CL2008003825A1 - Compuestos derivados de 4-pirrolidinbenzonitrilo, moduladores selectivos de receptores de androgeno; composicion farmaceutica; kit farmaceutico; y su uso en el tratamiento de una enfermedad o trastorno seleccionada de piel envejecida, enfermedad de alzheimer, anemia, artritis, gota, arterosclerosis, enfermedad osea, entre otras. - Google Patents
Compuestos derivados de 4-pirrolidinbenzonitrilo, moduladores selectivos de receptores de androgeno; composicion farmaceutica; kit farmaceutico; y su uso en el tratamiento de una enfermedad o trastorno seleccionada de piel envejecida, enfermedad de alzheimer, anemia, artritis, gota, arterosclerosis, enfermedad osea, entre otras.Info
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- CL2008003825A1 CL2008003825A1 CL2008003825A CL2008003825A CL2008003825A1 CL 2008003825 A1 CL2008003825 A1 CL 2008003825A1 CL 2008003825 A CL2008003825 A CL 2008003825A CL 2008003825 A CL2008003825 A CL 2008003825A CL 2008003825 A1 CL2008003825 A1 CL 2008003825A1
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- Prior art keywords
- disease
- gout
- anemia
- atherosclerosis
- alzheimer
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
Compuestos moduladores selectivos de receptores de andrógeno derivados de pirrolidin u oxazinoquinolina composición farmacéutica, útil para tratar una enfermedad o trastorno seleccionada de entre piel envejecida, enfermedad de Alzheimer, anemia, anorexia, artritis, gota, arterosclerosis, enfermedad ósea, caquexia, cáncer de mama, disfunción cardiaca.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US873107P | 2007-12-21 | 2007-12-21 | |
PCT/US2008/013657 WO2009082437A2 (en) | 2007-12-21 | 2008-12-12 | Selective androgen receptor modulators (sarms) and uses thereof |
Publications (1)
Publication Number | Publication Date |
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CL2008003825A1 true CL2008003825A1 (es) | 2009-05-29 |
Family
ID=40473943
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CL2008003825A CL2008003825A1 (es) | 2007-12-21 | 2008-12-19 | Compuestos derivados de 4-pirrolidinbenzonitrilo, moduladores selectivos de receptores de androgeno; composicion farmaceutica; kit farmaceutico; y su uso en el tratamiento de una enfermedad o trastorno seleccionada de piel envejecida, enfermedad de alzheimer, anemia, artritis, gota, arterosclerosis, enfermedad osea, entre otras. |
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EP (2) | EP2489656A1 (es) |
JP (2) | JP5539221B2 (es) |
KR (1) | KR101595238B1 (es) |
CN (2) | CN101945853B (es) |
AR (2) | AR092284A1 (es) |
BR (1) | BRPI0821090B8 (es) |
CA (1) | CA2709677C (es) |
CL (1) | CL2008003825A1 (es) |
DK (1) | DK2222636T3 (es) |
ES (1) | ES2413504T3 (es) |
HR (1) | HRP20130552T1 (es) |
MX (1) | MX2010006972A (es) |
PL (1) | PL2222636T3 (es) |
PT (1) | PT2222636E (es) |
TW (1) | TWI437003B (es) |
WO (1) | WO2009082437A2 (es) |
Families Citing this family (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7026484B2 (en) | 2001-02-23 | 2006-04-11 | Ligand Pharmaceuticals Incorporated | Tricyclic androgen receptor modulator compounds and methods |
CN1838956A (zh) | 2003-08-22 | 2006-09-27 | 配体药物公司 | 作为雄激素受体调节剂化合物的6-环氨基-2-喹啉酮衍生物 |
US8519158B2 (en) * | 2004-03-12 | 2013-08-27 | Ligand Pharmaceuticals Incorporated | Androgen receptor modulator compounds and methods |
US9884038B2 (en) | 2004-06-07 | 2018-02-06 | University Of Tennessee Research Foundation | Selective androgen receptor modulator and methods of use thereof |
US9889110B2 (en) | 2004-06-07 | 2018-02-13 | University Of Tennessee Research Foundation | Selective androgen receptor modulator for treating hormone-related conditions |
AU2006259474B2 (en) * | 2005-06-17 | 2011-10-27 | Ligand Pharmaceuticals Incorporated | Androgen receptor modulator compounds and methods |
US7968603B2 (en) | 2007-09-11 | 2011-06-28 | University Of Tennessee Research Foundation | Solid forms of selective androgen receptor modulators |
PT2222636E (pt) | 2007-12-21 | 2013-07-16 | Ligand Pharm Inc | Moduladores seletivos de recetores de andrógeno (sarms) e suas utilizações |
US8268872B2 (en) | 2008-02-22 | 2012-09-18 | Radius Health, Inc. | Selective androgen receptor modulators |
US8067448B2 (en) | 2008-02-22 | 2011-11-29 | Radius Health, Inc. | Selective androgen receptor modulators |
