CY1106714T1 - Παραγωγα αλκυλικων αιθερων ή τα αλατα τους - Google Patents

Παραγωγα αλκυλικων αιθερων ή τα αλατα τους

Info

Publication number
CY1106714T1
CY1106714T1 CY20071100909T CY071100909T CY1106714T1 CY 1106714 T1 CY1106714 T1 CY 1106714T1 CY 20071100909 T CY20071100909 T CY 20071100909T CY 071100909 T CY071100909 T CY 071100909T CY 1106714 T1 CY1106714 T1 CY 1106714T1
Authority
CY
Cyprus
Prior art keywords
group
action
integer
ring
alkyl ether
Prior art date
Application number
CY20071100909T
Other languages
English (en)
Inventor
Akihito Saitoh
Noboru Iwakami
Tamotsu Takamatsu
Original Assignee
Toyama Chemical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyama Chemical Co., Ltd. filed Critical Toyama Chemical Co., Ltd.
Publication of CY1106714T1 publication Critical patent/CY1106714T1/el

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12Oxygen or sulfur atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Indole Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Ένα παράγωγο αλκυλικού αιθέρα (αλκυλαιθέρα) που αντιπροσωπεύεται από το γενικό χημικό τύπο (δες σχέδιο) όπου το καθένα των R1 και R2 αντιπροσωπεύει μία ή περισσότερες ομάδες που επιλέγονται από ένα άτομο υδρογόνου, ένα άτομο αλογόνου, μια αλκυλομάδα, μια αρυλομάδα, μια αραλκυλομάδα, μια αλκοξυομάδα, μια αρυλοξυομάδα, μια ομάδα αλκυλοθείου, μια ομάδα αρυλοθείου, μια ομάδα αλκενυλίου, μια αλκενυλοξυομάδα, μια αμινομάδα, μια ομάδα αλκυλοσουλφονυλίου, μια ομάδα αρυλοσουλφονυλίου, μια ομάδα καρβαμοϋλίου, μια ετεροκυκλική ομάδα, μια ομάδα υδροξυλίου, μια ομάδα καρβοξυλίου, μια νιτροομάδα, μια οξοομάδα και τα παρόμοια το R3 είναι μια αλκυλαμινομάδα, μια αμινομάδα, μια υδροξυλομάδα ή τα συναφή• ο δακτύλιος Α είναι ένας 5-μελής ή 6-μελής ετεροαρωματικός δακτύλιος ή ένας δακτύλιος βενζενίου το καθένα των m και n είναι ένας ακέραιος από 1 έως 6 και το p είναι ένας ακέραιος από 1 έως 3, ή ένα άλας του, έχει τη δράση να προστατεύει νευρώνες, τη δράση να επιταχύνει την αναγέννηση των νεύρων και τη δράση να επιταχύνει την επέκταση των νευριτών και ως εκ τούτου είναι χρήσιμο σαν ένας θεραπευτικός παράγοντας για ασθένειες στα κεντρικά και περιφερικά νεύρα.
CY20071100909T 2001-10-19 2007-07-09 Παραγωγα αλκυλικων αιθερων ή τα αλατα τους CY1106714T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001321381 2001-10-19
PCT/JP2002/010827 WO2003035647A1 (fr) 2001-10-19 2002-10-18 Derives ou sels d'ether d'alkyle

Publications (1)

Publication Number Publication Date
CY1106714T1 true CY1106714T1 (el) 2012-05-23

Family

ID=19138603

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20071100909T CY1106714T1 (el) 2001-10-19 2007-07-09 Παραγωγα αλκυλικων αιθερων ή τα αλατα τους

Country Status (23)

