-25 | 1973-07-31 | Sigma Tau Ind Farmaceuti | Triamcinolone acetonide esters and process for their preparation |
SE378110B (pt) | 1972-05-19 | 1975-08-18 | Bofors Ab | |
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- 2013-08-23 BR BR112015003729A patent/BR112015003729A2/pt not_active Application Discontinuation
- 2013-08-23 EP EP13830374.8A patent/EP2888255B1/en not_active Not-in-force
- 2013-08-23 HU HUE13830374A patent/HUE040025T2/hu unknown
- 2013-08-23 RU RU2015105521A patent/RU2698197C2/ru active
- 2013-08-23 DK DK13830374.8T patent/DK2888255T3/en active
- 2013-08-23 CN CN201380050695.8A patent/CN104736535B/zh not_active Expired - Fee Related
- 2013-08-23 WO PCT/US2013/056346 patent/WO2014031936A2/en active Application Filing
- 2013-08-23 ES ES13830374.8T patent/ES2691643T3/es active Active
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- 2013-08-23 AU AU2013305633A patent/AU2013305633B2/en not_active Ceased
- 2013-08-23 US US13/974,258 patent/US9018380B2/en not_active Expired - Fee Related
- 2013-08-23 CA CA2882306A patent/CA2882306A1/en not_active Abandoned
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NZ704799A (en) | 2018-06-29 |
WO2014031936A2 (en) | 2014-02-27 |
ES2691643T3 (es) | 2018-11-28 |
IL237378B (en) | 2019-10-31 |
EP2888255A2 (en) | 2015-07-01 |
US11001594B2 (en) | 2021-05-11 |
US20150252058A1 (en) | 2015-09-10 |
HK1206713A1 (en) | 2016-01-15 |
US20190270753A1 (en) | 2019-09-05 |
CN104736535B (zh) | 2017-12-19 |
US10208059B2 (en) | 2019-02-19 |
US9018380B2 (en) | 2015-04-28 |
BR112015003729A2 (pt) | 2018-06-05 |
AU2013305633A1 (en) | 2015-02-26 |
IL237378A0 (en) | 2015-04-30 |
CA2882306A1 (en) | 2014-02-27 |
US20170121342A1 (en) | 2017-05-04 |
DK2888255T3 (en) | 2018-10-29 |
CN104736535A (zh) | 2015-06-24 |
AU2013305633B2 (en) | 2018-03-08 |
JP6453218B2 (ja) | 2019-01-16 |
EP2888255A4 (en) | 2016-04-13 |
US20140066424A1 (en) | 2014-03-06 |
JP2015526478A (ja) | 2015-09-10 |
US9481692B2 (en) | 2016-11-01 |
RU2698197C2 (ru) | 2019-08-23 |
HUE040025T2 (hu) | 2019-02-28 |
ZA201501024B (en) | 2019-01-30 |
WO2014031936A3 (en) | 2014-05-22 |
EP2888255B1 (en) | 2018-07-18 |
RU2015105521A (ru) | 2016-10-20 |
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