PT2473172E (pt) | 2009-09-01 | 2015-06-25 | Univ Duke | Composições de bisfosfonato e métodos para o tratamento de insuficiência cardíaca |
JP5964756B2 (ja) | 2010-02-04 | 2016-08-03 | ラジウス ヘルス,インコーポレイテッド | 選択的アンドロゲン受容体モジュレーター |
US8642632B2 (en) | 2010-07-02 | 2014-02-04 | Radius Health, Inc. | Selective androgen receptor modulators |
BR112013007685B1 (pt) * | 2010-09-28 | 2021-11-09 | Radius Pharmaceuticals, Inc | Compostos moduladores de receptor andrógeno seletivos, composição farmacêutica compreendendo os referidos compostos, método de identificação de um composto capaz de modular um receptor andrógeno, usos de um composto ou da composição e processo para a preparação de um composto |
SG193389A1 (en) | 2011-03-10 | 2013-10-30 | Xeris Pharmaceuticals Inc | Stable formulations for parenteral injection of peptide drugs |
BR112014010782A2 (pt) * | 2011-11-03 | 2017-06-13 | Gtx Inc | composições farmacêuticas de moduladores de receptor de androgênio seletivos e aplicações das mesmas |
CA2856030A1 (en) | 2011-11-16 | 2013-05-23 | Duke University | Bisphosphonate compositions and methods for treating and/or reducing cardiac dysfunction |
RU2666530C2 (ru) * | 2012-01-12 | 2018-09-11 | Йейл Юниверсити | Соединения и способы усиления деградации белков-мишеней и других полипептидов с помощью е3 убиквитин лигазы |
US9125805B2 (en) * | 2012-06-27 | 2015-09-08 | Xeris Pharmaceuticals, Inc. | Stable formulations for parenteral injection of small molecule drugs |
CA2891234C (en) * | 2012-12-03 | 2017-03-07 | Pfizer Inc. | Selective androgen receptor modulators |
US10441567B2 (en) * | 2014-01-17 | 2019-10-15 | Ligand Pharmaceuticals Incorporated | Methods and compositions for modulating hormone levels |
US9421264B2 (en) | 2014-03-28 | 2016-08-23 | Duke University | Method of treating cancer using selective estrogen receptor modulators |
WO2015149045A1 (en) | 2014-03-28 | 2015-10-01 | Duke University | Method of treating cancer using selective estrogen receptor modulators |
EP3143019B1 (en) * | 2014-05-15 | 2020-12-16 | Pfizer Inc | Crystalline form of 6-[(4r)-4-methyl-1,2-dioxido-1,2,6-thiadiazinan-2-yl]isoquinoline-1-carbonitrile |
RU2016146826A (ru) * | 2014-05-30 | 2018-07-04 | Пфайзер Инк. | Производные карбонитрилов как селективные модуляторы андрогенового рецептора |
JP6982495B2 (ja) | 2014-08-06 | 2021-12-17 | ゼリス ファーマシューティカルズ インコーポレイテッド | ペーストの皮内および/または皮下注射のためのシリンジ、キット、および方法 |
US9452174B2 (en) * | 2014-08-20 | 2016-09-27 | Professional Compounding Centers Of America | Oral transmucosal pharmaceutical compositions including testosterone and a C-SERM |
JOP20180072A1 (ar) * | 2014-09-11 | 2019-01-30 | Lilly Co Eli | علاج الأعراض المرتبطة بالعلاج بالحرمان من الأندروجين |
WO2016061135A1 (en) * | 2014-10-18 | 2016-04-21 | Vicus Therapeutics, Llc | Drug combinations with selective androgen receptor modulators (sarms) and methods of making and using them |
US10654809B2 (en) | 2016-06-10 | 2020-05-19 | University Of Tennessee Research Foundation | Selective androgen receptor degrader (SARD) ligands and methods of use thereof |
US10441570B2 (en) | 2015-04-21 | 2019-10-15 | University Of Tennessee Research Foundation | Selective androgen receptor degrader (SARD) Ligands and methods of use thereof |
US10035763B2 (en) | 2015-04-21 | 2018-07-31 | Gtx, Inc. | Selective androgen receptor degrader (SARD) ligands and methods of use thereof |
US9834507B2 (en) | 2015-04-21 | 2017-12-05 | University Of Tennessee Research Foundation | Selective androgen receptor degrader (SARD) ligands and methods of use thereof |
US9814698B2 (en) | 2015-04-21 | 2017-11-14 | University Of Tennessee Research Foundation | Selective androgen receptor degrader (SARD) ligands and methods of use thereof |
US10806720B2 (en) | 2015-04-21 | 2020-10-20 | University Of Tennessee Research Foundation | Selective androgen receptor degrader (SARD) ligands and methods of use thereof |
MX2017013565A (es) | 2015-04-21 | 2018-02-19 | Gtx Inc | Ligandos degradadores selectivos del receptor androgénico (sard) y sus métodos uso. |
US10093613B2 (en) | 2015-04-21 | 2018-10-09 | Gtx, Inc. | Selective androgen receptor degrader (SARD) ligands and methods of use thereof |
US10017471B2 (en) | 2015-04-21 | 2018-07-10 | University Of Tennessee Research Foundation | Selective androgen receptor degrader (SARD) ligands and methods of use thereof |
