CR9496A - Moduladores de androgenos - Google Patents
Moduladores de androgenosInfo
- Publication number
- CR9496A CR9496A CR9496A CR9496A CR9496A CR 9496 A CR9496 A CR 9496A CR 9496 A CR9496 A CR 9496A CR 9496 A CR9496 A CR 9496A CR 9496 A CR9496 A CR 9496A
- Authority
- CR
- Costa Rica
- Prior art keywords
- androgen modulators
- modulators
- androgen
- benzonitriles
- aspects
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/26—Androgens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Reproductive Health (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Gynecology & Obstetrics (AREA)
- Hematology (AREA)
- Pregnancy & Childbirth (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
La presente invencion se refiere a una nueva clase de benzonitrilos y a su uso como moduladores del receptor de androgeno. Otros aspectos de la invencion se refieren al uso de estos compuestos para disminuir el exceso de las secreciones sebaceas y para estimular el crecimiento del cabello.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US67803505P | 2005-05-05 | 2005-05-05 | |
US68211205P | 2005-05-18 | 2005-05-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
CR9496A true CR9496A (es) | 2007-12-04 |
Family
ID=37023044
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CR9496A CR9496A (es) | 2005-05-05 | 2007-11-02 | Moduladores de androgenos |
Country Status (25)
Country | Link |
---|---|
US (2) | US7674819B2 (es) |
EP (1) | EP1888524A1 (es) |
JP (1) | JP4174068B1 (es) |
KR (1) | KR20070116970A (es) |
CN (1) | CN101166718A (es) |
AP (1) | AP1932A (es) |
AR (1) | AR053721A1 (es) |
AU (1) | AU2006242927A1 (es) |
BR (1) | BRPI0610998A2 (es) |
CA (1) | CA2603866C (es) |
CR (1) | CR9496A (es) |
DO (1) | DOP2006000097A (es) |
EA (1) | EA200702158A1 (es) |
GT (1) | GT200600187A (es) |
IL (1) | IL186401A0 (es) |
MA (1) | MA29516B1 (es) |
MX (1) | MX2007013823A (es) |
NL (1) | NL1031752C2 (es) |
NO (1) | NO20076026L (es) |
PE (1) | PE20061388A1 (es) |
TN (1) | TNSN07409A1 (es) |
TW (1) | TW200724139A (es) |
UY (1) | UY29517A1 (es) |
WO (1) | WO2006117677A1 (es) |
ZA (1) | ZA200709385B (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2562672C (en) | 2004-04-22 | 2009-09-29 | Warner-Lambert Company Llc | 4-cyano-phenoxy derivatives as androgen modulators |
WO2006006065A1 (en) | 2004-07-08 | 2006-01-19 | Warner-Lambert Company Llc | Androgen modulators |
TW200724139A (en) * | 2005-05-05 | 2007-07-01 | Warner Lambert Co | Androgen modulators |
CA2670976C (en) | 2006-11-30 | 2015-01-27 | Atsushi Hasuoka | Cyclic amine compound |
CL2008002313A1 (es) * | 2007-08-07 | 2009-05-15 | Takeda Pharmaceuticals Co | Compuesto 4-[(2s, 3s)-2-etil-3-hidroxi-5-oxopirrolidin-1-il]-2-(trifluorometil)benzonitrilo o una de sus sales, modulador del receptor de androgenos; composicion farmaceutica; y uso del compuesto para la prevencion o el tratamiento de hipogonadismo, trastorno del climaterio masculino, debilidad, caquexia , osteoporosis, hipertrofia prostatica y amiotrofia. |
MX2012013465A (es) | 2010-05-17 | 2013-12-02 | Array Biopharma Inc | Lactamas sustituidas con piperidinilo como moduladores de gpr119. |
JP6872500B2 (ja) * | 2015-05-25 | 2021-05-19 | エステベ・キミカ・ソシエダッド・アノニマEsteve Quimica, S.A. | ブリバラセタムを製造する方法 |
