IL163742A0 - Irreversible selective androgen receptor modulators and methods of use thereof - Google Patents
Irreversible selective androgen receptor modulators and methods of use thereofInfo
- Publication number
- IL163742A0 IL163742A0 IL16374203A IL16374203A IL163742A0 IL 163742 A0 IL163742 A0 IL 163742A0 IL 16374203 A IL16374203 A IL 16374203A IL 16374203 A IL16374203 A IL 16374203A IL 163742 A0 IL163742 A0 IL 163742A0
- Authority
- IL
- Israel
- Prior art keywords
- methods
- androgen receptor
- receptor modulators
- selective androgen
- irreversible selective
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C233/05—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/26—Cyanate or isocyanate esters; Thiocyanate or isothiocyanate esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/50—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C261/00—Derivatives of cyanic acid
- C07C261/02—Cyanates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C265/00—Derivatives of isocyanic acid
- C07C265/12—Derivatives of isocyanic acid having isocyanate groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C331/00—Derivatives of thiocyanic acid or of isothiocyanic acid
- C07C331/02—Thiocyanates
- C07C331/10—Thiocyanates having sulfur atoms of thiocyanate groups bound to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C331/00—Derivatives of thiocyanic acid or of isothiocyanic acid
- C07C331/16—Isothiocyanates
- C07C331/28—Isothiocyanates having isothiocyanate groups bound to carbon atoms of six-membered aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Ophthalmology & Optometry (AREA)
- Reproductive Health (AREA)
- Emergency Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8467902A | 2002-02-28 | 2002-02-28 | |
| US42024802P | 2002-10-23 | 2002-10-23 | |
| PCT/US2003/003121 WO2003074473A2 (en) | 2002-02-28 | 2003-02-24 | Irreversible selective androgen receptor modulators and methods of use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL163742A0 true IL163742A0 (en) | 2005-12-18 |
Family
ID=27791168
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL16374203A IL163742A0 (en) | 2002-02-28 | 2003-02-24 | Irreversible selective androgen receptor modulators and methods of use thereof |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1487783A4 (en) |
| JP (1) | JP2005519111A (en) |
| KR (1) | KR20040104463A (en) |
| CN (1) | CN1646479A (en) |
| AU (1) | AU2003214971A1 (en) |
| CA (1) | CA2476651A1 (en) |
| EA (1) | EA200401121A1 (en) |
| HR (1) | HRP20040851A2 (en) |
| IL (1) | IL163742A0 (en) |
| MX (1) | MXPA04008412A (en) |
| TW (1) | TW200304806A (en) |
| WO (1) | WO2003074473A2 (en) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040260108A1 (en) * | 2001-06-25 | 2004-12-23 | Dalton James T. | Metabolites of selective androgen receptor modulators and methods of use thereof |
| AU2003287077B2 (en) * | 2002-10-15 | 2007-09-20 | University Of Tennessee Research Foundation | Methylene-bridged selective androgen receptor modulators and methods of use thereof |
| AU2003287076C1 (en) * | 2002-10-15 | 2010-03-04 | University Of Tennessee Research Foundation | Heterocyclic selective androgen receptor modulators and methods of use thereof |
| WO2004062612A2 (en) * | 2003-01-13 | 2004-07-29 | Gtx Inc. | Large-scale synthesis of selective androgen receptor modulators |
| JP2006516286A (en) * | 2003-01-22 | 2006-06-29 | ジーティーエックス・インコーポレイテッド | Treatment of diseases related to androgen depletion in women by SARM |
| EA200501761A1 (en) * | 2003-12-16 | 2006-04-28 | Джи Ти Икс, ИНК. | PROTECTIVE FORMS OF SELECTIVE MODULATORS OF ANDROGEN RECEPTORS AND METHODS OF THEIR APPLICATION |
| CA2554696C (en) | 2004-02-13 | 2009-06-30 | Warner-Lambert Company Llc | Androgen receptor modulators |
| US7507860B2 (en) | 2004-04-13 | 2009-03-24 | Pfizer Inc. | Androgen modulators |