US10865184B2 (en) | 2015-04-21 | 2020-12-15 | University Of Tennessee Research Foundation | Selective androgen receptor degrader (SARD) ligands and methods of use thereof |
US9649364B2 (en) | 2015-09-25 | 2017-05-16 | Xeris Pharmaceuticals, Inc. | Methods for producing stable therapeutic formulations in aprotic polar solvents |
US11590205B2 (en) | 2015-09-25 | 2023-02-28 | Xeris Pharmaceuticals, Inc. | Methods for producing stable therapeutic glucagon formulations in aprotic polar solvents |
CN108883083A (zh) * | 2016-02-25 | 2018-11-23 | 艾森潘帕克制药股份有限公司 | 两种氯米芬异构体的口服剂型及使用其治疗继发性腺功能减退症的方法 |
US11230523B2 (en) | 2016-06-10 | 2022-01-25 | University Of Tennessee Research Foundation | Selective androgen receptor degrader (SARD) ligands and methods of use thereof |
PT3474841T (pt) | 2016-06-22 | 2022-06-20 | Radius Health Inc | Métodos de tratamento do cancro de mama ar+ |
KR20230109795A (ko) | 2017-01-05 | 2023-07-20 | 래디어스 파마슈티컬스, 인코포레이티드 | Rad1901-2hcl의 다형 형태 |
US10603328B2 (en) * | 2017-04-28 | 2020-03-31 | City Of Hope | Methods of treating advanced prostate cancer |
KR20210030393A (ko) | 2018-07-04 | 2021-03-17 | 래디어스 파마슈티컬스, 인코포레이티드 | Rad1901-2hcl의 다형 형태 |
EP3956309A4 (en) * | 2019-04-19 | 2023-06-07 | Ligand Pharmaceuticals Inc. | CRYSTALLINE FORMS AND METHODS FOR PRODUCING CRYSTALLINE FORMS OF A COMPOUND |
US20230012570A1 (en) * | 2019-11-20 | 2023-01-19 | Medshine Discovery Inc. | Bicyclic compound used as selective androgen receptor modulator |
WO2021098810A1 (zh) * | 2019-11-20 | 2021-05-27 | 南京明德新药研发有限公司 | 用作选择性雄激素受体调节剂的化合物 |
US11904006B2 (en) | 2019-12-11 | 2024-02-20 | University Of Iowa Research Foundation | Poly(diaminosulfide) particle-based vaccine |
KR20230004498A (ko) * | 2020-04-17 | 2023-01-06 | 에싸 파마 아이엔씨. | N-말단 도메인 안드로겐 수용체 억제제의 고형분 형태 및 이의 용도 |
WO2022082183A1 (en) * | 2020-10-13 | 2022-04-21 | The Regents Of The University Of California | Compounds and methods for the treatment of inflammatory and metabolic diseases |
EP4001293A1 (de) * | 2020-11-23 | 2022-05-25 | Justus-Liebig-Universität Gießen | Tetrapeptid und dessen verwendung |
CN113024513A (zh) * | 2021-03-22 | 2021-06-25 | 中国药科大学 | 新型雄激素受体降解剂、制备方法和医药用途 |
CN113327235B (zh) * | 2021-06-04 | 2022-07-01 | 杭州健培科技有限公司 | 基于ct影像肌少症评估的图像处理方法和装置 |
WO2022271951A1 (en) | 2021-06-23 | 2022-12-29 | University Of Iowa Research Foundation | Sustained release formulations comprising a selective androgen receptor modulator |
WO2023028003A1 (en) * | 2021-08-23 | 2023-03-02 | Oxygen Biotech LLC | Treatment of covid-19 |
WO2024046605A1 (en) | 2022-09-02 | 2024-03-07 | National Center For Scientific Research "Demokritos" | Compounds for the detection of ligandrol |
CN115656392B (zh) * | 2022-12-14 | 2023-04-07 | 山东大学齐鲁医院 | 尿液代谢物在制备鉴别子宫内膜癌保留生育功能治疗孕激素耐药患者的产品中的应用 |
Family Cites Families (179)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US273995A (en) | 1883-03-13 | Jesse w | ||
US3710795A (en) | 1970-09-29 | 1973-01-16 | Alza Corp | Drug-delivery device with stretched, rate-controlling membrane |
GB1429184A (en) | 1972-04-20 | 1976-03-24 | Allen & Hanburys Ltd | Physically anti-inflammatory steroids for use in aerosols |
US4044126A (en) | 1972-04-20 | 1977-08-23 | Allen & Hanburys Limited | Steroidal aerosol compositions and process for the preparation thereof |
USRE28819E (en) | 1972-12-08 | 1976-05-18 | Syntex (U.S.A.) Inc. | Dialkylated glycol compositions and medicament preparations containing same |
US4319039A (en) | 1979-06-15 | 1982-03-09 | Merck & Co., Inc. | Preparation of ammonium salt of hypocholesteremic fermentation product |
US4294926A (en) | 1979-06-15 | 1981-10-13 | Merck & Co., Inc. | Hypocholesteremic fermentation products and process of preparation |
US4231938A (en) | 1979-06-15 | 1980-11-04 | Merck & Co., Inc. | Hypocholesteremic fermentation products and process of preparation |
US4444784A (en) | 1980-08-05 | 1984-04-24 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
DK149080C (da) | 1980-06-06 | 1986-07-28 | Sankyo Co | Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre |
US4328245A (en) | 1981-02-13 | 1982-05-04 | Syntex (U.S.A.) Inc. | Carbonate diester solutions of PGE-type compounds |
US4410545A (en) | 1981-02-13 | 1983-10-18 | Syntex (U.S.A.) Inc. | Carbonate diester solutions of PGE-type compounds |
