AU513679B2 - 4A-aryl Octahydro 1h-2pyrindine - Google Patents

4A-aryl Octahydro 1h-2pyrindine

Info

Publication number
AU513679B2
AU513679B2 AU30235/77A AU3023577A AU513679B2 AU 513679 B2 AU513679 B2 AU 513679B2 AU 30235/77 A AU30235/77 A AU 30235/77A AU 3023577 A AU3023577 A AU 3023577A AU 513679 B2 AU513679 B2 AU 513679B2
Authority
AU
Australia
Prior art keywords
2pyrindine
octahydro
aryl
aryl octahydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU30235/77A
Other languages
English (en)
Other versions
AU3023577A (en
Inventor
D. M Zimmerman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of AU3023577A publication Critical patent/AU3023577A/en
Application granted granted Critical
Publication of AU513679B2 publication Critical patent/AU513679B2/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D221/00Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04Ortho- or peri-condensed ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/757Unsaturated compounds containing a keto groups being part of a ring containing —CHO groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/94Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU30235/77A 1976-11-02 1977-11-01 4A-aryl Octahydro 1h-2pyrindine Expired AU513679B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73795876A 1976-11-02 1976-11-02
USUS737958 1976-11-02

Publications (2)

Publication Number Publication Date
AU3023577A AU3023577A (en) 1979-05-10
AU513679B2 true AU513679B2 (en) 1980-12-18

Family

ID=24965981

Family Applications (1)

Application Number Title Priority Date Filing Date
AU30235/77A Expired AU513679B2 (en) 1976-11-02 1977-11-01 4A-aryl Octahydro 1h-2pyrindine

Country Status (26)

Country Link
JP (1) JPS5356669A (ru)
AR (1) AR223454A1 (ru)
AT (1) ATA782177A (ru)
AU (1) AU513679B2 (ru)
BE (1) BE860314A (ru)
CA (1) CA1100136A (ru)
CS (1) CS211380B2 (ru)
DD (1) DD133795A5 (ru)
DE (1) DE2748466A1 (ru)
DK (1) DK485277A (ru)
ES (3) ES463784A1 (ru)
FR (1) FR2369267A1 (ru)
GB (1) GB1590155A (ru)
GR (1) GR70053B (ru)
HU (1) HU176231B (ru)
IE (1) IE45901B1 (ru)
IL (1) IL53236A0 (ru)
NL (1) NL7712053A (ru)
NZ (1) NZ185539A (ru)
PH (1) PH12590A (ru)
PL (3) PL108610B1 (ru)
PT (1) PT67194B (ru)
RO (3) RO77935A (ru)
SE (3) SE7712218L (ru)
SU (3) SU812174A3 (ru)
ZA (1) ZA776497B (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT68934A (en) * 1977-12-27 1979-01-01 Lilly Co Eli Process for preparing 4a-aryl-octahydro-1h-2-pyrindines
US4277608A (en) * 1979-06-21 1981-07-07 Eli Lilly And Company Method of preparing 4a-arylhexahydro-1H-2-pyrindines and 4a-aryloctahydroisoquinolines
US4236009A (en) * 1979-06-21 1980-11-25 Eli Lilly And Company Method of preparing 4A-arylhexahydro-1H-2-pyrindines and 4A-aryloctahydroisoquinolines
ZA9510829B (en) * 1994-12-23 1996-07-03 Smithkline Beecham Corp 3,3-(disubstituted)cyclohexan-1-one monomers and related compounds
EP2595989B1 (en) 2010-05-06 2016-07-13 Vertex Pharmaceuticals Incorporated Heterocyclic chromene-spirocyclic piperidine amides as modulators of ion channels
WO2012106499A1 (en) 2011-02-02 2012-08-09 Vertex Pharmaceuticals Incorporated Pyrrolopyrazine-spirocyclic piperidine amides as modulators of ion channels
US10385070B2 (en) 2011-02-18 2019-08-20 Vertex Pharmaceuticals Incorporated Chroman-spirocyclic piperidine amides as modulators of ion channels
US8828996B2 (en) 2011-03-14 2014-09-09 Vertex Pharmaceuticals Incorporated Morpholine-spirocyclic piperidine amides as modulators of ion channels

Also Published As

Publication number Publication date
SE7712218L (sv) 1978-05-03
ZA776497B (en) 1979-06-27
PT67194A (en) 1977-11-01
GB1590155A (en) 1981-05-28
DK485277A (da) 1978-05-03
DE2748466A1 (de) 1978-05-03
FR2369267B1 (ru) 1980-05-16
ES463783A1 (es) 1979-07-16
SU913941A3 (en) 1982-03-15
SE8103107L (sv) 1981-05-18
PL109690B1 (en) 1980-06-30
PL201885A1 (pl) 1978-12-04
FR2369267A1 (fr) 1978-05-26
PH12590A (en) 1979-06-27
JPS5356669A (en) 1978-05-23
CA1100136A (en) 1981-04-28
SU845777A3 (ru) 1981-07-07
IL53236A0 (en) 1977-12-30
IE45901B1 (en) 1982-12-29
NL7712053A (nl) 1978-05-05
PL108466B1 (en) 1980-04-30
PT67194B (en) 1979-03-23
BE860314A (fr) 1978-04-28
DD133795A5 (de) 1979-01-24
ATA782177A (de) 1981-10-15
PL108610B1 (en) 1980-04-30
HU176231B (en) 1981-01-28
ES463784A1 (es) 1978-06-16
GR70053B (ru) 1982-07-26
ES472276A1 (es) 1979-10-01
SU812174A3 (ru) 1981-03-07
AU3023577A (en) 1979-05-10
SE8103106L (sv) 1981-05-18
RO78300A (ro) 1982-04-12
CS211380B2 (en) 1982-02-26
RO77935A (ro) 1981-12-25
IE45901L (en) 1978-05-02
RO72900A (ro) 1981-11-04
NZ185539A (en) 1979-12-11
AR223454A1 (es) 1981-08-31

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