EE200000620A - 3-(amino- või aminoalküül)püridinooni derivaadid,nende valmistamismeetod ja kasutamine ning farmatseutiline kompositsioon - Google Patents
3-(amino- või aminoalküül)püridinooni derivaadid,nende valmistamismeetod ja kasutamine ning farmatseutiline kompositsioonInfo
- Publication number
- EE200000620A EE200000620A EEP200000620A EEP200000620A EE200000620A EE 200000620 A EE200000620 A EE 200000620A EE P200000620 A EEP200000620 A EE P200000620A EE P200000620 A EEP200000620 A EE P200000620A EE 200000620 A EE200000620 A EE 200000620A
- Authority
- EE
- Estonia
- Prior art keywords
- aminoalkyl
- amino
- preparation
- pharmaceutical composition
- pyridinone derivatives
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8308298P | 1998-04-27 | 1998-04-27 | |
| PCT/EP1999/003023 WO1999055676A1 (en) | 1998-04-27 | 1999-04-27 | 3-(amino- or aminoalkyl)pyridinone derivatives and their use for the treatment of hiv related diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EE200000620A true EE200000620A (et) | 2002-04-15 |
Family
ID=22176061
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EEP200000620A EE200000620A (et) | 1998-04-27 | 1999-04-27 | 3-(amino- või aminoalküül)püridinooni derivaadid,nende valmistamismeetod ja kasutamine ning farmatseutiline kompositsioon |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US6451822B1 (xx) |
| EP (1) | EP1073637B1 (xx) |
| JP (1) | JP2002513004A (xx) |
| KR (1) | KR20010087128A (xx) |
| CN (1) | CN1303378A (xx) |
| AP (1) | AP2000001991A0 (xx) |
| AT (1) | ATE334966T1 (xx) |
| AU (1) | AU4137899A (xx) |
| BG (1) | BG104984A (xx) |
| BR (1) | BR9909976A (xx) |
| CA (1) | CA2330304A1 (xx) |
| CZ (1) | CZ20003978A3 (xx) |
| DE (1) | DE69932611T2 (xx) |
| EE (1) | EE200000620A (xx) |
| HR (1) | HRP20000716A2 (xx) |
| HU (1) | HUP0101595A3 (xx) |
| ID (1) | ID27502A (xx) |
| IL (1) | IL139239A0 (xx) |
| MX (1) | MXPA00010490A (xx) |
| NO (1) | NO20005387L (xx) |
| NZ (1) | NZ508297A (xx) |
| PL (1) | PL343685A1 (xx) |
| RU (1) | RU2000129671A (xx) |
| SK (1) | SK16072000A3 (xx) |
| TR (1) | TR200003113T2 (xx) |
| WO (1) | WO1999055676A1 (xx) |
| ZA (1) | ZA200006037B (xx) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6436972B1 (en) * | 2000-04-10 | 2002-08-20 | Dalhousie University | Pyridones and their use as modulators of serine hydrolase enzymes |
| AU2001282938A1 (en) * | 2000-07-21 | 2002-02-05 | Elan Pharmaceuticals, Inc. | Alpha amino acid derivatives--inhibitors of leukocyte adhesion mediated by vla-4 |
| JP2004509867A (ja) * | 2000-09-19 | 2004-04-02 | サントル、ナショナール、ド、ラ、ルシェルシュ、シアンティフィク、（セーエヌエルエス） | Ｈｉｖ阻害特性を有するピリジノンおよびピリジンチオン誘導体 |
| US7482366B2 (en) | 2001-12-21 | 2009-01-27 | X-Ceptor Therapeutics, Inc. | Modulators of LXR |
| EP1465869B1 (en) | 2001-12-21 | 2013-05-15 | Exelixis Patent Company LLC | Modulators of lxr |
| US7642277B2 (en) * | 2002-12-04 | 2010-01-05 | Boehringer Ingelheim International Gmbh | Non-nucleoside reverse transcriptase inhibitors |
| BRPI0408704A (pt) * | 2003-03-24 | 2006-03-07 | Hoffmann La Roche | benzil-piridazinonas como inibidores de transcriptase reversa |
| EP1516873A1 (en) * | 2003-09-22 | 2005-03-23 | Facultés Universitaires Notre-Dame de la Paix | 2-pyridinone derivatives, having HIV inhibiting properties |