US4358603A (en) | 1981-04-16 | 1982-11-09 | Syntex (U.S.A.) Inc. | Acetal stabilized prostaglandin compositions |
JPS5889191A (ja) | 1981-11-20 | 1983-05-27 | Sankyo Co Ltd | 3−ヒドロキシ−ml−236b誘導体の製造法 |
US4409239A (en) | 1982-01-21 | 1983-10-11 | Syntex (U.S.A.) Inc. | Propylene glycol diester solutions of PGE-type compounds |
US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
FR2531088B1 (fr) | 1982-07-29 | 1987-08-28 | Sanofi Sa | Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation |
US5354772A (en) | 1982-11-22 | 1994-10-11 | Sandoz Pharm. Corp. | Indole analogs of mevalonolactone and derivatives thereof |
US4911165A (en) | 1983-01-12 | 1990-03-27 | Ethicon, Inc. | Pliabilized polypropylene surgical filaments |
US4729999A (en) | 1984-10-12 | 1988-03-08 | Bcm Technologies | Antiestrogen therapy for symptoms of estrogen deficiency |
US4761406A (en) | 1985-06-06 | 1988-08-02 | The Procter & Gamble Company | Regimen for treating osteoporosis |
US4681893A (en) | 1986-05-30 | 1987-07-21 | Warner-Lambert Company | Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis |
DE3623397A1 (de) | 1986-07-11 | 1988-01-14 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
US5071773A (en) | 1986-10-24 | 1991-12-10 | The Salk Institute For Biological Studies | Hormone receptor-related bioassays |
US4782084A (en) | 1987-06-29 | 1988-11-01 | Merck & Co., Inc. | HMG-COA reductase inhibitors |
US4885314A (en) | 1987-06-29 | 1989-12-05 | Merck & Co., Inc. | Novel HMG-CoA reductase inhibitors |
US4820850A (en) | 1987-07-10 | 1989-04-11 | Merck & Co., Inc. | Process for α-C-alkylation of the 8-acyl group on mevinolin and analogs thereof |
US4981784A (en) | 1987-12-02 | 1991-01-01 | The Salk Institute For Biological Studies | Retinoic acid receptor method |
US5033252A (en) | 1987-12-23 | 1991-07-23 | Entravision, Inc. | Method of packaging and sterilizing a pharmaceutical product |
US5052558A (en) | 1987-12-23 | 1991-10-01 | Entravision, Inc. | Packaged pharmaceutical product |
CA1339805C (en) | 1988-01-20 | 1998-04-07 | Yasuo Isomura | (cycloalkylamino)methylenebis(phosphonic acid) and medicines containing the same as an active |
US5180589A (en) | 1988-03-31 | 1993-01-19 | E. R. Squibb & Sons, Inc. | Pravastatin pharmaceuatical compositions having good stability |
US5030447A (en) | 1988-03-31 | 1991-07-09 | E. R. Squibb & Sons, Inc. | Pharmaceutical compositions having good stability |
US4916239A (en) | 1988-07-19 | 1990-04-10 | Merck & Co., Inc. | Process for the lactonization of mevinic acids and analogs thereof |
US5290946A (en) | 1988-10-13 | 1994-03-01 | Sandoz Ltd. | Processes for the synthesis of 3-(substituted indolyl-2-yl)propenaldehydes |
US5118853A (en) | 1988-10-13 | 1992-06-02 | Sandoz Ltd. | Processes for the synthesis of 3-disubstituted aminoacroleins |
US4929437A (en) | 1989-02-02 | 1990-05-29 | Merck & Co., Inc. | Coenzyme Q10 with HMG-CoA reductase inhibitors |
US5189164A (en) | 1989-05-22 | 1993-02-23 | Sandoz Ltd. | Processes for the synthesis of syn-(E)-3,5-dihydroxy-7-substituted hept-6-enoic and heptanoic acids and derivatives and intermediates thereof |
FI94339C (fi) | 1989-07-21 | 1995-08-25 | Warner Lambert Co | Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi |
US6710066B2 (en) | 1989-07-28 | 2004-03-23 | Queen's University At Kingston | Photochemotherapeutic method using 5-aminolevulinic acid and other precursors of endogenous porphyrins |
US5177080A (en) | 1990-12-14 | 1993-01-05 | Bayer Aktiengesellschaft | Substituted pyridyl-dihydroxy-heptenoic acid and its salts |
US7115554B1 (en) | 1993-05-06 | 2006-10-03 | Acorda Therapeutics, Inc. | Methods of increasing myotube formation or survival or muscle cell mitogenesis differentiation or survival using neuregulin GGF III |
US5217994A (en) | 1991-08-09 | 1993-06-08 | Merck & Co., Inc. | Method of inhibiting osteoclast-mediated bone resorption by administration of aminoalkyl-substituted phenyl derivatives |
US5204350A (en) | 1991-08-09 | 1993-04-20 | Merck & Co., Inc. | Method of inhibiting osteoclast-mediated bone resorption by administration of n-heterocyclicalkyl-substituted phenyl derivatives |
HU9203780D0 (en) | 1991-12-12 | 1993-03-29 | Sandoz Ag | Stabilized pharmaceutical products of hmg-coa reductase inhibitor and method for producing them |
