KR890009389A - 바이러스를 억제시키는 방법 - Google Patents
바이러스를 억제시키는 방법 Download PDFInfo
- Publication number
- KR890009389A KR890009389A KR1019880017028A KR880017028A KR890009389A KR 890009389 A KR890009389 A KR 890009389A KR 1019880017028 A KR1019880017028 A KR 1019880017028A KR 880017028 A KR880017028 A KR 880017028A KR 890009389 A KR890009389 A KR 890009389A
- Authority
- KR
- South Korea
- Prior art keywords
- dideoxy
- imino
- methyl
- ribitol
- fuconolactam
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/86—Oxygen atoms
- C07D211/88—Oxygen atoms attached in positions 2 and 6, e.g. glutarimide
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (7)
- (a) 디하이드록시메틸하이드록시피롤리딘의 N-메틸 유도체, (b) 1,4-디데옥시-1,4-이미노-L-아라비니톨, (c) 1,4-디데옥시-1,4-이미노-L-리비톨, (d) 1,4-디데옥시-1,4-이미노-D-리비톨, (e) 1,4-디데옥시-1,4-이미노-[N-메틸]-L-아라비니톨, (f) 1,4-디데옥시-1,4-이미노-[N-메틸]-D-리비톨, (g) 1,4-디데옥시-1,4-벤질이미노-L-리비톨, (h) 1,4-디데옥시-1,4-이미노-D-탈리톨, (i) 데옥시만노지리마이신의 N-메틸유도체, (j)1,5- 디데옥시-1,5-이미노-L-후코노락탐, (k) 1,5-디데옥시-1,5-이미노-[N-메틸]-L-후시톨, (l) 1,5-디데옥시-1,5-이미노-[N-W-메틸카프로에이트]-L-후시톨과 제약학적으로 허용되는 그들의 염유도체로 구성된 군을로부터 선택된 화합물을 바이러스 저해에 효과적인 양을 인체면역결핍증 환자에 투여함을 특징으로 하는 인체면역결핍증 유발 바이러스에 감염된 환자에서 면역결핍증 유발 바이러스를 저해하는 방법.
- 제 1 항에 있어서, 저해화합물은 1,4-디데옥시-1,4-이미노-L-아라비니톨임을 특징으로 하는 방법.
- 제 1 항에 있어서, 저해화합물은 1,4-디데옥시-1,4-이미노-D-리비톨임을 특징으로 하는 방법.
- 제 1 항에 있어서, 저해화합물은 1,5-디데옥시-1,5-이미노-L-후코노락탐임을 특징으로 하는 방법.
- 제 1 항에 있어서, 저해화합물은 1,5-디데옥시-1,5-이미노-[N-W-메틸 카프로에이트]-L-후시톨임을 특징으로 하는 방법.
- (a) 디하이드록시메틸디하드록시피롤리딘의 N-메틸유도체, (b) 1,4-디데옥시-1,4-이미노-L-후코노락탐, (c) 1,5-디데옥시-1,5-이미노-L-후코노락탐, (d)1,5-디데옥시-1,5-이미노-[N-메틸]-L-후시톨, (e) 1ㅡ5-디데옥시-1,5-이미노-[N-W-메틸-카프로에이트]-L-후시톨과 약제학적으로 허용되는 그들의 염 유도체로 구성된 군으로부터 선택된 화합물로서 인체 면역결핍증 유발 바이러스의 저해제로서 활성을 가짐을 특징으로 하는 신규의화합물.
- 1.5-디데옥시-1,5-이미노-[N-W-메틸-카프로에이트]-L-후시톨.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13621987A | 1987-12-21 | 1987-12-21 | |
US136,219 | 1987-12-21 | ||
US136.219 | 1987-12-21 | ||
US249,144 | 1988-09-26 | ||
US07/249,144 US4999360A (en) | 1987-12-21 | 1988-09-26 | Method of inhibiting virus |
US249.144 | 1988-09-26 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR890009389A true KR890009389A (ko) | 1989-08-01 |
KR910009994B1 KR910009994B1 (ko) | 1991-12-10 |
Family
ID=26834131
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019880017028A KR910009994B1 (ko) | 1987-12-21 | 1988-12-20 | 항바이러스제 |
Country Status (16)
Country | Link |
---|---|
US (1) | US4999360A (ko) |
EP (1) | EP0322395B1 (ko) |
JP (1) | JP2538014B2 (ko) |
KR (1) | KR910009994B1 (ko) |
AT (1) | ATE87206T1 (ko) |
AU (1) | AU607834B2 (ko) |
CA (1) | CA1316929C (ko) |
DE (1) | DE3879653T2 (ko) |
DK (1) | DK175113B1 (ko) |
FI (1) | FI93210C (ko) |
IE (1) | IE63095B1 (ko) |
IL (1) | IL88742A (ko) |
NO (1) | NO172340C (ko) |
NZ (1) | NZ227410A (ko) |
OA (1) | OA08937A (ko) |
PT (1) | PT89267B (ko) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE135346T1 (de) * | 1988-11-03 | 1996-03-15 | Searle & Co | Dideoxy-l-arabinitol derivate als antivirus- verbindungen |
US4894388A (en) * | 1988-12-22 | 1990-01-16 | Monsanto Company | Glycosidase inhibitors and use thereof |
US5100797A (en) * | 1989-06-27 | 1992-03-31 | Monsanto Company | Fucosidase inhibitors |
US5043273A (en) * | 1989-08-17 | 1991-08-27 | Monsanto Company | Phosphorylated glycosidase inhibitor prodrugs |
IT1239950B (it) * | 1990-03-28 | 1993-11-27 | Zambon Spa | Processo per la preparazione di composti con attivita' analgesica centrale |
US5536732A (en) * | 1990-04-27 | 1996-07-16 | Merrell Pharmaceuticals Inc. | N-derivatives of 1-deoxy nojirimycin |
US5252587A (en) * | 1990-04-27 | 1993-10-12 | Merrell Dow Pharmaceuticals, Inc. | N-derivatives of 1-deoxy nojirimycin |
US5290948A (en) * | 1990-09-17 | 1994-03-01 | Mcneilab, Inc. | Process for producing polyhydroxylated piperidines and pyrrolidines and compounds thereof |
GB9026271D0 (en) * | 1990-12-03 | 1991-01-16 | Alphey Thomas J W | Control of parasitic nematodes(a) |
US5258518A (en) * | 1992-04-01 | 1993-11-02 | G. D. Searle & Co. | 2-substituted tertiary carbinol derivatives of deoxynojirimycin |
US5451679A (en) * | 1994-03-08 | 1995-09-19 | G. D. Searle & Co. | 2-chloro and 2-bromo derivatives of 1,5-iminosugars |
EP1040827A3 (en) * | 1995-09-08 | 2000-10-11 | Novo Nordisk A/S | Use of 2-alkylpyrrolidines for the treatment of diabetes |
CN102399228B (zh) * | 2010-09-08 | 2013-10-16 | 中国科学院成都生物研究所 | N-烷基多羟基哌啶衍生物的制备方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1555654A (en) * | 1977-06-25 | 1979-11-14 | Exxon Research Engineering Co | Agricultural burner apparatus |
US4065562A (en) * | 1975-12-29 | 1977-12-27 | Nippon Shinyaku Co., Ltd. | Method and composition for reducing blood glucose levels |
DE3038901A1 (de) * | 1980-10-15 | 1982-05-06 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von n-substituierten derivaten des 1-desoxynojirimycins |
DE3507019A1 (de) * | 1985-02-28 | 1986-08-28 | Bayer Ag, 5090 Leverkusen | Neue derivate von 3,4,5-trihydroxypiperidin, verfahren zu ihrer herstellung und ihre verwendung |
DE3650377T2 (de) * | 1985-12-23 | 1996-02-22 | Hutchinson Fred Cancer Res | Regulierung der retroviralen replikation, infektion und pathogenese. |
-
1988
- 1988-09-26 US US07/249,144 patent/US4999360A/en not_active Expired - Lifetime
- 1988-12-20 IE IE379488A patent/IE63095B1/en not_active IP Right Cessation
- 1988-12-20 AU AU27068/88A patent/AU607834B2/en not_active Ceased
- 1988-12-20 OA OA59494A patent/OA08937A/xx unknown
- 1988-12-20 KR KR1019880017028A patent/KR910009994B1/ko not_active IP Right Cessation
- 1988-12-20 NZ NZ227410A patent/NZ227410A/en unknown
- 1988-12-20 EP EP88870192A patent/EP0322395B1/en not_active Expired - Lifetime
- 1988-12-20 PT PT89267A patent/PT89267B/pt active IP Right Revival
- 1988-12-20 FI FI885880A patent/FI93210C/fi not_active IP Right Cessation
- 1988-12-20 IL IL88742A patent/IL88742A/xx not_active IP Right Cessation
- 1988-12-20 CA CA000586466A patent/CA1316929C/en not_active Expired - Fee Related
- 1988-12-20 NO NO885655A patent/NO172340C/no not_active IP Right Cessation
- 1988-12-20 JP JP63321868A patent/JP2538014B2/ja not_active Expired - Fee Related
- 1988-12-20 AT AT88870192T patent/ATE87206T1/de not_active IP Right Cessation
- 1988-12-20 DE DE88870192T patent/DE3879653T2/de not_active Expired - Fee Related
- 1988-12-20 DK DK198807081A patent/DK175113B1/da not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
IL88742A0 (en) | 1989-07-31 |
JPH01230517A (ja) | 1989-09-14 |
IE63095B1 (en) | 1995-03-22 |
CA1316929C (en) | 1993-04-27 |
IL88742A (en) | 1993-08-18 |
AU2706888A (en) | 1989-06-22 |
PT89267B (pt) | 1993-12-31 |
NO885655D0 (no) | 1988-12-20 |
KR910009994B1 (ko) | 1991-12-10 |
EP0322395A1 (en) | 1989-06-28 |
AU607834B2 (en) | 1991-03-14 |
FI885880A (fi) | 1989-06-22 |
NO172340B (no) | 1993-03-29 |
DK175113B1 (da) | 2004-06-07 |
FI93210B (fi) | 1994-11-30 |
PT89267A (pt) | 1989-12-29 |
ATE87206T1 (de) | 1993-04-15 |
JP2538014B2 (ja) | 1996-09-25 |
DE3879653D1 (de) | 1993-04-29 |
OA08937A (fr) | 1989-10-31 |
EP0322395B1 (en) | 1993-03-24 |
NZ227410A (en) | 1991-06-25 |
FI885880A0 (fi) | 1988-12-20 |
DK708188A (da) | 1989-06-22 |
US4999360A (en) | 1991-03-12 |
IE883794L (en) | 1989-06-21 |
FI93210C (fi) | 1995-03-10 |
DK708188D0 (da) | 1988-12-20 |
NO885655L (no) | 1989-06-22 |
NO172340C (no) | 1993-07-07 |
DE3879653T2 (de) | 1993-10-14 |
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