PE20051168A1 - Benzonitrilos derivados como moduladores de receptores de androgenos - Google Patents

Benzonitrilos derivados como moduladores de receptores de androgenos

Info

Publication number
PE20051168A1
PE20051168A1 PE2005000159A PE2005000159A PE20051168A1 PE 20051168 A1 PE20051168 A1 PE 20051168A1 PE 2005000159 A PE2005000159 A PE 2005000159A PE 2005000159 A PE2005000159 A PE 2005000159A PE 20051168 A1 PE20051168 A1 PE 20051168A1
Authority
PE
Peru
Prior art keywords
haloalkyl
hydroxy
benzonitrile
trifluoromethyl
halogen
Prior art date
Application number
PE2005000159A
Other languages
English (en)
Inventor
Lain-Yen Hu
Huangshu Lei
Daniel Yunlong Du
Bruce Allen Lefker
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of PE20051168A1 publication Critical patent/PE20051168A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens

Abstract

SE REFIERE A UN COMPUESTOS BENZONITRILOS DE FORMULA (I), EN DONDE X1 ES HALOGENO O HALOALQUILO; X2 ES -CR3R4R5 (DONDE CADA R3, R4 Y R5 ES INDEPENDIENTEMENTE H, HALOGENO, ALQUILO(C1-C6), HALOALQUILO, HIDROXI ENTRE OTROS, -CH=CH2 O CHºCH; R1 Y R2 SON H, HALOGENO, ALQUILO(C1-C6), HALOALQUILO, HIDROXIALQUILO, TIOL Y TIOALQUILO; ALK1 ES ALQUILENO LINEAL(C1-C8) EN EL QUE HASTA 8 HIDROGENOS PUEDEN REEMPLAZARSE POR ALQUILO(C1-C6), HALOALQUILO, HALOGENO, HIDROXI, HIDROXIALQUILO, ENTRE OTROS; n ES 0, 1. SON COMPUESTOS PREFERIDOS: (1S,2S)-4-(2-HIDROXI-1-METIL-PROPOXI)-2-TRIFLUOROMETIL-BENZONITRILO, (1R,2R)-4-(2-HIDROXI-1-METIL-PROPOXI)-2-TRIFLUOROMETIL-BENZONITRILO, 4-(2-HIDROXI-1-METIL-PROPOXI)-2-TRIFLUOROMETIL-BENZONITRILO, ENTRE OTROS.TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA DE ADMINISTRACION TOPICA. ESTOS COMPUESTOS SON MODULADORES DE RECEPTORES DE ANDROGENOS POR LO QUE SON UTILES EN EL TRATAMIENTO DE ACNE, ALOPECIA Y PIEL GRASA
PE2005000159A 2004-02-13 2005-02-10 Benzonitrilos derivados como moduladores de receptores de androgenos PE20051168A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54473804P 2004-02-13 2004-02-13
US60564704P 2004-08-30 2004-08-30

Publications (1)

Publication Number Publication Date
PE20051168A1 true PE20051168A1 (es) 2006-02-18

Family

ID=34890476

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2005000159A PE20051168A1 (es) 2004-02-13 2005-02-10 Benzonitrilos derivados como moduladores de receptores de androgenos

Country Status (20)

Country Link
US (1) US7576128B2 (es)
EP (1) EP1716110A1 (es)
JP (1) JP3997255B2 (es)
KR (1) KR100783255B1 (es)
AP (1) AP2006003700A0 (es)
AR (1) AR047606A1 (es)
AU (1) AU2005214167B2 (es)
BR (1) BRPI0507670A (es)
CA (1) CA2554696C (es)
CR (1) CR8555A (es)
EA (1) EA009902B1 (es)
EC (1) ECSP066761A (es)
IL (1) IL176935A0 (es)
MA (1) MA28361A1 (es)
NO (1) NO20064053L (es)
PA (1) PA8623501A1 (es)
PE (1) PE20051168A1 (es)
TW (1) TW200534842A (es)
UY (1) UY28746A1 (es)
WO (1) WO2005080320A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1737813A1 (en) 2004-04-13 2007-01-03 Warner-Lambert Company LLC Androgen modulators
EP1740533A1 (en) 2004-04-22 2007-01-10 Warner-Lambert Company LLC Androgen modulators
JP4874965B2 (ja) 2004-07-08 2012-02-15 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー アンドロゲン調節剤
CA2573457A1 (en) * 2004-08-18 2006-02-23 Warner-Lambert Company Llc 4-(2-methoxy-phenoxy)-2-trifluoromethyl-benzonitrile as an androgen modulator
BRPI0514706A (pt) * 2004-08-31 2008-06-24 Warner Lambert Co moduladores de androgênio
TW200724139A (en) 2005-05-05 2007-07-01 Warner Lambert Co Androgen modulators
TW200708499A (en) * 2005-06-22 2007-03-01 Warner Lambert Co Process for producing ethers
WO2007007149A1 (en) * 2005-07-12 2007-01-18 Warner-Lambert Company Llc Androgen modulators
US20090170886A1 (en) * 2005-08-08 2009-07-02 Pfizer Inc Androgen modulators
EP3108879A1 (en) * 2015-06-25 2016-12-28 Cassiopea S.p.A. High concentration formulation
EP3833343B1 (en) * 2018-08-07 2024-02-21 Emory University Heterocyclic flavone derivatives, compositions, and methods related thereto

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Also Published As

Publication number Publication date
JP2007522199A (ja) 2007-08-09
AU2005214167B2 (en) 2008-08-07
TW200534842A (en) 2005-11-01
WO2005080320A1 (en) 2005-09-01
JP3997255B2 (ja) 2007-10-24
IL176935A0 (en) 2006-12-10
AP2006003700A0 (en) 2006-08-31
CR8555A (es) 2006-10-17
NO20064053L (no) 2006-11-08
CA2554696C (en) 2009-06-30
KR20060116223A (ko) 2006-11-14
CA2554696A1 (en) 2005-09-01
MA28361A1 (fr) 2006-12-01
US7576128B2 (en) 2009-08-18
EP1716110A1 (en) 2006-11-02
PA8623501A1 (es) 2005-08-30
AU2005214167A1 (en) 2005-09-01
US20050182132A1 (en) 2005-08-18
UY28746A1 (es) 2005-09-30
EA200601267A1 (ru) 2006-12-29
BRPI0507670A (pt) 2007-07-17
EA009902B1 (ru) 2008-04-28
KR100783255B1 (ko) 2007-12-06
ECSP066761A (es) 2006-11-16
AR047606A1 (es) 2006-01-25

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