Family Cites Families (104)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE298470C (es) | ||||
US6124343A (en) * | 1919-01-27 | 2000-09-26 | Rhone-Poulenc Rorer Limited | Substituted phenyl compounds with a substituent having a thienyl ring |
US3535365A (en) * | 1967-11-29 | 1970-10-20 | Merck & Co Inc | Preparation of 2,6-dichloro-4-methoxy-benzonitrile |
DE2062349A1 (de) | 1970-12-18 | 1972-06-29 | Farbenfabriken Bayer Ag, 5090 Leverkusen | Aminoaryloxy-ary!carbonsäurenitrile und ein Verfahren zu ihrer Herstellung |
SU469247A3 (ru) | 1972-01-14 | 1975-04-30 | Майлз Лабораториз Инк (Фирма) | Способ получени производных хромона |
US4029493A (en) * | 1973-02-23 | 1977-06-14 | Mobil Oil Corporation | Substituted phenoxybenzonitriles as herbicides |
FR2397387A1 (fr) * | 1976-04-27 | 1979-02-09 | Serobiologiques Lab Sa | 4,4'-bis-formyl-polyhalo-diphenoxyalcanes, procede de preparation et application a la synthese de 4,4'-dicyano-polyhalo-diphenoxyalcanes |
US4234595A (en) * | 1977-07-13 | 1980-11-18 | Mead Johnson & Company | 3-Indolyl-tertiary butylaminopropanols |
DE2862100D1 (en) | 1977-10-12 | 1983-01-05 | Ici Plc | Acylanilides, process for their manufacture and pharmaceutical and veterinary compositions containing them |
DD150456A5 (de) | 1979-03-01 | 1981-09-02 | Ciba Geigy Ag | Verfahren zur herstellung von derivaten des 3-amino-1,2-propandiols |
US4567201A (en) | 1981-11-25 | 1986-01-28 | Takeda Chemical Industries, Ltd. | Diphenoxypropane derivatives and compositions of antiasthmatic and antiinflammatory agents thereof |
GB8504093D0 (en) | 1985-02-18 | 1985-03-20 | Ici Plc | Alkene alkyne/cycloalkylene derivatives |
ATE28864T1 (de) | 1982-07-23 | 1987-08-15 | Ici Plc | Amide-derivate. |
DE3382646D1 (de) * | 1982-08-26 | 1993-01-28 | Merck Patent Gmbh | Cyclohexanderivate und ihre verwendung als komponenten fluessigkristalliner-dielektrika. |
JPS59144747A (ja) | 1983-02-04 | 1984-08-18 | Chisso Corp | 2−クロロ−4−アルキルオキシベンゾニトリル化合物 |
US4536321A (en) * | 1983-02-18 | 1985-08-20 | Chisso Corporation | Fluorobenzene derivatives and liquid crystal compositions containing the same |
DE3515633A1 (de) | 1985-05-02 | 1986-11-06 | Merck Patent Gmbh, 6100 Darmstadt | Benzonitrile |
IL80186A (en) | 1985-10-01 | 1990-09-17 | Ciba Geigy | Pyridinyl derivatives,their preparation and their use as microbicides |
EP0269383A3 (en) | 1986-11-21 | 1990-05-02 | A.H. Robins Company, Incorporated | 1-Aryloxy-4-[(4-aryl)-1-piperazinyl]-2-butanols useful as antiallergy agents |
JPS63227502A (ja) | 1987-03-17 | 1988-09-21 | Sds Biotech Kk | 防菌防カビ剤 |
US4992433A (en) * | 1987-11-23 | 1991-02-12 | Janssen Pharmaceutica N.V. | Novel pyridazinamine derivatives |
US4925590A (en) * | 1988-03-10 | 1990-05-15 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Derivatives of 4-cyano-2,3-difluorophenol |
DE3825170A1 (de) | 1988-07-23 | 1990-01-25 | Hoechst Ag, 65929 Frankfurt | Substituierte 5-(4-(4,5-dihydro-2-oxazolyl)-phenoxyalkylenoxyalkyl)-isoxazole, verfahren sowie 5-(phenoxyalkylenoxyalkyl)-isoxazole als zwischenprodukte zu ihrer herstellung und ihre verwendung zur bekaempfung von krankheiten, die durch infektion mit viren hervorgerufen wurden |
