BRPI0507670A - moduladores do receptor de androgênio - Google Patents
moduladores do receptor de androgênioInfo
- Publication number
- BRPI0507670A BRPI0507670A BRPI0507670-6A BRPI0507670A BRPI0507670A BR PI0507670 A BRPI0507670 A BR PI0507670A BR PI0507670 A BRPI0507670 A BR PI0507670A BR PI0507670 A BRPI0507670 A BR PI0507670A
- Authority
- BR
- Brazil
- Prior art keywords
- androgen receptor
- receptor modulators
- modulators
- androgen
- oxobenzonitriles
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
MODULADORES DO RECPTOR DE ANDROGêNIO A presnete invenção refer-se a uma nova classe de 4-oxobenzonitrilas, o uso das mesmas como moduladores de androgênio e ao seu uso para o tratamento da alopecia.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US54473804P | 2004-02-13 | 2004-02-13 | |
US60564704P | 2004-08-30 | 2004-08-30 | |
PCT/IB2005/000229 WO2005080320A1 (en) | 2004-02-13 | 2005-01-31 | Androgen receptor modulators |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0507670A true BRPI0507670A (pt) | 2007-07-17 |
Family
ID=34890476
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0507670-6A BRPI0507670A (pt) | 2004-02-13 | 2005-01-31 | moduladores do receptor de androgênio |
Country Status (20)
Country | Link |
---|---|
US (1) | US7576128B2 (pt) |
EP (1) | EP1716110A1 (pt) |
JP (1) | JP3997255B2 (pt) |
KR (1) | KR100783255B1 (pt) |
AP (1) | AP2006003700A0 (pt) |
AR (1) | AR047606A1 (pt) |
AU (1) | AU2005214167B2 (pt) |
BR (1) | BRPI0507670A (pt) |
CA (1) | CA2554696C (pt) |
CR (1) | CR8555A (pt) |
EA (1) | EA009902B1 (pt) |
EC (1) | ECSP066761A (pt) |
IL (1) | IL176935A0 (pt) |
MA (1) | MA28361A1 (pt) |
NO (1) | NO20064053L (pt) |
PA (1) | PA8623501A1 (pt) |
PE (1) | PE20051168A1 (pt) |
TW (1) | TW200534842A (pt) |
UY (1) | UY28746A1 (pt) |
WO (1) | WO2005080320A1 (pt) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1737813A1 (en) | 2004-04-13 | 2007-01-03 | Warner-Lambert Company LLC | Androgen modulators |
CA2562672C (en) | 2004-04-22 | 2009-09-29 | Warner-Lambert Company Llc | 4-cyano-phenoxy derivatives as androgen modulators |
JP4874965B2 (ja) * | 2004-07-08 | 2012-02-15 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | アンドロゲン調節剤 |
BRPI0514469A (pt) * | 2004-08-18 | 2008-06-10 | Warner Lambert Co | moduladores de androgênio |
KR20070049238A (ko) * | 2004-08-31 | 2007-05-10 | 워너-램버트 캄파니 엘엘씨 | 안드로겐 조절제 |
TW200724139A (en) | 2005-05-05 | 2007-07-01 | Warner Lambert Co | Androgen modulators |
TW200708499A (en) * | 2005-06-22 | 2007-03-01 | Warner Lambert Co | Process for producing ethers |
WO2007007149A1 (en) * | 2005-07-12 | 2007-01-18 | Warner-Lambert Company Llc | Androgen modulators |
US20090170886A1 (en) * | 2005-08-08 | 2009-07-02 | Pfizer Inc | Androgen modulators |
EP3108879A1 (en) * | 2015-06-25 | 2016-12-28 | Cassiopea S.p.A. | High concentration formulation |
EP3833343B1 (en) | 2018-08-07 | 2024-02-21 | Emory University | Heterocyclic flavone derivatives, compositions, and methods related thereto |
