CA1100136A - 4a-aryl octahydro-1h-2-pyrindines - Google Patents

4a-aryl octahydro-1h-2-pyrindines

Info

Publication number
CA1100136A
CA1100136A CA289,687A CA289687A CA1100136A CA 1100136 A CA1100136 A CA 1100136A CA 289687 A CA289687 A CA 289687A CA 1100136 A CA1100136 A CA 1100136A
Authority
CA
Canada
Prior art keywords
octahydro
pyrindine
hydroxyphenyl
phenyl
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA289,687A
Other languages
English (en)
French (fr)
Inventor
Dennis M. Zimmerman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Priority to CA000364856A priority Critical patent/CA1119175A/en
Application granted granted Critical
Publication of CA1100136A publication Critical patent/CA1100136A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/757—Unsaturated compounds containing a keto groups being part of a ring containing —CHO groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA289,687A 1976-11-02 1977-10-27 4a-aryl octahydro-1h-2-pyrindines Expired CA1100136A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA000364856A CA1119175A (en) 1976-11-02 1980-11-17 4a-aryl octahydro-1h-2-pyrindines

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73795876A 1976-11-02 1976-11-02
US737,958 1976-11-02

Publications (1)

Publication Number Publication Date
CA1100136A true CA1100136A (en) 1981-04-28

Family

ID=24965981

Family Applications (1)

Application Number Title Priority Date Filing Date
CA289,687A Expired CA1100136A (en) 1976-11-02 1977-10-27 4a-aryl octahydro-1h-2-pyrindines

Country Status (26)

Country Link
JP (1) JPS5356669A (ru)
AR (1) AR223454A1 (ru)
AT (1) ATA782177A (ru)
AU (1) AU513679B2 (ru)
BE (1) BE860314A (ru)
CA (1) CA1100136A (ru)
CS (1) CS211380B2 (ru)
DD (1) DD133795A5 (ru)
DE (1) DE2748466A1 (ru)
DK (1) DK485277A (ru)
ES (3) ES463784A1 (ru)
FR (1) FR2369267A1 (ru)
GB (1) GB1590155A (ru)
GR (1) GR70053B (ru)
HU (1) HU176231B (ru)
IE (1) IE45901B1 (ru)
IL (1) IL53236A0 (ru)
NL (1) NL7712053A (ru)
NZ (1) NZ185539A (ru)
PH (1) PH12590A (ru)
PL (3) PL108610B1 (ru)
PT (1) PT67194B (ru)
RO (3) RO77935A (ru)
SE (3) SE7712218L (ru)
SU (3) SU812174A3 (ru)
ZA (1) ZA776497B (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT68934A (en) * 1977-12-27 1979-01-01 Lilly Co Eli Process for preparing 4a-aryl-octahydro-1h-2-pyrindines
US4277608A (en) * 1979-06-21 1981-07-07 Eli Lilly And Company Method of preparing 4a-arylhexahydro-1H-2-pyrindines and 4a-aryloctahydroisoquinolines
US4236009A (en) * 1979-06-21 1980-11-25 Eli Lilly And Company Method of preparing 4A-arylhexahydro-1H-2-pyrindines and 4A-aryloctahydroisoquinolines
ZA9510829B (en) * 1994-12-23 1996-07-03 Smithkline Beecham Corp 3,3-(disubstituted)cyclohexan-1-one monomers and related compounds
EP2595989B1 (en) 2010-05-06 2016-07-13 Vertex Pharmaceuticals Incorporated Heterocyclic chromene-spirocyclic piperidine amides as modulators of ion channels
WO2012106499A1 (en) 2011-02-02 2012-08-09 Vertex Pharmaceuticals Incorporated Pyrrolopyrazine-spirocyclic piperidine amides as modulators of ion channels
US10385070B2 (en) 2011-02-18 2019-08-20 Vertex Pharmaceuticals Incorporated Chroman-spirocyclic piperidine amides as modulators of ion channels
US8828996B2 (en) 2011-03-14 2014-09-09 Vertex Pharmaceuticals Incorporated Morpholine-spirocyclic piperidine amides as modulators of ion channels

Also Published As

Publication number Publication date
SE7712218L (sv) 1978-05-03
ZA776497B (en) 1979-06-27
PT67194A (en) 1977-11-01
GB1590155A (en) 1981-05-28
DK485277A (da) 1978-05-03
DE2748466A1 (de) 1978-05-03
FR2369267B1 (ru) 1980-05-16
ES463783A1 (es) 1979-07-16
SU913941A3 (en) 1982-03-15
SE8103107L (sv) 1981-05-18
PL109690B1 (en) 1980-06-30
PL201885A1 (pl) 1978-12-04
FR2369267A1 (fr) 1978-05-26
PH12590A (en) 1979-06-27
JPS5356669A (en) 1978-05-23
SU845777A3 (ru) 1981-07-07
IL53236A0 (en) 1977-12-30
IE45901B1 (en) 1982-12-29
NL7712053A (nl) 1978-05-05
PL108466B1 (en) 1980-04-30
PT67194B (en) 1979-03-23
AU513679B2 (en) 1980-12-18
BE860314A (fr) 1978-04-28
DD133795A5 (de) 1979-01-24
ATA782177A (de) 1981-10-15
PL108610B1 (en) 1980-04-30
HU176231B (en) 1981-01-28
ES463784A1 (es) 1978-06-16
GR70053B (ru) 1982-07-26
ES472276A1 (es) 1979-10-01
SU812174A3 (ru) 1981-03-07
AU3023577A (en) 1979-05-10
SE8103106L (sv) 1981-05-18
RO78300A (ro) 1982-04-12
CS211380B2 (en) 1982-02-26
RO77935A (ro) 1981-12-25
IE45901L (en) 1978-05-02
RO72900A (ro) 1981-11-04
NZ185539A (en) 1979-12-11
AR223454A1 (es) 1981-08-31

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Legal Events

Date Code Title Description
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