EP1487783A4 - Modulateurs irreversibles selectifs de recepteur d'androgene et procede d'utilisation associes - Google Patents
Modulateurs irreversibles selectifs de recepteur d'androgene et procede d'utilisation associesInfo
- Publication number
- EP1487783A4 EP1487783A4 EP03710820A EP03710820A EP1487783A4 EP 1487783 A4 EP1487783 A4 EP 1487783A4 EP 03710820 A EP03710820 A EP 03710820A EP 03710820 A EP03710820 A EP 03710820A EP 1487783 A4 EP1487783 A4 EP 1487783A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- methods
- androgen receptor
- receptor modulators
- selective androgen
- irreversible selective
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C233/05—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/26—Cyanate or isocyanate esters; Thiocyanate or isothiocyanate esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/50—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C261/00—Derivatives of cyanic acid
- C07C261/02—Cyanates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C265/00—Derivatives of isocyanic acid
- C07C265/12—Derivatives of isocyanic acid having isocyanate groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C331/00—Derivatives of thiocyanic acid or of isothiocyanic acid
- C07C331/02—Thiocyanates
- C07C331/10—Thiocyanates having sulfur atoms of thiocyanate groups bound to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C331/00—Derivatives of thiocyanic acid or of isothiocyanic acid
- C07C331/16—Isothiocyanates
- C07C331/28—Isothiocyanates having isothiocyanate groups bound to carbon atoms of six-membered aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Ophthalmology & Optometry (AREA)
- Reproductive Health (AREA)
- Emergency Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8467902A | 2002-02-28 | 2002-02-28 | |
US453704P | 2002-02-28 | ||
US42024802P | 2002-10-23 | 2002-10-23 | |
US420248P | 2002-10-23 | ||
PCT/US2003/003121 WO2003074473A2 (fr) | 2002-02-28 | 2003-02-24 | Modulateurs irreversibles selectifs de recepteur d'androgene et procede d'utilisation associes |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1487783A2 EP1487783A2 (fr) | 2004-12-22 |
EP1487783A4 true EP1487783A4 (fr) | 2006-09-27 |
Family
ID=27791168
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP03710820A Withdrawn EP1487783A4 (fr) | 2002-02-28 | 2003-02-24 | Modulateurs irreversibles selectifs de recepteur d'androgene et procede d'utilisation associes |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP1487783A4 (fr) |
JP (1) | JP2005519111A (fr) |
KR (1) | KR20040104463A (fr) |
CN (1) | CN1646479A (fr) |
AU (1) | AU2003214971A1 (fr) |
CA (1) | CA2476651A1 (fr) |
EA (1) | EA200401121A1 (fr) |
HR (1) | HRP20040851A2 (fr) |
IL (1) | IL163742A0 (fr) |
MX (1) | MXPA04008412A (fr) |
TW (1) | TW200304806A (fr) |
WO (1) | WO2003074473A2 (fr) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040260108A1 (en) * | 2001-06-25 | 2004-12-23 | Dalton James T. | Metabolites of selective androgen receptor modulators and methods of use thereof |
WO2004035738A2 (fr) | 2002-10-15 | 2004-04-29 | University Of Tennessee Research Foundation | Modulateurs selectifs du recepteur des androgenes a liaison methylene et procedes d'utilisation associes |
WO2004035737A2 (fr) * | 2002-10-15 | 2004-04-29 | University Of Tennessee Research Foundation | Modulateurs heterocycliques selectifs du recepteur des androgenes et procedes d'utilisation associes |
WO2004062612A2 (fr) * | 2003-01-13 | 2004-07-29 | Gtx Inc. | Synthese a grande echelle de modulateurs selectifs de recepteur d'androgene |
JP2006516286A (ja) * | 2003-01-22 | 2006-06-29 | ジーティーエックス・インコーポレイテッド | Sarmによる女性のアンドロゲン減少に関連する病気の治療 |
JP2007513998A (ja) * | 2003-12-16 | 2007-05-31 | ジーティーエックス・インコーポレイテッド | 選択的アンドロゲン受容体調節剤のプロドラッグ及びその使用方法 |
BRPI0507670A (pt) | 2004-02-13 | 2007-07-17 | Warner Lambert Co | moduladores do receptor de androgênio |
CA2563291A1 (fr) | 2004-04-13 | 2005-10-27 | Warner-Lambert Company Llc | Derives de 4-cyanophenoxy-alkylcarboxyle comme modulateurs androgenes |
