CY2531B1 - Guanine derivative - Google Patents

Guanine derivative

Info

Publication number
CY2531B1
CY2531B1 CY0500061A CY0500061A CY2531B1 CY 2531 B1 CY2531 B1 CY 2531B1 CY 0500061 A CY0500061 A CY 0500061A CY 0500061 A CY0500061 A CY 0500061A CY 2531 B1 CY2531 B1 CY 2531B1
Authority
CY
Cyprus
Prior art keywords
guanine derivative
guanine
derivative
Prior art date
Application number
CY0500061A
Other languages
English (en)
Inventor
Barry Howard Carter
Jane Muse Partin
Peter Gregory Varlashkin
Richard Augustus Winnike
William Bayne Grubb Iii
Gregory Alan Conway
Philip George Lake
David Michael Skinner
David James Whatrup
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10768347&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY2531(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of CY2531B1 publication Critical patent/CY2531B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
CY0500061A 1995-01-20 2005-11-16 Guanine derivative CY2531B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9501178.9A GB9501178D0 (en) 1995-01-20 1995-01-20 Guanine derivative

Publications (1)

Publication Number Publication Date
CY2531B1 true CY2531B1 (en) 2006-04-12

Family

ID=10768347

Family Applications (1)

Application Number Title Priority Date Filing Date
CY0500061A CY2531B1 (en) 1995-01-20 2005-11-16 Guanine derivative

Country Status (40)

Country Link
US (1) US6107302A (sk)
EP (1) EP0804436B1 (sk)
JP (1) JP3176633B2 (sk)
KR (1) KR100376074B1 (sk)
CN (1) CN1049893C (sk)
AP (1) AP662A (sk)
AR (1) AR002270A1 (sk)
AT (1) ATE302777T1 (sk)
AU (1) AU702794B2 (sk)
BG (1) BG63393B1 (sk)
BR (1) BR9606768A (sk)
CA (1) CA2210799C (sk)
CY (1) CY2531B1 (sk)
CZ (1) CZ297065B6 (sk)
DE (1) DE69635106T2 (sk)
DK (1) DK0804436T3 (sk)
EA (1) EA000364B1 (sk)
EE (1) EE03528B1 (sk)
ES (1) ES2248806T3 (sk)
FI (1) FI973063A (sk)
GB (1) GB9501178D0 (sk)
GE (1) GEP20001940B (sk)
HR (1) HRP960024B1 (sk)
HU (1) HU222993B1 (sk)
IL (1) IL116831A (sk)
IN (1) IN182468B (sk)
IS (1) IS2268B (sk)
NO (1) NO315558B1 (sk)
NZ (1) NZ298851A (sk)
OA (1) OA10499A (sk)
PL (1) PL182175B1 (sk)
RO (1) RO118693B1 (sk)
RS (1) RS49518B (sk)
SI (1) SI0804436T1 (sk)
SK (1) SK285329B6 (sk)
TR (1) TR199700656T1 (sk)
UA (1) UA46001C2 (sk)
UY (1) UY25779A1 (sk)
WO (1) WO1996022291A1 (sk)
ZA (1) ZA96449B (sk)

Families Citing this family (60)

