CS204989B2 - Method of producing cephalosporin antibiotics - Google Patents

Method of producing cephalosporin antibiotics Download PDF

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Publication number
CS204989B2
CS204989B2 CS745783A CS591678A CS204989B2 CS 204989 B2 CS204989 B2 CS 204989B2 CS 745783 A CS745783 A CS 745783A CS 591678 A CS591678 A CS 591678A CS 204989 B2 CS204989 B2 CS 204989B2
Authority
CS
Czechoslovakia
Prior art keywords
isomer
compound
formula
syn
hydrogen
Prior art date
Application number
CS745783A
Other languages
Czech (cs)
English (en)
Inventor
Martin Ch Cook
Gordon I Gregory
Janice Bradshaw
Original Assignee
Glaxo Operations Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10410683&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CS204989(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxo Operations Ltd filed Critical Glaxo Operations Ltd
Publication of CS204989B2 publication Critical patent/CS204989B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CS745783A 1973-08-21 1974-08-20 Method of producing cephalosporin antibiotics CS204989B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3964573A GB1453049A (en) 1973-08-21 1973-08-21 Cephalosporing antibiotics

Publications (1)

Publication Number Publication Date
CS204989B2 true CS204989B2 (en) 1981-04-30

Family

ID=10410683

Family Applications (2)

Application Number Title Priority Date Filing Date
CS745783A CS204988B2 (en) 1973-08-21 1974-08-20 Process for preparing cephalosporine antibiotics
CS745783A CS204989B2 (en) 1973-08-21 1974-08-20 Method of producing cephalosporin antibiotics

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CS745783A CS204988B2 (en) 1973-08-21 1974-08-20 Process for preparing cephalosporine antibiotics

Country Status (32)

Country Link
JP (2) JPS562077B2 (ja)
AR (2) AR212076A1 (ja)
AT (1) AT340042B (ja)
AU (1) AU473550B2 (ja)
BE (1) BE819004R (ja)
BG (2) BG23903A3 (ja)
CA (1) CA1057283A (ja)
CH (2) CH613975A5 (ja)
CS (2) CS204988B2 (ja)
CY (1) CY945A (ja)
DD (1) DD114417A5 (ja)
DE (2) DE2439880C3 (ja)
DK (1) DK147683C (ja)
ES (2) ES429388A1 (ja)
FI (1) FI65623C (ja)
FR (1) FR2241318B2 (ja)
GB (1) GB1453049A (ja)
GT (1) GT198302370A (ja)
HK (1) HK17378A (ja)
HU (1) HU170000B (ja)
IE (1) IE39764B1 (ja)
IL (1) IL45505A (ja)
KE (1) KE2816A (ja)
LU (2) LU88269I2 (ja)
MY (1) MY7800188A (ja)
NL (1) NL154741B (ja)
NO (1) NO152751C (ja)
PL (2) PL115805B1 (ja)
RO (2) RO64129A (ja)
SU (1) SU633483A3 (ja)
YU (2) YU36737B (ja)
ZA (1) ZA745331B (ja)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1555471A (en) * 1975-06-19 1979-11-14 Glaxo Lab Ltd 7 carbamoylalkoxyimino acetamido 3 em 4 carboxylic acidsand derivatives thereof
CA1093549A (en) * 1976-02-16 1981-01-13 Michael Gregson Cephalosporin antibiotics
FR2345153A1 (fr) * 1976-03-25 1977-10-21 Roussel Uclaf Nouvelles alcoyloximes derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
GB1576625A (en) * 1976-04-12 1980-10-08 Fujisawa Pharmaceutical Co Syn isomer 3,7 disubstituted 3 cephem 4 carboxylic acid compounds and processes for the preparation thereof
FI771866A (ja) * 1976-06-28 1977-12-29 Fujisawa Pharmaceutical Co
GB1598568A (en) * 1977-04-19 1981-09-23 Glaxo Lab Ltd Esters of(6r,7r)-3-carbamoyloxymethyl-7-((z)-2-(fur-2-yl)-2-methoxyiminoacetamido)-ceph-3-em-4-carboxylic acid
FR2414509A1 (fr) * 1978-01-17 1979-08-10 Glaxo Group Ltd Procede de cristallisation de cefuroxime sodique
DE2804040C3 (de) * 1978-01-31 1981-03-19 Hoechst Ag, 6000 Frankfurt Verfahren zur Herstellung von Cephemverbindungen
US4341777A (en) * 1979-09-10 1982-07-27 Glaxo Group Limited Cephalosporin antibiotic
IT1190734B (it) * 1982-03-11 1988-02-24 Opos Biochimica Srl Procedimento per la preparazione di cefuroxima e intermedi impiegati in tale procedimento
GB8320520D0 (en) * 1983-07-29 1983-09-01 Glaxo Group Ltd Chemical process
GB8400024D0 (en) * 1984-01-03 1984-02-08 Glaxo Group Ltd Cephalosporin antibiotics
GB8810394D0 (en) * 1988-05-03 1988-06-08 Glaxo Group Ltd Chemical process
WO2000053609A1 (en) * 1999-03-09 2000-09-14 Ranbaxy Laboratories Limited Process for the preparation of cefuroxime
US20040191803A1 (en) * 2002-11-22 2004-09-30 Michela Gallagher Target for therapy of cognitive impairment
WO2004050663A2 (en) * 2002-12-05 2004-06-17 Orchid Chemicals & Pharmaceuticals Ltd An improved process for the preparation of cefuroxime sodium
JP2008275173A (ja) * 2008-08-04 2008-11-13 Toshiba Corp 分岐配管
EP2741750A1 (en) 2011-08-12 2014-06-18 Dhanuka Laboratories Ltd. Pharmaceutical composition comprising cefuroxime
WO2013038323A1 (en) 2011-09-13 2013-03-21 Unimark Remedies Ltd. Taste masked pharmaceutical compositions of cefuroxime axetil
KR101497420B1 (ko) 2013-07-05 2015-03-03 삼성중공업 주식회사 증발가스 저감용 액화천연가스 수송장치
CN105884799A (zh) * 2015-09-23 2016-08-24 石药集团中诺药业（石家庄）有限公司 一种新的头孢呋辛钠化合物

