GB1453049A - Cephalosporing antibiotics - Google Patents

Cephalosporing antibiotics

Info

Publication number
GB1453049A
GB1453049A GB3964573A GB3964573A GB1453049A GB 1453049 A GB1453049 A GB 1453049A GB 3964573 A GB3964573 A GB 3964573A GB 3964573 A GB3964573 A GB 3964573A GB 1453049 A GB1453049 A GB 1453049A
Authority
GB
United Kingdom
Prior art keywords
compound
syn isomer
ceph
phenyl
appropriate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3964573A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Laboratories Ltd
Original Assignee
Glaxo Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10410683&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GB1453049(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxo Laboratories Ltd filed Critical Glaxo Laboratories Ltd
Priority to GB3964573A priority Critical patent/GB1453049A/en
Priority to US05/413,970 priority patent/US3966717A/en
Priority to US05/497,113 priority patent/US3974153A/en
Priority to CY945A priority patent/CY945A/xx
Priority to RO7486148A priority patent/RO69607A/ro
Priority to RO7479828A priority patent/RO64129A/ro
Priority to JP9545674A priority patent/JPS562077B2/ja
Priority to CA207,441A priority patent/CA1057283A/en
Priority to BE147745A priority patent/BE819004R/xx
Priority to AU72531/74A priority patent/AU473550B2/en
Priority to ES429388A priority patent/ES429388A1/es
Priority to FI2456/74A priority patent/FI65623C/fi
Priority to CS745783A priority patent/CS204989B2/cs
Priority to ZA00745331A priority patent/ZA745331B/xx
Priority to YU2283/74A priority patent/YU36737B/xx
Priority to NO742986A priority patent/NO152751C/no
Priority to CS745783A priority patent/CS204988B2/cs
Priority to DE19742462376 priority patent/DE2462376A1/de
Priority to PL1974196434A priority patent/PL115805B1/pl
Priority to PL1974173581A priority patent/PL98962B1/pl
Priority to AR255247A priority patent/AR212076A1/es
Priority to BG7500031288A priority patent/BG23903A3/xx
Priority to BG7400027524A priority patent/BG25801A3/xx
Priority to IE1735/74A priority patent/IE39764B1/xx
Priority to AT676374A priority patent/AT340042B/de
Priority to CH1135374A priority patent/CH613975A5/xx
Priority to LU70765A priority patent/LU70765A1/xx
Priority to NL747411095A priority patent/NL154741B/xx
Priority to LU88269C priority patent/LU88269I2/xx
Priority to IL45505A priority patent/IL45505A/xx
Priority to DD180622A priority patent/DD114417A5/xx
Priority to DE2439880A priority patent/DE2439880C3/de
Priority to DK443274A priority patent/DK147683C/da
Priority to HUGA1166A priority patent/HU170000B/hu
Priority to FR7428750A priority patent/FR2241318B2/fr
Priority to ES437269A priority patent/ES437269A1/es
Priority to AR258764A priority patent/AR212156A1/es
Priority to SU762343055A priority patent/SU633483A3/ru
Priority to AT609976A priority patent/AT340597B/de
Publication of GB1453049A publication Critical patent/GB1453049A/en
Priority to US05/852,808 priority patent/US4138555A/en
Priority to CA293,802A priority patent/CA1048016A/en
Priority to KE2816A priority patent/KE2816A/xx
Priority to HK173/78A priority patent/HK17378A/xx
Priority to CH1013378A priority patent/CH615931A5/de
Priority to MY1978188A priority patent/MY7800188A/xx
Priority to JP7210780A priority patent/JPS5649388A/ja
Priority to YU307/81A priority patent/YU41231B/xx
Priority to FI831279A priority patent/FI831279L/fi
Priority to GT198302370A priority patent/GT198302370A/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
GB3964573A 1971-05-14 1973-08-21 Cephalosporing antibiotics Expired GB1453049A (en)

Priority Applications (49)