US7037888B1 (en) | 1992-04-03 | 2006-05-02 | Acorda Therapeutics, Inc. | Methods for treating muscle diseases and disorders |
US5576324A (en) | 1992-05-01 | 1996-11-19 | Kowa Co., Ltd. | Quinoline derivatives or salt thereof and remedy for cardiac diseases containing the same |
US5323907A (en) | 1992-06-23 | 1994-06-28 | Multi-Comp, Inc. | Child resistant package assembly for dispensing pharmaceutical medications |
TW366342B (en) | 1992-07-28 | 1999-08-11 | Lilly Co Eli | The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss |
US5298627A (en) | 1993-03-03 | 1994-03-29 | Warner-Lambert Company | Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
US5952281A (en) | 1993-08-04 | 1999-09-14 | Colgate Palmolive Company | Aqueous cleaning composition which may be in microemulsion form containing a silicone antifoam agent |
TW257765B (es) | 1993-08-25 | 1995-09-21 | Merck & Co Inc | |
US5510517A (en) | 1993-08-25 | 1996-04-23 | Merck & Co., Inc. | Process for producing N-amino-1-hydroxy-alkylidene-1,1-bisphosphonic acids |
DE4332384A1 (de) | 1993-09-23 | 1995-03-30 | Merck Patent Gmbh | Adhäsionsrezeptor-Antagonisten III |
US5501969A (en) | 1994-03-08 | 1996-03-26 | Human Genome Sciences, Inc. | Human osteoclast-derived cathepsin |
US5741796A (en) | 1994-05-27 | 1998-04-21 | Merck & Co., Inc. | Pyridyl and naphthyridyl compounds for inhibiting osteoclast-mediated bone resorption |
US5639754A (en) | 1994-07-12 | 1997-06-17 | Janssen Pharmaceutica N.V. | Urea and thiourea derivatives of azolones |
US5736357A (en) | 1994-10-27 | 1998-04-07 | Arris Pharmaceutical | Cathespin O protease |
US5688808A (en) | 1994-12-22 | 1997-11-18 | Ligand Pharmaceuticals Incorporated | Steroid receptor modulator compounds and methods |
US5710159A (en) | 1996-05-09 | 1998-01-20 | The Dupont Merck Pharmaceutical Company | Integrin receptor antagonists |
US5780426A (en) | 1995-06-07 | 1998-07-14 | Ixsys, Incorporated | Fivemer cyclic peptide inhibitors of diseases involving αv β3 |
US6008213A (en) | 1995-06-29 | 1999-12-28 | Smithkline Beecham Corporation | Integrin receptor antagonists |
ATE203234T1 (de) | 1995-08-30 | 2001-08-15 | Searle & Co | Meta-guanidine, harnstoff, thioharnstoff oder azacyklische aminobenzoesäure-derivate als integrin antagonisten |
US5760028A (en) | 1995-12-22 | 1998-06-02 | The Dupont Merck Pharmaceutical Company | Integrin receptor antagonists |
PL327626A1 (en) | 1995-12-29 | 1998-12-21 | Smithkline Beecham Corp | Antagonists of vitronectin receptor |
EP0889876B1 (en) | 1996-03-29 | 2001-07-25 | G.D. SEARLE & CO. | Meta-substituted phenylene sulphonamide derivatives |
EP0894084B1 (en) | 1996-03-29 | 2002-06-26 | G.D. Searle & Co. | Cinnamic acid derivatives and their use as integrin antagonists |
EP0889875B1 (en) | 1996-03-29 | 2001-06-20 | G.D. Searle & Co. | Cyclopropyl alkanoic acid derivatives |
ATE204857T1 (de) | 1996-03-29 | 2001-09-15 | Searle & Co | Meta-substituierte phenylenderivate und ihre verwendung als alphavbeta3 intergrin-antagonisten oder inhibitoren |
US5925655A (en) | 1996-04-10 | 1999-07-20 | Merck & Co., Inc. | αv β3 antagonists |
US7011812B1 (en) | 1996-05-03 | 2006-03-14 | Immunomedics, Inc. | Targeted combination immunotherapy of cancer and infectious diseases |
US6017924A (en) | 1996-06-27 | 2000-01-25 | Ligand Pharmaceuticals Incorporated | Androgen receptor modulator compounds and methods |
US5981546A (en) | 1996-08-29 | 1999-11-09 | Merck & Co., Inc. | Integrin antagonists |
US7053263B2 (en) | 1996-10-15 | 2006-05-30 | The Regents Of The University Of California | Mouse models of human prostate cancer progression |
US5952341A (en) | 1996-10-30 | 1999-09-14 | Merck & Co., Inc. | Integrin antagonists |
US5919792A (en) | 1996-10-30 | 1999-07-06 | Merck & Co., Inc. | Integrin antagonists |
US6995284B2 (en) | 2000-08-24 | 2006-02-07 | The University Of Tennessee Research Foundation | Synthesis of selective androgen receptor modulators |
US7205437B2 (en) | 1996-11-27 | 2007-04-17 | University Of Tennessee Research Foundation | Selective androgen receptor modulators |
AU749658C (en) | 1996-12-23 | 2004-04-29 | Elan Pharmaceuticals, Inc. | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds |
CO4920232A1 (es) | 1997-01-08 | 2000-05-29 | Smithkline Beecham Corp | Acidos aceticos dibenzo [a,d] cicloheptano con actividad antagonista del receptor de vitronectin |
