EP1487783A4 - Irreversible selective androgen receptor modulators and methods of use thereof - Google Patents

Irreversible selective androgen receptor modulators and methods of use thereof

Info

Publication number
EP1487783A4
EP1487783A4 EP03710820A EP03710820A EP1487783A4 EP 1487783 A4 EP1487783 A4 EP 1487783A4 EP 03710820 A EP03710820 A EP 03710820A EP 03710820 A EP03710820 A EP 03710820A EP 1487783 A4 EP1487783 A4 EP 1487783A4
Authority
EP
European Patent Office
Prior art keywords
methods
androgen receptor
receptor modulators
selective androgen
irreversible selective
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP03710820A
Other languages
German (de)
French (fr)
Other versions
EP1487783A2 (en
Inventor
James Dalton
Duane D Miller
Leonid I Kirkovsky
Dong Jin Hwang
Mitchell S Steiner
Karen A Veverka
Arnab Mukherjee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Tennessee Research Foundation
Original Assignee
University of Tennessee Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Tennessee Research Foundation filed Critical University of Tennessee Research Foundation
Publication of EP1487783A2 publication Critical patent/EP1487783A2/en
Publication of EP1487783A4 publication Critical patent/EP1487783A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C233/05—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/26—Cyanate or isocyanate esters; Thiocyanate or isothiocyanate esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/50—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C261/00—Derivatives of cyanic acid
    • C07C261/02—Cyanates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C265/00—Derivatives of isocyanic acid
    • C07C265/12—Derivatives of isocyanic acid having isocyanate groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C331/00—Derivatives of thiocyanic acid or of isothiocyanic acid
    • C07C331/02—Thiocyanates
    • C07C331/10—Thiocyanates having sulfur atoms of thiocyanate groups bound to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C331/00—Derivatives of thiocyanic acid or of isothiocyanic acid
    • C07C331/16—Isothiocyanates
    • C07C331/28—Isothiocyanates having isothiocyanate groups bound to carbon atoms of six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Emergency Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
EP03710820A 2002-02-28 2003-02-24 Irreversible selective androgen receptor modulators and methods of use thereof Withdrawn EP1487783A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US8467902A 2002-02-28 2002-02-28
US453704P 2002-02-28
US42024802P 2002-10-23 2002-10-23
US420248P 2002-10-23
PCT/US2003/003121 WO2003074473A2 (en) 2002-02-28 2003-02-24 Irreversible selective androgen receptor modulators and methods of use thereof

Publications (2)

Publication Number Publication Date
EP1487783A2 EP1487783A2 (en) 2004-12-22
EP1487783A4 true EP1487783A4 (en) 2006-09-27

Family

ID=27791168

Family Applications (1)

Application Number Title Priority Date Filing Date
EP03710820A Withdrawn EP1487783A4 (en) 2002-02-28 2003-02-24 Irreversible selective androgen receptor modulators and methods of use thereof

Country Status (12)

