ES8502119A1 - Un procedimiento para la produccion de derivados del acido penicilanico - Google Patents
Un procedimiento para la produccion de derivados del acido penicilanicoInfo
- Publication number
- ES8502119A1 ES8502119A1 ES524778A ES524778A ES8502119A1 ES 8502119 A1 ES8502119 A1 ES 8502119A1 ES 524778 A ES524778 A ES 524778A ES 524778 A ES524778 A ES 524778A ES 8502119 A1 ES8502119 A1 ES 8502119A1
- Authority
- ES
- Spain
- Prior art keywords
- bis
- antibacterial agents
- bridged
- hydroxymethyl
- certain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C68/00—Preparation of esters of carbonic or haloformic acids
- C07C68/06—Preparation of esters of carbonic or haloformic acids from organic carbonates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cephalosporin Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Steroid Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DEL ACIDO PENICILANICO.CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA XCH2OCOOCH2X, PARA OBTENER UN DERIVADO DE ACIDO PENICILANICO DE FORMULA (I), LLEVANDOSE A CABO LA REACCION EN UN DISOLVENTE ORGANICO INERTE A LA REACCION Y A UNA TEMPERATURA ENTRE C20JC Y B60JC, DONDE R ES H, HIDROXI, FORMILOXI, ALCANOILOXI DE C 2 A 7 Y OTROS; Q ES AZIDO, BENCILOXICARBONILAMINO; Y X ES CLORO, BROMO O YODO.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/334,017 US4359472A (en) | 1981-12-22 | 1981-12-22 | Bis-hydroxymethyl carbonate bridged antibacterial agents |
| AU23672/84A AU560708B2 (en) | 1981-12-22 | 1984-01-20 | Penicillin intermediates |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8502119A1 true ES8502119A1 (es) | 1984-12-16 |
| ES524778A0 ES524778A0 (es) | 1984-12-16 |
Family
ID=25619060
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES518490A Granted ES518490A0 (es) | 1981-12-22 | 1982-12-22 | Un procedimiento para la preparacion de ciertos carbonatos de 6-(2-amino-2-fenil-acetamido-penicilanoiloximetil)-1,1-dioxopenicilanoiloximetilo como agentes antibacterianos. |
| ES524779A Granted ES524779A0 (es) | 1981-12-22 | 1983-08-05 | Un procedimiento para la produccion de derivados del acido penicilanico |
| ES524778A Granted ES524778A0 (es) | 1981-12-22 | 1983-08-05 | Un procedimiento para la produccion de derivados del acido penicilanico |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES518490A Granted ES518490A0 (es) | 1981-12-22 | 1982-12-22 | Un procedimiento para la preparacion de ciertos carbonatos de 6-(2-amino-2-fenil-acetamido-penicilanoiloximetil)-1,1-dioxopenicilanoiloximetilo como agentes antibacterianos. |
| ES524779A Granted ES524779A0 (es) | 1981-12-22 | 1983-08-05 | Un procedimiento para la produccion de derivados del acido penicilanico |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US4359472A (es) |
| EP (1) | EP0082666B1 (es) |
| JP (1) | JPS58116490A (es) |
| KR (1) | KR860001362B1 (es) |
| AT (1) | ATE17853T1 (es) |
| AU (2) | AU535634B2 (es) |
| CS (1) | CS236779B2 (es) |
| DD (3) | DD216024A5 (es) |
| DE (1) | DE3269029D1 (es) |
| DK (1) | DK565582A (es) |
| EG (1) | EG15866A (es) |
| ES (3) | ES518490A0 (es) |
| FI (1) | FI75570C (es) |
| GR (1) | GR77097B (es) |
| HU (1) | HU188825B (es) |
| IE (1) | IE54334B1 (es) |
| IL (1) | IL67523A (es) |
| NO (2) | NO160300C (es) |
| NZ (1) | NZ202855A (es) |
| PH (1) | PH18490A (es) |
| PL (2) | PL140375B1 (es) |
| PT (1) | PT76011B (es) |
| SU (2) | SU1217261A3 (es) |
| YU (1) | YU42823B (es) |
| ZA (1) | ZA829375B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4359472A (en) * | 1981-12-22 | 1982-11-16 | Pfizer Inc. | Bis-hydroxymethyl carbonate bridged antibacterial agents |
| US4434173A (en) * | 1982-08-23 | 1984-02-28 | Pfizer Inc. | Bis-esters of 4,5-di(hydroxymethyl)-2-oxo-1,3-dioxole as antibacterial agents |