| US7622582B2 (en) * | 2004-05-17 | 2009-11-24 | Tibotec Bvba | Derivatives of 1-phenyl-benzofuro[3,2]pyridin-2(1H)-one |
| GB0420722D0 (en) * | 2004-09-17 | 2004-10-20 | Addex Pharmaceuticals Sa | Novel allosteric modulators |
| CA2605214C (en) * | 2004-12-31 | 2016-07-12 | Reddy Us Therapeutics, Inc. | Benzylamine derivatives as cetp inhibitors |
| ES2524922T3 (es) | 2005-05-10 | 2014-12-15 | Intermune, Inc. | Derivados de piridona para modular el sistema de proteína cinasa activada por estrés |
| WO2007027729A1 (en) | 2005-08-29 | 2007-03-08 | Vertex Pharmaceuticals Incorporated | 3, 5-disubstituted pyrid-2-ones useful as inhibitors of tec family of non-receptor tyrosine kinases |
| ES2361338T3 (es) | 2005-08-29 | 2011-06-16 | Vertex Pharmaceuticals Incorporated | Pirid-2-onas 3,5-disustituidas útiles como inhibidores de la familia tec de tirosina quinasas no ligadas a receptor. |
| CA2620269A1 (en) | 2005-08-29 | 2007-03-08 | Vertex Pharmaceuticals Incorporated | 3,5-disubstituted pyrid-2-ones useful as inhibitors of tec family of non-receptor tyrosine kinases |
| WO2007075487A2 (en) * | 2005-12-19 | 2007-07-05 | Syngenta Limited | Substituted aromatic heterocyclic compounds as fungicides |
| JP5539216B2 (ja) * | 2007-11-20 | 2014-07-02 | メルク・シャープ・アンド・ドーム・コーポレーション | 非ヌクレオシド系逆転写酵素阻害剤 |
| EP2296653B1 (en) | 2008-06-03 | 2016-01-27 | Intermune, Inc. | Compounds and methods for treating inflammatory and fibrotic disorders |
| KR20110041515A (ko) * | 2008-07-14 | 2011-04-21 | 한국화학연구원 | 비-뉴클레오사이드 역전사효소 억제제로서의 피리돈 유도체 |
| US8318737B2 (en) | 2009-09-02 | 2012-11-27 | Canthera Therapeutics Inc. | Compounds and compositions for treating cancer |
| US8349832B2 (en) * | 2009-09-02 | 2013-01-08 | Canthera Therapeutics | Compounds and compositions for treating cancer |
| CN102001994B (zh) * | 2010-10-22 | 2014-07-09 | 北京大学 | 吡啶酮类hiv-1逆转录酶抑制剂的制备及其应用 |
| CN103288719A (zh) * | 2012-03-05 | 2013-09-11 | 苏州欧凯医药技术有限公司 | 非核甘艾滋病毒抑制物-吡啶酮类先导体的合成 |
| AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
| JO3470B1 (ar) | 2012-10-08 | 2020-07-05 | Merck Sharp & Dohme | مشتقات 5- فينوكسي-3h-بيريميدين-4-أون واستخدامها كمثبطات ناسخ عكسي ل hiv |
| US10233195B2 (en) | 2014-04-02 | 2019-03-19 | Intermune, Inc. | Anti-fibrotic pyridinones |
| AU2015308350B2 (en) | 2014-08-29 | 2020-03-05 | Tes Pharma S.R.L. | Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase |
| KR102645602B1 (ko) * | 2018-12-18 | 2024-03-07 | 머크 샤프 앤드 돔 엘엘씨 | Hiv 감염된 세포에 대한 선택적 세포독성제로서의 피리미돈 유도체 |
| CA3141143A1 (en) * | 2019-05-22 | 2020-11-26 | Merck Sharp & Dohme Corp. | Pyridinone derivatives as selective cytotoxic agents against hiv infected cells |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL98526A0 (en) * | 1990-06-18 | 1992-07-15 | Merck & Co Inc | Pyridones,processes for their preparation and pharmaceutical compositions containing them |
| US5308854A (en) * | 1990-06-18 | 1994-05-03 | Merck & Co., Inc. | Inhibitors of HIV reverse transcriptase |
| FR2737496B1 (fr) * | 1995-07-31 | 1997-12-19 | Centre Nat Rech Scient | 4-aryl-thio-pyridin-2(1h)-ones, medicaments les contenant et leurs utilisations dans le traitement de maladies liees aux vih 1 et 2 |