IE902881A1 (en) | 1989-08-10 | 1991-02-27 | Glaxo Inc | Pyridazinones having cardiotonic and beta blocking¹activities |
US5051431A (en) | 1989-09-22 | 1991-09-24 | Glaxo Inc. | Pyridone nitriles useful in treating cardiovascular disease |
DE4017019A1 (de) | 1990-05-26 | 1991-11-28 | Hoechst Ag | Verwendung von substituierten ss-hydroxyethylaminen als potente hemmstoffe der exoenzyme von pilzen |
JPH04124183A (ja) | 1990-09-14 | 1992-04-24 | Mitsubishi Rayon Co Ltd | 光学活性パントラクトン誘導体 |
GB9025828D0 (en) | 1990-11-28 | 1991-01-09 | Shell Int Research | Herbicidal carboxamide derivatives |
JP3088777B2 (ja) | 1991-03-27 | 2000-09-18 | 富士薬品工業株式会社 | 新規光学分割剤及びそれを用いる光学活性アミンの製造方法 |
US5320825A (en) | 1991-05-01 | 1994-06-14 | Trustees Of The University Of Pennsylvania | Serotonin reuptake inhibitors for S.P.E.C.T. imaging |
JP3151929B2 (ja) | 1992-05-15 | 2001-04-03 | 大日本インキ化学工業株式会社 | フルオロシクロヘキセン誘導体 |
DE4217928A1 (de) | 1992-05-30 | 1993-12-02 | Hoechst Ag | Neue Mischungen aus Herbiziden und Antidots, neue (Hetero-)Aryloxy-Verbindungen, Verfahren zu deren Herstellung, diese enthaltenden Mittel und deren Verwendung |
JPH0641038A (ja) | 1992-07-17 | 1994-02-15 | Mitsubishi Kasei Corp | カルボン酸誘導体 |
KR950703280A (ko) | 1992-09-09 | 1995-09-20 | 미리암 디.메코너헤이 | 제초성 벤젠 화합물(Herbicidal Benzene Compounds) |
US5455274A (en) | 1992-12-09 | 1995-10-03 | Ciba-Geigy Corporation | Hydroxyamidine derivatives |
US5316755A (en) * | 1993-02-02 | 1994-05-31 | Sterling Winthrop Inc. | Compositions of iodophenoxy alkanes and iodophenyl ethers for visualization of the gastrointestinal tract |
US5326553A (en) | 1993-02-02 | 1994-07-05 | Sterling Winthrop Inc. | Compositions of iodophenoxy alkanes and iodophenyl ethers in film-forming materials for visualization of the gastrointestinal tract |
GB2278054A (en) | 1993-05-18 | 1994-11-23 | Zeneca Ltd | Compounds for the treatment of urinary incontinence |
GB9321162D0 (en) | 1993-10-13 | 1993-12-01 | Boots Co Plc | Therapeutic agents |
DE4339863A1 (de) | 1993-11-23 | 1995-05-24 | Bayer Ag | Substituierte Carbamoyltriazole |
TW262553B (es) | 1994-03-17 | 1995-11-11 | Hitachi Seisakusyo Kk | |
CA2187019A1 (en) | 1994-04-21 | 1995-11-02 | Stephen B. Ruddy | X-ray contrast compositions containing pharmaceutically acceptable clays |
JPH07309850A (ja) | 1994-05-16 | 1995-11-28 | Canon Inc | 光学活性化合物、それを含有する液晶組成物、それを有する液晶素子及びそれらを用いた表示方法、表示装置 |
CA2150326A1 (en) | 1994-05-27 | 1995-11-28 | Kimihiro Murakami | Azolyl methyl phenyl derivatives having aromatase inhibitory activity |
PT707007E (pt) | 1994-10-14 | 2002-06-28 | Merck Patent Gmbh | Derivados amino(tio)eter como agentes activos no snc |
JP3802581B2 (ja) | 1995-03-01 | 2006-07-26 | 富山化学工業株式会社 | 新規なビフェニル誘導体またはその塩およびそれらを含有する抗炎症剤 |
JPH08325154A (ja) | 1995-03-31 | 1996-12-10 | Mitsui Toatsu Chem Inc | 安息香酸誘導体およびそれを有効成分として含有するホスホリパーゼa2阻害剤 |
DE19534209A1 (de) * | 1995-09-15 | 1997-03-20 | Jenapharm Gmbh | Hormonales Mittel zur Behandlung der Haut |
US5843983A (en) | 1996-02-15 | 1998-12-01 | Sankyo Company, Limited | Diphenylethane compounds containing a saturated heterocyclic group, their preparation, and their therapeutic use |
ES2127106B1 (es) | 1996-03-21 | 1999-11-16 | Menarini Lab | Derivados benzopiranicos con accion antagonista de los leucotrienos, procedimiento para su preparacion y utilizacion de los mismos. |