Country Link
US (4) US7087594B2 (el)
EP (1) EP1437353B1 (el)
JP (1) JP4398247B2 (el)
KR (1) KR100956990B1 (el)
CN (2) CN100500662C (el)
AT (1) ATE364604T1 (el)
AU (1) AU2002344107B2 (el)
BR (1) BRPI0213393B8 (el)
CA (1) CA2464358C (el)
CY (1) CY1106714T1 (el)
DE (1) DE60220694T2 (el)
DK (1) DK1437353T3 (el)
ES (1) ES2287324T3 (el)
HU (1) HU230407B1 (el)
IL (2) IL161308A0 (el)
MX (1) MXPA04003541A (el)
NO (1) NO325780B1 (el)
NZ (1) NZ532328A (el)
PL (2) PL215264B1 (el)
PT (1) PT1437353E (el)
RO (1) RO122203B1 (el)
WO (1) WO2003035647A1 (el)
ZA (1) ZA200402806B (el)

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MXPA04012534A (es) 2002-06-14 2005-04-19 Toyama Chemical Co Ltd Composicion farmaceutica para mejorar la funcion cerebral y metodo para mejorar la funcion cerebral.
US20060205709A1 (en) * 2003-04-17 2006-09-14 Toyama Chemical Co., Ltd. Preventive/remedy for retinal nerve diseases containing alkyl ether derivatives or salts thereof
AU2011204959B2 (en) * 2005-03-28 2012-04-12 Toyama Chemical Co., Ltd. Process for production of 1-(3-(2-(1-benzothiophen-5-YL)- ethoxy)propyl)azetidin-3-ol or salts thereof
EP2248809B1 (en) 2005-03-28 2012-05-09 Toyama Chemical Co., Ltd. Alkyl-3-[2-(benzo[b]thiophen-5-yl)-ethoxy]-propanoates as intermediates in the production of Azetidin-3-ol derivatives
JP4902247B2 (ja) * 2005-04-08 2012-03-21 富山化学工業株式会社 2−(1−ベンゾチオフェン−5−イル)エタノールの新規製造法およびその中間体
JP2006328058A (ja) * 2005-04-27 2006-12-07 Toyama Chem Co Ltd 2−(1−ベンゾチオフェン−5−イル)エタノールの新規製造法およびその中間体
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PL2818165T3 (pl) 2012-02-22 2019-09-30 Fujifilm Toyama Chemical Co., Ltd. Stała kompozycja farmaceutyczna zawierająca 1-(3-(2-(1-benzotiofen-5-ylo)etoksy)propylo)-azetydyn-3-ol albo jego sól
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KR20180097581A (ko) 2015-12-25 2018-08-31 토야마 케미칼 컴퍼니 리미티드 1-(3-(2-(1-벤조티오펜-5-일)에톡시)프로필)아제티딘-3-올 또는 그 염을 포함하는 정제
WO2018124284A1 (ja) 2016-12-28 2018-07-05 富山化学工業株式会社 医薬組成物
JP7057286B2 (ja) 2016-12-28 2022-04-19 富士フイルム富山化学株式会社 医薬組成物
EP3563843A4 (en) * 2016-12-28 2019-12-11 FUJIFILM Toyama Chemical Co., Ltd. TOPICAL COMPOSITION
WO2018124282A1 (ja) 2016-12-28 2018-07-05 富山化学工業株式会社 医薬組成物およびその製造方法
CN116492335A (zh) 2017-06-02 2023-07-28 富士胶片富山化学株式会社 脑萎缩预防或治疗剂
CA3067458C (en) 2017-06-02 2022-11-01 Fujifilm Toyama Chemical Co., Ltd. Agent for reducing amount of amyloid .beta. protein
EP3636262A4 (en) 2017-06-02 2020-06-10 FUJIFILM Toyama Chemical Co., Ltd. AGENT FOR PREVENTING OR TREATING ALZHEIMER-LIKE DEMENTIA
EP3632430A4 (en) 2017-06-02 2020-06-10 FUJIFILM Toyama Chemical Co., Ltd. AGENT FOR THE PREVENTION OR TREATMENT OF SPINOCEREBELLOUS ATAXIA
JP7370859B2 (ja) 2017-06-02 2023-10-30 富士フイルム富山化学株式会社 タウオパチー予防または治療剤
EP3705121B1 (en) * 2017-10-30 2023-08-30 FUJIFILM Toyama Chemical Co., Ltd. Emopamil binding protein binding agent and use thereof
CN114853619B (zh) * 2022-05-19 2024-05-10 神隆医药(常熟)有限公司 一种适于工业化生产的n-甲基酪胺盐酸盐的制备方法

