CS236779B2 - Processing of new 6-(amino-2-phenylacetamide)penicillinyloxymethyl-1,1-dioxypenicillinoxylmethyl-carbonyl - Google Patents

Processing of new 6-(amino-2-phenylacetamide)penicillinyloxymethyl-1,1-dioxypenicillinoxylmethyl-carbonyl Download PDF

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Publication number
CS236779B2
CS236779B2 CS829473A CS947382A CS236779B2 CS 236779 B2 CS236779 B2 CS 236779B2 CS 829473 A CS829473 A CS 829473A CS 947382 A CS947382 A CS 947382A CS 236779 B2 CS236779 B2 CS 236779B2
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CS
Czechoslovakia
Prior art keywords
formula
defined above
starting materials
amino
process according
Prior art date
Application number
CS829473A
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Czech (cs)
English (en)
Inventor
Ernest S Hamanaka
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Priority to CS836767A priority Critical patent/CS236799B2/cs
Priority to CS836768A priority patent/CS236800B2/cs
Publication of CS236779B2 publication Critical patent/CS236779B2/cs

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C68/00—Preparation of esters of carbonic or haloformic acids
    • C07C68/06—Preparation of esters of carbonic or haloformic acids from organic carbonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Steroid Compounds (AREA)
CS829473A 1981-12-22 1982-12-21 Processing of new 6-(amino-2-phenylacetamide)penicillinyloxymethyl-1,1-dioxypenicillinoxylmethyl-carbonyl CS236779B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CS836767A CS236799B2 (cs) 1981-12-22 1983-09-16 Způsob výroby halogenmethy1-6-(2-fenylacetamido)- penicilanoyloxymethyl-karbonátů
CS836768A CS236800B2 (cs) 1981-12-22 1983-09-16 Způsob výroby halogenmethyl-l,l-dioxopenicilanoyloxymethyl-karbonátů

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/334,017 US4359472A (en) 1981-12-22 1981-12-22 Bis-hydroxymethyl carbonate bridged antibacterial agents
AU23672/84A AU560708B2 (en) 1981-12-22 1984-01-20 Penicillin intermediates

Publications (1)

Publication Number Publication Date
CS236779B2 true CS236779B2 (en) 1985-05-15

Family

ID=25619060

Family Applications (1)

Application Number Title Priority Date Filing Date
CS829473A CS236779B2 (en) 1981-12-22 1982-12-21 Processing of new 6-(amino-2-phenylacetamide)penicillinyloxymethyl-1,1-dioxypenicillinoxylmethyl-carbonyl

Country Status (25)