| CA2562672C (en) | 2004-04-22 | 2009-09-29 | Warner-Lambert Company Llc | 4-cyano-phenoxy derivatives as androgen modulators |
| UA87854C2 (en) | 2004-06-07 | 2009-08-25 | Мерк Энд Ко., Инк. | N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators |
| CA2570047C (en) | 2004-07-08 | 2010-09-28 | Warner-Lambert Company Llc | 4-cycloalkoxy benzonitriles as androgen modulators |
| JP2008509986A (en) * | 2004-08-18 | 2008-04-03 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | Androgen modulator |
| TW200724139A (en) | 2005-05-05 | 2007-07-01 | Warner Lambert Co | Androgen modulators |
| NZ720499A (en) * | 2013-12-23 | 2020-04-24 | Bcn Peptides Sa | Bicalutamide analogs or (s)-bicalutamide as exocytosis activating compounds for use in the treatment of a lysosomal storage disorder or glycogenosis |
| US10806720B2 (en) | 2015-04-21 | 2020-10-20 | University Of Tennessee Research Foundation | Selective androgen receptor degrader (SARD) ligands and methods of use thereof |
| US10654809B2 (en) | 2016-06-10 | 2020-05-19 | University Of Tennessee Research Foundation | Selective androgen receptor degrader (SARD) ligands and methods of use thereof |
| US10865184B2 (en) | 2015-04-21 | 2020-12-15 | University Of Tennessee Research Foundation | Selective androgen receptor degrader (SARD) ligands and methods of use thereof |
| US10093613B2 (en) | 2015-04-21 | 2018-10-09 | Gtx, Inc. | Selective androgen receptor degrader (SARD) ligands and methods of use thereof |
| US11230523B2 (en) | 2016-06-10 | 2022-01-25 | University Of Tennessee Research Foundation | Selective androgen receptor degrader (SARD) ligands and methods of use thereof |
| CN109310664A (en) * | 2016-06-10 | 2019-02-05 | 田纳西大学研究基金会 | Selective androgen receptor degradation agent (SARD) ligand and its application method |
| CN113137836B (en) * | 2021-04-23 | 2023-04-07 | 柳州东风容泰化工股份有限公司 | Drying method and system for preparing o-chlorobenzonitrile |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6071957A (en) * | 1996-11-27 | 2000-06-06 | The University Of Tennessee Research Corporation | Irreversible non-steroidal antagonist compound and its use in the treatment of prostate cancer |
| WO1998053826A1 (en) * | 1997-05-30 | 1998-12-03 | The University Of Tennessee Research Corporation | Non-steroidal agonist compounds and their use in male hormone therapy |
| ES2321933T3 (en) * | 2000-08-24 | 2009-06-15 | University Of Tennessee Research Foundation | SELECTIVE MODULATORS OF THE ANDROGEN RECEIVER AND METHODS OF USE OF THE SAME. |
-
2003
- 2003-02-24 AU AU2003214971A patent/AU2003214971A1/en not_active Abandoned
- 2003-02-24 MX MXPA04008412A patent/MXPA04008412A/en unknown
- 2003-02-24 WO PCT/US2003/003121 patent/WO2003074473A2/en not_active Application Discontinuation
- 2003-02-24 EP EP03710820A patent/EP1487783A4/en not_active Withdrawn
- 2003-02-24 CN CNA038047187A patent/CN1646479A/en active Pending
- 2003-02-24 IL IL16374203A patent/IL163742A0/en unknown
- 2003-02-24 KR KR10-2004-7013473A patent/KR20040104463A/en not_active Application Discontinuation
- 2003-02-24 EA EA200401121A patent/EA200401121A1/en unknown
- 2003-02-24 CA CA002476651A patent/CA2476651A1/en not_active Abandoned
- 2003-02-24 JP JP2003572945A patent/JP2005519111A/en active Pending
- 2003-02-27 TW TW092104206A patent/TW200304806A/en unknown
-
2004
- 2004-09-16 HR HR20040851A patent/HRP20040851A2/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| HRP20040851A2 (en) | 2005-02-28 |
| KR20040104463A (en) | 2004-12-10 |
| EP1487783A4 (en) | 2006-09-27 |
| JP2005519111A (en) | 2005-06-30 |
| EA200401121A1 (en) | 2005-10-27 |
| WO2003074473A3 (en) | 2003-12-18 |
| WO2003074473A2 (en) | 2003-09-12 |
| AU2003214971A1 (en) | 2003-09-16 |
| CN1646479A (en) | 2005-07-27 |
| EP1487783A2 (en) | 2004-12-22 |
| TW200304806A (en) | 2003-10-16 |
| CA2476651A1 (en) | 2003-09-12 |
| MXPA04008412A (en) | 2005-05-17 |
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