-
1999
- 1999-04-27 TR TR2000/03113T patent/TR200003113T2/xx unknown
- 1999-04-27 EP EP99924870A patent/EP1073637B1/en not_active Expired - Lifetime
- 1999-04-27 DE DE69932611T patent/DE69932611T2/de not_active Expired - Lifetime
- 1999-04-27 JP JP2000545836A patent/JP2002513004A/ja not_active Withdrawn
- 1999-04-27 HU HU0101595A patent/HUP0101595A3/hu unknown
- 1999-04-27 CN CN99806829A patent/CN1303378A/zh active Pending
- 1999-04-27 CA CA002330304A patent/CA2330304A1/en not_active Abandoned
- 1999-04-27 KR KR1020007011918A patent/KR20010087128A/ko not_active Application Discontinuation
- 1999-04-27 RU RU2000129671/04A patent/RU2000129671A/ru unknown
- 1999-04-27 AU AU41378/99A patent/AU4137899A/en not_active Abandoned
- 1999-04-27 AT AT99924870T patent/ATE334966T1/de not_active IP Right Cessation
- 1999-04-27 MX MXPA00010490A patent/MXPA00010490A/es unknown
- 1999-04-27 AP APAP/P/2000/001991A patent/AP2000001991A0/en unknown
- 1999-04-27 EE EEP200000620A patent/EE200000620A/xx unknown
- 1999-04-27 US US09/673,635 patent/US6451822B1/en not_active Expired - Fee Related
- 1999-04-27 PL PL99343685A patent/PL343685A1/xx unknown
- 1999-04-27 BR BR9909976-4A patent/BR9909976A/pt not_active IP Right Cessation
- 1999-04-27 NZ NZ508297A patent/NZ508297A/xx unknown
- 1999-04-27 SK SK1607-2000A patent/SK16072000A3/sk unknown
- 1999-04-27 CZ CZ20003978A patent/CZ20003978A3/cs unknown
- 1999-04-27 WO PCT/EP1999/003023 patent/WO1999055676A1/en active IP Right Grant
- 1999-04-27 ID IDW20002191A patent/ID27502A/id unknown
- 1999-04-27 IL IL13923999A patent/IL139239A0/xx unknown
-
2000
- 2000-10-23 HR HR20000716A patent/HRP20000716A2/hr not_active Application Discontinuation
- 2000-10-25 ZA ZA200006037A patent/ZA200006037B/en unknown
- 2000-10-26 NO NO20005387A patent/NO20005387L/no not_active Application Discontinuation
- 2000-11-24 BG BG104984A patent/BG104984A/xx unknown
-
2002
- 2002-07-15 US US10/194,240 patent/US6683079B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE69932611D1 (de) | 2006-09-14 |
| US6683079B2 (en) | 2004-01-27 |
| CZ20003978A3 (cs) | 2001-09-12 |
| PL343685A1 (en) | 2001-08-27 |
| AU4137899A (en) | 1999-11-16 |
| CA2330304A1 (en) | 1999-11-04 |
| JP2002513004A (ja) | 2002-05-08 |
| AP2000001991A0 (en) | 2000-12-31 |
| RU2000129671A (ru) | 2004-02-20 |
| CN1303378A (zh) | 2001-07-11 |
| HUP0101595A2 (hu) | 2001-11-28 |
| ID27502A (id) | 2001-04-12 |
| ATE334966T1 (de) | 2006-08-15 |
| MXPA00010490A (es) | 2002-10-17 |
| SK16072000A3 (sk) | 2002-04-04 |
| TR200003113T2 (tr) | 2001-05-21 |
| KR20010087128A (ko) | 2001-09-15 |
| NO20005387D0 (no) | 2000-10-26 |
| IL139239A0 (en) | 2001-11-25 |
| EP1073637A1 (en) | 2001-02-07 |
| NZ508297A (en) | 2002-12-20 |
| HRP20000716A2 (en) | 2001-06-30 |
| HUP0101595A3 (en) | 2002-12-28 |
| US6451822B1 (en) | 2002-09-17 |
| EP1073637B1 (en) | 2006-08-02 |
| DE69932611T2 (de) | 2007-10-11 |
| WO1999055676A1 (en) | 1999-11-04 |
| US20030125340A1 (en) | 2003-07-03 |
| BG104984A (en) | 2001-07-31 |
| ZA200006037B (en) | 2002-01-25 |
| BR9909976A (pt) | 2000-12-26 |
| NO20005387L (no) | 2000-12-04 |
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