NZ759585A - Agent for preventing or treating brain atrophy - Google Patents
Agent for preventing or treating brain atrophyInfo
- Publication number
- NZ759585A NZ759585A NZ759585A NZ75958518A NZ759585A NZ 759585 A NZ759585 A NZ 759585A NZ 759585 A NZ759585 A NZ 759585A NZ 75958518 A NZ75958518 A NZ 75958518A NZ 759585 A NZ759585 A NZ 759585A
- Authority
- NZ
- New Zealand
- Prior art keywords
- brain atrophy
- agent
- preventing
- suppressing
- treating brain
- Prior art date
Links
- 208000024806 Brain atrophy Diseases 0.000 title abstract 4
- HQNACSFBDBYLJP-UHFFFAOYSA-N 1-[3-[2-(1-benzothiophen-5-yl)ethoxy]propyl]azetidin-3-ol Chemical compound C1C(O)CN1CCCOCCC1=CC=C(SC=C2)C2=C1 HQNACSFBDBYLJP-UHFFFAOYSA-N 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 230000032683 aging Effects 0.000 abstract 1
- 239000013043 chemical agent Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention addresses the problem of providing a chemical agent for suppressing the progression of Alzheimer-type dementia and a method for suppressing the progression of Alzheimer-type dementia. 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or a salt thereof has an effect of suppressing brain atrophy, and is useful as a prophylactic or therapeutic agent for brain atrophy. Thus, it is possible to prevent or treat brain atrophy observed in the aging process or in neurodegenerative diseases by administering 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or a salt thereof.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2017109885 | 2017-06-02 | ||
| JP2017128472 | 2017-06-30 | ||
| JP2017145100 | 2017-07-27 | ||
| PCT/JP2018/021223 WO2018221729A1 (en) | 2017-06-02 | 2018-06-01 | Agent for preventing or treating brain atrophy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ759585A true NZ759585A (en) | 2022-02-25 |
Family
ID=64455855
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ759585A NZ759585A (en) | 2017-06-02 | 2018-06-01 | Agent for preventing or treating brain atrophy |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US11951092B2 (en) |
| EP (1) | EP3632431A4 (en) |
| JP (2) | JP7282028B2 (en) |
| KR (1) | KR20190137936A (en) |
| CN (3) | CN116473962A (en) |
| AU (1) | AU2018276638B2 (en) |
| BR (1) | BR112019024851A2 (en) |
| CA (1) | CA3067453C (en) |
| IL (1) | IL270922A (en) |
| MX (1) | MX2019014310A (en) |
| NZ (1) | NZ759585A (en) |
| RU (1) | RU2759727C2 (en) |
| SG (1) | SG11201911512SA (en) |
| WO (1) | WO2018221729A1 (en) |
| ZA (1) | ZA201907973B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ759585A (en) * | 2017-06-02 | 2022-02-25 | Fujifilm Toyama Chemical Co Ltd | Agent for preventing or treating brain atrophy |
| WO2018221732A1 (en) | 2017-06-02 | 2018-12-06 | 富山化学工業株式会社 | AMYLOID-β PROTEIN LEVEL DECREASING AGENT |
| NZ759647A (en) | 2017-06-02 | 2022-02-25 | Fujifilm Toyama Chemical Co Ltd | Agent for preventing or treating spinocerebellar ataxia |
| JPWO2018221728A1 (en) | 2017-06-02 | 2020-04-02 | 富士フイルム富山化学株式会社 | Agent for preventing or treating Alzheimer's disease |
| US11548878B2 (en) | 2017-10-30 | 2023-01-10 | Fujifilm Toyama Chemical Co., Ltd. | Emopamil binding protein binding agent and use thereof |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2302808C (en) | 1997-09-05 | 2010-05-18 | Human Genome Sciences, Inc. | 50 human secreted proteins |
| GB9824207D0 (en) | 1998-11-04 | 1998-12-30 | Zeneca Ltd | Neurological disorders |
| BRPI0213393B8 (en) | 2001-10-19 | 2021-05-25 | Fujifilm Toyama Chemical Co Ltd | alkyl ether derivatives, or one of its salts, process for producing an alkyl ether derivative, alkyl amide derivative, or one of its salts, and pharmaceutical composition |
| SI2389937T1 (en) | 2002-06-14 | 2018-10-30 | Toyama Chemical Co., Ltd, | Medicinal composition for improving brain function |
| AU2004229283B2 (en) | 2003-04-17 | 2009-02-05 | Toyama Chemical Co., Ltd. | Preventive/remedy for retinal nerve diseases containing alkyl ether derivatives or salts thereof |
| US8119625B2 (en) * | 2006-04-26 | 2012-02-21 | Toyama Chemical Co., Ltd. | Neurogenesis inducer or neuropathy therapeutic agent comprising alkyl ether derivative or salt thereof |
| SI2011796T1 (en) * | 2006-04-26 | 2015-02-27 | Toyama Chemical Co., Ltd. | Neurogenesis inducer or neuropathy therapeutic agent comprising alkyl ether derivative or salt thereof |
| NZ587532A (en) | 2008-03-04 | 2012-07-27 | Vernalis R&D Ltd | Azetidine derivatives for inhibition of faah activity |
| FR2934596B1 (en) | 2008-07-30 | 2015-04-10 | Trophos | NOVEL CHOLEST-4-EN-3-ONE OXIME DERIVATIVES, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM, AND PROCESS FOR PREPARING THE SAME |
| NO2419104T3 (en) | 2009-04-13 | 2018-04-07 | ||
| JP5808319B2 (en) | 2009-05-11 | 2015-11-10 | フォルム ファーマシューティカルズ、インコーポレイテッド | Treatment of cognitive impairment using specific α7 nicotinic acid receptors in combination with acetylcholinesterase inhibitors |
| US20110262442A1 (en) | 2009-11-06 | 2011-10-27 | Adenios, Inc. | Compositions for treating cns disorders |
| CN104159583B (en) * | 2012-02-22 | 2018-04-13 | 富山化学工业株式会社 | Solid composite medicament containing 1 (3 (2 (1 benzothiophene, 5 base) ethyoxyl) propyl group) azetidine, 3 alcohol or its salt |
| AU2013292519B2 (en) | 2012-07-19 | 2017-12-07 | Drexel University | Sigma receptor ligands for modulating cellular protein homeostasis |
| EP2903980B1 (en) | 2012-10-01 | 2017-07-19 | F. Hoffmann-La Roche AG | Benzimidazoles as cns active agents |
| LT3100725T (en) * | 2014-01-31 | 2020-08-10 | Fujifilm Toyama Chemical Co., Ltd. | Post nerve injury rehabilitation effect-enhancing agent comprising an alkyl ether derivative or a salt thereof |
| WO2015163318A1 (en) | 2014-04-25 | 2015-10-29 | レジリオ株式会社 | Therapeutic agent for diseases associated with nerve axon dysfunction, including therapeutic agent for alzheimer's disease |
| WO2015188368A1 (en) | 2014-06-13 | 2015-12-17 | Merck Sharp & Dohme Corp. | Pyrrolo[2,3-c]pyridines as imaging agents for neurofibrilary tangles |
| WO2016051799A1 (en) | 2014-10-01 | 2016-04-07 | 学校法人同志社 | 2-aminohydroquinone derivative and tau aggregation inhibitor |
| SG11201705727TA (en) | 2015-02-02 | 2017-08-30 | Ucb Biopharma Sprl | 9h-pyrrolo-dipyridine derivatives |
| US20160324851A1 (en) | 2015-05-07 | 2016-11-10 | Axovant Sciences, Ltd. | Methods of treating a neurodegenerative disease |
| EP3308782B1 (en) | 2015-06-11 | 2022-01-19 | Toyama Chemical Co., Ltd. | Sigma-receptor binding agent |
