NO885655L - Analogifremgangsmaate for fremstilling av terapeutisk aktive n-methylpyrrolidin- og fucitolderivater. - Google Patents

Analogifremgangsmaate for fremstilling av terapeutisk aktive n-methylpyrrolidin- og fucitolderivater.

Info

Publication number
NO885655L
NO885655L NO88885655A NO885655A NO885655L NO 885655 L NO885655 L NO 885655L NO 88885655 A NO88885655 A NO 88885655A NO 885655 A NO885655 A NO 885655A NO 885655 L NO885655 L NO 885655L
Authority
NO
Norway
Prior art keywords
dideoxy
imino
methyl
ribitol
derivatives
Prior art date
Application number
NO88885655A
Other languages
English (en)
Other versions
NO885655D0 (no
NO172340C (no
NO172340B (no
Inventor
Raymond Allen Dwek
George William John Fleet
Thomas William Rademacher
Original Assignee
Monsanto Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monsanto Co filed Critical Monsanto Co
Publication of NO885655D0 publication Critical patent/NO885655D0/no
Publication of NO885655L publication Critical patent/NO885655L/no
Publication of NO172340B publication Critical patent/NO172340B/no
Publication of NO172340C publication Critical patent/NO172340C/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40Oxygen atoms
    • C07D211/44Oxygen atoms attached in position 4
    • C07D211/46Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12Oxygen or sulfur atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/86Oxygen atoms
    • C07D211/88Oxygen atoms attached in positions 2 and 6, e.g. glutarimide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
NO885655A 1987-12-21 1988-12-20 Analogifremgangsmaate for fremstilling av terapeutisk aktiv 1,5-dideoxy-1,5-imino-(n-omega-methyl-caproat)-l-fucitol NO172340C (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13621987A 1987-12-21 1987-12-21
US07/249,144 US4999360A (en) 1987-12-21 1988-09-26 Method of inhibiting virus

Publications (4)

Publication Number Publication Date
NO885655D0 NO885655D0 (no) 1988-12-20
NO885655L true NO885655L (no) 1989-06-22
NO172340B NO172340B (no) 1993-03-29
NO172340C NO172340C (no) 1993-07-07

Family

ID=26834131

Family Applications (1)

Application Number Title Priority Date Filing Date
NO885655A NO172340C (no) 1987-12-21 1988-12-20 Analogifremgangsmaate for fremstilling av terapeutisk aktiv 1,5-dideoxy-1,5-imino-(n-omega-methyl-caproat)-l-fucitol

Country Status (16)

Country Link
US (1) US4999360A (no)
EP (1) EP0322395B1 (no)
JP (1) JP2538014B2 (no)
KR (1) KR910009994B1 (no)
AT (1) ATE87206T1 (no)
AU (1) AU607834B2 (no)
CA (1) CA1316929C (no)
DE (1) DE3879653T2 (no)
DK (1) DK175113B1 (no)
FI (1) FI93210C (no)
IE (1) IE63095B1 (no)
IL (1) IL88742A (no)
NO (1) NO172340C (no)
NZ (1) NZ227410A (no)
OA (1) OA08937A (no)
PT (1) PT89267B (no)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0367747B1 (en) * 1988-11-03 1996-03-13 G.D. Searle & Co. Dideoxy-L-arabinitol derivatives as antiviral compounds
US4894388A (en) * 1988-12-22 1990-01-16 Monsanto Company Glycosidase inhibitors and use thereof
US5100797A (en) * 1989-06-27 1992-03-31 Monsanto Company Fucosidase inhibitors
US5043273A (en) * 1989-08-17 1991-08-27 Monsanto Company Phosphorylated glycosidase inhibitor prodrugs
IT1239950B (it) * 1990-03-28 1993-11-27 Zambon Spa Processo per la preparazione di composti con attivita' analgesica centrale
US5252587A (en) * 1990-04-27 1993-10-12 Merrell Dow Pharmaceuticals, Inc. N-derivatives of 1-deoxy nojirimycin
US5536732A (en) * 1990-04-27 1996-07-16 Merrell Pharmaceuticals Inc. N-derivatives of 1-deoxy nojirimycin
US5290948A (en) * 1990-09-17 1994-03-01 Mcneilab, Inc. Process for producing polyhydroxylated piperidines and pyrrolidines and compounds thereof
GB9026271D0 (en) * 1990-12-03 1991-01-16 Alphey Thomas J W Control of parasitic nematodes(a)
US5258518A (en) * 1992-04-01 1993-11-02 G. D. Searle & Co. 2-substituted tertiary carbinol derivatives of deoxynojirimycin
US5451679A (en) * 1994-03-08 1995-09-19 G. D. Searle & Co. 2-chloro and 2-bromo derivatives of 1,5-iminosugars
EP0858335B1 (en) * 1995-09-08 2003-03-12 Novo Nordisk A/S 2-alkylpyrrolidines
CN102399228B (zh) * 2010-09-08 2013-10-16 中国科学院成都生物研究所 N-烷基多羟基哌啶衍生物的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1555654A (en) * 1977-06-25 1979-11-14 Exxon Research Engineering Co Agricultural burner apparatus
US4065562A (en) * 1975-12-29 1977-12-27 Nippon Shinyaku Co., Ltd. Method and composition for reducing blood glucose levels
DE3038901A1 (de) * 1980-10-15 1982-05-06 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von n-substituierten derivaten des 1-desoxynojirimycins
DE3507019A1 (de) * 1985-02-28 1986-08-28 Bayer Ag, 5090 Leverkusen Neue derivate von 3,4,5-trihydroxypiperidin, verfahren zu ihrer herstellung und ihre verwendung
EP0252962B1 (en) * 1985-12-23 1995-08-23 Fred Hutchinson Cancer Research Center Regulating retroviral replication, infection, and pathogenesis

Also Published As

Publication number Publication date
IE63095B1 (en) 1995-03-22
OA08937A (fr) 1989-10-31
FI93210C (fi) 1995-03-10
ATE87206T1 (de) 1993-04-15
NO885655D0 (no) 1988-12-20
DK175113B1 (da) 2004-06-07
FI885880A (fi) 1989-06-22
NO172340C (no) 1993-07-07
PT89267A (pt) 1989-12-29
JP2538014B2 (ja) 1996-09-25
KR890009389A (ko) 1989-08-01
DE3879653D1 (de) 1993-04-29
DK708188D0 (da) 1988-12-20
AU607834B2 (en) 1991-03-14
PT89267B (pt) 1993-12-31
IL88742A (en) 1993-08-18
DE3879653T2 (de) 1993-10-14
DK708188A (da) 1989-06-22
NZ227410A (en) 1991-06-25
NO172340B (no) 1993-03-29
US4999360A (en) 1991-03-12
FI93210B (fi) 1994-11-30
CA1316929C (en) 1993-04-27
KR910009994B1 (ko) 1991-12-10
AU2706888A (en) 1989-06-22
FI885880A0 (fi) 1988-12-20
EP0322395A1 (en) 1989-06-28
IL88742A0 (en) 1989-07-31
EP0322395B1 (en) 1993-03-24
IE883794L (en) 1989-06-21
JPH01230517A (ja) 1989-09-14

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