CY2236B1 - Dry mix formulation for bisphosphonic acids - Google Patents
Dry mix formulation for bisphosphonic acidsInfo
- Publication number
- CY2236B1 CY2236B1 CY0100005A CY0100005A CY2236B1 CY 2236 B1 CY2236 B1 CY 2236B1 CY 0100005 A CY0100005 A CY 0100005A CY 0100005 A CY0100005 A CY 0100005A CY 2236 B1 CY2236 B1 CY 2236B1
- Authority
- CY
- Cyprus
- Prior art keywords
- bisphosphonic acid
- stearate
- amino
- lactose
- hydroxybutylidene
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
- A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/04—Drugs for disorders of the urinary system for urolithiasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Neurosurgery (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Anti-Oxidant Or Stabilizer Compositions (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/984,399 US5358941A (en) | 1992-12-02 | 1992-12-02 | Dry mix formulation for bisphosphonic acids with lactose |
Publications (1)
Publication Number | Publication Date |
---|---|
CY2236B1 true CY2236B1 (en) | 2003-07-04 |
Family
ID=25530524
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY0100005A CY2236B1 (en) | 1992-12-02 | 2001-04-04 | Dry mix formulation for bisphosphonic acids |
Country Status (32)
Country | Link |
---|---|
US (5) | US5358941A (xx) |
EP (2) | EP0690719B1 (xx) |
JP (3) | JP3365634B2 (xx) |
KR (2) | KR100286063B1 (xx) |
CN (3) | CN1554349A (xx) |
AT (1) | ATE196736T1 (xx) |
AU (1) | AU677264C (xx) |
BG (1) | BG62795B1 (xx) |
CA (1) | CA2149052C (xx) |
CY (1) | CY2236B1 (xx) |
CZ (2) | CZ289966B6 (xx) |
DE (1) | DE69329533T2 (xx) |
DK (1) | DK0690719T3 (xx) |
ES (1) | ES2150979T3 (xx) |
FI (1) | FI113839B (xx) |
GR (1) | GR3034936T3 (xx) |
HK (1) | HK1009252A1 (xx) |
HU (1) | HU220604B1 (xx) |
IL (1) | IL107741A (xx) |
LV (1) | LV12715B (xx) |
MX (1) | MX9307569A (xx) |
NO (1) | NO308986B1 (xx) |
NZ (1) | NZ258442A (xx) |
PL (1) | PL309245A1 (xx) |
PT (1) | PT690719E (xx) |
RO (1) | RO113429B1 (xx) |
RU (1) | RU2148405C1 (xx) |
SK (1) | SK282100B6 (xx) |
TW (1) | TW422707B (xx) |
UA (1) | UA46701C2 (xx) |
WO (1) | WO1994012200A1 (xx) |
ZA (1) | ZA938979B (xx) |
Families Citing this family (100)
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US6096342A (en) | 1997-03-12 | 2000-08-01 | The Procter & Gamble Company | Dosage forms of risedronate |
KR100274734B1 (ko) * | 1991-11-22 | 2000-12-15 | 제이코버스 코넬리스 레이서 | 리제드로네이트 지연-방출성 조성물 |
US6406714B1 (en) | 1992-12-02 | 2002-06-18 | Merck & Co., Inc. | Dry mix formulation for bisphosphonic acids |
US5358941A (en) * | 1992-12-02 | 1994-10-25 | Merck & Co., Inc. | Dry mix formulation for bisphosphonic acids with lactose |
US20010007863A1 (en) * | 1998-06-18 | 2001-07-12 | Merck & Co., Inc. | Wet granulation formulation for bisphosphonic acids |
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DK0800384T3 (da) * | 1994-12-14 | 2001-04-17 | Enbalt Trading Ltd | Pharmaceutiske tabletformuleringer til direkte kompression |
EP0824341A4 (en) * | 1995-05-12 | 1999-07-07 | Merck & Co Inc | PREVENTING TOOTH LOSS THROUGH ADMINISTRATION OF ALENDRONATE OR ITS SALTS |
JPH11506757A (ja) * | 1995-06-06 | 1999-06-15 | メルク エンド カンパニー インコーポレーテッド | 二ナトリウムアレンドロネート製剤 |
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US6117856A (en) * | 1996-02-14 | 2000-09-12 | Binderman; Itzhak | Topical bisphosphonates for prevention of bone resorption |
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DE19719680A1 (de) | 1997-05-09 | 1998-11-19 | Boehringer Mannheim Gmbh | Verwendung von Diphosphonsäuren zur präventiven Behandlung von Spätfolgen bei Harnblasenerweiterung oder Harnblasenersatz |
AU729912B2 (en) * | 1997-06-11 | 2001-02-15 | Warner Chilcott Company, Llc | Film-coated tablet for improved upper gastrointestinal tract safety |
US20010031244A1 (en) * | 1997-06-13 | 2001-10-18 | Chiesi Farmaceutici S.P.A. | Pharmaceutical aerosol composition |
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1992
- 1992-12-02 US US07/984,399 patent/US5358941A/en not_active Expired - Lifetime
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1993
- 1993-11-17 DK DK94901568T patent/DK0690719T3/da active
- 1993-11-17 SK SK731-95A patent/SK282100B6/sk not_active IP Right Cessation
- 1993-11-17 US US08/454,100 patent/US5681590A/en not_active Expired - Fee Related
- 1993-11-17 AT AT94901568T patent/ATE196736T1/de not_active IP Right Cessation
- 1993-11-17 EP EP94901568A patent/EP0690719B1/en not_active Revoked
- 1993-11-17 CA CA002149052A patent/CA2149052C/en not_active Expired - Fee Related
- 1993-11-17 PL PL93309245A patent/PL309245A1/xx unknown
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- 1993-11-17 KR KR10-2000-7011455A patent/KR100473750B1/ko not_active IP Right Cessation
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- 1993-11-17 CZ CZ19951346A patent/CZ289966B6/cs not_active IP Right Cessation
- 1993-11-17 WO PCT/US1993/011172 patent/WO1994012200A1/en not_active Application Discontinuation
- 1993-11-17 JP JP51323894A patent/JP3365634B2/ja not_active Expired - Lifetime
- 1993-11-17 UA UA95062620A patent/UA46701C2/uk unknown
- 1993-11-17 NZ NZ258442A patent/NZ258442A/en not_active IP Right Cessation
- 1993-11-17 HU HU9501590A patent/HU220604B1/hu unknown
- 1993-11-17 RU RU95113467A patent/RU2148405C1/ru active
- 1993-11-17 EP EP00202632A patent/EP1051975A1/en not_active Withdrawn
- 1993-11-17 DE DE69329533T patent/DE69329533T2/de not_active Revoked
- 1993-11-24 TW TW082109904A patent/TW422707B/zh not_active IP Right Cessation
- 1993-11-24 IL IL107741A patent/IL107741A/xx not_active IP Right Cessation
- 1993-12-01 MX MX9307569A patent/MX9307569A/es unknown
- 1993-12-01 CN CNA2004100488350A patent/CN1554349A/zh active Pending
- 1993-12-01 ZA ZA938979A patent/ZA938979B/xx unknown
- 1993-12-01 CN CN93120408A patent/CN1066624C/zh not_active Expired - Lifetime
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1995
- 1995-05-23 BG BG99663A patent/BG62795B1/bg unknown
- 1995-06-01 NO NO952184A patent/NO308986B1/no active IP Right Maintenance
- 1995-06-01 FI FI952685A patent/FI113839B/fi not_active IP Right Cessation
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1997
- 1997-10-08 US US08/946,849 patent/US5882656A/en not_active Expired - Lifetime
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1998
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- 1998-08-28 US US09/141,782 patent/US6090410A/en not_active Expired - Lifetime
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1999
- 1999-03-31 CN CNB991047494A patent/CN1160076C/zh not_active Expired - Lifetime
- 1999-11-02 US US09/432,859 patent/US6194004B1/en not_active Expired - Lifetime
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2000
- 2000-11-29 GR GR20000402643T patent/GR3034936T3/el not_active IP Right Cessation
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2001
- 2001-04-04 CY CY0100005A patent/CY2236B1/xx unknown
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