Application Number Priority Date Filing Date Title
GB3964573A GB1453049A (en) 1973-08-21 1973-08-21 Cephalosporing antibiotics
US05/413,970 US3966717A (en) 1971-05-14 1973-11-08 7-β-Acylamido-3-carbamoyloxymethylceph-3-em-4-carboxylic acids and salts thereof
US05/497,113 US3974153A (en) 1971-05-14 1974-08-13 7-Hydrocarbonoxy imino-acetamido-3-carbamoyloxy methylceph-3-em-4 carboxylic acids
CY945A CY945A (en) 1973-08-21 1974-08-13 Cephalosporin antibiotics
RO7486148A RO69607A (ro) 1973-08-21 1974-08-19 Procedeu pentru prepararea unor 3-carbamoiloximetilcefalosporine
RO7479828A RO64129A (fr) 1973-08-21 1974-08-19 Procede pour la preparation des derives du cephalospori
JP9545674A JPS562077B2 (ja) 1973-08-21 1974-08-20
CA207,441A CA1057283A (en) 1973-08-21 1974-08-20 3-carbamoyloxymethyl-7-(2-(fur-2-yl)-2-methoxyiminoacetamido) ceph-3-em-4-carboxylic acid
BE147745A BE819004R (fr) 1973-08-21 1974-08-20 Perfectionnements relatifs aux antibiotiques
AU72531/74A AU473550B2 (en) 1973-08-21 1974-08-20 Improvements in or relating to antibiotics
ES429388A ES429388A1 (es) 1973-08-21 1974-08-20 Procedimiento para la preparacion de antibioticos de acido 7-(2-aril-2(oxiimino eterificado)acetamido)-3-carbamoiloxi- metilcef-3-em-4-carboxilico.
FI2456/74A FI65623C (fi) 1973-08-21 1974-08-20 Foerfarande foer framstaellning av antibiotiskt aktiv (6r 7r)-3-karbamoyloximetyl-7-(2-(fur-2-yl)-2-metoxiiminoacetamido)-cef-3-em-4-karboxylsyra samt dennas icke-giftiga salter
CS745783A CS204989B2 (en) 1973-08-21 1974-08-20 Method of producing cephalosporin antibiotics
ZA00745331A ZA745331B (en) 1973-08-21 1974-08-20 Improvements in or relating to antibiotics
YU2283/74A YU36737B (en) 1973-08-21 1974-08-20 Process for obtaining an antibiotic compound
NO742986A NO152751C (no) 1973-08-21 1974-08-20 Analogifremgangsmaate ved fremstilling av et terapeutisk virksomt cephalosporinderivat.
CS745783A CS204988B2 (en) 1973-08-21 1974-08-20 Process for preparing cephalosporine antibiotics
DE19742462376 DE2462376A1 (de) 1973-08-21 1974-08-20 Antibiotika und verfahren zu ihrer herstellung
PL1974196434A PL115805B1 (en) 1973-08-21 1974-08-20 Process for preparing novel derivatives of cephalosporin
PL1974173581A PL98962B1 (pl) 1973-08-21 1974-08-20 Sposob wytwarzania nowych pochodnych cefalosporyny
AR255247A AR212076A1 (es) 1973-08-21 1974-08-20 Procedimiento para la preparacion de antibioticos de acido 7b-/2-aril-2-(oximino eterificado)acetamido/-3-carbamoiloximetilcef-3-em-4-carboxilico
BG7500031288A BG23903A3 (en) 1973-08-21 1974-08-20 Method of preparing 7-b(2-aryl-2(etherified oximino)acetamido)3-carbamoil-oxymethyl-ceph-3-em-4-carboxylic acid
BG7400027524A BG25801A3 (en) 1973-08-21 1974-08-20 A method of obtaining 7-beta-mean opening bracket 2-aryl-2-(eterified oximine)acetamine mean closing bracket-3-carbamoiloxymethyl-ceph-3-em-4-carbonic acid
IE1735/74A IE39764B1 (en) 1973-08-21 1974-08-20 Cephalosporin antibiotics
AT676374A AT340042B (de) 1973-08-21 1974-08-20 Verfahren zur herstellung von neuen antibiotischen verbindungen
