MXPA05013756A - Piperazinil-ariloxi y piperazinil-heteroariloxi-n-aril-lactamas novedosas. - Google Patents
Piperazinil-ariloxi y piperazinil-heteroariloxi-n-aril-lactamas novedosas.Info
- Publication number
- MXPA05013756A MXPA05013756A MXPA05013756A MXPA05013756A MXPA05013756A MX PA05013756 A MXPA05013756 A MX PA05013756A MX PA05013756 A MXPA05013756 A MX PA05013756A MX PA05013756 A MXPA05013756 A MX PA05013756A MX PA05013756 A MXPA05013756 A MX PA05013756A
- Authority
- MX
- Mexico
- Prior art keywords
- piperazinyl
- disorder
- heteroaryloxy
- aryloxy
- novel
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
- C07D211/76—Oxygen atoms attached in position 2 or 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyrrole Compounds (AREA)
Abstract
La presente invencion se refiere a compuestos de Formula I (ver Formula I) en los que Ar, Y y G son como se definio en la memoria descriptiva, a es 1 a 4, Z y W son carbono o nitrogeno y n es 1, 2 o 3; y a composiciones farmaceuticas que comprenden el compuesto de Formula I y un portador farmaceuticamente eficaz y a un metodo util en el tratamiento o prevencion en mamiferos, incluyendo seres humanos, de un trastorno o afeccion seleccionado/a del grupo que consiste en: ansiedad, depresion, distimia, trastorno depresivo grave, jaqueca, trastorno por estres postraumatico, trastorno de la personalidad por evitacion, trastorno de la personalidad fronteriza y fobias.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US47943603P | 2003-06-18 | 2003-06-18 | |
PCT/IB2004/001942 WO2004110994A1 (en) | 2003-06-18 | 2004-06-07 | Novel piperazinyl-aryloxy and piperazinyl-heteroaryloxy-n-aryl lactams |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA05013756A true MXPA05013756A (es) | 2006-03-08 |
Family
ID=33551884
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA05013756A MXPA05013756A (es) | 2003-06-18 | 2004-06-07 | Piperazinil-ariloxi y piperazinil-heteroariloxi-n-aril-lactamas novedosas. |
Country Status (7)
Country | Link |
---|---|
US (1) | US7101885B2 (es) |
EP (1) | EP1638932A1 (es) |
JP (1) | JP2006527757A (es) |
BR (1) | BRPI0410561A (es) |
CA (1) | CA2528644A1 (es) |
MX (1) | MXPA05013756A (es) |
WO (1) | WO2004110994A1 (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3997255B2 (ja) | 2004-02-13 | 2007-10-24 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | アンドロゲンレセプターモジュレーター |
US7507860B2 (en) | 2004-04-13 | 2009-03-24 | Pfizer Inc. | Androgen modulators |
WO2005102990A1 (en) | 2004-04-22 | 2005-11-03 | Warner-Lambert Company Llc | Androgen modulators |
WO2005113535A2 (en) * | 2004-05-21 | 2005-12-01 | Pfizer Products Inc. | Pyrazinylmethyl lactam derivatives |
MXPA06014473A (es) * | 2004-06-25 | 2007-03-01 | Pfizer Prod Inc | Piridil piperazinas para el tratamiento de trastornos de sistema nervioso central. |
BRPI0513020A (pt) | 2004-07-08 | 2008-04-22 | Warner Lambert Co | moduladores de andrÈgenio, seus usos, composição farmacêutica, formulação farmacêutica tópica e artigo de fabricação |
WO2006106416A1 (en) * | 2005-04-08 | 2006-10-12 | Pfizer Products Inc. | PYRIDIL-LACTAMS AND THEIR USE 5 -HTl RECEPTORS LIGAN |
TW200724139A (en) | 2005-05-05 | 2007-07-01 | Warner Lambert Co | Androgen modulators |
CA2725680A1 (en) | 2008-05-30 | 2009-12-03 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
US9586900B2 (en) | 2012-09-05 | 2017-03-07 | Bristol-Myers Squibb Company | Pyrrolone or pyrrolidinone melanin concentrating hormone receptor-1 antagonists |
EP2892897A1 (en) * | 2012-09-05 | 2015-07-15 | Bristol-Myers Squibb Company | Pyrrolone or pyrrolidinone melanin concentrating hormone receptor-1 antagonists |
AR092924A1 (es) | 2012-10-09 | 2015-05-06 | Sanofi Sa | Derivados de pirrolidinona como moduladores de gpr119 para el tratamiento de diabetes, obesidad, dislipidemia y trastornos relacionados |
JP6440625B2 (ja) | 2012-11-14 | 2018-12-19 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 精神分裂病を処置するための方法および組成物 |
AR099937A1 (es) | 2014-04-04 | 2016-08-31 | Sanofi Sa | Compuestos de isoindolinona como moduladores de gpr119 para el tratamiento de diabetes, obesidad, dislipidemia y trastornos relacionados |
AR099936A1 (es) * | 2014-04-04 | 2016-08-31 | Sanofi Sa | Heterociclos condensados sustituidos como moduladores de gpr119 para el tratamiento de la diabetes, obesidad, dislipidemia y trastornos relacionados |
US9896434B2 (en) | 2014-04-04 | 2018-02-20 | Sanofi | Substituted indanone compounds as GPR119 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders |
US10112929B2 (en) | 2015-03-09 | 2018-10-30 | Bristol-Myers Squibb Company | Lactams as inhibitors of rock |
CA2995395C (en) | 2015-08-31 | 2024-04-16 | Nutramax Laboratories, Inc. | Compositions comprising magnolia, phellodendron, theanine and/or whey protein |
AR110988A1 (es) | 2017-02-21 | 2019-05-22 | Sanofi Sa | Compuestos de azetidina como moduladores de gpr119 para el tratamiento de la diabetes, la obesidad, la dislipidemia y trastornos relacionados |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9725931D0 (en) * | 1997-12-05 | 1998-02-04 | Smithkline Beecham Plc | Novel compounds |
TR200200795T2 (tr) * | 1999-09-25 | 2002-07-22 | Smithkline Beecham P. L. C. | 5-HT1B antagonistleri olarak piperazin türevleri |
-
2004
- 2004-06-07 BR BRPI0410561-3A patent/BRPI0410561A/pt not_active IP Right Cessation
- 2004-06-07 JP JP2006516539A patent/JP2006527757A/ja active Pending
- 2004-06-07 WO PCT/IB2004/001942 patent/WO2004110994A1/en not_active Application Discontinuation
- 2004-06-07 CA CA002528644A patent/CA2528644A1/en not_active Abandoned
- 2004-06-07 MX MXPA05013756A patent/MXPA05013756A/es not_active Application Discontinuation
- 2004-06-07 EP EP04736237A patent/EP1638932A1/en not_active Withdrawn
- 2004-06-15 US US10/868,055 patent/US7101885B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2528644A1 (en) | 2004-12-23 |
WO2004110994A1 (en) | 2004-12-23 |
US20040266781A1 (en) | 2004-12-30 |
JP2006527757A (ja) | 2006-12-07 |
BRPI0410561A (pt) | 2006-06-20 |
US7101885B2 (en) | 2006-09-05 |
EP1638932A1 (en) | 2006-03-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MXPA05013756A (es) | Piperazinil-ariloxi y piperazinil-heteroariloxi-n-aril-lactamas novedosas. | |
MXPA04000622A (es) | Pirazolilcarboxanilidas como funguicidas. | |
EP1478322A4 (en) | Beta 2'-OR 3'-HALONUCLEOSIDE | |
WO2002100845A8 (en) | Hv protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis | |
IL160440A (en) | Dihydropteridinones, method for producing the same and the use thereof as medicaments | |
WO2005035525A3 (en) | 2-amido-4-aryloxy-1-carbonylpyrrolidine derivatives as inhibitors of serine proteases, particularly hcv ns3-ns4a protease | |
MXPA03011006A (es) | Compuestos de cicloalquil urea benzo-fusionados 1,4-disustituidos. | |
MX9701893A (es) | Nuevos inhibidores de la prostaglandinsintasa. | |
WO2003087092A3 (en) | Inhibitors of serine proteases, particularly hepatitis c virus ns3 - ns4 protease | |
AU2003301959A1 (en) | Substituted cycloalkyl p1' hepatitis c virus inhibitors | |
DE60214179D1 (de) | IMIDAZOi1,2-AöPYRIDIN-DERIVATE ZUR PROPHYLAXE UND BEHANDLUNG VON HERPES-INFEKTIONEN | |
TW200716556A (en) | Methods of synthesizing 6-alkylaminoquinoline derivatives | |
ATE432278T1 (de) | Verbindungen zur behandlung von krankheiten | |
CY1109906T1 (el) | Παραγωγα c3-kyano εποθιλονης | |
EA199800620A1 (ru) | Замещенные n-[(аминоиминометил или аминометил)фенил] пропиламиды | |
MXPA05013059A (es) | Derivados de 2-amino-piridina como agonistas del adrenoceptor beta-2. | |
MXPA03010724A (es) | Compuestos de carbamato y oxamida como inhibidores de la produccion de citocina. | |
ATE364043T1 (de) | Pyrazolo-pyridine für die behandlung von herpes- ansteckungen | |
MXPA05010440A (es) | Amidas del acido isoquinolina-5-sulfonico como inhibidores de la akt (proteina quinasa b). | |
WO2003099266A3 (en) | Acetamides and benzamides that are useful in treating sexual dysfunction | |
WO2003039480A3 (en) | Method of treating disorder related to high cholesterol concentration | |
TW200505865A (en) | Compounds useful for the treatment of diseases | |
MXPA05012391A (es) | Tratamiento de trastornos psicoticos y depresivos. | |
DE60222899D1 (de) | Verbindungen, verfahren und zusammensetzungen für die behandlung von infektionen mit dem rinderdiarrhö-virus (bvdv) und dem hepatitis-c-virus (hcv) | |
GB0216001D0 (en) | Process and composition |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |