WO2007145349A3 - Substituted pyrrole derivatives - Google Patents

Substituted pyrrole derivatives Download PDF

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Publication number
WO2007145349A3
WO2007145349A3 PCT/JP2007/062194 JP2007062194W WO2007145349A3 WO 2007145349 A3 WO2007145349 A3 WO 2007145349A3 JP 2007062194 W JP2007062194 W JP 2007062194W WO 2007145349 A3 WO2007145349 A3 WO 2007145349A3
Authority
WO
WIPO (PCT)
Prior art keywords
optionally substituted
pyrrole derivatives
cyano
alkyl
hydrogen atom
Prior art date
Application number
PCT/JP2007/062194
Other languages
French (fr)
Other versions
WO2007145349A2 (en
Inventor
Mitsuhiro Ito
Nobuyuki Matsunaga
Masami Yamada
Takenori Hitaka
Satoshi Yamamoto
Original Assignee
Takeda Pharmaceutical
Mitsuhiro Ito
Nobuyuki Matsunaga
Masami Yamada
Takenori Hitaka
Satoshi Yamamoto
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical, Mitsuhiro Ito, Nobuyuki Matsunaga, Masami Yamada, Takenori Hitaka, Satoshi Yamamoto filed Critical Takeda Pharmaceutical
Publication of WO2007145349A2 publication Critical patent/WO2007145349A2/en
Publication of WO2007145349A3 publication Critical patent/WO2007145349A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

The present invention provides novel pyrrole derivatives represented by formula (I): wherein R1 represents a hydrogen atom, cyano, optionally halogenated C1-6 alkyl or an optionally substituted C1-6 alkoxy-carbonyl; R2 and R4 may be the same or different and represent a hydrogen atom, C1-6 alkyl, C2-6 alkenyl substituted with an optionally substituted hydroxy, an optionally substituted or oxidized thiol, etc.; R3 represents an optionally substituted thiazolyl, an optionally substituted pyrazolyl, an optionally substituted oxazolyl, etc.; and R5 represents an optionally substituted phenyl having a cyano at the 4- or 3-position, and androgen receptor antagonists containing the same.
PCT/JP2007/062194 2006-06-13 2007-06-12 Substituted pyrrole derivatives WO2007145349A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006163992 2006-06-13
JP2006-163992 2006-06-13

Publications (2)

Publication Number Publication Date
WO2007145349A2 WO2007145349A2 (en) 2007-12-21
WO2007145349A3 true WO2007145349A3 (en) 2008-04-03

Family

ID=38832218

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2007/062194 WO2007145349A2 (en) 2006-06-13 2007-06-12 Substituted pyrrole derivatives

Country Status (4)

Country Link
AR (1) AR061439A1 (en)
PE (1) PE20080938A1 (en)
TW (1) TW200813007A (en)
WO (1) WO2007145349A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009082437A2 (en) 2007-12-21 2009-07-02 Ligand Pharmaceuticals Incorporated Selective androgen receptor modulators (sarms) and uses thereof
CN103102325B (en) * 2013-01-16 2014-11-12 浙江大学宁波理工学院 Synthetic method of 2-bromomethyl-4-carboxylate imidazole

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1466902A1 (en) * 2001-12-28 2004-10-13 Takeda Chemical Industries, Ltd. Androgen receptor antagonists

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1466902A1 (en) * 2001-12-28 2004-10-13 Takeda Chemical Industries, Ltd. Androgen receptor antagonists

Also Published As

Publication number Publication date
AR061439A1 (en) 2008-08-27
TW200813007A (en) 2008-03-16
WO2007145349A2 (en) 2007-12-21
PE20080938A1 (en) 2008-09-02

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