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MXPA04012534A (es) 2002-06-14 2005-04-19 Toyama Chemical Co Ltd Composicion farmaceutica para mejorar la funcion cerebral y metodo para mejorar la funcion cerebral.
US20060205709A1 (en) 2003-04-17 2006-09-14 Toyama Chemical Co., Ltd. Preventive/remedy for retinal nerve diseases containing alkyl ether derivatives or salts thereof
EP2248809B1 (en) 2005-03-28 2012-05-09 Toyama Chemical Co., Ltd. Alkyl-3-[2-(benzo[b]thiophen-5-yl)-ethoxy]-propanoates as intermediates in the production of Azetidin-3-ol derivatives
JP5695293B2 (ja) 2006-04-26 2015-04-01 富山化学工業株式会社 アルキルエーテル誘導体またはその塩を含有する神経細胞新生誘導剤および精神障害治療剤
US8119625B2 (en) 2006-04-26 2012-02-21 Toyama Chemical Co., Ltd. Neurogenesis inducer or neuropathy therapeutic agent comprising alkyl ether derivative or salt thereof
JP5255441B2 (ja) 2006-08-04 2013-08-07 富山化学工業株式会社 アルキルエーテル誘導体またはその塩を含有するプロテインキナーゼc活性促進剤
NZ589448A (en) 2008-05-28 2011-09-30 Toyama Chemical Co Ltd Novel benzothiophene oxide derivative and salt thereof

Also Published As

Publication number Publication date
CN101643470B (zh) 2012-08-01
BRPI0213393B8 (pt) 2021-05-25
PL369601A1 (en) 2005-05-02
DE60220694T2 (de) 2008-02-07
DE60220694D1 (de) 2007-07-26
US7087594B2 (en) 2006-08-08
ZA200402806B (en) 2005-06-29
BR0213393A (pt) 2005-01-11
CA2464358C (en) 2011-05-24
CN1571786A (zh) 2005-01-26
EP1437353A1 (en) 2004-07-14
HUP0500017A2 (hu) 2005-04-28
US7468443B2 (en) 2008-12-23
US20060194781A1 (en) 2006-08-31
CN101643470A (zh) 2010-02-10
ATE364604T1 (de) 2007-07-15
NZ532328A (en) 2005-07-29
WO2003035647A1 (fr) 2003-05-01
JPWO2003035647A1 (ja) 2005-07-28
DK1437353T3 (da) 2007-08-06
EP1437353B1 (en) 2007-06-13
IL161308A0 (en) 2004-09-27
US20090111992A1 (en) 2009-04-30
JP4398247B2 (ja) 2010-01-13
US8129535B2 (en) 2012-03-06
KR100956990B1 (ko) 2010-05-11
USRE43676E1 (en) 2012-09-18
MXPA04003541A (es) 2004-07-22
BRPI0213393B1 (pt) 2018-12-04
NO325780B1 (no) 2008-07-14
AU2002344107B2 (en) 2007-11-01
KR20040050919A (ko) 2004-06-17
CA2464358A1 (en) 2003-05-01
IL161308A (en) 2011-06-30
HUP0500017A3 (en) 2011-07-28
PL402986A1 (pl) 2013-04-29
NO20041531L (no) 2004-04-15
PL217872B1 (pl) 2014-08-29
US20050070521A1 (en) 2005-03-31
EP1437353A4 (en) 2005-01-19
ES2287324T3 (es) 2007-12-16
PT1437353E (pt) 2007-08-28
PL215264B1 (pl) 2013-11-29
RO122203B1 (ro) 2009-02-27
HU230407B1 (hu) 2016-04-28
CN100500662C (zh) 2009-06-17

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