CH1135374A CH613975A5 (en) 1973-08-21 1974-08-20 Process for the preparation of the syn isomer or of a mixture of syn isomer and anti isomer, where the content of the syn isomer is at least 90%, of 7-acylaminoceph-3-em-4-carboxylic acids with antibiotic activity
LU70765A LU70765A1 (ja) 1973-08-21 1974-08-20
NL747411095A NL154741B (nl) 1973-08-21 1974-08-20 Werkwijze voor de bereiding van een geneesmiddel met een antibiotische werking, alsmede het verkregen gevormde geneesmiddel en werkwijze voor de bereiding van een ether, afgeleid van een (6r, 7r)-3-acyloxymethyl-7-(2-aryl-2-hydroxyiminoacetylamino) cef-3-em-4-carbonzuurverbinding.
LU88269C LU88269I2 (ja) 1973-08-21 1974-08-20
IL45505A IL45505A (en) 1973-08-21 1974-08-20 7-(2-aryl-2-(etherified oximino)acetamido)-3-(carbamoyloxyymethyl)-ceph-3-em-4-carboxylic acids and their derivatives,their preparation and pharmaceutical compositions comprising them
DD180622A DD114417A5 (ja) 1973-08-21 1974-08-20
DE2439880A DE2439880C3 (de) 1973-08-21 1974-08-20 (6R, 7R)-3-Carbamoyloxymethyl-7- [2-(fur-2-yl)-2methoxyiminoacetamido] -ceph-S-em^carbonsäure und Verfahren zur ihrer Herstellung
DK443274A DK147683C (da) 1973-08-21 1974-08-20 Analogifremgangsmaade til fremstilling af cephalosporinforbindelser eller ugiftige salte, biologisk acceptable estere, 1-oxyder eller solvater deraf
HUGA1166A HU170000B (ja) 1973-08-21 1974-08-21
FR7428750A FR2241318B2 (ja) 1973-08-21 1974-08-21
ES437269A ES437269A1 (es) 1973-08-21 1975-04-30 Un procedimiento para la preparacion de un antibiotico de acido 7beta-(2-aril-2-(oxiimino eterificado) acetamido)-3- carbamoiloximetilcef-3-em-4-carboxilico.
AR258764A AR212156A1 (es) 1973-08-21 1975-05-13 Procedimiento para la preparacion de un antibiotico de acido 7b-(2-aril-2-(oximino esterificado)acetamido)-3-carbamoiloximetilcef-3-em-4-carboxilico
SU762343055A SU633483A3 (ru) 1973-08-21 1976-04-08 Способ получени цефалоспориновых производных в виде син-изомера или смеси син- и антиизомеров, или их солей
AT609976A AT340597B (de) 1973-08-21 1976-08-17 Verfahren zur herstellung von neuen antibiotischen verbindungen
US05/852,808 US4138555A (en) 1971-05-14 1977-11-18 (6R,7R)-7-[2-aryl-2-(etherified oximino)acetamido]-3-carbamoyloxymethylceph-3-em-4-carboxylic acid 1-oxides
CA293,802A CA1048016A (en) 1973-08-21 1977-12-23 Antibiotics
KE2816A KE2816A (en) 1973-08-21 1978-02-06 Cephalosporin antibiotics
HK173/78A HK17378A (en) 1973-08-21 1978-03-30 Cephalosporin antibiotics
CH1013378A CH615931A5 (en) 1973-08-21 1978-09-28 Process for the preparation of the syn isomer or of a mixture of syn and anti isomers, the content of the syn isomer being at least 90%, of 7-acylaminoceph-3-em-4-carboxylic acids
MY1978188A MY7800188A (en) 1973-08-21 1978-12-31 Cephalosporin antibiotics
JP7210780A JPS5649388A (en) 1973-08-21 1980-05-28 Manufacture of antibiotic compound
YU307/81A YU41231B (en) 1973-08-21 1981-02-05 Process for obtaining new antibiotic compounds
FI831279A FI831279L (fi) 1973-08-21 1983-04-15 Foerfarande foer framstaellning av antibiotiskt aktiv (6r,7r)-3-karbamoyloximetyl-7-/2-fur-2-yl)-2-metoxiiminoacetamido/-cef-3-em-4-karboxylsyra samt dennas icke-giftiga salter och estrar
GT198302370A GT198302370A (es) 1973-08-21 1983-05-30 Mejoras en o relativas a antibioticos

