CR9983A - Compuesto de cinamida bicilico - Google Patents

Compuesto de cinamida bicilico

Info

Publication number
CR9983A
CR9983A CR9983A CR9983A CR9983A CR 9983 A CR9983 A CR 9983A CR 9983 A CR9983 A CR 9983A CR 9983 A CR9983 A CR 9983A CR 9983 A CR9983 A CR 9983A
Authority
CR
Costa Rica
Prior art keywords
group
optionally substituted
cinamide
bicycle
composite
Prior art date
Application number
CR9983A
Other languages
English (en)
Inventor
Kimura Teiji
Kawano Koki
Doi Eriko
Kitazawa Noritaka
Takishi Mamoru
Ito Koichi
Kaneko Toshihiko
Sasaki Takeo
Miyagawa Takehiko
Hagiwara Hiroaki
Yoshida Yu
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Publication of CR9983A publication Critical patent/CR9983A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Un compuesto de cinamida bicíclico representado por la fórmula general (I): en donde representa un enlace sencillo o un enlace doble; Ar1 representa un grupo fenilo o grupo piridinilo opcionalmente substituido por uno hasta tres substituyentes; R1 y R2 cada uno representa un grupo alquilo C1-6, un grupo hidroxilo, etc.; Z1 representa un grupo metileno opcionalmente substituido o grupo vinileno, un átomo de oxígeno, o un grupo imino opcionalmente substituido ppor un grupo alquilo C1-6 o un grupo acilo C1-6.
CR9983A 2005-11-24 2008-05-16 Compuesto de cinamida bicilico CR9983A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2005337963 2005-11-24
JP2006205538 2006-07-28

Publications (1)

Publication Number Publication Date
CR9983A true CR9983A (es) 2008-08-21

Family

ID=38067057

Family Applications (1)

Application Number Title Priority Date Filing Date
CR9983A CR9983A (es) 2005-11-24 2008-05-16 Compuesto de cinamida bicilico

Country Status (26)

Country Link
US (1) US8048878B2 (es)
EP (1) EP1953158B1 (es)
JP (1) JP5178203B2 (es)
KR (1) KR101296239B1 (es)
AR (1) AR057915A1 (es)
AU (1) AU2006317468B2 (es)
BR (1) BRPI0618890A2 (es)
CA (1) CA2629512C (es)
CR (1) CR9983A (es)
EA (1) EA014427B1 (es)
EC (1) ECSP088466A (es)
ES (1) ES2394364T3 (es)
GE (1) GEP20115172B (es)
HK (1) HK1122806A1 (es)
HN (1) HN2008000792A (es)
MA (1) MA29968B1 (es)
ME (1) ME00040B (es)
MY (1) MY144596A (es)
NO (1) NO20082805L (es)
NZ (1) NZ568422A (es)
PE (1) PE20071029A1 (es)
PL (1) PL1953158T3 (es)
RS (1) RS20080242A (es)
SA (1) SA06270432B1 (es)
TW (1) TWI370130B (es)
WO (1) WO2007060821A1 (es)

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US7482345B2 (en) * 2005-12-05 2009-01-27 Meng-Hsin Chen P38 kinase inhibiting agents
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SA07280403B1 (ar) 2006-07-28 2010-12-01 إيساي أر أند دي منجمنت كو. ليمتد ملح رباعي لمركب سيناميد
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CA2689948A1 (en) * 2007-06-01 2008-12-18 Schering Corporation Gamma secretase modulators
JP5121346B2 (ja) * 2007-08-07 2013-01-16 国立大学法人 長崎大学 光学活性プロリンエステル誘導体およびｎ−ホルミル光学活性プロリン誘導体の製造方法
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JP5503663B2 (ja) * 2008-11-13 2014-05-28 メルク・シャープ・アンド・ドーム・コーポレーション ガンマセクレターゼモジュレータ
BRPI1007883A2 (pt) 2009-02-26 2016-02-23 Eisai R&D Man Co Ltd sal, e, cristal.
KR20110122746A (ko) 2009-02-26 2011-11-10 에자이 알앤드디 매니지먼트 가부시키가이샤 질소를 함유하는 융합된 헤테로사이클릭 화합물 및 β 아밀로이드 생산 저해제로서의 용도
JP2012176901A (ja) * 2009-09-25 2012-09-13 Eisai R & D Management Co Ltd 新規ベンゾニトリル化合物およびその製造方法
US8486967B2 (en) 2010-02-17 2013-07-16 Hoffmann-La Roche Inc. Heteroaryl substituted piperidines
KR20130121076A (ko) * 2010-06-15 2013-11-05 에자이 알앤드디 매니지먼트 가부시키가이샤 Ｈｃｖ 감염증 치료제
JP6095208B2 (ja) * 2012-12-04 2017-03-15 学校法人慶應義塾 環化化合物の製造方法、及び、環化化合物を含有する溶液の発光方法
DK3552017T3 (da) * 2016-12-09 2022-05-16 Denali Therapeutics Inc Forbindelser, der er anvendelige som ripk1-inhibitorer
CN110914275A (zh) * 2017-05-17 2020-03-24 戴纳立制药公司 化合物、组合物及方法
WO2021071832A1 (en) * 2019-10-07 2021-04-15 D.E. Shaw Research, Llc Aryl heterobicyclic compounds as kv1.3 potassium shaker channel blockers

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Also Published As

Publication number Publication date
AR057915A1 (es) 2007-12-26
NZ568422A (en) 2010-09-30
GEP20115172B (en) 2011-03-10
MA29968B1 (fr) 2008-11-03
KR101296239B1 (ko) 2013-08-13
EP1953158A1 (en) 2008-08-06
AU2006317468A1 (en) 2007-05-31
US8048878B2 (en) 2011-11-01
KR20080072057A (ko) 2008-08-05
ES2394364T3 (es) 2013-01-31
RS20080242A (xx) 2009-09-08
JPWO2007060821A1 (ja) 2009-05-07
ME00040B (me) 2010-06-10
EA014427B1 (ru) 2010-12-30
JP5178203B2 (ja) 2013-04-10
BRPI0618890A2 (pt) 2013-01-08
AU2006317468B2 (en) 2011-10-13
ECSP088466A (es) 2008-08-29
PE20071029A1 (es) 2007-11-17
SA06270432B1 (ar) 2011-06-22
HN2008000792A (es) 2010-09-17
HK1122806A1 (en) 2009-05-29
EP1953158A4 (en) 2010-09-01
PL1953158T3 (pl) 2013-02-28
WO2007060821A1 (ja) 2007-05-31
EA200801417A1 (ru) 2009-02-27
TWI370130B (en) 2012-08-11
MY144596A (en) 2011-10-14
TW200804372A (en) 2008-01-16
CA2629512A1 (en) 2007-05-31
EP1953158B1 (en) 2012-09-12
US20090181945A1 (en) 2009-07-16
NO20082805L (no) 2008-08-20
CA2629512C (en) 2014-04-22

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