Country Link
EP (1) EP1487783A4 (en)
JP (1) JP2005519111A (en)
KR (1) KR20040104463A (en)
CN (1) CN1646479A (en)
AU (1) AU2003214971A1 (en)
CA (1) CA2476651A1 (en)
EA (1) EA200401121A1 (en)
HR (1) HRP20040851A2 (en)
IL (1) IL163742A0 (en)
MX (1) MXPA04008412A (en)
TW (1) TW200304806A (en)
WO (1) WO2003074473A2 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040260108A1 (en) * 2001-06-25 2004-12-23 Dalton James T. Metabolites of selective androgen receptor modulators and methods of use thereof
US7214693B2 (en) * 2002-10-15 2007-05-08 University Of Tennessee Research Foundation Heterocyclic selective androgen receptor modulators and methods of use thereof
EP1562594A4 (en) * 2002-10-15 2008-12-17 Univ Tennessee Res Foundation Methylene-bridged selective androgen receptor modulators and methods of use thereof
US7968721B2 (en) * 2003-01-13 2011-06-28 University Of Tennessee Research Foundation Large-scale synthesis of selective androgen receptor modulators
US20050032750A1 (en) * 2003-01-22 2005-02-10 Steiner Mitchell S. Treating androgen deficiency in female (ADIF)-associated conditions with SARMS
MXPA06000119A (en) * 2003-12-16 2006-03-21 Gtx Inc Prodrugs of selective androgen receptor modulators and methods of use thereof.
WO2005080320A1 (en) 2004-02-13 2005-09-01 Warner-Lambert Company Llc Androgen receptor modulators
EP1737813A1 (en) 2004-04-13 2007-01-03 Warner-Lambert Company LLC Androgen modulators
CA2562672C (en) 2004-04-22 2009-09-29 Warner-Lambert Company Llc 4-cyano-phenoxy derivatives as androgen modulators
UA87854C2 (en) 2004-06-07 2009-08-25 Мерк Энд Ко., Инк. N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
BRPI0513020A (en) 2004-07-08 2008-04-22 Warner Lambert Co androgen modulators, their uses, pharmaceutical composition, topical pharmaceutical formulation and article of manufacture
BRPI0514469A (en) * 2004-08-18 2008-06-10 Warner Lambert Co androgen modulators
TW200724139A (en) 2005-05-05 2007-07-01 Warner Lambert Co Androgen modulators
PL3086784T3 (en) * 2013-12-23 2019-09-30 Bcn Peptides, S.A. Bicalutamide analogs or (s)-bicalutamide as exocytosis activating compounds for use in the treatment of a lysosomal storage disorder or glycogenosis
US10865184B2 (en) 2015-04-21 2020-12-15 University Of Tennessee Research Foundation Selective androgen receptor degrader (SARD) ligands and methods of use thereof
US10654809B2 (en) 2016-06-10 2020-05-19 University Of Tennessee Research Foundation Selective androgen receptor degrader (SARD) ligands and methods of use thereof
US10093613B2 (en) 2015-04-21 2018-10-09 Gtx, Inc. Selective androgen receptor degrader (SARD) ligands and methods of use thereof
US10806720B2 (en) 2015-04-21 2020-10-20 University Of Tennessee Research Foundation Selective androgen receptor degrader (SARD) ligands and methods of use thereof
US11230523B2 (en) 2016-06-10 2022-01-25 University Of Tennessee Research Foundation Selective androgen receptor degrader (SARD) ligands and methods of use thereof
KR102481319B1 (en) * 2016-06-10 2022-12-26 유니버시티 오브 테네시 리서치 파운데이션 Selective Androgen Receptor Degrader (SARD) Ligands and Methods of Use Thereof
CN113137836B (en) * 2021-04-23 2023-04-07 柳州东风容泰化工股份有限公司 Drying method and system for preparing o-chlorobenzonitrile

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998053826A1 (en) * 1997-05-30 1998-12-03 The University Of Tennessee Research Corporation Non-steroidal agonist compounds and their use in male hormone therapy
WO2002016310A1 (en) * 2000-08-24 2002-02-28 The University Of Tennessee Research Corporation Selective androgen receptor modulators and methods of use thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6071957A (en) * 1996-11-27 2000-06-06 The University Of Tennessee Research Corporation Irreversible non-steroidal antagonist compound and its use in the treatment of prostate cancer

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998053826A1 (en) * 1997-05-30 1998-12-03 The University Of Tennessee Research Corporation Non-steroidal agonist compounds and their use in male hormone therapy
WO2002016310A1 (en) * 2000-08-24 2002-02-28 The University Of Tennessee Research Corporation Selective androgen receptor modulators and methods of use thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DALTON J T ET AL: "Discovery of nonsteroidal androgens", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 244, no. 1, 1998, pages 1 - 4, XP002385138, ISSN: 0006-291X *
KIRKOVSKY L. ET AL: "Chiral nonsteroidal affinity ligands for the androgen receptor. 1. Bicalutamide analogues bearing electrophilic groups in the B aromatic ring", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 43, no. 4, 24 February 2000 (2000-02-24), pages 581 - 590, XP002207426, ISSN: 0022-2623 *

Also Published As

Publication number Publication date
EA200401121A1 (en) 2005-10-27
JP2005519111A (en) 2005-06-30
CA2476651A1 (en) 2003-09-12
MXPA04008412A (en) 2005-05-17
EP1487783A2 (en) 2004-12-22
HRP20040851A2 (en) 2005-02-28
TW200304806A (en) 2003-10-16
CN1646479A (en) 2005-07-27
WO2003074473A3 (en) 2003-12-18
KR20040104463A (en) 2004-12-10
IL163742A0 (en) 2005-12-18
AU2003214971A1 (en) 2003-09-16
WO2003074473A2 (en) 2003-09-12

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Inventor name: MUKHERJEE, ARNAB

Inventor name: VEVERKA, KAREN, A.

Inventor name: STEINER, MITCHELL, S.

Inventor name: HWANG, DONG JIN

Inventor name: KIRKOVSKY, LEONID, I.

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