US6017925A (en) | 1997-01-17 | 2000-01-25 | Merck & Co., Inc. | Integrin antagonists |
US6017926A (en) | 1997-12-17 | 2000-01-25 | Merck & Co., Inc. | Integrin receptor antagonists |
US6048861A (en) | 1997-12-17 | 2000-04-11 | Merck & Co., Inc. | Integrin receptor antagonists |
US6066648A (en) | 1997-12-17 | 2000-05-23 | Merck & Co., Inc. | Integrin receptor antagonists |
EP1054871A2 (en) | 1998-04-01 | 2000-11-29 | Du Pont Pharmaceuticals Company | Pyrimidines and triazines as integrin antagonists |
CA2325389A1 (en) | 1998-06-22 | 1999-12-29 | James E. Audia | Compounds for inhibiting beta-amyloid peptide release and/or its synthesis |
CA2338275A1 (en) | 1998-07-29 | 2000-02-10 | Merck & Co., Inc. | Integrin receptor antagonists |
HRP990246A2 (en) | 1998-08-07 | 2000-06-30 | Du Pont Pharm Co | Succinoylamino benzodiazepines as inhibitors of a beta protein production |
WO2000012512A1 (en) | 1998-08-28 | 2000-03-09 | Destiny Pharma Limited | Porphyrin derivatives, their use in photodynamic therapy and medical devices containing them |
US6596298B2 (en) | 1998-09-25 | 2003-07-22 | Warner-Lambert Company | Fast dissolving orally comsumable films |
WO2000038618A2 (en) | 1998-12-24 | 2000-07-06 | Du Pont Pharmaceuticals Company | SUCCINOYLAMINO BENZODIAZEPINES AS INHIBITORS OF Aβ PROTEIN PRODUCTION |
US6602274B1 (en) | 1999-01-15 | 2003-08-05 | Light Sciences Corporation | Targeted transcutaneous cancer therapy |
US6162242A (en) | 1999-01-21 | 2000-12-19 | Peyman; Gholam A. | Selective photodynamic treatment |
CN1345334A (zh) | 1999-01-29 | 2002-04-17 | 伊姆克罗尼系统公司 | 对kdr特异的抗体及其应用 |
CN1348442A (zh) | 1999-02-26 | 2002-05-08 | 默克公司 | 新的磺胺化合物及其应用 |
WO2000061186A1 (en) | 1999-04-08 | 2000-10-19 | Arch Development Corporation | Use of anti-vegf antibody to enhance radiation in cancer therapy |
US6566372B1 (en) | 1999-08-27 | 2003-05-20 | Ligand Pharmaceuticals Incorporated | Bicyclic androgen and progesterone receptor modulator compounds and methods |
DE60027443D1 (de) | 1999-08-27 | 2006-05-24 | Ligand Pharm Inc | Androgenrezeptor-modulatorverbindungen und verfahren |
AU6941200A (en) | 1999-08-27 | 2001-03-26 | Ligand Pharmaceuticals Incorporated | 8-substituted-6-trifluoromethyl-9-pyrido(3,2-g)quinoline compounds as androgen receptor modulators |
US6420364B1 (en) | 1999-09-13 | 2002-07-16 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compound useful as reversible inhibitors of cysteine proteases |
BR0014269A (pt) | 1999-09-13 | 2002-07-02 | Bristol Myers Squibb Pharma Co | Compostos de lactamas, seus sais e pró-drogas farmaceuticamente aceitáveis, composição farmacêutica, método de tratamento de disfunções neurológicas associadas com a produção de "beta"-amilóide, método de inibição da atividade da "alfa"-secretase e usos dos compostos |
AU7997700A (en) | 1999-10-08 | 2001-04-23 | Du Pont Pharmaceuticals Company | Amino lactam sulfonamides as inhibitors of abeta protein production |
CA2388750A1 (en) | 1999-11-09 | 2001-05-17 | James Edmund Audia | .beta.-aminoacid compounds useful for inhibiting .beta.-amyloid peptide release and/or its synthesis |
EP1230220A1 (en) | 1999-11-09 | 2002-08-14 | Eli Lilly And Company | Beta-aminoacid compounds useful for inhibiting beta-amyloid peptide release and/or its synthesis |
CA2396257A1 (en) | 2000-01-06 | 2001-07-12 | Merck Frosst Canada & Co./Merck Frosst Canada & Cie | Novel compounds and compositions as protease inhibitors |
CA2397665A1 (en) | 2000-01-24 | 2001-07-26 | Merck & Co., Inc. | Alpha v integrin receptor antagonists |
US6756511B2 (en) | 2000-01-24 | 2004-06-29 | Merck Sharp & Dohme Limited | Gamma-secretase inhibitors |
WO2001060826A2 (en) | 2000-02-17 | 2001-08-23 | Bristol-Myers Squibb Pharma Company | SUCCINOYLAMINO CARBOCYCLES AND HETEROCYCLES AS INHIBITORS OF Aβ PROTEIN PRODUCTION |
WO2001062259A1 (en) | 2000-02-25 | 2001-08-30 | Hollis Eden Pharmaceuticals | Method of treatment of prostate cancer |
GB0005251D0 (en) | 2000-03-03 | 2000-04-26 | Merck Sharp & Dohme | Therapeutic compounds |
AU2001240861B2 (en) | 2000-03-20 | 2006-03-30 | Merck Frosst Canada Ltd | Sulphonamido-substituted bridged bicycloalkyl derivatives |
US7067116B1 (en) | 2000-03-23 | 2006-06-27 | Warner-Lambert Company Llc | Fast dissolving orally consumable solid film containing a taste masking agent and pharmaceutically active agent at weight ratio of 1:3 to 3:1 |
