SI8710406B - Tablete s podaljšanim delovanjem na osnovi hidroksipropilmetilceluloze z veliko molsko maso in postopek za njihovo pripravo - Google Patents

Tablete s podaljšanim delovanjem na osnovi hidroksipropilmetilceluloze z veliko molsko maso in postopek za njihovo pripravo Download PDF

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Publication number
SI8710406B
SI8710406B SI8710406A SI8710406A SI8710406B SI 8710406 B SI8710406 B SI 8710406B SI 8710406 A SI8710406 A SI 8710406A SI 8710406 A SI8710406 A SI 8710406A SI 8710406 B SI8710406 B SI 8710406B
Authority
SI
Slovenia
Prior art keywords
weight
sustained release
molecular weight
tablets
hydroxypropylmethylcellulose
Prior art date
Application number
SI8710406A
Other languages
English (en)
Other versions
SI8710406A (en
Inventor
Milojka Mohar
Ljuba Kremžar
Zdenka Jerala-Štrukelj
Janja Urbančič-Smerkolj
Andrej Lenardič
Polona Cvelbar
Frida Lah-Gros
Vida Nikolič
Marija Lampret
Mihela Mavec
Mirjan Žorž
Zdravko Kopitar
Original Assignee
Lek
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lek filed Critical Lek
Publication of SI8710406A publication Critical patent/SI8710406A/sl
Publication of SI8710406B publication Critical patent/SI8710406B/sl

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Claims (2)

  1. - · -24 PATENTNA ZAHTEVKA 1. Tablete s podaljšanim delovanjem, ki vsebujejo aminofilin, teofilin, ketoprofen ali propranolol hidroklorid kot terapevtsko aktivno sredstvo, hidroksipropilmetil-celulozo, ki ima vsebnost metoksila od 28 do 30 mas. %, hidroksipropoksila od 7,5 do 12 mas.% in povprečno molekulsko maso vsaj 50.000, v količini od 20 do 40 mas.% tablete, kot nosilno osnovo, od 10 do 20 mas.% mikrokristalne celuloze, druge običajne farmacevtsko sprejemljive pomožne snovi in dodatno do 10 mas.% glicerol ditripalmitostearata.
  2. 2. Postopek za pripravo tablet s podaljšanim delovanjem po zahtevku 1, označen s tem, da stisnemo in oblikujemo zmes terapevtskega sredstva in nosilne osnove, ki obsega hidroksipropilmetilcelulozo, ki ima vsebnost metoksila od 28 do 30 mas.%, hidroksipropoksila od 7,5 do 12 mas.% in povprečno molekulsko maso vsaj 50.000, v količini od 20 do 40 mas.% tablete, od 10 do 20 mas.% mikrokristalne celuloze, druge običajne farmacevtsko sprejemljive pomožne snovi, dodatno pa vsebuje do 10 mas.% glicerol ditripalmitostearata. Za LEK, tovarna farmacevtskih in kemičnih izdelkov, d.d.: PftTEHTKA PiSMSS UUBUANA , t
SI8710406A 1987-03-11 1987-03-11 Tablete s podaljšanim delovanjem na osnovi hidroksipropilmetilceluloze z veliko molsko maso in postopek za njihovo pripravo SI8710406B (sl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
YU40687A YU47044B (sh) 1987-03-11 1987-03-11 Postupak za dobijanje tableta sa produženim delovanjem na bazi hidroksipropil-metilceluloze velike molekularne mase

Publications (2)

Publication Number Publication Date
SI8710406A SI8710406A (en) 1996-08-31
SI8710406B true SI8710406B (sl) 1998-08-31

Family

ID=25549781

Family Applications (1)

Application Number Title Priority Date Filing Date
SI8710406A SI8710406B (sl) 1987-03-11 1987-03-11 Tablete s podaljšanim delovanjem na osnovi hidroksipropilmetilceluloze z veliko molsko maso in postopek za njihovo pripravo

Country Status (5)

Country Link
EP (1) EP0284849B1 (sl)
JP (1) JPH0757726B2 (sl)
DE (1) DE3882765T2 (sl)
SI (1) SI8710406B (sl)
YU (1) YU47044B (sl)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5948437A (en) * 1996-05-23 1999-09-07 Zeneca Limited Pharmaceutical compositions using thiazepine
ID20270A (id) * 1997-05-18 1998-11-19 Adel Abdel Wadood Gomaa Prof D Preparat topikal yang baru untuk pengobatan ketidak-fungsian penis
US5895663A (en) * 1997-07-31 1999-04-20 L. Perrigo Company Pseudoephedrine hydrochloride extended-release tablets
US5851555A (en) * 1997-08-15 1998-12-22 Fuisz Technologies Ltd. Controlled release dosage forms containing water soluble drugs
US7771746B2 (en) 1999-12-03 2010-08-10 Polichem Sa Methods for making sustained-release pharmaceutical compositions of ergot alkaloids having improved bioavailability and compositions thereof
MXPA02005291A (es) * 1999-12-03 2004-06-21 Polichem Sa Metodos para elaborar composiciones farmaceuticas de liberacion sostenida de alcaloides de cornezuelo de centeno que tienen biodisponibilidad mejorada y composiciones de los mismos.
AU2003232398A1 (en) * 2002-06-07 2003-12-22 Ranbaxy Laboratories Limited Sustained release oral dosage forms of gabapentin
US20060039974A1 (en) * 2002-09-11 2006-02-23 Takeda Pharmaceutical Company Limited Sustained release preparation
US20040109889A1 (en) 2002-12-04 2004-06-10 Bunick Frank J. Surface treatment composition for soft substrates
US8039009B2 (en) * 2004-06-17 2011-10-18 Forest Laboratories Holdings Limited Modified release formulations of memantine oral dosage forms
EP2070520A1 (en) 2007-12-11 2009-06-17 LEK Pharmaceuticals D.D. Pharmaceutical composition comprising at least one active agent and a binder, which swells in an acidic media
WO2011099573A1 (ja) * 2010-02-12 2011-08-18 大正製薬株式会社 徐放性製剤
CN108721238A (zh) * 2017-04-17 2018-11-02 上海葆隆生物科技有限公司 一种碳酸锂缓释片

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4259314A (en) * 1979-12-10 1981-03-31 Hans Lowey Method and composition for the preparation of controlled long-acting pharmaceuticals
JPS61501511A (ja) * 1984-03-21 1986-07-24 アメリカン・ホ−ム・プロダクツ・コ−ポレイション 徐放性医薬カプセル
NL8600161A (nl) * 1985-02-05 1986-09-01 Sandoz Ag Farmaceutische preparaten die 9,10-dihydroergotalkaloiden bevatten.
GB2181053B (en) * 1985-10-01 1990-05-23 Sandoz Ltd Pharmaceutical formulations with controlled release of the active substance
US4734285A (en) * 1985-10-28 1988-03-29 The Dow Chemical Company Sustained release compositions

Also Published As

Publication number Publication date
DE3882765D1 (de) 1993-09-09
EP0284849A1 (en) 1988-10-05
DE3882765T2 (de) 1994-03-10
EP0284849B1 (en) 1993-08-04
JPS63290818A (ja) 1988-11-28
SI8710406A (en) 1996-08-31
YU47044B (sh) 1994-12-28
YU40687A (en) 1991-02-28
JPH0757726B2 (ja) 1995-06-21

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Effective date: 20061108