CS211380B2 - Method of making the 4a-aryl-octyhydro-1h-2-pyrindines - Google Patents

Method of making the 4a-aryl-octyhydro-1h-2-pyrindines Download PDF

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Publication number
CS211380B2
CS211380B2 CS777150A CS715077A CS211380B2 CS 211380 B2 CS211380 B2 CS 211380B2 CS 777150 A CS777150 A CS 777150A CS 715077 A CS715077 A CS 715077A CS 211380 B2 CS211380 B2 CS 211380B2
Authority
CS
Czechoslovakia
Prior art keywords
octahydro
pyrindine
formula
hydroxyphenyl
methoxyphenyl
Prior art date
Application number
CS777150A
Other languages
Czech (cs)
English (en)
Inventor
Dennis M Zimmerman
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Priority to CS804469A priority Critical patent/CS211381B2/cs
Publication of CS211380B2 publication Critical patent/CS211380B2/cs

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/757—Unsaturated compounds containing a keto groups being part of a ring containing —CHO groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
CS777150A 1976-11-02 1977-11-02 Method of making the 4a-aryl-octyhydro-1h-2-pyrindines CS211380B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CS804469A CS211381B2 (cs) 1976-11-02 1980-06-24 Způsob výroby cis-4a-aryl oktahydro-lH-2-pyrindinů

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US73795876A 1976-11-02 1976-11-02

Publications (1)

Publication Number Publication Date
CS211380B2 true CS211380B2 (en) 1982-02-26

Family

ID=24965981

Family Applications (1)

Application Number Title Priority Date Filing Date
CS777150A CS211380B2 (en) 1976-11-02 1977-11-02 Method of making the 4a-aryl-octyhydro-1h-2-pyrindines

Country Status (26)

Country Link
JP (1) JPS5356669A (ru)
AR (1) AR223454A1 (ru)
AT (1) ATA782177A (ru)
AU (1) AU513679B2 (ru)
BE (1) BE860314A (ru)
CA (1) CA1100136A (ru)
CS (1) CS211380B2 (ru)
DD (1) DD133795A5 (ru)
DE (1) DE2748466A1 (ru)
DK (1) DK485277A (ru)
ES (3) ES463784A1 (ru)
FR (1) FR2369267A1 (ru)
GB (1) GB1590155A (ru)
GR (1) GR70053B (ru)
HU (1) HU176231B (ru)
IE (1) IE45901B1 (ru)
IL (1) IL53236A0 (ru)
NL (1) NL7712053A (ru)
NZ (1) NZ185539A (ru)
PH (1) PH12590A (ru)
PL (3) PL108610B1 (ru)
PT (1) PT67194B (ru)
RO (3) RO72900A (ru)
SE (3) SE7712218L (ru)
SU (3) SU812174A3 (ru)
ZA (1) ZA776497B (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL117572B1 (en) * 1977-12-27 1981-08-31 Lilly Co Eli Process for preparing novel derivatives of trans-4a-phenyl-2,3,4,4a,5,6,7,7a-octahydro-1h-2-pyrindine3,4,4a,5,6,7,7a-oktagidro-1h-2-piridina
US4236009A (en) * 1979-06-21 1980-11-25 Eli Lilly And Company Method of preparing 4A-arylhexahydro-1H-2-pyrindines and 4A-aryloctahydroisoquinolines
US4277608A (en) * 1979-06-21 1981-07-07 Eli Lilly And Company Method of preparing 4a-arylhexahydro-1H-2-pyrindines and 4a-aryloctahydroisoquinolines
ZA9510829B (en) * 1994-12-23 1996-07-03 Smithkline Beecham Corp 3,3-(disubstituted)cyclohexan-1-one monomers and related compounds
US8598164B2 (en) 2010-05-06 2013-12-03 Vertex Pharmaceuticals Incorporated Heterocyclic chromene-spirocyclic piperidine amides as modulators of ion channels
EP2670752B1 (en) 2011-02-02 2016-03-16 Vertex Pharmaceuticals Incorporated Pyrrolopyrazine-spirocyclic piperidine amides as modulators of ion channels
EP2675812B1 (en) 2011-02-18 2017-08-30 Vertex Pharmaceuticals Incorporated Chroman - spirocyclic piperidine amides as modulators of ion channels
CN103517910B (zh) 2011-03-14 2016-12-14 沃泰克斯药物股份有限公司 作为离子通道调节剂的吗啉-螺环哌啶酰胺

Also Published As

Publication number Publication date
NZ185539A (en) 1979-12-11
SE8103106L (sv) 1981-05-18
SE7712218L (sv) 1978-05-02
PT67194A (en) 1977-11-01
AR223454A1 (es) 1981-08-31
PL108610B1 (en) 1980-04-30
PL108466B1 (en) 1980-04-30
CA1100136A (en) 1981-04-28
SU812174A3 (ru) 1981-03-07
AU513679B2 (en) 1980-12-18
IE45901B1 (en) 1982-12-29
ES463783A1 (es) 1979-07-16
FR2369267A1 (fr) 1978-05-26
ATA782177A (de) 1981-10-15
RO77935A (ro) 1981-12-25
FR2369267B1 (ru) 1980-05-16
IE45901L (en) 1978-05-02
AU3023577A (en) 1979-05-10
PH12590A (en) 1979-06-27
PL201885A1 (pl) 1978-12-04
JPS5356669A (en) 1978-05-23
ES472276A1 (es) 1979-10-01
SU845777A3 (ru) 1981-07-07
GR70053B (ru) 1982-07-26
PL109690B1 (en) 1980-06-30
PT67194B (en) 1979-03-23
GB1590155A (en) 1981-05-28
RO72900A (ro) 1981-11-04
SE8103107L (sv) 1981-05-18
BE860314A (fr) 1978-04-28
DK485277A (da) 1978-05-03
RO78300A (ro) 1982-04-12
NL7712053A (nl) 1978-05-05
DE2748466A1 (de) 1978-05-03
ES463784A1 (es) 1978-06-16
ZA776497B (en) 1979-06-27
SU913941A3 (en) 1982-03-15
HU176231B (en) 1981-01-28
IL53236A0 (en) 1977-12-30
DD133795A5 (de) 1979-01-24

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