HUP0101595A2 - 3-(Amino- vagy amino-alkil)-piridinon-származékok, eljárás előállításukra és alkalmazásuk HIV-vel kapcsolatos betegségek kezelésére szolgáló gyógyszerkészítmények előállítására, valamint a vegyületeket tartalmazó gyógyszerkészítmények - Google Patents

3-(Amino- vagy amino-alkil)-piridinon-származékok, eljárás előállításukra és alkalmazásuk HIV-vel kapcsolatos betegségek kezelésére szolgáló gyógyszerkészítmények előállítására, valamint a vegyületeket tartalmazó gyógyszerkészítmények

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Publication number
HUP0101595A2
HUP0101595A2 HU0101595A HUP0101595A HUP0101595A2 HU P0101595 A2 HUP0101595 A2 HU P0101595A2 HU 0101595 A HU0101595 A HU 0101595A HU P0101595 A HUP0101595 A HU P0101595A HU P0101595 A2 HUP0101595 A2 HU P0101595A2
Authority
HU
Hungary
Prior art keywords
pharmaceutical compositions
producing
aminoalkyl
amino
group
Prior art date
Application number
HU0101595A
Other languages
English (en)
Inventor
Anne-Marie Aubertin
Emile Bisagni
Valérie Dolle
David Grierson
Claude Monneret
Chi Hung Nguyen
Original Assignee
Centre National De La Recherche Scientifique
Institut Curie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National De La Recherche Scientifique, Institut Curie filed Critical Centre National De La Recherche Scientifique
Publication of HUP0101595A2 publication Critical patent/HUP0101595A2/hu
Publication of HUP0101595A3 publication Critical patent/HUP0101595A3/hu

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

A találmány tárgyát az általános képletű vegyületetek - ahol Q -NR1R2vagy -R0NR1R2 általános képletű csoport, amelyben R0, R1 és R2 adottesetben különböző szubsztituensekkel szubszituált alkiléncsoport; vagyR1 és R2 együttesen kétértékű -R1-R2- csoportot képezhet; R3arilcsoport vagy adott esetben szubsztituált mono- vagy biciklikusheterociklusos csoport; R4, R5 és R6 egymástól függetlenül különféleszubsztituált és szubsztituálatlan alkil-, alkenil-csoport, stb.; Yjelentése oxigén- vagy kénatom; X és Z különböző képletű csoportok -és N-oxidjaik, sztereoizomer formáik vagy gyógyszerészetilegelfogadható sóik, az előállításukra szolgáló eljárás és ezekettartalmazó, a humán immunhiány vírus (HIV) reverz transzkriptázátgátló gyógyszerkészítmények képezik. Ó
HU0101595A 1998-04-27 1999-04-27 3-(amino- or aminoalkyl)pyridinone derivatives, process for producing them, use of them for producing pharmaceutical compositions suitable for treating hiv related diseases and pharmaceutical compositions HUP0101595A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8308298P 1998-04-27 1998-04-27
PCT/EP1999/003023 WO1999055676A1 (en) 1998-04-27 1999-04-27 3-(amino- or aminoalkyl)pyridinone derivatives and their use for the treatment of hiv related diseases

Publications (2)

Publication Number Publication Date
HUP0101595A2 true HUP0101595A2 (hu) 2001-11-28
HUP0101595A3 HUP0101595A3 (en) 2002-12-28

Family

ID=22176061

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0101595A HUP0101595A3 (en) 1998-04-27 1999-04-27 3-(amino- or aminoalkyl)pyridinone derivatives, process for producing them, use of them for producing pharmaceutical compositions suitable for treating hiv related diseases and pharmaceutical compositions

Country Status (27)