EP1268454A1 (en) | 2000-03-31 | 2003-01-02 | Bristol-Myers Squibb Pharma Company | Succinoylamino heterocycles as inhibitors of a-beta protein production |
AU2001253108A1 (en) | 2000-04-03 | 2001-10-15 | Bristol-Myers Squibb Pharma Company | Cyclic lactams as inhibitors of a-beta protein production |
WO2001074783A1 (en) | 2000-04-03 | 2001-10-11 | Dupont Pharmaceuticals Company | Cyclic lactams as inhibitors of a βετα protein production |
US6835727B2 (en) | 2000-04-06 | 2004-12-28 | Merck Frosst Canada & Co. | Cathepsin cysteine protease inhibitors |
GB0008710D0 (en) | 2000-04-07 | 2000-05-31 | Merck Sharp & Dohme | Therapeutic compounds |
WO2001077086A1 (en) | 2000-04-11 | 2001-10-18 | Dupont Pharmaceuticals Company | SUBSTITUTED LACTAMS AS INHIBITORS OF Aβ PROTEIN PRODUCTION |
GB0012671D0 (en) | 2000-05-24 | 2000-07-19 | Merck Sharp & Dohme | Therapeutic agents |
MXPA02000862A (es) | 2000-06-01 | 2003-07-14 | Bristol Myers Squibb Pharma Co | Lactamas substituidas por succinatos ciclicos como inhibidores de la produccion de proteina abeta. |
US7291673B2 (en) | 2000-06-02 | 2007-11-06 | Eidgenossiche Technische Hochschule Zurich | Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds |
US6806284B1 (en) | 2000-06-22 | 2004-10-19 | Ceram Optec Industries, Inc. | Photosensitizers with ligand targeting properties for tumor therapy |
AU8821301A (en) | 2000-06-28 | 2002-01-08 | Bristol Myers Squibb Co | Selective androgen receptor modulators and methods for their identification, design and use |
AU2001267904A1 (en) | 2000-06-30 | 2002-01-14 | Chugai Seiyaku Kabushiki Kaisha | Novel antiandrogenic agent |
US6432944B1 (en) | 2000-07-06 | 2002-08-13 | Bristol-Myers Squibb Company | Benzodiazepinone β-amyloid inhibitors: arylacetamidoalanyl derivatives |
AU2001277935B2 (en) | 2000-07-26 | 2005-08-04 | Merck & Co., Inc. | Alpha v integrin receptor antagonists |
US7026500B2 (en) | 2000-08-24 | 2006-04-11 | University Of Tennessee Research Foundation | Halogenated selective androgen receptor modulators and methods of use thereof |
US7855229B2 (en) | 2000-08-24 | 2010-12-21 | University Of Tennessee Research Foundation | Treating wasting disorders with selective androgen receptor modulators |
DE60124322T2 (de) | 2000-08-24 | 2007-05-31 | University Of Tennessee Research Foundation, Knoxville | Selektive modulatoren des androgenrezeptors und methoden zu deren verwendung |
US6998500B2 (en) | 2000-08-24 | 2006-02-14 | University Of Tennessee Research Foundation | Selective androgen receptor modulators and methods of use thereof |
US6838484B2 (en) | 2000-08-24 | 2005-01-04 | University Of Tennessee Research Foundation | Formulations comprising selective androgen receptor modulators |
IL154425A0 (en) | 2000-08-24 | 2003-09-17 | Univ Tennessee Res H Corp | Selective androgen receptor modulators and methods of use thereof |
JP2002088073A (ja) | 2000-09-08 | 2002-03-27 | Yamanouchi Pharmaceut Co Ltd | 抗アンドロゲン剤 |
GB0025173D0 (en) | 2000-10-13 | 2000-11-29 | Merck Sharp & Dohme | Therapeutic agents |
DE60112957T2 (de) | 2000-11-02 | 2006-05-18 | Merck Sharp & Dohme Ltd., Hoddesdon | Sulfamide als gamma-secretase-inhibitoren |
UA74849C2 (en) | 2000-11-17 | 2006-02-15 | Lilly Co Eli | Lactam |
AU2002245123B2 (en) | 2000-12-13 | 2007-05-24 | Arqule, Inc. | Heterocyclic sulfonamide inhibitors of beta amyloid production |
US7214690B2 (en) * | 2001-02-23 | 2007-05-08 | Ligand Pharmaceuticals Incorporated | Tricyclic quinolinone and tricyclic quinoline androgen receptor modulator compounds and methods |
US7026484B2 (en) | 2001-02-23 | 2006-04-11 | Ligand Pharmaceuticals Incorporated | Tricyclic androgen receptor modulator compounds and methods |
DE60229114D1 (en) | 2001-03-02 | 2008-11-13 | Axys Pharm Inc | Cathepsincystein-proteasehemmer |
GB0108592D0 (en) | 2001-04-05 | 2001-05-23 | Merck Sharp & Dohme | Therapeutic agents |
GB0108591D0 (en) | 2001-04-05 | 2001-05-23 | Merck Sharp & Dohme | Therapeutic agents |
US7157604B2 (en) | 2001-08-13 | 2007-01-02 | Merck & Co., Inc. | Selective estrogen receptor modulators |
MXPA04001607A (es) | 2001-08-21 | 2004-07-08 | Merck Sharp & Dohme | Ciclohexilsulfonas novedosas. |
GB0120347D0 (en) | 2001-08-21 | 2001-10-17 | Merck Sharp & Dohme | Therapeutic agents |