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3964573A GB1453049A (en) 1973-08-21 1973-08-21 Cephalosporing antibiotics

Publications (1)

Publication Number Publication Date
GB1453049A true GB1453049A (en) 1976-10-20

Family

ID=10410683

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3964573A Expired GB1453049A (en) 1971-05-14 1973-08-21 Cephalosporing antibiotics

Country Status (32)

Country Link
JP (2) JPS562077B2 (ja)
AR (2) AR212076A1 (ja)
AT (1) AT340042B (ja)
AU (1) AU473550B2 (ja)
BE (1) BE819004R (ja)
BG (2) BG23903A3 (ja)
CA (1) CA1057283A (ja)
CH (2) CH613975A5 (ja)
CS (2) CS204988B2 (ja)
CY (1) CY945A (ja)
DD (1) DD114417A5 (ja)
DE (2) DE2439880C3 (ja)
DK (1) DK147683C (ja)
ES (2) ES429388A1 (ja)
FI (1) FI65623C (ja)
FR (1) FR2241318B2 (ja)
GB (1) GB1453049A (ja)
GT (1) GT198302370A (ja)
HK (1) HK17378A (ja)
HU (1) HU170000B (ja)
IE (1) IE39764B1 (ja)
IL (1) IL45505A (ja)
KE (1) KE2816A (ja)
LU (2) LU88269I2 (ja)
MY (1) MY7800188A (ja)
NL (1) NL154741B (ja)
NO (1) NO152751C (ja)
PL (2) PL115805B1 (ja)
RO (2) RO64129A (ja)
SU (1) SU633483A3 (ja)
YU (2) YU36737B (ja)
ZA (1) ZA745331B (ja)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2387988A1 (fr) * 1977-04-19 1978-11-17 Glaxo Lab Ltd Esters de cefuroxime, leur preparation et leur application therapeutique
GB2145408A (en) * 1983-07-29 1985-03-27 Glaxo Group Ltd Improvements in or relating to preparing sodium cefuroxime
GB2218093A (en) * 1988-05-03 1989-11-08 Glaxo Group Ltd Cephalosporin carbamoylation
WO2004050663A2 (en) * 2002-12-05 2004-06-17 Orchid Chemicals & Pharmaceuticals Ltd An improved process for the preparation of cefuroxime sodium
WO2013024373A1 (en) 2011-08-12 2013-02-21 Dhanuka Laboratories Ltd. Pharmaceutical composition comprising cefuroxime
WO2013038323A1 (en) 2011-09-13 2013-03-21 Unimark Remedies Ltd. Taste masked pharmaceutical compositions of cefuroxime axetil
CN105884799A (zh) * 2015-09-23 2016-08-24 石药集团中诺药业（石家庄）有限公司 一种新的头孢呋辛钠化合物

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1555471A (en) * 1975-06-19 1979-11-14 Glaxo Lab Ltd 7 carbamoylalkoxyimino acetamido 3 em 4 carboxylic acidsand derivatives thereof
CA1093549A (en) * 1976-02-16 1981-01-13 Michael Gregson Cephalosporin antibiotics
FR2345153A1 (fr) * 1976-03-25 1977-10-21 Roussel Uclaf Nouvelles alcoyloximes derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
GB1576625A (en) * 1976-04-12 1980-10-08 Fujisawa Pharmaceutical Co Syn isomer 3,7 disubstituted 3 cephem 4 carboxylic acid compounds and processes for the preparation thereof
FI771866A (ja) * 1976-06-28 1977-12-29 Fujisawa Pharmaceutical Co
FR2414509A1 (fr) * 1978-01-17 1979-08-10 Glaxo Group Ltd Procede de cristallisation de cefuroxime sodique
DE2804040C3 (de) * 1978-01-31 1981-03-19 Hoechst Ag, 6000 Frankfurt Verfahren zur Herstellung von Cephemverbindungen
US4341777A (en) * 1979-09-10 1982-07-27 Glaxo Group Limited Cephalosporin antibiotic
IT1190734B (it) * 1982-03-11 1988-02-24 Opos Biochimica Srl Procedimento per la preparazione di cefuroxima e intermedi impiegati in tale procedimento
GB8400024D0 (en) * 1984-01-03 1984-02-08 Glaxo Group Ltd Cephalosporin antibiotics
WO2000053609A1 (en) * 1999-03-09 2000-09-14 Ranbaxy Laboratories Limited Process for the preparation of cefuroxime
US20040191803A1 (en) * 2002-11-22 2004-09-30 Michela Gallagher Target for therapy of cognitive impairment
JP2008275173A (ja) * 2008-08-04 2008-11-13 Toshiba Corp 分岐配管
KR101497420B1 (ko) 2013-07-05 2015-03-03 삼성중공업 주식회사 증발가스 저감용 액화천연가스 수송장치