DE19612032A1 (de) | 1996-03-27 | 1997-10-09 | Basf Ag | Substituierte 1-Methyl-3-benzyluracile |
JP3515284B2 (ja) | 1996-06-24 | 2004-04-05 | カルソニックカンセイ株式会社 | 車両用エアコンシステムのドア制御装置 |
JPH107647A (ja) | 1996-06-25 | 1998-01-13 | Yamanouchi Pharmaceut Co Ltd | 新規なチオ尿素誘導体又はその塩 |
US5847166A (en) * | 1996-10-10 | 1998-12-08 | Massachusetts Institute Of Technology | Synthesis of aryl ethers |
US6071957A (en) * | 1996-11-27 | 2000-06-06 | The University Of Tennessee Research Corporation | Irreversible non-steroidal antagonist compound and its use in the treatment of prostate cancer |
JP3191943B2 (ja) | 1997-02-04 | 2001-07-23 | ドン ワ ファーマシューティカル インダストリアル カンパニー リミテッド | 3−アミノ−1,2−ベンゾイソオキサゾール誘導体類とその製造方法及び用途 |
US6013668A (en) | 1997-08-13 | 2000-01-11 | Bristol-Myers Squibb Company | Enantiomers of 4-[[(cyanoimino) [(1,2,2-trimethylpropyl) amino]methyl]amino]benzonitrile |
US6297239B1 (en) | 1997-10-08 | 2001-10-02 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
AU2094700A (en) | 1998-12-04 | 2000-06-26 | Basf Aktiengesellschaft | Method for producing pyrazolylbenzoyl derivatives and novel pyrazolylbenzoyl derivatives |
WO2000034269A1 (en) | 1998-12-09 | 2000-06-15 | American Home Products Corporation | Thiourea inhibitors of herpes viruses |
US6184249B1 (en) | 1998-12-18 | 2001-02-06 | Biophysica, Inc. | Androgen receptor suppressors in the therapy and diagnosis of prostate cancer, alopecia and other hyper-androgenic syndromes |
GB9904786D0 (en) | 1999-03-02 | 1999-04-28 | Merck Sharp & Dohme | Therapeutic agents |
JP2003528802A (ja) | 1999-04-02 | 2003-09-30 | ニューロゲン コーポレイション | N−ベンゾイミダゾリルメチル−及びn−インドリルメチル−ベンズアミド並びにcrf調節物質としてのそれらの使用 |
WO2001056989A2 (en) | 2000-02-01 | 2001-08-09 | Cor Therapeutics, Inc. | Inhibitors of factor xa |
WO2002006196A1 (en) | 2000-07-13 | 2002-01-24 | Merck Patent Gmbh | Chiral compounds i |
BR0113610A (pt) | 2000-08-31 | 2003-06-24 | Pfizer | Derivados da fenoxibenzilamina como inibidores seletivos de recuperação de serotonina |
GB0021670D0 (en) | 2000-09-04 | 2000-10-18 | Astrazeneca Ab | Chemical compounds |
ES2321693T3 (es) * | 2000-09-06 | 2009-06-10 | Emisphere Technologies, Inc. | Compuestos de acido cianofenoxi carboxilico y composiciones para la administracion de agentes activos. |
ATE407924T1 (de) | 2000-10-06 | 2008-09-15 | Mitsubishi Tanabe Pharma Corp | Stickstoffhaltige, fünfgliedrige ringverbindungen |
WO2002036734A2 (en) | 2000-10-12 | 2002-05-10 | Merck & Co., Inc. | Aza-and polyaza-naphthalenyl ketones useful as hiv integrase inhibitors |
ATE337780T1 (de) | 2000-11-24 | 2006-09-15 | Smithkline Beecham Plc | Indoly-lsulphonyl-verbindungen zur behandlung von störungen des zns |
AU2002236775A1 (en) | 2001-01-16 | 2002-07-30 | Seok-Ki Choi | Sodium channel modulators |
MXPA03006885A (es) | 2001-01-31 | 2003-11-13 | Pfizer Prod Inc | Derivados de eteres utiles como agentes inhibidores de las isozimas pde4. |
DE10110438A1 (de) | 2001-03-05 | 2002-09-19 | Bayer Ag | Substituierte 2-Oxy-3,5-dicyano-4-aryl-6-aminopyridine und ihre Verwendung |
PT1377556E (pt) | 2001-04-10 | 2007-06-06 | Pfizer Ltd | Derivados de pirazole para tratamento do hiv |
AR035700A1 (es) | 2001-05-08 | 2004-06-23 | Astrazeneca Ab | Derivados de arilheteroalquilamina, composicion farmaceutica, usos de estos derivados para la fabricacion de medicamentos, metodos de tratamiento, y proceso para la preparacion de estos derivados |
DE10126434A1 (de) | 2001-05-31 | 2002-12-05 | Bayer Ag | Thiochromenone |
GB0202679D0 (en) | 2002-02-05 | 2002-03-20 | Glaxo Group Ltd | Novel compounds |
KR20100112659A (ko) | 2002-02-07 | 2010-10-19 | 지티엑스, 인코포레이티드 | 선택적 안드로겐 수용체 조절자를 이용한 양성 전립선 과형성증의 치료 방법 |
TW200302722A (en) | 2002-02-13 | 2003-08-16 | Astrazeneca Ab | Therapeutic agents |
US6933321B2 (en) * | 2002-02-15 | 2005-08-23 | Endorecherche, Inc. | Antiandrogenic biphenyls |
IL163742A0 (en) | 2002-02-28 | 2005-12-18 | Univ Tennessee Res Foundation | Irreversible selective androgen receptor modulators and methods of use thereof |
JP2005521717A (ja) | 2002-03-26 | 2005-07-21 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | グルココルチコイドミメチックス、その製造方法、その医薬組成物、及び使用 |
EP1348701A1 (en) | 2002-03-28 | 2003-10-01 | Warner-Lambert Company LLC | (2,4-disubstituted-thiazol-5-yl) amine compounds as PDE7 inhibitors |
EP1348433A1 (en) | 2002-03-28 | 2003-10-01 | Warner-Lambert Company LLC | Thiazol-2-yl-imine compounds as PDE-7 inhibitors |
DE10218963A1 (de) * | 2002-04-27 | 2003-11-20 | Aventis Pharma Gmbh | Zubereitungen zur topischen Applikation von antiandrogen wirksamen Substanzen |
US6875438B2 (en) * | 2002-04-27 | 2005-04-05 | Aventis Pharma Deutschland Gmbh | Preparations for topical administration of substances having antiandrogenic activity |
US6951884B2 (en) * | 2002-06-12 | 2005-10-04 | Hoffmann-La Roche Inc. | Fluorobenzamides and uses thereof |
JP4468173B2 (ja) | 2002-08-14 | 2010-05-26 | チバ ホールディング インコーポレーテッド | 緑色光の改善された透明度を有する液晶ディスプレイおよびカラーフィルタ |
US20050288346A1 (en) | 2002-08-26 | 2005-12-29 | Cube Rowena V | Acetophenone potentiators of metabotropic glutamate receptors |
WO2004110994A1 (en) | 2003-06-18 | 2004-12-23 | Pfizer Products Inc. | Novel piperazinyl-aryloxy and piperazinyl-heteroaryloxy-n-aryl lactams |
FI20030958A0 (fi) | 2003-06-27 | 2003-06-27 | Orion Corp | Uusia yhdisteitä |
GB0324551D0 (en) | 2003-10-21 | 2003-11-26 | Karobio Ab | Novel compounds |
JP2007521328A (ja) | 2003-11-20 | 2007-08-02 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | アンドロゲン受容体モジュレーター |
CA2554696C (en) * | 2004-02-13 | 2009-06-30 | Warner-Lambert Company Llc | Androgen receptor modulators |
EP1737813A1 (en) | 2004-04-13 | 2007-01-03 | Warner-Lambert Company LLC | Androgen modulators |
CA2562672C (en) * | 2004-04-22 | 2009-09-29 | Warner-Lambert Company Llc | 4-cyano-phenoxy derivatives as androgen modulators |
ES2307175T3 (es) | 2004-05-07 | 2008-11-16 | Janssen Pharmaceutica Nv | Derivados de adamantil-pirrolidin-2-ona como inhibidores dela 11-beta-hidroxiesteroide-deshidrogenasa. |
WO2006006065A1 (en) * | 2004-07-08 | 2006-01-19 | Warner-Lambert Company Llc | Androgen modulators |
CA2577448A1 (en) * | 2004-08-18 | 2006-02-23 | Warner-Lambert Company Llc | Androgen modulators |
MX2007001248A (es) | 2004-08-18 | 2007-03-23 | Warner Lambert Co | Moduladores de androgenos. |
WO2006024942A1 (en) * | 2004-08-31 | 2006-03-09 | Warner-Lambert Company Llc | Androgen modulators |