WO2005102990A1 (fr) * | 2004-04-22 | 2005-11-03 | Warner-Lambert Company Llc | Modulateurs des androgenes |
UA87854C2 (en) | 2004-06-07 | 2009-08-25 | Мерк Энд Ко., Инк. | N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators |
EP1781598A1 (fr) | 2004-07-08 | 2007-05-09 | Warner-Lambert Company LLC | Modulateurs d'androgenes |
JP2008509986A (ja) * | 2004-08-18 | 2008-04-03 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | アンドロゲンモジュレーター |
TW200724139A (en) | 2005-05-05 | 2007-07-01 | Warner Lambert Co | Androgen modulators |
CA2934772C (fr) * | 2013-12-23 | 2021-04-27 | Bcn Peptides, S.A. | Analogues de bicalutamide ou (s)-bicalutamide en tant que composes activant l'exocytose destines au traitement de trouble de surcharge lysosomale ou de glycogenose |
US10654809B2 (en) | 2016-06-10 | 2020-05-19 | University Of Tennessee Research Foundation | Selective androgen receptor degrader (SARD) ligands and methods of use thereof |
US10093613B2 (en) | 2015-04-21 | 2018-10-09 | Gtx, Inc. | Selective androgen receptor degrader (SARD) ligands and methods of use thereof |
US10314797B2 (en) * | 2016-06-10 | 2019-06-11 | University Of Tennessee Research Foundation | Selective androgen receptor degrader (SARD) ligands and methods of use thereof |
US10806720B2 (en) | 2015-04-21 | 2020-10-20 | University Of Tennessee Research Foundation | Selective androgen receptor degrader (SARD) ligands and methods of use thereof |
US10865184B2 (en) | 2015-04-21 | 2020-12-15 | University Of Tennessee Research Foundation | Selective androgen receptor degrader (SARD) ligands and methods of use thereof |
US11230523B2 (en) | 2016-06-10 | 2022-01-25 | University Of Tennessee Research Foundation | Selective androgen receptor degrader (SARD) ligands and methods of use thereof |
CN113137836B (zh) * | 2021-04-23 | 2023-04-07 | 柳州东风容泰化工股份有限公司 | 一种制备邻氯苯腈的干燥方法及系统 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998053826A1 (fr) * | 1997-05-30 | 1998-12-03 | The University Of Tennessee Research Corporation | Composes agonistes non steroidiens et leur utilisation dans le cadre de therapies a base d'hormones males |
WO2002016310A1 (fr) * | 2000-08-24 | 2002-02-28 | The University Of Tennessee Research Corporation | Modulateurs selectifs du recepteur androgenique et procedes d'utilisation de ces derniers |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6071957A (en) * | 1996-11-27 | 2000-06-06 | The University Of Tennessee Research Corporation | Irreversible non-steroidal antagonist compound and its use in the treatment of prostate cancer |
-
2003
- 2003-02-24 KR KR10-2004-7013473A patent/KR20040104463A/ko not_active Application Discontinuation
- 2003-02-24 WO PCT/US2003/003121 patent/WO2003074473A2/fr not_active Application Discontinuation
- 2003-02-24 MX MXPA04008412A patent/MXPA04008412A/es unknown
- 2003-02-24 JP JP2003572945A patent/JP2005519111A/ja active Pending
- 2003-02-24 EP EP03710820A patent/EP1487783A4/fr not_active Withdrawn
- 2003-02-24 CA CA002476651A patent/CA2476651A1/fr not_active Abandoned
- 2003-02-24 CN CNA038047187A patent/CN1646479A/zh active Pending
- 2003-02-24 EA EA200401121A patent/EA200401121A1/ru unknown
- 2003-02-24 IL IL16374203A patent/IL163742A0/xx unknown
- 2003-02-24 AU AU2003214971A patent/AU2003214971A1/en not_active Abandoned
- 2003-02-27 TW TW092104206A patent/TW200304806A/zh unknown
-
2004
- 2004-09-16 HR HR20040851A patent/HRP20040851A2/hr not_active Application Discontinuation
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998053826A1 (fr) * | 1997-05-30 | 1998-12-03 | The University Of Tennessee Research Corporation | Composes agonistes non steroidiens et leur utilisation dans le cadre de therapies a base d'hormones males |
WO2002016310A1 (fr) * | 2000-08-24 | 2002-02-28 | The University Of Tennessee Research Corporation | Modulateurs selectifs du recepteur androgenique et procedes d'utilisation de ces derniers |
Non-Patent Citations (2)
Title |
---|
DALTON J T ET AL: "Discovery of nonsteroidal androgens", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 244, no. 1, 1998, pages 1 - 4, XP002385138, ISSN: 0006-291X * |
KIRKOVSKY L. ET AL: "Chiral nonsteroidal affinity ligands for the androgen receptor. 1. Bicalutamide analogues bearing electrophilic groups in the B aromatic ring", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 43, no. 4, 24 February 2000 (2000-02-24), pages 581 - 590, XP002207426, ISSN: 0022-2623 * |
Also Published As
Publication number | Publication date |
---|---|
HRP20040851A2 (en) | 2005-02-28 |
AU2003214971A1 (en) | 2003-09-16 |
JP2005519111A (ja) | 2005-06-30 |
TW200304806A (en) | 2003-10-16 |
EP1487783A2 (fr) | 2004-12-22 |
WO2003074473A2 (fr) | 2003-09-12 |
EA200401121A1 (ru) | 2005-10-27 |
CA2476651A1 (fr) | 2003-09-12 |
MXPA04008412A (es) | 2005-05-17 |
IL163742A0 (en) | 2005-12-18 |
CN1646479A (zh) | 2005-07-27 |
WO2003074473A3 (fr) | 2003-12-18 |
KR20040104463A (ko) | 2004-12-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL165792A0 (en) | N-bridged selective androgen receptor modulators and methods of use thereof | |
EP1562906A4 (fr) | Modulateurs heterocycliques selectifs du recepteur des androgenes et procedes d'utilisation associes | |
EP1562594A4 (fr) | Modulateurs selectifs du recepteur des androgenes a liaison methylene et procedes d'utilisation associes | |
IL163742A0 (en) | Irreversible selective androgen receptor modulators and methods of use thereof | |
EP1420796A4 (fr) | Modulateurs du recepteur des androgenes et leurs procedes d'utilisation | |
IL154425A0 (en) | Selective androgen receptor modulators and methods of use thereof | |
IL178717A0 (en) | Metabolites of selective androgen receptor modulators and methods of use thereof | |
AU2003251970A8 (en) | Modulators of the glucocorticoid receptor and method | |
IL163744A (en) | Multi-substituted selective androgen receptor modulators and uses thereof | |
IL172042A0 (en) | Prodrugs of selective androgen receptor and methods of use thereof | |
AU2003259717A8 (en) | Modulators of rabggt and methods of use thereof | |
EP1718626A4 (fr) | Modulateurs sulfonylpyrrolodines de la fonction du recepteur des androgenes et procede | |
AU2003288902A8 (en) | Microcapsules and methods of use | |
EP1691729A4 (fr) | Dispositif d'encapsulation et procedes d'utilisation | |
EP1521747A4 (fr) | Modulateurs de kinase de type recepteur et procedes d'utilisation | |
AU2003294264A8 (en) | Non-steroidal farnesoid x receptor modulators and methods for the use thereof | |
TWI340738B (en) | Modulators of the glucocorticoid receptor | |
EP1663204A4 (fr) | Modulateurs c-kit et leurs procedes d'utilisation | |
GB2395196B (en) | Microfluidic device and methods for construction and application | |
AU2003290869A8 (en) | Embolization device and a method of using the same | |
HK1079789A1 (zh) | 血管靜態毒性試劑及其使用方法 | |
EP1474445A4 (fr) | Glyco-isoformes d'adiponectine, et utilisations correspondantes | |
EP1610774A4 (fr) | Modulateurs de tie-2 et procedes d'utilisation | |
EP1611123A4 (fr) | Modulateurs de tie-2 et procedes d'utilisation | |
EP1622567A4 (fr) | Modulateurs du recepteur d'androgenes et leur methode d'utilisation |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20040928 |
|
AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT SE SI SK TR |
|
AX | Request for extension of the european patent |
Extension state: AL LT LV MK RO |
|
RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: MUKHERJEE, ARNAB Inventor name: VEVERKA, KAREN, A. Inventor name: STEINER, MITCHELL, S. Inventor name: HWANG, DONG JIN Inventor name: KIRKOVSKY, LEONID, I. Inventor name: MILLER, DUANE, D. Inventor name: DALTON, JAMES |
|
REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 1068130 Country of ref document: HK |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20060824 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20060901 |
|
REG | Reference to a national code |
Ref country code: HK Ref legal event code: WD Ref document number: 1068130 Country of ref document: HK |