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2387988A1 (fr) * 1977-04-19 1978-11-17 Glaxo Lab Ltd Esters de cefuroxime, leur preparation et leur application therapeutique
GB2145408A (en) * 1983-07-29 1985-03-27 Glaxo Group Ltd Improvements in or relating to preparing sodium cefuroxime
AU567359B2 (en) * 1983-07-29 1987-11-19 Glaxo Group Limited Preparation of sodium cefuroxime
GB2218093A (en) * 1988-05-03 1989-11-08 Glaxo Group Ltd Cephalosporin carbamoylation
WO2004050663A2 (en) * 2002-12-05 2004-06-17 Orchid Chemicals & Pharmaceuticals Ltd An improved process for the preparation of cefuroxime sodium
WO2004050663A3 (en) * 2002-12-05 2004-10-28 Orchid Chemicals & Pharm Ltd An improved process for the preparation of cefuroxime sodium
WO2013024373A1 (en) 2011-08-12 2013-02-21 Dhanuka Laboratories Ltd. Pharmaceutical composition comprising cefuroxime
WO2013038323A1 (en) 2011-09-13 2013-03-21 Unimark Remedies Ltd. Taste masked pharmaceutical compositions of cefuroxime axetil
CN105884799A (zh) * 2015-09-23 2016-08-24 石药集团中诺药业（石家庄）有限公司 一种新的头孢呋辛钠化合物

Also Published As

Publication number Publication date
DK443274A (ja) 1975-04-28
LU70765A1 (ja) 1975-12-09
CH615931A5 (en) 1980-02-29
ES437269A1 (es) 1977-01-01
FI65623C (fi) 1984-06-11
JPS5649388A (en) 1981-05-02
CS204988B2 (en) 1981-04-30
IE39764B1 (en) 1978-12-20
IL45505A (en) 1979-01-31
ZA745331B (en) 1975-10-29
PL98962B1 (pl) 1978-06-30
CH613975A5 (en) 1979-10-31
DE2462376A1 (de) 1976-11-25
BE819004R (fr) 1975-02-20
HK17378A (en) 1978-04-07
YU41231B (en) 1986-12-31
DD114417A5 (ja) 1975-08-05
HU170000B (ja) 1977-03-28
JPS562077B2 (ja) 1981-01-17
YU30781A (en) 1983-02-28
CA1057283A (en) 1979-06-26
IL45505A0 (en) 1974-11-29
ES429388A1 (es) 1976-08-16
FI65623B (fi) 1984-02-29
AT340042B (de) 1977-11-25
DE2439880B2 (de) 1979-02-22
NO152751C (no) 1985-11-13
NL154741B (nl) 1977-10-17
BG23903A3 (en) 1977-11-10
AR212076A1 (es) 1978-05-15
JPS5052083A (ja) 1975-05-09
NO742986L (ja) 1975-03-17
BG25801A3 (en) 1978-12-12
MY7800188A (en) 1978-12-31
LU88269I2 (ja) 1994-02-03
NL7411095A (nl) 1975-02-25
YU228374A (en) 1982-06-18
NO152751B (no) 1985-08-05
DK147683C (da) 1985-05-13
RO69607A (ro) 1980-08-15
FI245674A (ja) 1975-02-22
CY945A (en) 1978-06-23
FR2241318A2 (ja) 1975-03-21
DE2439880A1 (de) 1975-04-03
AU473550B2 (en) 1976-06-24
IE39764L (en) 1975-02-21
KE2816A (en) 1978-02-24
RO64129A (fr) 1979-03-15
GT198302370A (es) 1984-11-20
FR2241318B2 (ja) 1979-08-10
AU7253174A (en) 1976-02-26
ATA676374A (de) 1977-03-15
PL115805B1 (en) 1981-05-30
DE2439880C3 (de) 1979-10-18
AR212156A1 (es) 1978-05-31
CS204989B2 (en) 1981-04-30
DK147683B (da) 1984-11-12
YU36737B (en) 1984-08-31
SU633483A3 (ru) 1978-11-15

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
704A Declaration that licence is not available as of right for an excepted use (par. 4a/1977)
PE20 Patent expired after termination of 20 years

Effective date: 19940812