Family Cites Families (95)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE298470C (pt) | ||||
US6124343A (en) * | 1919-01-27 | 2000-09-26 | Rhone-Poulenc Rorer Limited | Substituted phenyl compounds with a substituent having a thienyl ring |
US3535365A (en) * | 1967-11-29 | 1970-10-20 | Merck & Co Inc | Preparation of 2,6-dichloro-4-methoxy-benzonitrile |
DE2062349A1 (de) | 1970-12-18 | 1972-06-29 | Farbenfabriken Bayer Ag, 5090 Leverkusen | Aminoaryloxy-ary!carbonsäurenitrile und ein Verfahren zu ihrer Herstellung |
SU469247A3 (ru) | 1972-01-14 | 1975-04-30 | Майлз Лабораториз Инк (Фирма) | Способ получени производных хромона |
US4029493A (en) | 1973-02-23 | 1977-06-14 | Mobil Oil Corporation | Substituted phenoxybenzonitriles as herbicides |
AT330150B (de) * | 1973-02-28 | 1976-06-10 | Boehringer Sohn Ingelheim | Verfahren zur herstellung von neuen 1-phenoxy-2-hydroxy -3- propargylaminopropanen und von deren saureadditionssalzen |
FR2397387A1 (fr) * | 1976-04-27 | 1979-02-09 | Serobiologiques Lab Sa | 4,4'-bis-formyl-polyhalo-diphenoxyalcanes, procede de preparation et application a la synthese de 4,4'-dicyano-polyhalo-diphenoxyalcanes |
US4234595A (en) * | 1977-07-13 | 1980-11-18 | Mead Johnson & Company | 3-Indolyl-tertiary butylaminopropanols |
EP0002309B1 (en) | 1977-10-12 | 1982-12-01 | Imperial Chemical Industries Plc | Acylanilides, process for their manufacture and pharmaceutical and veterinary compositions containing them |
DD150456A5 (de) | 1979-03-01 | 1981-09-02 | Ciba Geigy Ag | Verfahren zur herstellung von derivaten des 3-amino-1,2-propandiols |
US4567201A (en) | 1981-11-25 | 1986-01-28 | Takeda Chemical Industries, Ltd. | Diphenoxypropane derivatives and compositions of antiasthmatic and antiinflammatory agents thereof |
GB8504093D0 (en) | 1985-02-18 | 1985-03-20 | Ici Plc | Alkene alkyne/cycloalkylene derivatives |
ATE28864T1 (de) | 1982-07-23 | 1987-08-15 | Ici Plc | Amide-derivate. |
EP0107759B1 (de) | 1982-08-26 | 1992-12-16 | MERCK PATENT GmbH | Cyclohexanderivate und ihre Verwendung als Komponenten Flüssigkristalliner-Dielektrika |
JPS59144747A (ja) | 1983-02-04 | 1984-08-18 | Chisso Corp | 2−クロロ−4−アルキルオキシベンゾニトリル化合物 |
US4536321A (en) | 1983-02-18 | 1985-08-20 | Chisso Corporation | Fluorobenzene derivatives and liquid crystal compositions containing the same |
DE3515633A1 (de) | 1985-05-02 | 1986-11-06 | Merck Patent Gmbh, 6100 Darmstadt | Benzonitrile |
PH23700A (en) | 1985-10-01 | 1989-09-27 | Ciba Geigy Ag | Microbicides |
EP0269383A3 (en) | 1986-11-21 | 1990-05-02 | A.H. Robins Company, Incorporated | 1-Aryloxy-4-[(4-aryl)-1-piperazinyl]-2-butanols useful as antiallergy agents |
JPS63227502A (ja) | 1987-03-17 | 1988-09-21 | Sds Biotech Kk | 防菌防カビ剤 |
US4992433A (en) * | 1987-11-23 | 1991-02-12 | Janssen Pharmaceutica N.V. | Novel pyridazinamine derivatives |
US4925590A (en) * | 1988-03-10 | 1990-05-15 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Derivatives of 4-cyano-2,3-difluorophenol |
