AR061439A1 - Derivados sustituidos de pirrol - Google Patents

Derivados sustituidos de pirrol

Info

Publication number
AR061439A1
AR061439A1 ARP070102559A ARP070102559A AR061439A1 AR 061439 A1 AR061439 A1 AR 061439A1 AR P070102559 A ARP070102559 A AR P070102559A AR P070102559 A ARP070102559 A AR P070102559A AR 061439 A1 AR061439 A1 AR 061439A1
Authority
AR
Argentina
Prior art keywords
optionally substituted
alkyl
optionally
substituted
cyano
Prior art date
Application number
ARP070102559A
Other languages
English (en)
Inventor
S Yamamoto
M Ito
N Matsunaga
M Yamada
T Hitaka
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of AR061439A1 publication Critical patent/AR061439A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Reivindicacion 1: Un compuesto caracterizado por la formula (1) donde R1 representa (1) un átomo de hidrogeno, (2) ciano, (3) un alquilo C1-6 opcionalmente halogenado o (4) un alcoxi C1-6-carbonilo opcionalmente sustituido. R2 y R4 son iguales o diferentes y cada uno representa (1) un átomo de hidrogeno, (2) un alquilo C1-6 (3) un cicloalquilo C3-6, (4) trifluorometilo, (5) un amino-alquilo C3-6, (6) un alquilo C1-C mono-o disustituido, (7) un alquilo C1-6 opcionalmente halogenado sustituido con un hidroxi opcionalmente sustituido (8) un alquenilo C2-6 sustituido con un hidroxi opcionalmente sustituido, (9) un alquilo C1-6 sustituido con un tiol opcionalmente sustituido y opcionalmente oxidado, (10), ciano (11) un acilo, (12) un 1,3-dioxolan-2-ilo, R3 representa (1) un tiazolilo opcionalmente sustituido, (2) un pirazolilo opcionalmente sustituido, (3) un oxazolilo opcionalmente sustituido, (4) un imidazo [1,2,3-triazolilo opcionalmente sustituido, (6) un 1,2,4-triazolilo opcionalmente sustituido o (7) un tetrazolilo opcionalmente sustituido, y R5 representa un fenilo que tiene un ciano en la posicion 4 o 3 y además puede estar sustituido, con la salvedad que están excluidos 4-(4-cianofenil)-1-((4-ciano-1.3-tiazol-2- il)metil)-2,5-dimetil-1H-pirrol-3-carboxilato de metilo, 4-(4-cianofenil)-2,5-dimetil-1-((1-tritil-1H-1,2,3-triazol-4-il) metil-1H-pirrol-3-carbonitrilo y 4-(4-cianofenil)-2,5-dimetil-1-(1H-1,2,3-triazol-4-ilmetil)-1H-pirrol-3-carbonitrilo, o una sal del mismo.
ARP070102559A 2006-06-13 2007-06-12 Derivados sustituidos de pirrol AR061439A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2006163992 2006-06-13

Publications (1)

Publication Number Publication Date
AR061439A1 true AR061439A1 (es) 2008-08-27

Family

ID=38832218

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP070102559A AR061439A1 (es) 2006-06-13 2007-06-12 Derivados sustituidos de pirrol

Country Status (4)

Country Link
AR (1) AR061439A1 (es)
PE (1) PE20080938A1 (es)
TW (1) TW200813007A (es)
WO (1) WO2007145349A2 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104188971B (zh) 2007-12-21 2017-05-03 配体药物公司 选择性雄激素受体调节剂(sarm)及其应用
CN103102325B (zh) * 2013-01-16 2014-11-12 浙江大学宁波理工学院 一种2-溴代甲基-4-羧酸乙酯噻唑的合成方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003057669A1 (fr) * 2001-12-28 2003-07-17 Takeda Chemical Industries, Ltd. Antagonistes du recepteur androgene

Also Published As

Publication number Publication date
PE20080938A1 (es) 2008-09-02
TW200813007A (en) 2008-03-16
WO2007145349A2 (en) 2007-12-21
WO2007145349A3 (en) 2008-04-03

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal