CS227301B2 - Method of preparing n-substituted aziridine-2-carboxylic acid derivatives - Google Patents

Method of preparing n-substituted aziridine-2-carboxylic acid derivatives Download PDF

Info

Publication number
CS227301B2
CS227301B2 CS795237A CS523779A CS227301B2 CS 227301 B2 CS227301 B2 CS 227301B2 CS 795237 A CS795237 A CS 795237A CS 523779 A CS523779 A CS 523779A CS 227301 B2 CS227301 B2 CS 227301B2
Authority
CS
Czechoslovakia
Prior art keywords
group
cyano
radical
phenyl
aziridine
Prior art date
Application number
CS795237A
Other languages
Czech (cs)
English (en)
Inventor
Elmar Dr Bosies
Herbert Dr Berger
Wolfgang Dr Kampe
Uwo Dr Bicker
Alfred Dr Grafe
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of CS227301B2 publication Critical patent/CS227301B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D203/08—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CS795237A 1978-08-03 1979-07-27 Method of preparing n-substituted aziridine-2-carboxylic acid derivatives CS227301B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19782833986 DE2833986A1 (de) 1978-08-03 1978-08-03 Immunstimulierende n-substituierte aziridin-2-carbonsaeurederivate, verfahren zu ihrer herstellung sowie arzneimittel, die diese substanzen enthalten

Publications (1)

Publication Number Publication Date
CS227301B2 true CS227301B2 (en) 1984-04-16

Family

ID=6046078

Family Applications (1)

Application Number Title Priority Date Filing Date
CS795237A CS227301B2 (en) 1978-08-03 1979-07-27 Method of preparing n-substituted aziridine-2-carboxylic acid derivatives

Country Status (39)

Country Link
US (3) US4321194A (de)
JP (2) JPS5522694A (de)
KR (1) KR860000320B1 (de)
AR (1) AR228945A1 (de)
AT (1) AT379382B (de)
AU (1) AU524572B2 (de)
BE (1) BE878020A (de)
CA (1) CA1142530A (de)
CH (1) CH645540A5 (de)
CS (1) CS227301B2 (de)
DD (1) DD145267A5 (de)
DE (1) DE2833986A1 (de)
DK (1) DK156431C (de)
EG (1) EG14369A (de)
ES (1) ES483116A1 (de)
FI (1) FI70570C (de)
FR (2) FR2432317A1 (de)
GB (2) GB2106896B (de)
GR (1) GR74424B (de)
HK (1) HK13285A (de)
HU (1) HU184610B (de)
IE (1) IE48462B1 (de)
IL (1) IL57939A (de)
IT (1) IT1123503B (de)
KE (1) KE3493A (de)
LU (1) LU81563A1 (de)
MY (1) MY8600045A (de)
NL (1) NL187239C (de)
NO (1) NO152413C (de)
NZ (1) NZ191169A (de)
OA (1) OA06310A (de)
PH (1) PH19007A (de)
PL (1) PL126531B1 (de)
PT (1) PT70009A (de)
SE (1) SE445552B (de)
SG (1) SG85784G (de)
SU (1) SU1145927A3 (de)
YU (1) YU41169B (de)
ZA (1) ZA793966B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3446713A1 (de) * 1984-12-21 1986-06-26 Boehringer Mannheim Gmbh, 6800 Mannheim N-substituierte aziridin-2-carbonsaeurederivate, verfahren zu deren herstellung sowie diese substanzen enthaltende arzneimittel
JPS6287512A (ja) * 1985-10-11 1987-04-22 ベ−リンガ−・マンハイム・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング 選択的免疫抑制剤
US4925835A (en) * 1986-05-01 1990-05-15 Sloan-Kettering Institute For Cancer Research Aziridinyl putrescine containing compositions and their uses in treating prostate cancer
KR19980083844A (ko) * 1997-05-19 1998-12-05 이웅열 새로운 아지리딘 유도체 및 그 제조방법
FR2776292B1 (fr) * 1998-03-20 2004-09-10 Oncopharm Cephalotaxanes porteurs de chaine laterale et leur procede de synthese
KR20010000195A (ko) * 2000-08-10 2001-01-05 하현준 (2ｒ)- 및 (2ｓ)-아지리딘-2-카르복실산 에스테르 및(2ｒ)- 및 (2ｓ)-2-히드록시메틸 아지리딘 제조 방법
WO2002041871A2 (en) * 2000-11-21 2002-05-30 Board Of Regents, The University Of Texas System Composition comprising an imexon or derivatives thereof and lipids
US20030129222A1 (en) * 2000-11-21 2003-07-10 Gabriel Lopez-Berestein Liposomal imexon
US6982263B2 (en) * 2001-06-08 2006-01-03 Boehringer Ingelheim Pharmaceuticals, Inc. Nitriles useful as reversible inhibitors of cysteine proteases