DE3825170A1 (de) | 1988-07-23 | 1990-01-25 | Hoechst Ag | Substituierte 5-(4-(4,5-dihydro-2-oxazolyl)-phenoxyalkylenoxyalkyl)-isoxazole, verfahren sowie 5-(phenoxyalkylenoxyalkyl)-isoxazole als zwischenprodukte zu ihrer herstellung und ihre verwendung zur bekaempfung von krankheiten, die durch infektion mit viren hervorgerufen wurden |
JPH03141264A (ja) | 1989-08-10 | 1991-06-17 | Glaxo Inc | 強心活性およびベータ遮断活性を有するピリダジノン |
US5051431A (en) | 1989-09-22 | 1991-09-24 | Glaxo Inc. | Pyridone nitriles useful in treating cardiovascular disease |
DE4017019A1 (de) | 1990-05-26 | 1991-11-28 | Hoechst Ag | Verwendung von substituierten ss-hydroxyethylaminen als potente hemmstoffe der exoenzyme von pilzen |
JPH04124183A (ja) | 1990-09-14 | 1992-04-24 | Mitsubishi Rayon Co Ltd | 光学活性パントラクトン誘導体 |
GB9025828D0 (en) | 1990-11-28 | 1991-01-09 | Shell Int Research | Herbicidal carboxamide derivatives |
JP3088777B2 (ja) | 1991-03-27 | 2000-09-18 | 富士薬品工業株式会社 | 新規光学分割剤及びそれを用いる光学活性アミンの製造方法 |
US5320825A (en) | 1991-05-01 | 1994-06-14 | Trustees Of The University Of Pennsylvania | Serotonin reuptake inhibitors for S.P.E.C.T. imaging |
JP3151929B2 (ja) | 1992-05-15 | 2001-04-03 | 大日本インキ化学工業株式会社 | フルオロシクロヘキセン誘導体 |
DE4217928A1 (de) | 1992-05-30 | 1993-12-02 | Hoechst Ag | Neue Mischungen aus Herbiziden und Antidots, neue (Hetero-)Aryloxy-Verbindungen, Verfahren zu deren Herstellung, diese enthaltenden Mittel und deren Verwendung |
JPH0641038A (ja) | 1992-07-17 | 1994-02-15 | Mitsubishi Kasei Corp | カルボン酸誘導体 |
WO1994005153A1 (en) | 1992-09-09 | 1994-03-17 | E.I. Du Pont De Nemours And Company | Herbicidal benzene compounds |
US5455274A (en) | 1992-12-09 | 1995-10-03 | Ciba-Geigy Corporation | Hydroxyamidine derivatives |
US5316755A (en) * | 1993-02-02 | 1994-05-31 | Sterling Winthrop Inc. | Compositions of iodophenoxy alkanes and iodophenyl ethers for visualization of the gastrointestinal tract |
US5326553A (en) | 1993-02-02 | 1994-07-05 | Sterling Winthrop Inc. | Compositions of iodophenoxy alkanes and iodophenyl ethers in film-forming materials for visualization of the gastrointestinal tract |
GB2278054A (en) | 1993-05-18 | 1994-11-23 | Zeneca Ltd | Compounds for the treatment of urinary incontinence |
GB9321162D0 (en) | 1993-10-13 | 1993-12-01 | Boots Co Plc | Therapeutic agents |
DE4339863A1 (de) | 1993-11-23 | 1995-05-24 | Bayer Ag | Substituierte Carbamoyltriazole |
TW262553B (pt) | 1994-03-17 | 1995-11-11 | Hitachi Seisakusyo Kk | |
AU1897795A (en) | 1994-04-21 | 1995-11-16 | Nycomed Imaging As | X-ray contrast compositions containing pharmaceutically acceptable clays |
JPH07309850A (ja) | 1994-05-16 | 1995-11-28 | Canon Inc | 光学活性化合物、それを含有する液晶組成物、それを有する液晶素子及びそれらを用いた表示方法、表示装置 |
EP0684235A1 (en) | 1994-05-27 | 1995-11-29 | Mochida Pharmaceutical Co., Ltd. | Novel azolyl methyl phenyl derivatives having aromatase inhibitory activity |
ES2169102T3 (es) | 1994-10-14 | 2002-07-01 | Merck Patent Gmbh | (r)-(-)-2-(5-(4-fluorfenil)-3-piridilmetilaminometil)-cromano como agente activo sobre el sistema nervioso central. |
JP3802581B2 (ja) | 1995-03-01 | 2006-07-26 | 富山化学工業株式会社 | 新規なビフェニル誘導体またはその塩およびそれらを含有する抗炎症剤 |
JPH08325154A (ja) | 1995-03-31 | 1996-12-10 | Mitsui Toatsu Chem Inc | 安息香酸誘導体およびそれを有効成分として含有するホスホリパーゼa2阻害剤 |
DE19534209A1 (de) * | 1995-09-15 | 1997-03-20 | Jenapharm Gmbh | Hormonales Mittel zur Behandlung der Haut |
US5843983A (en) | 1996-02-15 | 1998-12-01 | Sankyo Company, Limited | Diphenylethane compounds containing a saturated heterocyclic group, their preparation, and their therapeutic use |
ES2127106B1 (es) | 1996-03-21 | 1999-11-16 | Menarini Lab | Derivados benzopiranicos con accion antagonista de los leucotrienos, procedimiento para su preparacion y utilizacion de los mismos. |
DE19612032A1 (de) | 1996-03-27 | 1997-10-09 | Basf Ag | Substituierte 1-Methyl-3-benzyluracile |
JPH107647A (ja) | 1996-06-25 | 1998-01-13 | Yamanouchi Pharmaceut Co Ltd | 新規なチオ尿素誘導体又はその塩 |
US5847166A (en) | 1996-10-10 | 1998-12-08 | Massachusetts Institute Of Technology | Synthesis of aryl ethers |
US6071957A (en) | 1996-11-27 | 2000-06-06 | The University Of Tennessee Research Corporation | Irreversible non-steroidal antagonist compound and its use in the treatment of prostate cancer |
EP1019384A1 (en) | 1997-02-04 | 2000-07-19 | Dong Wha Pharmaceutical Industrial Co. Ltd. | 3-amino-1,2-benzoisoxazole derivatives, process for preparation, and use thereof |
US6013668A (en) * | 1997-08-13 | 2000-01-11 | Bristol-Myers Squibb Company | Enantiomers of 4-[[(cyanoimino) [(1,2,2-trimethylpropyl) amino]methyl]amino]benzonitrile |
RU2192412C2 (ru) * | 1997-09-18 | 2002-11-10 | Басф Акциенгезельшафт | Производные бензамидоксимов, промежуточные продукты, фунгицидные средства, способ борьбы с фитопатогенными грибами |
US6297239B1 (en) | 1997-10-08 | 2001-10-02 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
AU2094700A (en) | 1998-12-04 | 2000-06-26 | Basf Aktiengesellschaft | Method for producing pyrazolylbenzoyl derivatives and novel pyrazolylbenzoyl derivatives |
WO2000034269A1 (en) | 1998-12-09 | 2000-06-15 | American Home Products Corporation | Thiourea inhibitors of herpes viruses |
US6184249B1 (en) | 1998-12-18 | 2001-02-06 | Biophysica, Inc. | Androgen receptor suppressors in the therapy and diagnosis of prostate cancer, alopecia and other hyper-androgenic syndromes |
GB9904786D0 (en) | 1999-03-02 | 1999-04-28 | Merck Sharp & Dohme | Therapeutic agents |
AU3931400A (en) | 1999-04-02 | 2000-10-23 | Neurogen Corporation | N-benzimidazolylmethyl- and n-indolylmethyl-benzamides and their use as crf modulators |
WO2001056989A2 (en) | 2000-02-01 | 2001-08-09 | Cor Therapeutics, Inc. | Inhibitors of factor xa |
ATE384036T1 (de) | 2000-07-13 | 2008-02-15 | Merck Patent Gmbh | Chirale verbindungen i |
WO2002018333A1 (en) | 2000-08-31 | 2002-03-07 | Pfizer Limited | Phenoxybenzylamine derivatives as selective serotonin re-uptake inhibitors |
GB0021670D0 (en) | 2000-09-04 | 2000-10-18 | Astrazeneca Ab | Chemical compounds |
AU2002211805A1 (en) * | 2000-09-06 | 2002-03-22 | Emisphere Technologies, Inc. | Cyanophenoxy carboxylic acid compounds and compositions for delivering active agents |
AU9419701A (en) | 2000-10-06 | 2002-04-22 | Tanabe Seiyaku Co | Aliphatic nitrogenous five-membered ring compounds |
US20050010048A1 (en) | 2000-10-12 | 2005-01-13 | Linghang Zhuang | Aza-and polyaza-naphthalenly ketones useful as hiv integrase inhibitors |
JP2004517072A (ja) | 2000-11-24 | 2004-06-10 | スミスクライン ビーチャム パブリック リミテッド カンパニー | Cns障害の治療において有用な化合物 |
US6646012B2 (en) | 2001-01-16 | 2003-11-11 | Theravance, Inc. | Sodium channel modulators |
PL364910A1 (en) | 2001-01-31 | 2004-12-27 | Pfizer Products Inc. | Ether derivatives useful as inhibitors of pde4 isozymes |
DE10110438A1 (de) | 2001-03-05 | 2002-09-19 | Bayer Ag | Substituierte 2-Oxy-3,5-dicyano-4-aryl-6-aminopyridine und ihre Verwendung |
WO2002085860A1 (en) | 2001-04-10 | 2002-10-31 | Pfizer Limited | Pyrazole derivatives for treating hiv |
AR035700A1 (es) | 2001-05-08 | 2004-06-23 | Astrazeneca Ab | Derivados de arilheteroalquilamina, composicion farmaceutica, usos de estos derivados para la fabricacion de medicamentos, metodos de tratamiento, y proceso para la preparacion de estos derivados |
DE10126434A1 (de) | 2001-05-31 | 2002-12-05 | Bayer Ag | Thiochromenone |
GB0202679D0 (en) | 2002-02-05 | 2002-03-20 | Glaxo Group Ltd | Novel compounds |
EA200901492A1 (ru) | 2002-02-07 | 2010-08-30 | Юниверсити Оф Теннесси Рисерч Фаундейшн | Лечение доброкачественной гиперплазии простаты селективным модулятором рецептора андрогенов (sarm) |
TW200302722A (en) | 2002-02-13 | 2003-08-16 | Astrazeneca Ab | Therapeutic agents |
MXPA04007870A (es) * | 2002-02-15 | 2005-06-20 | Endorech Inc | Derivados de bifenilo y su uso como agentes antiandrogenicos. |
AU2003214971A1 (en) | 2002-02-28 | 2003-09-16 | University Of Tennessee Research Foundation | Irreversible selective androgen receptor modulators and methods of use thereof |
AU2003230700A1 (en) | 2002-03-26 | 2003-10-13 | Boehringer Ingelheim Pharmaceuticals, Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof |
EP1348433A1 (en) | 2002-03-28 | 2003-10-01 | Warner-Lambert Company LLC | Thiazol-2-yl-imine compounds as PDE-7 inhibitors |
EP1348701A1 (en) | 2002-03-28 | 2003-10-01 | Warner-Lambert Company LLC | (2,4-disubstituted-thiazol-5-yl) amine compounds as PDE7 inhibitors |
DE10218963A1 (de) * | 2002-04-27 | 2003-11-20 | Aventis Pharma Gmbh | Zubereitungen zur topischen Applikation von antiandrogen wirksamen Substanzen |
US6875438B2 (en) * | 2002-04-27 | 2005-04-05 | Aventis Pharma Deutschland Gmbh | Preparations for topical administration of substances having antiandrogenic activity |
US6951884B2 (en) * | 2002-06-12 | 2005-10-04 | Hoffmann-La Roche Inc. | Fluorobenzamides and uses thereof |
US7582230B2 (en) | 2002-08-14 | 2009-09-01 | Ciba Specialty Chemicals Corporation | Liquid crystal display and colour filter with improved transparency for green light |