| US4448732A (en) * | 1982-09-07 | 1984-05-15 | Pfizer Inc. | 2-Oxo-1,3-dioxol-4-ylmethyl esters of penicillanic acid 1,1-dioxide |
| US4530792A (en) * | 1982-11-01 | 1985-07-23 | Pfizer Inc. | Process and intermediates for preparation of 1,1-dioxopenicillanoyloxymethyl 6-beta-aminopenicillanate |
| CN112724162B (zh) * | 2020-12-28 | 2022-06-10 | 华南农业大学 | 一种阿莫西林-舒巴坦杂合分子的合成方法及应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2985648A (en) * | 1958-10-06 | 1961-05-23 | Doyle Frank Peter | Alpha-aminobenzylpenicillins |
| BE639104A (es) * | 1962-11-02 | |||
| US3520876A (en) * | 1967-11-01 | 1970-07-21 | American Home Prod | Process for the preparation of 6-(alpha-aminoacylamino)penicillanic acids |
| BE784800A (fr) * | 1971-06-15 | 1972-10-02 | Yamanouchi Pharma Co Ltd | Procede de preparation de nouveaux derives esters oxymethyliques de la penicilline et de la cephalosporine |
| GB1425827A (en) * | 1972-03-13 | 1976-02-18 | Astra Laekemedel Ab | Penicillins and cephalosporins |
| ES436565A1 (es) * | 1974-06-05 | 1977-04-01 | Bristol Myers Co | Un procedimiento para la preparacion de acidos acetamidope- nicilanicos. |
| US4234579A (en) * | 1977-06-07 | 1980-11-18 | Pfizer Inc. | Penicillanic acid 1,1-dioxides as β-lactamase inhibitors |
| KR830001903B1 (ko) * | 1979-02-13 | 1983-09-19 | 레오 파마슈티칼 프로덕츠 리미티드 | 페니실란산유도체의 제조방법 |
| IE49880B1 (en) | 1979-02-13 | 1986-01-08 | Leo Pharm Prod Ltd | Penicillin derivatives |
| US4244951A (en) * | 1979-05-16 | 1981-01-13 | Pfizer Inc. | Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide |
| US4359472A (en) * | 1981-12-22 | 1982-11-16 | Pfizer Inc. | Bis-hydroxymethyl carbonate bridged antibacterial agents |
-
1981
- 1981-12-22 US US06/334,017 patent/US4359472A/en not_active Expired - Fee Related
-
1982
- 1982-12-14 DE DE8282306684T patent/DE3269029D1/de not_active Expired
- 1982-12-14 AT AT82306684T patent/ATE17853T1/de not_active IP Right Cessation
- 1982-12-14 EP EP82306684A patent/EP0082666B1/en not_active Expired
- 1982-12-16 SU SU823523150A patent/SU1217261A3/ru active
- 1982-12-17 PL PL1982239590A patent/PL140375B1/pl unknown
- 1982-12-17 PL PL1982248638A patent/PL140731B1/pl unknown
- 1982-12-17 YU YU2800/82A patent/YU42823B/xx unknown
- 1982-12-19 EG EG741/82A patent/EG15866A/xx active
- 1982-12-20 IL IL67523A patent/IL67523A/xx unknown
- 1982-12-20 DD DD82261278A patent/DD216024A5/de unknown
- 1982-12-20 PH PH28301A patent/PH18490A/en unknown
- 1982-12-20 DD DD82261283A patent/DD222315A5/de unknown
- 1982-12-20 DD DD82246272A patent/DD208621A5/de unknown
- 1982-12-21 ZA ZA829375A patent/ZA829375B/xx unknown
- 1982-12-21 CS CS829473A patent/CS236779B2/cs unknown
- 1982-12-21 GR GR70133A patent/GR77097B/el unknown
- 1982-12-21 JP JP57224794A patent/JPS58116490A/ja active Granted
- 1982-12-21 FI FI824408A patent/FI75570C/fi not_active IP Right Cessation
- 1982-12-21 AU AU91722/82A patent/AU535634B2/en not_active Ceased
- 1982-12-21 NO NO824304A patent/NO160300C/no unknown
- 1982-12-21 DK DK565582A patent/DK565582A/da not_active Application Discontinuation
- 1982-12-21 IE IE3035/82A patent/IE54334B1/en unknown
- 1982-12-21 PT PT76011A patent/PT76011B/pt unknown
- 1982-12-21 KR KR8205729A patent/KR860001362B1/ko active
- 1982-12-21 HU HU824104A patent/HU188825B/hu unknown
- 1982-12-22 ES ES518490A patent/ES518490A0/es active Granted
-
1983
- 1983-08-05 ES ES524779A patent/ES524779A0/es active Granted
- 1983-08-05 ES ES524778A patent/ES524778A0/es active Granted
- 1983-08-10 NO NO832871A patent/NO832871L/no unknown
- 1983-09-20 SU SU833644103A patent/SU1169541A3/ru active
- 1983-12-20 NZ NZ202855A patent/NZ202855A/en unknown
-
1984
- 1984-01-20 AU AU23672/84A patent/AU560708B2/en not_active Ceased
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