Also Published As

Publication number Publication date
DK443274A (ja) 1975-04-28
LU70765A1 (ja) 1975-12-09
CH615931A5 (en) 1980-02-29
ES437269A1 (es) 1977-01-01
FI65623C (fi) 1984-06-11
JPS5649388A (en) 1981-05-02
CS204988B2 (en) 1981-04-30
IE39764B1 (en) 1978-12-20
IL45505A (en) 1979-01-31
ZA745331B (en) 1975-10-29
PL98962B1 (pl) 1978-06-30
CH613975A5 (en) 1979-10-31
DE2462376A1 (de) 1976-11-25
BE819004R (fr) 1975-02-20
HK17378A (en) 1978-04-07
YU41231B (en) 1986-12-31
DD114417A5 (ja) 1975-08-05
HU170000B (ja) 1977-03-28
JPS562077B2 (ja) 1981-01-17
GB1453049A (en) 1976-10-20
YU30781A (en) 1983-02-28
CA1057283A (en) 1979-06-26
IL45505A0 (en) 1974-11-29
ES429388A1 (es) 1976-08-16
FI65623B (fi) 1984-02-29
AT340042B (de) 1977-11-25
DE2439880B2 (de) 1979-02-22
NO152751C (no) 1985-11-13
NL154741B (nl) 1977-10-17
BG23903A3 (en) 1977-11-10
AR212076A1 (es) 1978-05-15
JPS5052083A (ja) 1975-05-09
NO742986L (ja) 1975-03-17
BG25801A3 (en) 1978-12-12
MY7800188A (en) 1978-12-31
LU88269I2 (ja) 1994-02-03
NL7411095A (nl) 1975-02-25
YU228374A (en) 1982-06-18
NO152751B (no) 1985-08-05
DK147683C (da) 1985-05-13
RO69607A (ro) 1980-08-15
FI245674A (ja) 1975-02-22
CY945A (en) 1978-06-23
FR2241318A2 (ja) 1975-03-21
DE2439880A1 (de) 1975-04-03
AU473550B2 (en) 1976-06-24
IE39764L (en) 1975-02-21
KE2816A (en) 1978-02-24
RO64129A (fr) 1979-03-15
GT198302370A (es) 1984-11-20
FR2241318B2 (ja) 1979-08-10
AU7253174A (en) 1976-02-26
ATA676374A (de) 1977-03-15
PL115805B1 (en) 1981-05-30
DE2439880C3 (de) 1979-10-18
AR212156A1 (es) 1978-05-31
DK147683B (da) 1984-11-12
YU36737B (en) 1984-08-31
SU633483A3 (ru) 1978-11-15

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