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GB9501178D0 (en) * 1995-01-20 1995-03-08 Wellcome Found Guanine derivative
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WO2003040145A1 (en) * 2001-11-05 2003-05-15 Glaxo Group Limited Anhydrous crystal form of valaciclovir hydrochloride
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US7407955B2 (en) 2002-08-21 2008-08-05 Boehringer Ingelheim Pharma Gmbh & Co., Kg 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
US20050043329A1 (en) * 2002-09-06 2005-02-24 Shlomit Wizel Crystalline forms of valacyclovir hydrochloride
US20050059684A1 (en) * 2002-10-16 2005-03-17 Ben-Zion Dolitzky Method for reducing residual alcohols in crystalline valacyclovir hydrochloride
ATE335743T1 (de) * 2002-10-16 2006-09-15 Teva Pharma Verfahren zur verminderung von restalkoholen im kristallinen valacyclovir-hydrochlorid
AU2003289995A1 (en) * 2002-12-09 2004-06-30 Texcontor Etablissement Anhydrous crystalline form of valacyclovir hydrochloride
US7786302B2 (en) 2003-05-30 2010-08-31 Eczacibasi-Zentiva Kimyasal Urunler Sanayi Ve Ticaret A.S. Crystalline forms of valacyclovir hydrochloride
CA2527708A1 (en) 2003-06-02 2005-01-06 Teva Pharmaceutical Industries Ltd. Crystalline forms of valacyclovir hydrochloride
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DE102004054054A1 (de) 2004-11-05 2006-05-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
US20060178512A1 (en) * 2005-02-04 2006-08-10 Cheruthur Govindan Method for preparing amino acid esters of nucleoside analogues
EP1891071B1 (en) * 2005-05-25 2012-02-22 Eli Lilly And Company Cyclopropanecarboxylate esters of acyclovir
EP1746098A1 (en) 2005-07-21 2007-01-24 SOLMAG S.p.A. Valacyclovir polymorphs and a process for the preparation thereof
DE102005035891A1 (de) * 2005-07-30 2007-02-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
US20070112193A1 (en) * 2005-11-14 2007-05-17 Khunt Mayur D Valacyclovir process
EP1852108A1 (en) 2006-05-04 2007-11-07 Boehringer Ingelheim Pharma GmbH & Co.KG DPP IV inhibitor formulations
PE20080251A1 (es) * 2006-05-04 2008-04-25 Boehringer Ingelheim Int Usos de inhibidores de dpp iv
CN102838599A (zh) 2006-05-04 2012-12-26 贝林格尔.英格海姆国际有限公司 多晶型
CN1903854B (zh) * 2006-08-09 2012-05-23 丽珠医药集团股份有限公司 一种合成盐酸伐昔洛韦的方法
US20080167325A1 (en) * 2006-12-27 2008-07-10 Bs Praveen Kumar Valacyclovir compositions
US20080281099A1 (en) * 2007-05-07 2008-11-13 Mayur Devjibhai Khunt Process for purifying valacyclovir hydrochloride and intermediates thereof
GB0710277D0 (en) * 2007-05-30 2007-07-11 Univ Birmingham Use of antivirals in the treatment of medical disorders
NZ600126A (en) * 2007-08-17 2013-12-20 Boehringer Ingelheim Int Purine derivatives for use in the treatment of fap-related diseases
JPWO2009031576A1 (ja) * 2007-09-03 2010-12-16 味の素株式会社 バラシクロビル塩酸塩結晶の製造方法
US20090076039A1 (en) * 2007-09-14 2009-03-19 Protia, Llc Deuterium-enriched valacyclovir
PE20140960A1 (es) 2008-04-03 2014-08-15 Boehringer Ingelheim Int Formulaciones que comprenden un inhibidor de dpp4
PE20100156A1 (es) * 2008-06-03 2010-02-23 Boehringer Ingelheim Int Tratamiento de nafld
BRPI0916997A2 (pt) 2008-08-06 2020-12-15 Boehringer Ingelheim International Gmbh Inibidor de dpp-4 e seu uso
UY32030A (es) 2008-08-06 2010-03-26 Boehringer Ingelheim Int "tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
AU2009281122C1 (en) * 2008-08-15 2016-04-21 Boehringer Ingelheim International Gmbh Purin derivatives for use in the treatment of fab-related diseases
AU2009290911A1 (en) 2008-09-10 2010-03-18 Boehringer Ingelheim International Gmbh Combination therapy for the treatment of diabetes and related conditions
US20200155558A1 (en) 2018-11-20 2020-05-21 Boehringer Ingelheim International Gmbh Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
AU2009331471B2 (en) 2008-12-23 2015-09-03 Boehringer Ingelheim International Gmbh Salt forms of organic compound
AR074990A1 (es) 2009-01-07 2011-03-02 Boehringer Ingelheim Int Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina
KR102668834B1 (ko) 2009-11-27 2024-05-24 베링거 인겔하임 인터내셔날 게엠베하 리나글립틴과 같은 ｄｐｐ－ｉｖ 억제제를 사용한 유전자형 검사된 당뇨병 환자의 치료
ES2935300T3 (es) 2010-05-05 2023-03-03 Boehringer Ingelheim Int Combiterapia
WO2011158252A1 (en) 2010-06-15 2011-12-22 Matrix Laboratories Ltd Process for the preparation of valacyclovir hydrochloride polymorphic form ii
KR20230051307A (ko) 2010-06-24 2023-04-17 베링거 인겔하임 인터내셔날 게엠베하 당뇨병 요법
US9034883B2 (en) 2010-11-15 2015-05-19 Boehringer Ingelheim International Gmbh Vasoprotective and cardioprotective antidiabetic therapy
CN102584825B (zh) * 2011-01-17 2014-04-02 四川科伦药物研究有限公司 一种合成盐酸伐昔洛韦的方法
EA030121B1 (ru) 2011-07-15 2018-06-29 Бёрингер Ингельхайм Интернациональ Гмбх Замещенные хиназолины, их получение и их применение в фармацевтических композициях
EP2852592A4 (en) * 2011-11-25 2015-12-23 Piramal Entpr Ltd PROCESS FOR THE PREPARATION OF VALACYCLOVIR CHLORHYDRATE
US9555001B2 (en) 2012-03-07 2017-01-31 Boehringer Ingelheim International Gmbh Pharmaceutical composition and uses thereof
WO2013171167A1 (en) 2012-05-14 2013-11-21 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp -4 inhibitor for use in the treatment of podocytes related disorders and/or nephrotic syndrome
WO2013174767A1 (en) 2012-05-24 2013-11-28 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
ES2950384T3 (es) 2014-02-28 2023-10-09 Boehringer Ingelheim Int Uso médico de un inhibidor de DPP-4
EP4233840A3 (en) 2016-06-10 2023-10-18 Boehringer Ingelheim International GmbH Combinations of linagliptin and metformin
CN110437231B (zh) * 2019-09-04 2022-04-29 上药康丽（常州）药业有限公司 一种盐酸伐昔洛韦无水晶型ⅰ的制备方法
US20230218644A1 (en) 2020-04-16 2023-07-13 Som Innovation Biotech, S.A. Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus

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* Cited by examiner, † Cited by third party
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AP55A (en) * 1987-08-15 1989-09-26 The Wellcome Foundation Ltd Therapeutic Acyclic Nucleosides
EP0702682B1 (en) * 1993-06-10 2001-03-14 Rolabo Sl Process for the preparation of amino acid esters of nucleoside analogues
GB9501178D0 (en) * 1995-01-20 1995-03-08 Wellcome Found Guanine derivative

Also Published As

Publication number Publication date
AU702794B2 (en) 1999-03-04
UY25779A1 (es) 2000-08-21
PL182175B1 (pl) 2001-11-30
AU4453996A (en) 1996-08-07
BG101833A (en) 1998-04-30
PL321326A1 (en) 1997-12-08
JPH11503718A (ja) 1999-03-30
SI0804436T1 (sl) 2006-02-28
DE69635106D1 (de) 2005-09-29
UA46001C2 (uk) 2002-05-15
IS4527A (is) 1997-07-15
OA10499A (en) 2002-04-10
NO973326D0 (no) 1997-07-18
NZ298851A (en) 1999-01-28
EE03528B1 (et) 2001-10-15
TR199700656T1 (xx) 1998-03-21
WO1996022291A1 (en) 1996-07-25
IS2268B (is) 2007-07-15
BG63393B1 (bg) 2001-12-29
CN1049893C (zh) 2000-03-01
CA2210799C (en) 2008-06-10
FI973063A (fi) 1997-09-18
AR002270A1 (es) 1998-03-11
RO118693B1 (ro) 2003-09-30
HRP960024A2 (en) 1997-10-31
EP0804436A1 (en) 1997-11-05
ATE302777T1 (de) 2005-09-15
CA2210799A1 (en) 1996-07-25
MX9705462A (es) 1997-10-31
NO973326L (no) 1997-09-16
GB9501178D0 (en) 1995-03-08
KR100376074B1 (ko) 2003-06-02
AP662A (en) 1998-08-19
US6107302A (en) 2000-08-22
SK96597A3 (en) 1998-02-04
HUP9801836A2 (hu) 1999-05-28
SK285329B6 (sk) 2006-11-03
CZ229497A3 (en) 1997-12-17
DE69635106T2 (de) 2006-06-08
BR9606768A (pt) 1997-12-30
KR19980701525A (ko) 1998-05-15
IL116831A0 (en) 1996-05-14
IN182468B (sk) 1999-04-17
HU222993B1 (hu) 2004-01-28
HUP9801836A3 (en) 1999-06-28
IL116831A (en) 1998-10-30
ES2248806T3 (es) 2006-03-16
EE9700175A (et) 1998-02-16
EA000364B1 (ru) 1999-06-24
CZ297065B6 (cs) 2006-08-16
FI973063A0 (fi) 1997-07-18
AP9701058A0 (en) 1997-10-31
RS49518B (sr) 2006-10-27
EA199700124A1 (ru) 1997-12-30
HRP960024B1 (en) 2005-08-31
YU3396A (sh) 1998-12-23
CN1179159A (zh) 1998-04-15
GEP20001940B (en) 2000-02-05
DK0804436T3 (da) 2005-12-27
EP0804436B1 (en) 2005-08-24
JP3176633B2 (ja) 2001-06-18
ZA96449B (en) 1996-08-07
NO315558B1 (no) 2003-09-22

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