| KR102703879B1 (en) | 2015-12-25 | 2024-09-05 | 후지필름 도야마 케미컬 가부시키가이샤 | Tablets containing 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidine-3-ol or its salt |
| NZ759585A (en) * | 2017-06-02 | 2022-02-25 | Fujifilm Toyama Chemical Co Ltd | Agent for preventing or treating brain atrophy |
| JPWO2018221728A1 (en) | 2017-06-02 | 2020-04-02 | 富士フイルム富山化学株式会社 | Agent for preventing or treating Alzheimer's disease |
| NZ759647A (en) | 2017-06-02 | 2022-02-25 | Fujifilm Toyama Chemical Co Ltd | Agent for preventing or treating spinocerebellar ataxia |
| WO2018221731A1 (en) | 2017-06-02 | 2018-12-06 | 富山化学工業株式会社 | Agent for preventing or treating tauopathy |
| WO2018221732A1 (en) | 2017-06-02 | 2018-12-06 | 富山化学工業株式会社 | AMYLOID-β PROTEIN LEVEL DECREASING AGENT |
| US11548878B2 (en) | 2017-10-30 | 2023-01-10 | Fujifilm Toyama Chemical Co., Ltd. | Emopamil binding protein binding agent and use thereof |
-
2018
- 2018-06-01 NZ NZ759585A patent/NZ759585A/en unknown
- 2018-06-01 CN CN202310470444.0A patent/CN116473962A/en active Pending
- 2018-06-01 RU RU2019138166A patent/RU2759727C2/en active
- 2018-06-01 BR BR112019024851A patent/BR112019024851A2/en unknown
- 2018-06-01 CN CN201880035394.0A patent/CN110709078A/en active Pending
- 2018-06-01 CN CN202310474317.8A patent/CN116492335A/en active Pending
- 2018-06-01 AU AU2018276638A patent/AU2018276638B2/en active Active
- 2018-06-01 SG SG11201911512SA patent/SG11201911512SA/en unknown
- 2018-06-01 KR KR1020197035347A patent/KR20190137936A/en not_active IP Right Cessation
- 2018-06-01 MX MX2019014310A patent/MX2019014310A/en unknown
- 2018-06-01 WO PCT/JP2018/021223 patent/WO2018221729A1/en active Application Filing
- 2018-06-01 EP EP18810520.9A patent/EP3632431A4/en active Pending
- 2018-06-01 CA CA3067453A patent/CA3067453C/en active Active
- 2018-06-01 US US16/617,739 patent/US11951092B2/en active Active
- 2018-06-01 JP JP2019521348A patent/JP7282028B2/en active Active
-
2019
- 2019-11-25 IL IL270922A patent/IL270922A/en unknown
- 2019-11-29 ZA ZA2019/07973A patent/ZA201907973B/en unknown
-
2023
- 2023-02-15 JP JP2023021443A patent/JP2023053337A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN116492335A (en) | 2023-07-28 |
| CN110709078A (en) | 2020-01-17 |
| EP3632431A1 (en) | 2020-04-08 |
| AU2018276638B2 (en) | 2021-04-08 |
| CN116473962A (en) | 2023-07-25 |
| JPWO2018221729A1 (en) | 2020-04-09 |
| RU2759727C2 (en) | 2021-11-17 |
| IL270922A (en) | 2020-01-30 |
| US20200215030A1 (en) | 2020-07-09 |
| ZA201907973B (en) | 2022-03-30 |
| MX2019014310A (en) | 2022-06-10 |
| RU2019138166A (en) | 2021-07-09 |
| JP7282028B2 (en) | 2023-05-26 |
| WO2018221729A1 (en) | 2018-12-06 |
| CA3067453C (en) | 2021-11-23 |
| SG11201911512SA (en) | 2020-01-30 |
| EP3632431A4 (en) | 2020-06-03 |
| US11951092B2 (en) | 2024-04-09 |
| KR20190137936A (en) | 2019-12-11 |
| CA3067453A1 (en) | 2018-12-06 |
| JP2023053337A (en) | 2023-04-12 |
| RU2019138166A3 (en) | 2021-07-09 |
| BR112019024851A2 (en) | 2020-06-09 |
| AU2018276638A1 (en) | 2019-12-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 01 JUN 2024 BY CPA GLOBAL Effective date: 20230427 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 01 JUN 2025 BY ABHISHEK KUMAR - CPA-PTO PAYMENTS Effective date: 20240502 |