WO2004018386A2 (en) | 2002-08-26 | 2004-03-04 | Merck & Co., Inc. | Acetophenone potentiators of metabotropic glutamate receptors |
MXPA05013756A (es) | 2003-06-18 | 2006-03-08 | Pfizer Prod Inc | Piperazinil-ariloxi y piperazinil-heteroariloxi-n-aril-lactamas novedosas. |
FI20030958A0 (fi) | 2003-06-27 | 2003-06-27 | Orion Corp | Uusia yhdisteitä |
JP4874965B2 (ja) | 2004-07-08 | 2012-02-15 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | アンドロゲン調節剤 |
TW200708499A (en) * | 2005-06-22 | 2007-03-01 | Warner Lambert Co | Process for producing ethers |
-
2005
- 2005-01-31 BR BRPI0507670-6A patent/BRPI0507670A/pt not_active IP Right Cessation
- 2005-01-31 WO PCT/IB2005/000229 patent/WO2005080320A1/en active Application Filing
- 2005-01-31 EP EP05702380A patent/EP1716110A1/en not_active Withdrawn
- 2005-01-31 JP JP2006552708A patent/JP3997255B2/ja not_active Expired - Fee Related
- 2005-01-31 AP AP2006003700A patent/AP2006003700A0/xx unknown
- 2005-01-31 AU AU2005214167A patent/AU2005214167B2/en not_active Ceased
- 2005-01-31 KR KR1020067016272A patent/KR100783255B1/ko not_active IP Right Cessation
- 2005-01-31 CA CA002554696A patent/CA2554696C/en not_active Expired - Fee Related
- 2005-01-31 EA EA200601267A patent/EA009902B1/ru not_active IP Right Cessation
- 2005-02-03 TW TW094103441A patent/TW200534842A/zh unknown
- 2005-02-08 US US11/053,010 patent/US7576128B2/en not_active Expired - Fee Related
- 2005-02-10 AR ARP050100477A patent/AR047606A1/es not_active Application Discontinuation
- 2005-02-10 PE PE2005000159A patent/PE20051168A1/es not_active Application Discontinuation
- 2005-02-11 PA PA20058623501A patent/PA8623501A1/es unknown
- 2005-02-11 UY UY28746A patent/UY28746A1/es not_active Application Discontinuation
-
2006
- 2006-07-18 IL IL176935A patent/IL176935A0/en unknown
- 2006-08-09 EC EC2006006761A patent/ECSP066761A/es unknown
- 2006-08-10 CR CR8555A patent/CR8555A/es not_active Application Discontinuation
- 2006-08-11 MA MA29267A patent/MA28361A1/fr unknown
- 2006-09-08 NO NO20064053A patent/NO20064053L/no not_active Application Discontinuation
Also Published As
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AR047606A1 (es) | 2006-01-25 |
PA8623501A1 (es) | 2005-08-30 |
JP2007522199A (ja) | 2007-08-09 |
KR20060116223A (ko) | 2006-11-14 |
PE20051168A1 (es) | 2006-02-18 |
US7576128B2 (en) | 2009-08-18 |
AP2006003700A0 (en) | 2006-08-31 |
ECSP066761A (es) | 2006-11-16 |
WO2005080320A1 (en) | 2005-09-01 |
TW200534842A (en) | 2005-11-01 |
US20050182132A1 (en) | 2005-08-18 |
NO20064053L (no) | 2006-11-08 |
CR8555A (es) | 2006-10-17 |
EA009902B1 (ru) | 2008-04-28 |
KR100783255B1 (ko) | 2007-12-06 |
AU2005214167A1 (en) | 2005-09-01 |
UY28746A1 (es) | 2005-09-30 |
MA28361A1 (fr) | 2006-12-01 |
JP3997255B2 (ja) | 2007-10-24 |
CA2554696A1 (en) | 2005-09-01 |
EP1716110A1 (en) | 2006-11-02 |
EA200601267A1 (ru) | 2006-12-29 |
CA2554696C (en) | 2009-06-30 |
IL176935A0 (en) | 2006-12-10 |
AU2005214167B2 (en) | 2008-08-07 |
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