SU913941A3 - Process for producing cis-derivatives of pyridine or their pharmaceutically acceptable acid salts - Google Patents

Process for producing cis-derivatives of pyridine or their pharmaceutically acceptable acid salts

Info

Publication number
SU913941A3
SU913941A3 SU782669355A SU2669355A SU913941A3 SU 913941 A3 SU913941 A3 SU 913941A3 SU 782669355 A SU782669355 A SU 782669355A SU 2669355 A SU2669355 A SU 2669355A SU 913941 A3 SU913941 A3 SU 913941A3
Authority
SU
USSR - Soviet Union
Prior art keywords
pyridine
derivatives
pharmaceutically acceptable
acid salts
acceptable acid
Prior art date
Application number
SU782669355A
Other languages
English (en)
Inventor
Dennis Majkl Zimmerman
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of SU913941A3 publication Critical patent/SU913941A3/ru

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D221/00Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04Ortho- or peri-condensed ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/757Unsaturated compounds containing a keto groups being part of a ring containing —CHO groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/94Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
SU782669355A 1976-11-02 1978-10-03 Process for producing cis-derivatives of pyridine or their pharmaceutically acceptable acid salts SU913941A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US73795876A 1976-11-02 1976-11-02

Publications (1)

Publication Number Publication Date
SU913941A3 true SU913941A3 (en) 1982-03-15

Family

ID=24965981

Family Applications (3)

Application Number Title Priority Date Filing Date
SU772539649A SU812174A3 (ru) 1976-11-02 1977-11-02 Способ получени производныхциС-4A-фЕНилОКТАгидРО-1H-2-пиРиН-диНА или иХ СОлЕй
SU782669395A SU845777A3 (ru) 1976-11-02 1978-10-03 Способ получени цис-4а-фенил-2,3,4,4а,5,6,7,7A-ОКТАгидРО-1H-2-пиРиНдиНОВ или иХфАРМАцЕВТичЕСКи пРиЕМлЕМыХ СОлЕй
SU782669355A SU913941A3 (en) 1976-11-02 1978-10-03 Process for producing cis-derivatives of pyridine or their pharmaceutically acceptable acid salts

Family Applications Before (2)

Application Number Title Priority Date Filing Date
SU772539649A SU812174A3 (ru) 1976-11-02 1977-11-02 Способ получени производныхциС-4A-фЕНилОКТАгидРО-1H-2-пиРиН-диНА или иХ СОлЕй
SU782669395A SU845777A3 (ru) 1976-11-02 1978-10-03 Способ получени цис-4а-фенил-2,3,4,4а,5,6,7,7A-ОКТАгидРО-1H-2-пиРиНдиНОВ или иХфАРМАцЕВТичЕСКи пРиЕМлЕМыХ СОлЕй

Country Status (26)

Country Link
JP (1) JPS5356669A (ru)
AR (1) AR223454A1 (ru)
AT (1) ATA782177A (ru)
AU (1) AU513679B2 (ru)
BE (1) BE860314A (ru)
CA (1) CA1100136A (ru)
CS (1) CS211380B2 (ru)
DD (1) DD133795A5 (ru)
DE (1) DE2748466A1 (ru)
DK (1) DK485277A (ru)
ES (3) ES463784A1 (ru)
FR (1) FR2369267A1 (ru)
GB (1) GB1590155A (ru)
GR (1) GR70053B (ru)
HU (1) HU176231B (ru)
IE (1) IE45901B1 (ru)
IL (1) IL53236A0 (ru)
NL (1) NL7712053A (ru)
NZ (1) NZ185539A (ru)
PH (1) PH12590A (ru)
PL (3) PL108466B1 (ru)
PT (1) PT67194B (ru)
RO (3) RO72900A (ru)
SE (3) SE7712218L (ru)
SU (3) SU812174A3 (ru)
ZA (1) ZA776497B (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ189230A (en) * 1977-12-27 1981-05-15 Lilly Co Eli Trans-4a-aryl-2-substituted-octahydro-1h-2-pyrindines
US4277608A (en) * 1979-06-21 1981-07-07 Eli Lilly And Company Method of preparing 4a-arylhexahydro-1H-2-pyrindines and 4a-aryloctahydroisoquinolines
US4236009A (en) * 1979-06-21 1980-11-25 Eli Lilly And Company Method of preparing 4A-arylhexahydro-1H-2-pyrindines and 4A-aryloctahydroisoquinolines
ZA9510829B (en) * 1994-12-23 1996-07-03 Smithkline Beecham Corp 3,3-(disubstituted)cyclohexan-1-one monomers and related compounds
WO2011140425A1 (en) 2010-05-06 2011-11-10 Vertex Pharmaceuticals Incorporated Heterocyclic chromene-spirocyclic piperidine amides as modulators of ion channels
DK2670752T3 (en) 2011-02-02 2016-07-04 Vertex Pharma PYRROLOPYRAZINE SPIROCYCLIC PIPERIDINAMIDE AS ION CHANNEL MODULATORS
JP5940562B2 (ja) 2011-02-18 2016-06-29 バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated イオンチャネルのモジュレーターとしてのクロマン−スピロ環式ピペリジンアミド
ES2618929T3 (es) 2011-03-14 2017-06-22 Vertex Pharmaceuticals Incorporated Morfolina-Spiro piperidina amida cíclica como moduladores del canal iónico

Also Published As

Publication number Publication date
HU176231B (en) 1981-01-28
GR70053B (ru) 1982-07-26
NZ185539A (en) 1979-12-11
CS211380B2 (en) 1982-02-26
SE7712218L (sv) 1978-05-03
AU3023577A (en) 1979-05-10
PL108466B1 (en) 1980-04-30
SE8103107L (sv) 1981-05-18
DK485277A (da) 1978-05-03
RO77935A (ro) 1981-12-25
ES463784A1 (es) 1978-06-16
PT67194B (en) 1979-03-23
BE860314A (fr) 1978-04-28
ES472276A1 (es) 1979-10-01
IE45901B1 (en) 1982-12-29
IE45901L (en) 1978-05-02
NL7712053A (nl) 1978-05-05
PL109690B1 (en) 1980-06-30
ATA782177A (de) 1981-10-15
PL201885A1 (pl) 1978-12-04
GB1590155A (en) 1981-05-28
FR2369267B1 (ru) 1980-05-16
SU812174A3 (ru) 1981-03-07
FR2369267A1 (fr) 1978-05-26
PH12590A (en) 1979-06-27
AR223454A1 (es) 1981-08-31
SE8103106L (sv) 1981-05-18
JPS5356669A (en) 1978-05-23
IL53236A0 (en) 1977-12-30
RO72900A (ro) 1981-11-04
ES463783A1 (es) 1979-07-16
PT67194A (en) 1977-11-01
DD133795A5 (de) 1979-01-24
SU845777A3 (ru) 1981-07-07
CA1100136A (en) 1981-04-28
ZA776497B (en) 1979-06-27
PL108610B1 (en) 1980-04-30
RO78300A (ro) 1982-04-12
DE2748466A1 (de) 1978-05-03
AU513679B2 (en) 1980-12-18

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