CY1119019T1 - Πολλαπλες παραλλαγες μηνιγγιοκοκκικης πρωτεϊνης νμβ 1870 - Google Patents
Πολλαπλες παραλλαγες μηνιγγιοκοκκικης πρωτεϊνης νμβ 1870Info
- Publication number
- CY1119019T1 CY1119019T1 CY20171100655T CY171100655T CY1119019T1 CY 1119019 T1 CY1119019 T1 CY 1119019T1 CY 20171100655 T CY20171100655 T CY 20171100655T CY 171100655 T CY171100655 T CY 171100655T CY 1119019 T1 CY1119019 T1 CY 1119019T1
- Authority
- CY
- Cyprus
- Prior art keywords
- nmb
- variants
- meningococcal
- variant
- different
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/285—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pasteurellaceae (F), e.g. Haemophilus influenza
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Η μηνιγγιοκοκκική πρωτεΐνη ΝΜΒ 1870 έχει περιγραφεί στην προηγούμενη τέχνη. Οι εφευρέτες έχουν βρει ότι ΝΜΒ 1870 είναι ένα αποτελεσματικό αντιγόνο για έγερση αντισώματος αντι-μηνιγγιοκοκκικών αποκρίσεων και ότι είναι εκφρασμένη σε όλη την έκταση των μηνιγγιοκοκκικών οροομάδων. Σαράντα-δύο διαφορετικές ΝΜΒ 1870 αλληλουχίες έχουν πιστοποιηθεί και αυτές ομαδοποιούνται σε τρεις παραλλαγές. Ορός διεγειρόμενος έναντι μιας δοθείσας παραλλαγής είναι βακτηριοκτόνος εντός της ίδιας παραλλακτικής ομάδας, αλλά δεν είναι δραστικός έναντι στελεχών που εκφράζουν μία από τις άλλες δύο παραλλαγές, δηλ. υπάρχει εγκάρσια προστασία εντός της παραλλαγής αλλά όχι εγκάρσια προστασία μεταξύ των παραλλαγών. Συνεπώς, για μεγίστη εγκάρσιου στελέχους αποτελεσματικότητα, η εφεύρεση χρησιμοποιεί μείγματα που περιλαμβάνουν διαφορετικές παραλλαγές της ΝΜΒ 1870.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0227346.4A GB0227346D0 (en) | 2002-11-22 | 2002-11-22 | 741 |
EP03780528.0A EP1562983B2 (en) | 2002-11-22 | 2003-11-21 | Multiple variants of meningococcal protein nmb1870 |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1119019T1 true CY1119019T1 (el) | 2018-01-10 |
Family
ID=9948377
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20141100741T CY1115778T1 (el) | 2002-11-22 | 2014-09-11 | Πολλαπλες παραλλαγες της πρωτεϊνης μηνiγγιτιδοκοκκου νμβ1870 |
CY20171100655T CY1119019T1 (el) | 2002-11-22 | 2017-06-21 | Πολλαπλες παραλλαγες μηνιγγιοκοκκικης πρωτεϊνης νμβ 1870 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20141100741T CY1115778T1 (el) | 2002-11-22 | 2014-09-11 | Πολλαπλες παραλλαγες της πρωτεϊνης μηνiγγιτιδοκοκκου νμβ1870 |
Country Status (19)
Country | Link |
---|---|
US (6) | US20060251670A1 (el) |
EP (4) | EP2258717A3 (el) |
JP (3) | JP4767540B2 (el) |
CN (1) | CN100381464C (el) |
AU (1) | AU2003288681B2 (el) |
BR (1) | BR0316501A (el) |
CA (2) | CA2507009A1 (el) |
CY (2) | CY1115778T1 (el) |
DK (3) | DK2261239T3 (el) |
ES (3) | ES2436747T5 (el) |
GB (1) | GB0227346D0 (el) |
HK (1) | HK1088342A1 (el) |
HU (1) | HUE034257T2 (el) |
MX (1) | MXPA05005442A (el) |
NZ (1) | NZ540206A (el) |
PT (3) | PT1562983E (el) |
RU (1) | RU2336091C2 (el) |
SI (3) | SI2261239T1 (el) |
WO (1) | WO2004048404A2 (el) |
Families Citing this family (96)
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DK1228217T3 (da) | 1999-04-30 | 2013-02-25 | Novartis Vaccines & Diagnostic | Konserverede neisseria-antigener |
CN102580072A (zh) | 1999-05-19 | 2012-07-18 | 诺华疫苗和诊断有限公司 | 组合式奈瑟球菌组合物 |
CA2864069A1 (en) | 1999-10-29 | 2001-05-03 | Novartis Vaccines And Diagnostics S.R.L. | Neisserial antigenic peptides |
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EP2631245A1 (en) | 2008-03-10 | 2013-08-28 | Children's Hospital & Research Center at Oakland | Chimeric factor H binding proteins (fHBP) containing a heterologous B domain and methods of use |
EP2331562A4 (en) | 2008-09-03 | 2012-07-04 | Childrens Hosp & Res Ct Oak | PEPTIDES WITH AN EPITOPE OF A DOMAIN OF THE FACTOR H-BINDING PROTEIN AND METHOD OF USE |
IT1394288B1 (it) | 2008-09-12 | 2012-06-06 | Novartis Vaccines & Diagnostic | Immunogeni di proteine che legano il fattore h. |
GB0819633D0 (en) | 2008-10-25 | 2008-12-03 | Isis Innovation | Composition |
EP2411048B1 (en) | 2009-03-24 | 2020-05-06 | GlaxoSmithKline Biologicals SA | Adjuvanting meningococcal factor h binding protein |
CA2779816A1 (en) | 2009-10-27 | 2011-05-05 | Novartis Ag | Modified meningococcal fhbp polypeptides |
CN103002910A (zh) | 2010-03-10 | 2013-03-27 | 葛兰素史密丝克莱恩生物有限公司 | 疫苗组合物 |
BR112012024348B1 (pt) | 2010-03-30 | 2022-11-08 | Children's Hospital & Research Center At Oakland | Composição imunogênica, seu uso, proteína de ligação ao fator h de ocorrência não natural, e célula bacteriana geneticamente modificada |
EP2612148B1 (en) | 2010-09-04 | 2019-06-12 | GlaxoSmithKline Biologicals SA | Bactericidal antibody assays to assess immunogenicity and potency of meningococcal capsular saccharide vaccines |
CN103096920B (zh) | 2010-09-10 | 2016-03-23 | 惠氏有限责任公司 | 脑膜炎奈瑟球菌orf2086抗原的非脂质化变体 |
WO2013177397A1 (en) | 2012-05-24 | 2013-11-28 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Multivalent meningococcal conjugates and methods for preparing cojugates |
JP6324961B2 (ja) | 2012-09-06 | 2018-05-16 | ノバルティス アーゲー | 血清群b髄膜炎菌とd/t/pとの組み合わせワクチン |
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