BE860314A - 4a-aryl-octahydro-1h-2-pyrindines a activite analgesique - Google Patents

4a-aryl-octahydro-1h-2-pyrindines a activite analgesique

Info

Publication number
BE860314A
BE860314A BE1008483A BE1008483A BE860314A BE 860314 A BE860314 A BE 860314A BE 1008483 A BE1008483 A BE 1008483A BE 1008483 A BE1008483 A BE 1008483A BE 860314 A BE860314 A BE 860314A
Authority
BE
Belgium
Prior art keywords
pyrindins
octahydro
aryl
analgesic activity
analgesic
Prior art date
Application number
BE1008483A
Other languages
English (en)
French (fr)
Inventor
D M Zimmerman
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of BE860314A publication Critical patent/BE860314A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/757—Unsaturated compounds containing a keto groups being part of a ring containing —CHO groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
BE1008483A 1976-11-02 1977-10-28 4a-aryl-octahydro-1h-2-pyrindines a activite analgesique BE860314A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US73795876A 1976-11-02 1976-11-02

Publications (1)

Publication Number Publication Date
BE860314A true BE860314A (fr) 1978-04-28

Family

ID=24965981

Family Applications (1)

Application Number Title Priority Date Filing Date
BE1008483A BE860314A (fr) 1976-11-02 1977-10-28 4a-aryl-octahydro-1h-2-pyrindines a activite analgesique

Country Status (26)

Country Link
JP (1) JPS5356669A (xx)
AR (1) AR223454A1 (xx)
AT (1) ATA782177A (xx)
AU (1) AU513679B2 (xx)
BE (1) BE860314A (xx)
CA (1) CA1100136A (xx)
CS (1) CS211380B2 (xx)
DD (1) DD133795A5 (xx)
DE (1) DE2748466A1 (xx)
DK (1) DK485277A (xx)
ES (3) ES463784A1 (xx)
FR (1) FR2369267A1 (xx)
GB (1) GB1590155A (xx)
GR (1) GR70053B (xx)
HU (1) HU176231B (xx)
IE (1) IE45901B1 (xx)
IL (1) IL53236A0 (xx)
NL (1) NL7712053A (xx)
NZ (1) NZ185539A (xx)
PH (1) PH12590A (xx)
PL (3) PL108466B1 (xx)
PT (1) PT67194B (xx)
RO (3) RO72900A (xx)
SE (3) SE7712218L (xx)
SU (3) SU812174A3 (xx)
ZA (1) ZA776497B (xx)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4236009A (en) * 1979-06-21 1980-11-25 Eli Lilly And Company Method of preparing 4A-arylhexahydro-1H-2-pyrindines and 4A-aryloctahydroisoquinolines
US4277608A (en) * 1979-06-21 1981-07-07 Eli Lilly And Company Method of preparing 4a-arylhexahydro-1H-2-pyrindines and 4a-aryloctahydroisoquinolines

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ189230A (en) * 1977-12-27 1981-05-15 Lilly Co Eli Trans-4a-aryl-2-substituted-octahydro-1h-2-pyrindines
ZA9510829B (en) * 1994-12-23 1996-07-03 Smithkline Beecham Corp 3,3-(disubstituted)cyclohexan-1-one monomers and related compounds
US8598164B2 (en) 2010-05-06 2013-12-03 Vertex Pharmaceuticals Incorporated Heterocyclic chromene-spirocyclic piperidine amides as modulators of ion channels
PL2670752T3 (pl) 2011-02-02 2016-09-30 Pirolopirazynowe spirocykliczne piperydynoamidy jako modulatory kanałów jonowych
US10385070B2 (en) 2011-02-18 2019-08-20 Vertex Pharmaceuticals Incorporated Chroman-spirocyclic piperidine amides as modulators of ion channels
CA2829803A1 (en) 2011-03-14 2012-09-20 Vertex Pharmaceuticals Incorporated Morpholine-spirocyclic piperidine amides as modulators of ion channels

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4236009A (en) * 1979-06-21 1980-11-25 Eli Lilly And Company Method of preparing 4A-arylhexahydro-1H-2-pyrindines and 4A-aryloctahydroisoquinolines
US4277608A (en) * 1979-06-21 1981-07-07 Eli Lilly And Company Method of preparing 4a-arylhexahydro-1H-2-pyrindines and 4a-aryloctahydroisoquinolines

Also Published As

Publication number Publication date
ZA776497B (en) 1979-06-27
IE45901B1 (en) 1982-12-29
SU845777A3 (ru) 1981-07-07
PL201885A1 (pl) 1978-12-04
RO78300A (ro) 1982-04-12
SE8103107L (sv) 1981-05-18
PL108610B1 (en) 1980-04-30
IL53236A0 (en) 1977-12-30
NL7712053A (nl) 1978-05-05
SU913941A3 (en) 1982-03-15
PL109690B1 (en) 1980-06-30
SE7712218L (sv) 1978-05-02
AU513679B2 (en) 1980-12-18
PH12590A (en) 1979-06-27
PT67194A (en) 1977-11-01
IE45901L (en) 1978-05-02
NZ185539A (en) 1979-12-11
ES463784A1 (es) 1978-06-16
GR70053B (xx) 1982-07-26
CS211380B2 (en) 1982-02-26
FR2369267A1 (fr) 1978-05-26
FR2369267B1 (xx) 1980-05-16
RO72900A (ro) 1981-11-04
SE8103106L (sv) 1981-05-18
PL108466B1 (en) 1980-04-30
AU3023577A (en) 1979-05-10
CA1100136A (en) 1981-04-28
HU176231B (en) 1981-01-28
DK485277A (da) 1978-05-03
AR223454A1 (es) 1981-08-31
RO77935A (ro) 1981-12-25
DD133795A5 (de) 1979-01-24
DE2748466A1 (de) 1978-05-03
JPS5356669A (en) 1978-05-23
SU812174A3 (ru) 1981-03-07
ATA782177A (de) 1981-10-15
GB1590155A (en) 1981-05-28
ES472276A1 (es) 1979-10-01
ES463783A1 (es) 1979-07-16
PT67194B (en) 1979-03-23

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