Country Link
US (2) US6451822B1 (hu)
EP (1) EP1073637B1 (hu)
JP (1) JP2002513004A (hu)
KR (1) KR20010087128A (hu)
CN (1) CN1303378A (hu)
AP (1) AP2000001991A0 (hu)
AT (1) ATE334966T1 (hu)
AU (1) AU4137899A (hu)
BG (1) BG104984A (hu)
BR (1) BR9909976A (hu)
CA (1) CA2330304A1 (hu)
CZ (1) CZ20003978A3 (hu)
DE (1) DE69932611T2 (hu)
EE (1) EE200000620A (hu)
HR (1) HRP20000716A2 (hu)
HU (1) HUP0101595A3 (hu)
ID (1) ID27502A (hu)
IL (1) IL139239A0 (hu)
MX (1) MXPA00010490A (hu)
NO (1) NO20005387L (hu)
NZ (1) NZ508297A (hu)
PL (1) PL343685A1 (hu)
RU (1) RU2000129671A (hu)
SK (1) SK16072000A3 (hu)
TR (1) TR200003113T2 (hu)
WO (1) WO1999055676A1 (hu)
ZA (1) ZA200006037B (hu)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6436972B1 (en) * 2000-04-10 2002-08-20 Dalhousie University Pyridones and their use as modulators of serine hydrolase enzymes
US6803370B2 (en) * 2000-07-21 2004-10-12 Elan Pharmaceuticals, Inc. Alpha amino acid derivatives—inhibitors of leukocyte adhesion mediated by VLA-4
US7115608B2 (en) 2000-09-19 2006-10-03 Centre National De La Recherche Schentifique Pyridinone and pyridinethione derivatives having HIV inhibiting properties
US7482366B2 (en) 2001-12-21 2009-01-27 X-Ceptor Therapeutics, Inc. Modulators of LXR
EP1465869B1 (en) 2001-12-21 2013-05-15 Exelixis Patent Company LLC Modulators of lxr
US7642277B2 (en) * 2002-12-04 2010-01-05 Boehringer Ingelheim International Gmbh Non-nucleoside reverse transcriptase inhibitors
JP4485520B2 (ja) * 2003-03-24 2010-06-23 エフ．ホフマン−ラ ロシュ アーゲー 逆転写酵素阻害剤としてのベンジル−ピリダジノン類
EP1516873A1 (en) * 2003-09-22 2005-03-23 Facultés Universitaires Notre-Dame de la Paix 2-pyridinone derivatives, having HIV inhibiting properties
CN1953982B (zh) * 2004-05-17 2011-07-06 泰博特克药品有限公司 4-取代-1,5-二氢-吡啶并[3,2-b]吲哚-2-酮
GB0420722D0 (en) * 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
WO2006073973A2 (en) * 2004-12-31 2006-07-13 Reddy Us Therapeutics, Inc. Novel benzylamine derivatives as cetp inhibitors
EA015252B1 (ru) 2005-05-10 2011-06-30 Интермьюн, Инк. Способ модуляции стресс-активированной протеинкиназной системы
US7786120B2 (en) 2005-08-29 2010-08-31 Vertex Pharmaceuticals Incorporated Pyridones useful as inhibitors of kinases
ATE548363T1 (de) 2005-08-29 2012-03-15 Vertex Pharma 3,5-disubstituierte pyrid-2-one, die sich als inhibitoren der tec-familie von nicht-rezeptor- tyrosinkinasen eignen
US7786130B2 (en) 2005-08-29 2010-08-31 Vertex Pharmaceuticals Incorporated Pyridones useful as inhibitors of kinases
RU2448104C2 (ru) * 2005-12-19 2012-04-20 Зингента Лимитед Замещенные ароматические гетероциклические соединения, как фунгициды
CA2705834A1 (en) * 2007-11-20 2009-05-28 Merck Sharp & Dohme Corp. Pyridinone non-nucleoside reverse transcriptase inhibitors
CN102099036B (zh) 2008-06-03 2015-05-27 英特芒尼公司 用于治疗炎性疾患和纤维化疾患的化合物和方法
KR20110041515A (ko) * 2008-07-14 2011-04-21 한국화학연구원 비-뉴클레오사이드 역전사효소 억제제로서의 피리돈 유도체
US8349832B2 (en) * 2009-09-02 2013-01-08 Canthera Therapeutics Compounds and compositions for treating cancer
US8318737B2 (en) 2009-09-02 2012-11-27 Canthera Therapeutics Inc. Compounds and compositions for treating cancer
CN102001994B (zh) * 2010-10-22 2014-07-09 北京大学 吡啶酮类hiv-1逆转录酶抑制剂的制备及其应用
CN103288719A (zh) * 2012-03-05 2013-09-11 苏州欧凯医药技术有限公司 非核甘艾滋病毒抑制物-吡啶酮类先导体的合成
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
JO3470B1 (ar) 2012-10-08 2020-07-05 Merck Sharp & Dohme مشتقات 5- فينوكسي-3h-بيريميدين-4-أون واستخدامها كمثبطات ناسخ عكسي ل hiv
CN110452216B (zh) 2014-04-02 2022-08-26 英特穆恩公司 抗纤维化吡啶酮类
EP3186242B1 (en) 2014-08-29 2021-10-06 Tes Pharma S.r.l. Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase
JP7045528B2 (ja) * 2018-12-18 2022-03-31 メルク・シャープ・アンド・ドーム・コーポレーション Ｈｉｖに感染した細胞に対する選択的細胞毒性薬としてのピリミドン誘導体
CN114026081A (zh) * 2019-05-22 2022-02-08 默沙东公司 作为针对hiv感染的细胞的选择性细胞毒性剂的吡啶酮衍生物

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Publication number Priority date Publication date Assignee Title
NZ238576A (en) * 1990-06-18 1994-12-22 Merck & Co Inc Pyridinone derivatives, preparation and pharmaceutical compositions thereof
US5308854A (en) * 1990-06-18 1994-05-03 Merck & Co., Inc. Inhibitors of HIV reverse transcriptase
FR2737496B1 (fr) * 1995-07-31 1997-12-19 Centre Nat Rech Scient 4-aryl-thio-pyridin-2(1h)-ones, medicaments les contenant et leurs utilisations dans le traitement de maladies liees aux vih 1 et 2

Also Published As

Publication number Publication date
ID27502A (id) 2001-04-12
DE69932611D1 (de) 2006-09-14
CZ20003978A3 (cs) 2001-09-12
NZ508297A (en) 2002-12-20
RU2000129671A (ru) 2004-02-20
ZA200006037B (en) 2002-01-25
US6683079B2 (en) 2004-01-27
HUP0101595A3 (en) 2002-12-28
HRP20000716A2 (en) 2001-06-30
AP2000001991A0 (en) 2000-12-31
ATE334966T1 (de) 2006-08-15
CN1303378A (zh) 2001-07-11
EP1073637A1 (en) 2001-02-07
MXPA00010490A (es) 2002-10-17
EE200000620A (et) 2002-04-15
JP2002513004A (ja) 2002-05-08
NO20005387L (no) 2000-12-04
IL139239A0 (en) 2001-11-25
US6451822B1 (en) 2002-09-17
WO1999055676A1 (en) 1999-11-04
US20030125340A1 (en) 2003-07-03
AU4137899A (en) 1999-11-16
CA2330304A1 (en) 1999-11-04
TR200003113T2 (tr) 2001-05-21
SK16072000A3 (sk) 2002-04-04
DE69932611T2 (de) 2007-10-11
BG104984A (en) 2001-07-31
EP1073637B1 (en) 2006-08-02
NO20005387D0 (no) 2000-10-26
PL343685A1 (en) 2001-08-27
KR20010087128A (ko) 2001-09-15
BR9909976A (pt) 2000-12-26

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