DK1807072T3 (da) | 2004-10-29 | 2009-03-16 | Lilly Co Eli | Cycloalkyllactamderivater som inhibitorer af 11-beta-hydroxysteroid-dehydrogenase 1 |
TW200724139A (en) * | 2005-05-05 | 2007-07-01 | Warner Lambert Co | Androgen modulators |
-
2006
- 2006-04-18 TW TW095113833A patent/TW200724139A/zh unknown
- 2006-04-24 JP JP2008509535A patent/JP4174068B1/ja not_active Expired - Fee Related
- 2006-04-24 KR KR1020077025374A patent/KR20070116970A/ko not_active Application Discontinuation
- 2006-04-24 AP AP2007004197A patent/AP1932A/xx active
- 2006-04-24 MX MX2007013823A patent/MX2007013823A/es unknown
- 2006-04-24 AU AU2006242927A patent/AU2006242927A1/en not_active Abandoned
- 2006-04-24 EA EA200702158A patent/EA200702158A1/ru unknown
- 2006-04-24 BR BRPI0610998-5A patent/BRPI0610998A2/pt not_active IP Right Cessation
- 2006-04-24 EP EP06744704A patent/EP1888524A1/en not_active Withdrawn
- 2006-04-24 CA CA2603866A patent/CA2603866C/en not_active Expired - Fee Related
- 2006-04-24 CN CNA2006800145004A patent/CN101166718A/zh active Pending
- 2006-04-24 WO PCT/IB2006/001266 patent/WO2006117677A1/en not_active Application Discontinuation
- 2006-04-26 DO DO2006000097A patent/DOP2006000097A/es unknown
- 2006-05-02 US US11/415,935 patent/US7674819B2/en not_active Expired - Fee Related
- 2006-05-03 AR ARP060101785A patent/AR053721A1/es unknown
- 2006-05-03 PE PE2006000465A patent/PE20061388A1/es not_active Application Discontinuation
- 2006-05-03 UY UY29517A patent/UY29517A1/es not_active Application Discontinuation
- 2006-05-04 GT GT200600187A patent/GT200600187A/es unknown
- 2006-05-04 NL NL1031752A patent/NL1031752C2/nl not_active IP Right Cessation
- 2006-11-07 US US11/557,225 patent/US7799823B2/en not_active Expired - Fee Related
-
2007
- 2007-10-07 IL IL186401A patent/IL186401A0/en unknown
- 2007-10-31 ZA ZA200709385A patent/ZA200709385B/xx unknown
- 2007-11-02 TN TNP2007000409A patent/TNSN07409A1/fr unknown
- 2007-11-02 CR CR9496A patent/CR9496A/es unknown
- 2007-11-05 MA MA30351A patent/MA29516B1/fr unknown
- 2007-11-22 NO NO20076026A patent/NO20076026L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
TNSN07409A1 (fr) | 2009-03-17 |
CA2603866C (en) | 2011-05-31 |
AP1932A (en) | 2008-12-15 |
IL186401A0 (en) | 2008-01-20 |
UY29517A1 (es) | 2006-11-30 |
NL1031752A1 (nl) | 2006-11-13 |
NL1031752C2 (nl) | 2007-03-19 |
US20070072936A1 (en) | 2007-03-29 |
KR20070116970A (ko) | 2007-12-11 |
WO2006117677A1 (en) | 2006-11-09 |
BRPI0610998A2 (pt) | 2010-08-10 |
US7799823B2 (en) | 2010-09-21 |
US20060252796A1 (en) | 2006-11-09 |
CA2603866A1 (en) | 2006-11-09 |
DOP2006000097A (es) | 2006-11-15 |
NO20076026L (no) | 2007-11-22 |
CN101166718A (zh) | 2008-04-23 |
AP2007004197A0 (en) | 2007-10-31 |
TW200724139A (en) | 2007-07-01 |
GT200600187A (es) | 2006-11-28 |
AR053721A1 (es) | 2007-05-16 |
JP2008540397A (ja) | 2008-11-20 |
EP1888524A1 (en) | 2008-02-20 |
MX2007013823A (es) | 2008-02-05 |
ZA200709385B (en) | 2008-10-29 |
AU2006242927A1 (en) | 2006-11-09 |
JP4174068B1 (ja) | 2008-10-29 |
US7674819B2 (en) | 2010-03-09 |
MA29516B1 (fr) | 2008-06-02 |
PE20061388A1 (es) | 2007-01-15 |
EA200702158A1 (ru) | 2008-08-29 |
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