AR036375A1 (es) | 2001-08-30 | 2004-09-01 | Novartis Ag | Compuestos pirrolo [2,3-d] pirimidina -2- carbonitrilo, un proceso para su preparacion, una composicion farmaceutica y el uso de dichos compuestos para la preparacion de medicamentos |
EP1439841B1 (en) | 2001-10-19 | 2007-09-19 | Merck & Co., Inc. | Androgen receptor modulators and methods of use thereof |
CA2465416A1 (en) | 2001-11-06 | 2003-05-15 | Merck & Co., Inc. | Amine salts of an integrin receptor antagonist |
BR0214801A (pt) | 2001-11-29 | 2005-01-11 | Gtx Inc | Prevenção e tratamento de osteoporose induzida pela privação de andrógeno |
DK1463497T3 (da) | 2001-12-06 | 2012-01-30 | Gtx Inc | Behandling af muskelsvind med selektive androgenreceptormodulatorer |
IL163825A0 (en) | 2002-03-13 | 2005-12-18 | Merck & Co Inc | Fluorinated 4-azasteroid derivatives as androgen receptor modulators |
US6723750B2 (en) | 2002-03-15 | 2004-04-20 | Allergan, Inc. | Photodynamic therapy for pre-melanomas |
ATE481397T1 (de) | 2002-04-24 | 2010-10-15 | Merck Sharp & Dohme | Modulatoren des östrogenrezeptors |
CA2484340C (en) * | 2002-04-26 | 2011-05-03 | Ortho-Mcneil Pharmaceutical, Inc. | 2-(quinolonyl)-fused heterocycles as androgen receptor modulators |
EP1534663A4 (en) | 2002-06-17 | 2006-08-30 | Univ Tennessee Res Foundation | SELECTIVE MODULATORS OF THE N-BRIDGE ANDROGEN RECEPTOR AND METHODS OF USE |
US7241411B2 (en) | 2002-08-23 | 2007-07-10 | Acupac Packaging, Inc. | Thin film strips |
WO2004022526A1 (en) | 2002-09-04 | 2004-03-18 | Merck Frosst Canada & Co. | Cathepsin cysteine protease inhibitors |
AU2003287076C1 (en) | 2002-10-15 | 2010-03-04 | University Of Tennessee Research Foundation | Heterocyclic selective androgen receptor modulators and methods of use thereof |
CA2502209A1 (en) | 2002-10-15 | 2004-04-29 | University Of Tennessee Research Foundation | Methylene-bridged selective androgen receptor modulators and methods of use thereof |
US20060148893A1 (en) | 2003-06-10 | 2006-07-06 | Blanc Jean-Baptiste E | Chemical compounds |
CN1838956A (zh) | 2003-08-22 | 2006-09-27 | 配体药物公司 | 作为雄激素受体调节剂化合物的6-环氨基-2-喹啉酮衍生物 |
EP1670483A4 (en) | 2003-09-10 | 2010-02-17 | Merck & Co Inc | 17-heterocyclic 4-azasteroid derivatives as androgen receptor modules |
JP2007511526A (ja) | 2003-11-13 | 2007-05-10 | ディービーシー エルエルシー | 溶解性薄膜キサントン・サプリメント |
TW200530181A (en) | 2004-01-13 | 2005-09-16 | Bristol Myers Squibb Co | Heterocyclic compounds useful as growth hormone secretagogues |
US8519158B2 (en) | 2004-03-12 | 2013-08-27 | Ligand Pharmaceuticals Incorporated | Androgen receptor modulator compounds and methods |
JP4917018B2 (ja) | 2004-05-03 | 2012-04-18 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 選択的アンドローゲン受容体モジュレーター(sarms)としての新規インドール化合物 |
JP2007537236A (ja) | 2004-05-11 | 2007-12-20 | ファイザー・プロダクツ・インク | 筋骨格の脆弱性を治療するためのベンゾニトリル誘導体 |
CA2566942A1 (en) | 2004-05-17 | 2005-12-08 | Acadia Pharmaceuticals Inc. | Androgen receptor modulators and method of treating disease using the same |
UA87854C2 (en) | 2004-06-07 | 2009-08-25 | Мерк Энд Ко., Инк. | N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators |
AR051597A1 (es) | 2004-11-01 | 2007-01-24 | Merck & Co Inc | Moduladores de los receptores de estrogeno |
TW200628446A (en) | 2004-12-14 | 2006-08-16 | Takeda Pharmaceuticals Co | Substituted pyrrole derivative |
US7301026B2 (en) | 2005-05-05 | 2007-11-27 | Merck & Co., Inc | Process for making fluorinated 4-azasteroid derivatives |
CA2608419A1 (en) * | 2005-05-13 | 2006-11-23 | Eli Lilly And Company | Substituted n-arylpyrrolidines as selective androgen receptor modulators |
AU2006259474B2 (en) | 2005-06-17 | 2011-10-27 | Ligand Pharmaceuticals Incorporated | Androgen receptor modulator compounds and methods |
US20090227571A1 (en) | 2005-07-01 | 2009-09-10 | Ligand Pharmaceuticals Incorporated | Androgen Receptor Modulator Compounds and Methods |
JP5070054B2 (ja) | 2005-08-01 | 2012-11-07 | 武田薬品工業株式会社 | 環状アミン化合物 |
WO2007075884A2 (en) | 2005-12-21 | 2007-07-05 | Ligand Pharmaceuticals Incorporated | Androgen receptor modulator compounds and methods |
AR061439A1 (es) | 2006-06-13 | 2008-08-27 | Takeda Pharmaceutical | Derivados sustituidos de pirrol |
PT2222636E (pt) | 2007-12-21 | 2013-07-16 | Ligand Pharm Inc | Moduladores seletivos de recetores de andrógeno (sarms) e suas utilizações |
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