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1470223A1 (de) * 1962-09-05 1969-12-04 Siegfried Ag Verfahren zur Herstellung neuer stickstoffhaltiger Heterocyclen
DE2528460A1 (de) * 1975-06-26 1977-01-13 Boehringer Mannheim Gmbh Verwendung von l-carboxamido-2- cyan-aziridin als immunstimulans
DE2530960A1 (de) 1975-07-11 1977-01-27 Huels Chemische Werke Ag 2-(n-substituierte)-aziridinyl-delta hoch 2 -oxazoline und verfahren zu ihrer herstellung
DE2538672A1 (de) * 1975-08-30 1977-03-10 Boehringer Mannheim Gmbh Verwendung von derivaten der propionsaeure
DE2656240C2 (de) * 1976-12-11 1983-11-03 Boehringer Mannheim Gmbh, 6800 Mannheim Neue Aziridin-Derivate, Verfahren zu deren Herstellung und pharmazeutische Mittel
CA1092606A (en) * 1976-10-05 1980-12-30 Herbert Berger 1-(n-acylcarbamoyl)-2-cyano-aziridines and the preparation thereof
GB1550065A (en) * 1976-10-29 1979-08-08 Inst Organicheskogo Sinteza Ak Pharmaceutical composition processing antitumour activity
AR218645A1 (es) * 1976-12-11 1980-06-30 Boehringer Mannheim Gmbh Procedimiento para preparar derivados de esteres del acido 1-aziridina-carboxilico

Also Published As

Publication number Publication date
OA06310A (fr) 1981-06-30
US4410532A (en) 1983-10-18
FI70570C (fi) 1986-09-24
US4409236A (en) 1983-10-11
KR860000320B1 (ko) 1986-04-09
FI792393A (fi) 1980-02-04
GR74424B (de) 1984-06-28
NO152413B (no) 1985-06-17
ES483116A1 (es) 1980-04-16
ZA793966B (en) 1980-08-27
BE878020A (fr) 1980-02-01
NL187239C (nl) 1991-07-16
CA1142530A (en) 1983-03-08
IL57939A (en) 1985-02-28
JPS5522694A (en) 1980-02-18
JPH0257523B2 (de) 1990-12-05
YU188179A (en) 1983-06-30
IT1123503B (it) 1986-04-30
DE2833986C2 (de) 1988-04-07
PL217527A1 (de) 1980-07-01
IL57939A0 (en) 1979-11-30
DK320379A (da) 1980-02-04
SE7906461L (sv) 1980-02-04
GB2106896B (en) 1983-08-17
HU184610B (en) 1984-09-28
NZ191169A (en) 1981-01-23
SU1145927A3 (ru) 1985-03-15
FR2432317A1 (fr) 1980-02-29
HK13285A (en) 1985-03-01
FR2432317B1 (de) 1983-03-18
FR2445316A1 (fr) 1980-07-25
AU4930879A (en) 1980-02-07
NL7905855A (nl) 1980-02-05
EG14369A (en) 1983-12-31
GB2026863A (en) 1980-02-13
AU524572B2 (en) 1982-09-23
MY8600045A (en) 1986-12-31
AT379382B (de) 1985-12-27
FR2445316B1 (de) 1983-07-29
YU41169B (en) 1986-12-31
PH19007A (en) 1985-12-03
KR830000902A (ko) 1983-04-28
AR228945A1 (es) 1983-05-13
SE445552B (sv) 1986-06-30
JPS6243991B2 (de) 1987-09-17
IT7924769A0 (it) 1979-07-30
ATA531479A (de) 1985-05-15
GB2026863B (en) 1983-03-30
DK156431C (da) 1990-01-22
NO792545L (no) 1980-02-05
DE2833986A1 (de) 1980-02-21
FI70570B (fi) 1986-06-06
IE791478L (en) 1980-02-03
PT70009A (de) 1979-08-01
SG85784G (en) 1985-06-07
JPS63258415A (ja) 1988-10-25
CH645540A5 (de) 1984-10-15
PL126531B1 (en) 1983-08-31
IE48462B1 (en) 1985-01-23
DD145267A5 (de) 1980-12-03
LU81563A1 (de) 1980-08-08
KE3493A (en) 1985-02-01
NO152413C (no) 1985-09-25
US4321194A (en) 1982-03-23
DK156431B (da) 1989-08-21
GB2106896A (en) 1983-04-20

Similar Documents

Publication Publication Date Title
TWI791511B (zh) 細胞凋亡誘導劑
KR100256707B1 (ko) 데아자푸린 유도체; 새로운 부류의 crf1 특이 리간드
US4397848A (en) N-Substituted aziridine-2-carboxylic acid immunostimulant derivatives
US4512998A (en) Anthelmintic benzimidazole carbamates
JP2006510737A (ja) ニコチンアミド系キナーゼ阻害薬
CS227301B2 (en) Method of preparing n-substituted aziridine-2-carboxylic acid derivatives
US11168078B2 (en) Sulfoximine, sulfonimidamide, sulfondiimine and diimidosulfonamide compounds as inhibitors of indoleamine 2,3-dioxygenase
EP1100786B1 (de) Antivirale pyrimidindion-derivate und verfahren zu ihrer herstellung
FR2537584A1 (fr) Pyrazoloquinoleines substituees particulieres, procede pour leur preparation, preparations pharmaceutiques contenant ces composes et leur application therapeutique
US11306108B2 (en) Chemical compounds
CA2508171C (en) Nicotinamide-based kinase inhibitors
US4112089A (en) 4-Substituted-1,3-dithiolan-2-ylidene malonates and pharmaceutical compositions containing the same
US11459331B2 (en) Chemical compounds
KR100352899B1 (ko) 새로운3-페닐설포닐-3,7-디아자바이사이클로[3,3,1]노난-화합물을함유하는약제
JPH02503670A (ja) １，２，３，４，１０，１４ｂ‐ヘキサヒドロジベンゾ〔ｃ，ｆ〕ピラジノ〔１，２‐ａ〕アゼピノ誘導体及び１０‐アザ，１０‐オキサ及び１０‐チア類似体
US20230100692A1 (en) Synthetic process and novel intermediates
US2807617A (en) Acylpiperazines and methods of preparing the same
AT390952B (de) Verfahren zur herstellung von neuen furan- oder thiophenderivaten
AU2003291839B2 (en) Nicotinamide-based kinase inhibitors
WO2005072082A2 (en) 2-guanidinylimidazolidinedione compounds and methods of making and using thereof
DE3343884C2 (de)
US3836529A (en) Derivatives of 2-methylthio-and 2-phenyl-4,6-dichloro-5-pyrimidine-carboxaldehyde
GB2080794A (en) 1,6-Naphthyridine derivatives
JP2022537291A (ja) ヘテロ環式誘導体及びその使用
EP2260841A2 (de) Verbindungen mit antiparasitäere Aktivität und diese enthaltende Medikamente