Country Link
US (1) US4359472A (no)
EP (1) EP0082666B1 (no)
JP (1) JPS58116490A (no)
KR (1) KR860001362B1 (no)
AT (1) ATE17853T1 (no)
AU (2) AU535634B2 (no)
CS (1) CS236779B2 (no)
DD (3) DD222315A5 (no)
DE (1) DE3269029D1 (no)
DK (1) DK565582A (no)
EG (1) EG15866A (no)
ES (3) ES518490A0 (no)
FI (1) FI75570C (no)
GR (1) GR77097B (no)
HU (1) HU188825B (no)
IE (1) IE54334B1 (no)
IL (1) IL67523A (no)
NO (2) NO160300C (no)
NZ (1) NZ202855A (no)
PH (1) PH18490A (no)
PL (2) PL140375B1 (no)
PT (1) PT76011B (no)
SU (2) SU1217261A3 (no)
YU (1) YU42823B (no)
ZA (1) ZA829375B (no)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4359472A (en) * 1981-12-22 1982-11-16 Pfizer Inc. Bis-hydroxymethyl carbonate bridged antibacterial agents
US4434173A (en) * 1982-08-23 1984-02-28 Pfizer Inc. Bis-esters of 4,5-di(hydroxymethyl)-2-oxo-1,3-dioxole as antibacterial agents
US4448732A (en) * 1982-09-07 1984-05-15 Pfizer Inc. 2-Oxo-1,3-dioxol-4-ylmethyl esters of penicillanic acid 1,1-dioxide
US4530792A (en) * 1982-11-01 1985-07-23 Pfizer Inc. Process and intermediates for preparation of 1,1-dioxopenicillanoyloxymethyl 6-beta-aminopenicillanate
CN112724162B (zh) * 2020-12-28 2022-06-10 华南农业大学 一种阿莫西林-舒巴坦杂合分子的合成方法及应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2985648A (en) * 1958-10-06 1961-05-23 Doyle Frank Peter Alpha-aminobenzylpenicillins
NL299897A (no) * 1962-11-02
US3520876A (en) * 1967-11-01 1970-07-21 American Home Prod Process for the preparation of 6-(alpha-aminoacylamino)penicillanic acids
BE784800A (fr) * 1971-06-15 1972-10-02 Yamanouchi Pharma Co Ltd Procede de preparation de nouveaux derives esters oxymethyliques de la penicilline et de la cephalosporine
GB1425827A (en) * 1972-03-13 1976-02-18 Astra Laekemedel Ab Penicillins and cephalosporins
ES436565A1 (es) * 1974-06-05 1977-04-01 Bristol Myers Co Un procedimiento para la preparacion de acidos acetamidope- nicilanicos.
US4234579A (en) * 1977-06-07 1980-11-18 Pfizer Inc. Penicillanic acid 1,1-dioxides as β-lactamase inhibitors
IE49880B1 (en) 1979-02-13 1986-01-08 Leo Pharm Prod Ltd Penicillin derivatives
ZA80796B (en) * 1979-02-13 1981-02-25 Leo Pharm Prod Ltd Chemical compounds
US4244951A (en) * 1979-05-16 1981-01-13 Pfizer Inc. Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide
US4359472A (en) * 1981-12-22 1982-11-16 Pfizer Inc. Bis-hydroxymethyl carbonate bridged antibacterial agents

Also Published As

Publication number Publication date
NO824304L (no) 1983-06-23
YU280082A (en) 1985-04-30
ES524778A0 (es) 1984-12-16
IE823035L (en) 1983-06-22
AU560708B2 (en) 1987-04-16
DD222315A5 (de) 1985-05-15
DD208621A5 (de) 1984-04-04
IE54334B1 (en) 1989-08-30
NO160300B (no) 1988-12-27
AU2367284A (en) 1984-05-10
SU1217261A3 (ru) 1986-03-07
IL67523A0 (en) 1983-05-15
ATE17853T1 (de) 1986-02-15
EP0082666B1 (en) 1986-02-05
NO160300C (no) 1989-04-05
US4359472A (en) 1982-11-16
EG15866A (en) 1986-09-30
DE3269029D1 (en) 1986-03-20
HU188825B (en) 1986-05-28
DK565582A (da) 1983-06-23
IL67523A (en) 1986-04-29
ES8502119A1 (es) 1984-12-16
AU535634B2 (en) 1984-03-29
PL140731B1 (en) 1987-05-30
ES8402157A1 (es) 1984-02-01
PT76011A (en) 1983-01-01
PL140375B1 (en) 1987-04-30
ES524779A0 (es) 1985-01-01
GR77097B (no) 1984-09-06
PT76011B (en) 1985-12-13
PH18490A (en) 1985-08-02
JPH0119394B2 (no) 1989-04-11
JPS58116490A (ja) 1983-07-11
FI75570B (fi) 1988-03-31
YU42823B (en) 1988-12-31
SU1169541A3 (ru) 1985-07-23
FI824408A0 (fi) 1982-12-21
ZA829375B (en) 1983-10-26
AU9172282A (en) 1983-08-04
KR860001362B1 (ko) 1986-09-16
NO832871L (no) 1983-06-23
PL239590A1 (en) 1985-01-16
ES8502443A1 (es) 1985-01-01
FI824408L (fi) 1983-06-23
ES518490A0 (es) 1984-02-01
DD216024A5 (de) 1984-11-28
FI75570C (fi) 1988-07-11
NZ202855A (en) 1985-09-13
EP0082666A1 (en) 1983-06-29
PL248638A1 (en) 1985-05-07

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